IL80319A - 4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL80319A
Authority: IL; Israel
Prior art keywords: sub; pyrrolo; imidazo; oxadiazolyl; dihydro
Prior art date: 1985-10-17

Application number

IL80319A

Other languages

English (en)

Original Assignee

Ferrosan As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-17

Filing date

1986-10-15

Publication date

1990-03-19

1986-10-15 Application filed by Ferrosan As filed Critical Ferrosan As

1990-03-19 Publication of IL80319A publication Critical patent/IL80319A/xx

Links

238000002360 preparation method Methods 0.000 title abstract 2
125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000000895 acaricidal effect Effects 0.000 abstract 1
239000000642 acaricide Substances 0.000 abstract 1
230000000507 anthelmentic effect Effects 0.000 abstract 1
239000000921 anthelmintic agent Substances 0.000 abstract 1
229940124339 anthelmintic agent Drugs 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000003326 hypnotic agent Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
239000002917 insecticide Substances 0.000 abstract 1
239000002664 nootropic agent Substances 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Tropical Medicine & Parasitology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Lubricants (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Cosmetics (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL80319A 1985-10-17 1986-10-15 4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them IL80319A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK476885A DK476885D0 (da)	1985-10-17	1985-10-17	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf

Publications (1)

Publication Number	Publication Date
IL80319A true IL80319A (en)	1990-03-19

Family

ID=8136485

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL80319A IL80319A (en)	1985-10-17	1986-10-15	4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them

Country Status (18)

Country	Link
US (5)	US4774245A (de)
EP (2)	EP0220845A1 (de)
JP (2)	JPH0753731B2 (de)
KR (1)	KR940010034B1 (de)
AT (1)	ATE48844T1 (de)
AU (2)	AU6417886A (de)
CA (2)	CA1275411C (de)
DE (1)	DE3667665D1 (de)
DK (1)	DK476885D0 (de)
ES (1)	ES2014234B3 (de)
FI (2)	FI82050C (de)
GR (1)	GR3000367T3 (de)
IE (1)	IE59642B1 (de)
IL (1)	IL80319A (de)
NO (2)	NO163776C (de)
NZ (2)	NZ217958A (de)
PH (1)	PH22556A (de)
PT (2)	PT83571B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
CA1297099C (en) *	1985-10-17	1992-03-10	Frank Watjen	Quinazoline compounds and their preparation and use
DK174086D0 (da) *	1986-04-16	1986-04-16	Ferrosan As	Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
DK155524C (da) *	1987-03-18	1989-09-11	Ferrosan As	Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) *	1988-06-01	1989-12-15	Ferrosan As	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK161148C (da) *	1988-06-14	1991-11-18	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne
GB8823475D0 (en) *	1988-10-06	1988-11-16	Merck Sharp & Dohme	Chemical compounds
DK626288D0 (da) *	1988-11-10	1988-11-10	Ferrosan As	Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
ATE105839T1 (de) *	1989-03-23	1994-06-15	Pfizer	Antiallergische mittel auf der basis von diazepin.
DK443589D0 (da) *	1989-09-08	1989-09-08	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588389D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588489D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
US5276028A (en) *	1990-06-22	1994-01-04	Nordisk A/S	Imidazoquinoxaline compounds
US5371080A (en) *	1990-06-22	1994-12-06	Novo Nordisk A/S	Imidazoquinazoline compounds and their use
DK151890D0 (da) *	1990-06-22	1990-06-22	Ferrosan As	Heterocykliske forbindelser deres fremstilling og brug
DK41191D0 (da) *	1991-03-07	1991-03-07	Novo Nordisk As	Heterocycliske forbindelser, deres fremstilling og anvendelse
AU657986B2 (en) *	1991-06-14	1995-03-30	Pharmacia & Upjohn Company	Imidazo(1,5-a)quinoxalines
US5561227A (en) *	1991-07-23	1996-10-01	Schering Corporation	Process for the stereospecific synthesis of azetidinones
ES2107548T3 (es) *	1991-07-23	1997-12-01	Schering Corp	Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion.
AU4035893A (en) *	1991-12-17	1993-07-19	Upjohn Company, The	3-substituted imidazo (1,5-a) and imidazo (1,5-a)-triazolo (1,5-c) quinoxalines and quinazolines with cns activity
US5244906A (en) *	1992-01-23	1993-09-14	Dowelanco	Insect control with substituted oxadiazole and thiadiazole compounds
JP3512110B2 (ja) *	1992-02-13	2004-03-29	ファルマシア・アンド・アップジョン・カンパニー	ベンゾジアゼピン受容体結合剤として有用な４−オキソ−および４Ｈ−イミダゾ（５，１−ｃ）（１，４）ベンゾオキサジン類
GB9212486D0 (en) *	1992-06-12	1992-07-22	Erba Carlo Spa	Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation
CA2143246C (en) *	1994-03-16	2000-08-22	Thierry Godel	Imidazodiazepines
GB2328940B (en) *	1997-09-05	1999-12-08	Dong Kook Pharm Co Ltd	A process for preparing benzodiazepine derivatives
JP2009523820A (ja) *	2006-01-23	2009-06-25	アミラファーマシューティカルス，インコーポレーテッド	５−リポキシゲナーゼの三環系抑制剤
WO2009024325A2 (en) *	2007-08-20	2009-02-26	Evotec Neurosciences Gmbh	Treatment of sleep disorders
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
TWI421252B (zh)	2009-07-09	2014-01-01	Irm Llc	用於治療寄生蟲疾病之化合物及組合物
US10189841B2 (en)	2015-11-20	2019-01-29	Forma Therapeutics, Inc.	Purinones as ubiquitin-specific protease 1 inhibitors
TWI791515B (zh)	2017-04-24	2023-02-11	瑞士商諾華公司	治療療法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4118386A (en) *	1977-04-04	1978-10-03	Hoffmann-La Roche Inc.	Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
US4668678A (en) *	1980-05-09	1987-05-26	Usv Pharmaceutical Corporation	Triazoloquinoxalin-1,4-diones
CA1184175A (en) *	1981-02-27	1985-03-19	Walter Hunkeler	Imidazodiazepines
US4440929A (en) *	1981-07-16	1984-04-03	Usv Pharmaceutical Corporation	Imidazoquinoxaline compounds
DK151808C (da) *	1982-11-16	1988-06-20	Ferrosan As	Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
FI850191A7 (fi) *	1984-01-19	1985-07-20	Hoffmann La Roche	Imidatsodiatsepiini-johdannaisia.
US4771051A (en) *	1985-05-17	1988-09-13	A/S Ferrosan	3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
CA1297099C (en) *	1985-10-17	1992-03-10	Frank Watjen	Quinazoline compounds and their preparation and use
FR2598147B1 (fr) *	1986-04-30	1988-08-26	Pasteur Institut	Immunogene isole de mollusques, son procede de preparation, reactifs de diagnostic des bilharzioses humaines, vaccins contre les schistosomiases et compositions immunisantes comprenant ledit immunogene.

1985
- 1985-10-17 DK DK476885A patent/DK476885D0/da not_active Application Discontinuation
1986
- 1986-09-26 US US06/912,776 patent/US4774245A/en not_active Expired - Fee Related
- 1986-09-26 US US06/912,777 patent/US4870073A/en not_active Expired - Fee Related
- 1986-10-01 CA CA000519557A patent/CA1275411C/en not_active Expired - Lifetime
- 1986-10-01 EP EP86307543A patent/EP0220845A1/de not_active Withdrawn
- 1986-10-01 CA CA000519556A patent/CA1293723C/en not_active Expired - Lifetime
- 1986-10-01 AT AT86307542T patent/ATE48844T1/de not_active IP Right Cessation
- 1986-10-01 DE DE8686307542T patent/DE3667665D1/de not_active Expired - Lifetime
- 1986-10-01 ES ES86307542T patent/ES2014234B3/es not_active Expired - Lifetime
- 1986-10-01 EP EP86307542A patent/EP0225013B1/de not_active Expired
- 1986-10-13 NO NO864062A patent/NO163776C/no unknown
- 1986-10-13 FI FI864125A patent/FI82050C/fi not_active IP Right Cessation
- 1986-10-13 FI FI864124A patent/FI864124A7/fi not_active IP Right Cessation
- 1986-10-13 NO NO864061A patent/NO864061L/no unknown
- 1986-10-15 IL IL80319A patent/IL80319A/xx not_active IP Right Cessation
- 1986-10-16 PH PH34375A patent/PH22556A/en unknown
- 1986-10-16 IE IE273386A patent/IE59642B1/en not_active IP Right Cessation
- 1986-10-16 NZ NZ217958A patent/NZ217958A/xx unknown
- 1986-10-16 NZ NZ217957A patent/NZ217957A/xx unknown
- 1986-10-17 AU AU64178/86A patent/AU6417886A/en not_active Abandoned
- 1986-10-17 JP JP61247307A patent/JPH0753731B2/ja not_active Expired - Lifetime
- 1986-10-17 KR KR1019860008728A patent/KR940010034B1/ko not_active Expired - Fee Related
- 1986-10-17 AU AU64179/86A patent/AU591937B2/en not_active Ceased
- 1986-10-17 JP JP61247306A patent/JPS62155278A/ja active Pending
- 1986-10-17 PT PT83571A patent/PT83571B/pt unknown
- 1986-10-17 PT PT83572A patent/PT83572B/pt not_active IP Right Cessation
1987
- 1987-10-13 US US07/108,272 patent/US4795749A/en not_active Expired - Fee Related
1989
- 1989-02-02 US US07/305,969 patent/US4886797A/en not_active Expired - Fee Related
- 1989-02-02 US US07/305,970 patent/US4880799A/en not_active Expired - Fee Related
1990
- 1990-03-01 GR GR90400114T patent/GR3000367T3/el unknown

Also Published As

Publication number	Publication date
FI82050B (fi)	1990-09-28
EP0225013A1 (de)	1987-06-10
PT83571A (en)	1986-11-01
FI82050C (fi)	1991-01-10
NO864061D0 (no)	1986-10-13
FI864124A7 (fi)	1987-04-18
ES2014234B3 (es)	1990-07-01
ATE48844T1 (de)	1990-01-15
CA1275411C (en)	1990-10-23
GR3000367T3 (en)	1991-06-07
AU6417986A (en)	1987-04-30
NO163776C (no)	1990-07-18
NZ217957A (en)	1989-02-24
KR940010034B1 (ko)	1994-10-21
PT83572B (pt)	1988-10-14
DE3667665D1 (de)	1990-01-25
KR870004032A (ko)	1987-05-07
NO864062D0 (no)	1986-10-13
US4795749A (en)	1989-01-03
NO864061L (no)	1987-04-21
FI864125A7 (fi)	1987-04-18
AU6417886A (en)	1987-04-30
CA1293723C (en)	1991-12-31
EP0220845A1 (de)	1987-05-06
NZ217958A (en)	1989-02-24
EP0225013B1 (de)	1989-12-20
DK476885D0 (da)	1985-10-17
FI864125A0 (fi)	1986-10-13
US4774245A (en)	1988-09-27
PH22556A (en)	1988-10-17
PT83571B (en)	1988-03-09
IE59642B1 (en)	1994-03-09
NO163776B (no)	1990-04-09
PT83572A (en)	1986-11-01
IE862733L (en)	1987-04-17
NO864062L (no)	1987-04-21
US4886797A (en)	1989-12-12
US4870073A (en)	1989-09-26
JPS62155278A (ja)	1987-07-10
JPH0753731B2 (ja)	1995-06-07
AU591937B2 (en)	1989-12-21
JPS62161785A (ja)	1987-07-17
US4880799A (en)	1989-11-14
FI864124A0 (fi)	1986-10-13

Legal Events

Date	Code	Title	Description
1996-12-05	KB	Patent renewed
2001-06-14	RH	Patent void

Publication	Publication Date	Title
IL80319A (en)	1990-03-19	4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them
PT86186A (en)	1987-12-01	Process for the preparation of benzimidazol derivatives and of pharmaceutical compositions containing the same
HUT41402A (en)	1987-04-28	Fungicide compositions containing azolyl-methyl-oxirane derivatives and process for preparing the active ingredients
ATE90345T1 (de)	1993-06-15	Bis-naphthalimide, ihre herstellung und verwendung.
MY101791A (en)	1992-01-31	New benzimidazole derivatives
GR3025742T3 (en)	1998-03-31	New pyrazine derivatives, their preparation and their use.
IL76456A0 (en)	1986-01-31	1-substituted tetralin derivatives,their preparation and pharmaceutical compositions containing them
EP0321968A3 (en)	1990-10-31	Compounds active on the cardiovascular system
AU530678B2 (en)	1983-07-28	Phosphono-hydroxy-acetic acid
SE8700555L (sv)	1987-08-15	Purinderivat, deras framstellning och lekemedel innehallande dessa
IL82925A0 (en)	1987-12-20	Tetrahydrobenzothiazoles,their preparation and pharmaceutical compositions containing them
IL67400A0 (en)	1983-05-15	3,7alpha-diazacyclohepta(j,k)fluorene derivatives,their preparation and pharmaceutical compositions containing them
ES488565A1 (es)	1980-10-01	Procedimiento para la preparacion de 8-aril-5,6,7,8-tetrahi-dropirazolo (3,4-b) (1,5) diazepin-1h,4h-5,7-dionas
EP0321967A3 (en)	1990-10-24	Compounds active on the cardiovascular system
ES8103041A1 (es)	1981-02-16	Procedimiento para la preparacion de sulfonilsemicarbazidas
IL85508A0 (en)	1988-08-31	Benzylaminoaryl-dihydropyridinelactones,their preparation and their use in medicaments