DD261154A5 - Verfahren zur herstellung einer hypoglykaemisch wirksamen thiozolidindion-verbindung - Google Patents

Verfahren zur herstellung einer hypoglykaemisch wirksamen thiozolidindion-verbindung Download PDF

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Publication number
DD261154A5
DD261154A5 DD86290390A DD29039086A DD261154A5 DD 261154 A5 DD261154 A5 DD 261154A5 DD 86290390 A DD86290390 A DD 86290390A DD 29039086 A DD29039086 A DD 29039086A DD 261154 A5 DD261154 A5 DD 261154A5
Authority
DD
German Democratic Republic
Prior art keywords
mixture
compound
mmol
benzyl
oil
Prior art date
Application number
DD86290390A
Other languages
German (de)
English (en)
Inventor
James F Eggler
Gerald F Holland
Michael R Johnson
Robert A Volkmann
Original Assignee
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Publication date
Application filed by ������@���Kk�� filed Critical ������@���Kk��
Publication of DD261154A5 publication Critical patent/DD261154A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Detergent Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Soil Working Implements (AREA)
  • Saccharide Compounds (AREA)
DD86290390A 1985-05-21 1986-05-20 Verfahren zur herstellung einer hypoglykaemisch wirksamen thiozolidindion-verbindung DD261154A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1985/000962 WO1986007056A1 (fr) 1985-05-21 1985-05-21 Diones de thiazolidine hypoglycemique

Publications (1)

Publication Number Publication Date
DD261154A5 true DD261154A5 (de) 1988-10-19

Family

ID=22188690

Family Applications (1)

Application Number Title Priority Date Filing Date
DD86290390A DD261154A5 (de) 1985-05-21 1986-05-20 Verfahren zur herstellung einer hypoglykaemisch wirksamen thiozolidindion-verbindung

Country Status (26)

Country Link
US (1) US4703052A (fr)
EP (1) EP0207605B1 (fr)
JP (1) JPS61271287A (fr)
KR (1) KR870000903B1 (fr)
CN (1) CN1007248B (fr)
AT (1) ATE50256T1 (fr)
AU (2) AU560179B2 (fr)
CA (1) CA1279320C (fr)
DD (1) DD261154A5 (fr)
DE (1) DE3668892D1 (fr)
DK (1) DK233586A (fr)
EG (1) EG18043A (fr)
ES (1) ES8707210A1 (fr)
FI (1) FI89268C (fr)
GR (1) GR861297B (fr)
HU (1) HU210339B (fr)
IE (1) IE58674B1 (fr)
IL (1) IL78831A (fr)
MY (1) MY108496A (fr)
NO (1) NO166448C (fr)
PH (2) PH22313A (fr)
PL (1) PL147479B1 (fr)
PT (1) PT82610B (fr)
WO (1) WO1986007056A1 (fr)
YU (1) YU44573B (fr)
ZA (1) ZA863762B (fr)

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US4791125A (en) * 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
US5130379A (en) * 1988-03-08 1992-07-14 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5120754A (en) * 1988-03-08 1992-06-09 Pfizer Inc. Thiazolidinedione hypoglycemic agents
WO1989008652A1 (fr) * 1988-03-08 1989-09-21 Pfizer Inc. Derives de thiazolidinedione comme agents hypoglycemiques
WO1989008651A1 (fr) * 1988-03-08 1989-09-21 Pfizer Inc. Derives de thiaxolidinedione hypoglycemiques
US5223522A (en) * 1988-03-08 1993-06-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents
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US5330998A (en) * 1988-03-08 1994-07-19 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
US5053420A (en) * 1989-10-13 1991-10-01 Pershadsingh Harrihar A Thiazolidine derivatives for the treatment of hypertension
WO1991007107A1 (fr) * 1989-11-13 1991-05-30 Pfizer Inc. Agents d'oxazolidinedione hypoglycemiques
US5036079A (en) * 1989-12-07 1991-07-30 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5089637A (en) * 1990-03-21 1992-02-18 Pfizer Inc. Process and intermediates for 2r-benzyl-chroman-6-carbaldehyde
EP0454501B1 (fr) * 1990-04-27 2001-09-05 Sankyo Company Limited Dérivés de benzylidène thiazolidines, leur préparation et leur utilisation pour l'inhibition de péroxydes lipidiques
US5037842A (en) * 1990-06-05 1991-08-06 Pfizer Inc. Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
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US5158966A (en) * 1991-02-22 1992-10-27 The University Of Colorado Foundation, Inc. Method of treating type i diabetes
TW222626B (fr) 1991-07-22 1994-04-21 Pfizer
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US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
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JP2845743B2 (ja) * 1992-12-28 1999-01-13 三菱化学株式会社 新規なナフタレン誘導体
US5594016A (en) * 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
JP3195455B2 (ja) * 1993-01-06 2001-08-06 ウェルファイド株式会社 キノリン−３−酢酸誘導体、その製造法と用途
DE4317320A1 (de) * 1993-05-25 1994-12-01 Boehringer Mannheim Gmbh Neue Thiazolidindione und diese enthaltende Arzneimittel
US6046222A (en) * 1993-09-15 2000-04-04 Warner-Lambert Company Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
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US6878749B2 (en) 1999-09-17 2005-04-12 Novartis Ag Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
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Also Published As

Publication number Publication date
NO870241L (no) 1987-03-20
KR860009010A (ko) 1986-12-19
AU5758086A (en) 1987-01-08
PT82610B (pt) 1988-11-30
ES8707210A1 (es) 1987-07-16
IE58674B1 (en) 1993-11-03
HU210339B (en) 1995-03-28
PL147479B1 (en) 1989-06-30
NO870241D0 (no) 1987-01-20
DE3668892D1 (en) 1990-03-15
JPS61271287A (ja) 1986-12-01
ZA863762B (en) 1988-05-25
DK233586D0 (da) 1986-05-20
JPH0586953B2 (fr) 1993-12-14
WO1986007056A1 (fr) 1986-12-04
EP0207605B1 (fr) 1990-02-07
AU560179B2 (en) 1987-04-02
HUT45247A (en) 1988-06-28
NO166448B (no) 1991-04-15
DK233586A (da) 1986-11-22
YU83786A (en) 1987-12-31
KR870000903B1 (ko) 1987-05-04
IL78831A0 (en) 1986-09-30
ATE50256T1 (de) 1990-02-15
AU583991B2 (en) 1989-05-11
AU7507487A (en) 1987-10-15
YU44573B (en) 1990-10-31
GR861297B (en) 1986-09-16
PH22313A (en) 1988-07-29
FI89268C (fi) 1993-09-10
IL78831A (en) 1990-11-29
FI870219L (fi) 1987-01-20
IE861336L (en) 1986-11-21
PT82610A (en) 1986-06-01
ES555147A0 (es) 1987-07-16
MY108496A (en) 1996-10-31
CN1007248B (zh) 1990-03-21
CN86104075A (zh) 1987-03-11
EP0207605A1 (fr) 1987-01-07
FI870219A0 (fi) 1987-01-20
US4703052A (en) 1987-10-27
FI89268B (fi) 1993-05-31
EG18043A (en) 1992-11-30
NO166448C (no) 1991-07-24
CA1279320C (fr) 1991-01-22
PH25226A (en) 1991-03-27

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