IL81117A - 2-alkyl-6h-pyrimido-(5,4-b)(1,4)oxazin-7(8h)-ones,their preparation and pharmaceutical compositions containing them - Google Patents

2-alkyl-6h-pyrimido-(5,4-b)(1,4)oxazin-7(8h)-ones,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL81117A
Authority: IL; Israel
Prior art keywords: group; stands; hydrogen; alkyl; alkyl group
Prior art date: 1985-12-30

Application number

IL81117A

Other languages

English (en)

Other versions

IL81117A0 (en

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-30

Filing date

1986-12-30

Publication date

1990-07-12

1986-12-30 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

1987-03-31 Publication of IL81117A0 publication Critical patent/IL81117A0/xx

1990-07-12 Publication of IL81117A publication Critical patent/IL81117A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
-1 mercapto, aminocarbonyl Chemical group 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
MVENYXPBNYAZJK-UHFFFAOYSA-N 6h-pyrimido[5,4-b][1,4]oxazine Chemical class N1=CN=C2N=CCOC2=C1 MVENYXPBNYAZJK-UHFFFAOYSA-N 0.000 abstract 1
125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
230000017531 blood circulation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 abstract 1
230000002107 myocardial effect Effects 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000005936 piperidyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Indole Compounds (AREA)

IL81117A 1985-12-30 1986-12-30 2-alkyl-6h-pyrimido-(5,4-b)(1,4)oxazin-7(8h)-ones,their preparation and pharmaceutical compositions containing them IL81117A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU855042A HU195822B (en)	1985-12-30	1985-12-30	Process for producing new pyrimido/5,4-b//1,h/oxazine derivatives

Publications (2)

Publication Number	Publication Date
IL81117A0 IL81117A0 (en)	1987-03-31
IL81117A true IL81117A (en)	1990-07-12

Family

ID=10969567

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL81117A IL81117A (en)	1985-12-30	1986-12-30	2-alkyl-6h-pyrimido-(5,4-b)(1,4)oxazin-7(8h)-ones,their preparation and pharmaceutical compositions containing them

Country Status (20)

Country	Link
US (1)	US4748175A (cs)
EP (1)	EP0228094B1 (cs)
JP (1)	JPS62228082A (cs)
CN (1)	CN1021734C (cs)
AT (1)	ATE66232T1 (cs)
AU (1)	AU586380B2 (cs)
CA (1)	CA1287052C (cs)
CS (1)	CS268822B2 (cs)
DD (1)	DD256701A5 (cs)
DE (1)	DE3680893D1 (cs)
DK (1)	DK630186A (cs)
ES (1)	ES2003643A6 (cs)
FI (1)	FI82469C (cs)
GR (1)	GR862962B (cs)
HU (1)	HU195822B (cs)
IL (1)	IL81117A (cs)
NO (1)	NO170935C (cs)
NZ (1)	NZ218795A (cs)
SU (2)	SU1567122A3 (cs)
YU (1)	YU46039B (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5067754A (en)	1980-10-29	1991-11-26	Propietary Technology, Inc.	Swivelable quick connector assembly
IE64917B1 (en) *	1988-02-05	1995-09-20	Riker Laboratories Inc	Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators
GB2359551A (en) *	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4215216A (en) *	1979-04-18	1980-07-29	American Home Products Corporation	7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives

1985
- 1985-12-30 HU HU855042A patent/HU195822B/hu not_active IP Right Cessation
1986
- 1986-12-23 NZ NZ218795A patent/NZ218795A/xx unknown
- 1986-12-29 DK DK630186A patent/DK630186A/da not_active Application Discontinuation
- 1986-12-30 SU SU864028913A patent/SU1567122A3/ru active
- 1986-12-30 CS CS8610262A patent/CS268822B2/cs unknown
- 1986-12-30 EP EP86118122A patent/EP0228094B1/de not_active Expired - Lifetime
- 1986-12-30 NO NO865347A patent/NO170935C/no unknown
- 1986-12-30 CA CA000526548A patent/CA1287052C/en not_active Expired - Lifetime
- 1986-12-30 US US06/947,700 patent/US4748175A/en not_active Expired - Fee Related
- 1986-12-30 IL IL81117A patent/IL81117A/xx not_active IP Right Cessation
- 1986-12-30 YU YU227986A patent/YU46039B/sh unknown
- 1986-12-30 GR GR862962A patent/GR862962B/el unknown
- 1986-12-30 FI FI865344A patent/FI82469C/fi not_active IP Right Cessation
- 1986-12-30 DD DD86298832A patent/DD256701A5/de not_active IP Right Cessation
- 1986-12-30 DE DE8686118122T patent/DE3680893D1/de not_active Expired - Lifetime
- 1986-12-30 AU AU67043/86A patent/AU586380B2/en not_active Ceased
- 1986-12-30 AT AT86118122T patent/ATE66232T1/de not_active IP Right Cessation
- 1986-12-30 ES ES8603622A patent/ES2003643A6/es not_active Expired
- 1986-12-30 CN CN86108914A patent/CN1021734C/zh not_active Expired - Fee Related
1987
- 1987-01-05 JP JP62000083A patent/JPS62228082A/ja active Pending
1988
- 1988-06-14 SU SU884355907A patent/SU1567123A3/ru active

Also Published As

Publication number	Publication date
NO865347L (no)	1987-07-01
ES2003643A6 (es)	1988-11-01
YU46039B (sh)	1992-12-21
NO170935C (no)	1992-12-30
SU1567123A3 (ru)	1990-05-23
NZ218795A (cs)	1989-02-24
ATE66232T1 (de)	1991-08-15
FI82469B (fi)	1990-11-30
JPS62228082A (ja)	1987-10-06
CN86108914A (zh)	1987-09-30
EP0228094A3 (en)	1988-10-12
HUT44032A (en)	1988-01-28
YU227986A (en)	1988-02-29
DD256701A5 (de)	1988-05-18
CA1287052C (en)	1991-07-30
CS268822B2 (en)	1990-04-11
AU6704386A (en)	1987-07-02
AU586380B2 (en)	1989-07-06
CN1021734C (zh)	1993-08-04
EP0228094A2 (de)	1987-07-08
GR862962B (en)	1987-05-05
US4748175A (en)	1988-05-31
SU1567122A3 (ru)	1990-05-23
NO170935B (no)	1992-09-21
IL81117A0 (en)	1987-03-31
DE3680893D1 (de)	1991-09-19
FI865344A7 (fi)	1987-07-01
CS1026286A2 (en)	1989-08-14
HU195822B (en)	1988-07-28
FI865344A0 (fi)	1986-12-30
DK630186A (da)	1987-07-01
DK630186D0 (da)	1986-12-29
FI82469C (fi)	1991-03-11
EP0228094B1 (de)	1991-08-14

Legal Events

Date	Code	Title	Description
1997-11-20	RH	Patent void

Publication	Publication Date	Title
DE3567870D1 (en)	1989-03-02	Xanthine derivatives, processes for their preparation and pharmaceutical compositions containing them
IL96550A0 (en)	1991-09-16	Amino acid derivatives,their manufacture and pharmaceutical compositions containing them
DE68925223D1 (de)	1996-02-08	3-Alkenyl-1-azabicyclo(3.2.0)hept-2-en-2-carbonsäure-Verbindungen
HU900063D0 (en)	1990-03-28	Process for preparation of new 2-amino-pyrimidinone-derivatives
PH25532A (en)	1991-07-24	Novel n-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives, pharm,aceutical composition containing said compound, method of use thereof
IL90552A0 (en)	1990-01-18	Condensed pyrazole 3-oxo-propanenitrile derivatives,their preparation and pharmaceutical compositions containing them
AU586380B2 (en)	1989-07-06	Pyrimido ``5,4-b````1,4`` oxazine derivatives and pharmaceutical compositions containing them
HU893127D0 (en)	1990-01-28	Process for the preparation of novel spiro-(imidazolidino-naphtaline) derivatives and pharmaceutical compositions containing such compounds as active ingredient
IL81337A (en)	1991-06-30	Heptanoyl-glu-asp-ala-amino acid immunostimulants,process for their preparation and pharmaceutical compositions containing them
DE69429753D1 (de)	2002-03-14	Anitbiotisch wirksame Cephalosporine und Verfahren zu ihrer Herstellung
ES2006390A6 (es)	1989-04-16	Procedimiento de preparacion de nuevos derivados de morfolina.
IL61911A (en)	1983-10-31	2,3-dihydro-imidazo(1,2-b)pyridazine derivatives,their preparation and pharmaceutical compositions containing them
HU901631D0 (en)	1990-06-28	Process for the preparation of thienyl-piperazine derivatives and pharmaceutical compositions containing them
MX9703074A (es)	1997-07-31	Inhibidores de sintesis de apoliproteina-b.
IE38219L (en)	1974-03-08	Substituted 2-hydrazonomethyl-3-hydroxy-4-aza-2, 4-¹pentadiene nitriles