IL80776A - N-benzoyl urea compounds,process for their preparation and antitumorous compositions containing them - Google Patents
N-benzoyl urea compounds,process for their preparation and antitumorous compositions containing themInfo
- Publication number
- IL80776A IL80776A IL80776A IL8077686A IL80776A IL 80776 A IL80776 A IL 80776A IL 80776 A IL80776 A IL 80776A IL 8077686 A IL8077686 A IL 8077686A IL 80776 A IL80776 A IL 80776A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- compositions containing
- urea compounds
- benzoyl urea
- antitumorous
- Prior art date
Links
- HRYILSDLIGTCOP-UHFFFAOYSA-N N-benzoylurea Chemical class NC(=O)NC(=O)C1=CC=CC=C1 HRYILSDLIGTCOP-UHFFFAOYSA-N 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27818085 | 1985-12-11 | ||
| JP27988485 | 1985-12-12 | ||
| JP60280694 | 1985-12-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL80776A0 IL80776A0 (en) | 1987-02-27 |
| IL80776A true IL80776A (en) | 1991-03-10 |
Family
ID=27336532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL80776A IL80776A (en) | 1985-12-11 | 1986-11-26 | N-benzoyl urea compounds,process for their preparation and antitumorous compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4863924A (da) |
| EP (1) | EP0226104B1 (da) |
| JP (1) | JPH0745473B2 (da) |
| KR (1) | KR870006016A (da) |
| AR (1) | AR244667A1 (da) |
| AT (1) | ATE60760T1 (da) |
| AU (1) | AU594098B2 (da) |
| DE (1) | DE3677478D1 (da) |
| DK (2) | DK164054C (da) |
| ES (1) | ES2033675T3 (da) |
| GR (1) | GR3001905T3 (da) |
| IL (1) | IL80776A (da) |
| NZ (1) | NZ218440A (da) |
| PL (1) | PL151012B1 (da) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ212208A (en) * | 1984-06-15 | 1988-04-29 | Ishihara Sangyo Kaisha | N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions |
| JPS62185013A (ja) * | 1986-02-08 | 1987-08-13 | Green Cross Corp:The | 易吸収性医薬組成物 |
| DK5489A (da) * | 1988-01-11 | 1989-07-12 | Duphar Int Res | Anvendelse af substituerede amidforbindelser til fremstilling af farmaceutiske praeparater til behandling af haematologiske sygdomme |
| US5166180A (en) * | 1988-01-11 | 1992-11-24 | Duphar International Research B.V. | Method of treating hematologic diseases and pharmaceutical composition to be used therefor |
| JPH029855A (ja) * | 1988-03-31 | 1990-01-12 | Ishihara Sangyo Kaisha Ltd | 置換ベンゼン誘導体、それらの製造方法及びそれらを含有する抗癌性組成物 |
| FR2637282B1 (fr) * | 1988-09-13 | 1990-12-07 | Oreal | Para-aminophenols 2-substitues et leur utilisation pour la teinture des fibres keratiniques |
| US5202487A (en) * | 1988-09-13 | 1993-04-13 | L'oreal | 2-substituted para-aminophenols and their use for dyeing keratinous fibres |
| JPH02196719A (ja) * | 1989-01-24 | 1990-08-03 | Green Cross Corp:The | 粉末状医薬組成物 |
| NZ234551A (en) * | 1989-07-28 | 1991-10-25 | Ishihara Sangyo Kaisha | Benzoylurea derivatives and antitumour compositions |
| US6344476B1 (en) * | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
| US20080300281A1 (en) * | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| EP2298311B1 (en) | 1999-01-13 | 2012-05-09 | Bayer HealthCare LLC | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| US7351834B1 (en) | 1999-01-13 | 2008-04-01 | Bayer Pharmaceuticals Corporation | ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1140840B1 (en) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| EP1437344A4 (en) * | 2001-09-28 | 2006-09-20 | Takeda Pharmaceutical | BENZENE DERIVATIVES AND PROCESS FOR THE PREPARATION AND USE THEREOF |
| EP2305255B1 (en) * | 2001-12-03 | 2012-08-22 | Bayer HealthCare LLC | Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers |
| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| ATE529406T1 (de) | 2002-02-11 | 2011-11-15 | Bayer Healthcare Llc | Aryl-harnstoffe als kinase inhibitoren |
| DK1478358T3 (da) | 2002-02-11 | 2013-10-07 | Bayer Healthcare Llc | Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese |
| WO2003068223A1 (en) * | 2002-02-11 | 2003-08-21 | Bayer Corporation | Aryl ureas with raf kinase and angiogenesis inhibiting activity |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| EP1636585B2 (en) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl ureas with kinase inhibiting activity |
| PL1663978T3 (pl) | 2003-07-23 | 2008-04-30 | Bayer Healthcare Llc | Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów |
| RU2006122853A (ru) * | 2003-11-28 | 2008-01-10 | Новартис АГ (CH) | Производные диарилмочевины для лечения заболеваний, зависимых от протеинкиназы |
| DE602006017188D1 (de) | 2005-03-07 | 2010-11-11 | Bayer Schering Pharma Ag | Pharmazeutische zusammensetzung mit einem omega-carboxyaryl-substituierten diphenylharnstoff zur behandlung von krebs |
| WO2015108779A1 (en) | 2014-01-16 | 2015-07-23 | E. I. Du Pont De Nemours And Company | Pyrimidinyloxy benzene derivatives as herbicides |
| RU2735278C2 (ru) | 2015-03-18 | 2020-10-29 | ЭфЭмСи Корпорейшн | Замещенные производные пиримидинилокси-пиридина в качестве гербицидов |
| TWI828952B (zh) * | 2015-06-05 | 2024-01-11 | 美商艾佛艾姆希公司 | 作為除草劑之嘧啶氧基苯衍生物 |
| WO2017011288A1 (en) | 2015-07-13 | 2017-01-19 | E I Du Pont De Nemours And Company | Aryloxypyrimidinyl ethers as herbicides |
| EP3619206B1 (en) | 2017-05-02 | 2024-02-14 | FMC Corporation | Pyrimidinyloxy benzo-fused compounds as herbicides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5615272A (en) * | 1979-07-17 | 1981-02-14 | Ishihara Sangyo Kaisha Ltd | N-benzoyl-n'-phenylurea compound, its preparation, and insecticide containing the same |
| CA1233822A (en) * | 1982-12-30 | 1988-03-08 | David T. Chou | Pesticidal benzoyl ureas and process for preparation |
| NZ212208A (en) * | 1984-06-15 | 1988-04-29 | Ishihara Sangyo Kaisha | N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions |
| JPS6133176A (ja) * | 1984-07-24 | 1986-02-17 | Ishihara Sangyo Kaisha Ltd | Ｎ−ニトロベンゾイル−ｎ’−ピリダジニルオキシフエニルウレア系化合物、それらの製造方法及びそれらを含有する抗癌剤 |
| JPS6193163A (ja) * | 1984-10-12 | 1986-05-12 | Ishihara Sangyo Kaisha Ltd | Ｎ−ベンゾイル−ｎ′−フエニルウレア系化合物、それらの製造方法並びにそれらを含有する抗癌剤 |
| US4727077A (en) * | 1985-02-20 | 1988-02-23 | Ishihara Sangyo Kaisha Ltd. | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them |
-
1986
- 1986-11-20 AU AU65581/86A patent/AU594098B2/en not_active Ceased
- 1986-11-26 IL IL80776A patent/IL80776A/xx unknown
- 1986-11-28 EP EP86116595A patent/EP0226104B1/en not_active Expired - Lifetime
- 1986-11-28 NZ NZ218440A patent/NZ218440A/xx unknown
- 1986-11-28 DE DE8686116595T patent/DE3677478D1/de not_active Expired - Fee Related
- 1986-11-28 AT AT86116595T patent/ATE60760T1/de not_active IP Right Cessation
- 1986-11-28 ES ES198686116595T patent/ES2033675T3/es not_active Expired - Lifetime
- 1986-12-05 AR AR86306114A patent/AR244667A1/es active
- 1986-12-08 US US06/939,025 patent/US4863924A/en not_active Expired - Fee Related
- 1986-12-08 JP JP29192186A patent/JPH0745473B2/ja not_active Expired - Lifetime
- 1986-12-10 PL PL1986262901A patent/PL151012B1/pl unknown
- 1986-12-10 KR KR860010558A patent/KR870006016A/ko not_active Ceased
- 1986-12-11 DK DK596586A patent/DK164054C/da not_active IP Right Cessation
-
1991
- 1991-05-03 GR GR91400577T patent/GR3001905T3/el unknown
- 1991-06-18 DK DK118391A patent/DK118391A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6399056A (ja) | 1988-04-30 |
| GR3001905T3 (en) | 1992-11-23 |
| US4863924A (en) | 1989-09-05 |
| PL151012B1 (en) | 1990-07-31 |
| DK164054C (da) | 1992-09-28 |
| NZ218440A (en) | 1989-06-28 |
| DK118391D0 (da) | 1991-06-18 |
| ES2033675T3 (es) | 1993-04-01 |
| ATE60760T1 (de) | 1991-02-15 |
| JPH0745473B2 (ja) | 1995-05-17 |
| DK596586A (da) | 1987-06-12 |
| AU594098B2 (en) | 1990-03-01 |
| AR244667A1 (es) | 1993-11-30 |
| KR870006016A (ko) | 1987-07-08 |
| AU6558186A (en) | 1987-06-18 |
| EP0226104B1 (en) | 1991-02-06 |
| PL262901A1 (en) | 1988-09-29 |
| DK118391A (da) | 1991-06-18 |
| DK164054B (da) | 1992-05-04 |
| EP0226104A2 (en) | 1987-06-24 |
| EP0226104A3 (en) | 1988-09-07 |
| DE3677478D1 (de) | 1991-03-14 |
| IL80776A0 (en) | 1987-02-27 |
| DK596586D0 (da) | 1986-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed |