IL82710A - 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it - Google Patents

3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it

Info

Publication number: IL82710A
Authority: IL; Israel
Prior art keywords: dichlorophenyl; diamino; production; pharmaceutical compositions; compositions containing
Prior art date: 1986-05-30

Application number

IL82710A

Other languages

English (en)

Other versions

IL82710A0 (en

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-30

Filing date

1987-05-29

Publication date

1992-01-15

1987-05-29 Application filed by Wellcome Found filed Critical Wellcome Found

1987-11-30 Publication of IL82710A0 publication Critical patent/IL82710A0/xx

1992-01-15 Publication of IL82710A publication Critical patent/IL82710A/xx

Links

CJIDZLNMKONKAD-UHFFFAOYSA-N 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxyethanesulfonic acid Chemical compound OCCS(O)(=O)=O.NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl CJIDZLNMKONKAD-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
239000007864 aqueous solution Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

IL82710A 1986-05-30 1987-05-29 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it IL82710A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB868613183A GB8613183D0 (en)	1986-05-30	1986-05-30	Triazine salt

Publications (2)

Publication Number	Publication Date
IL82710A0 IL82710A0 (en)	1987-11-30
IL82710A true IL82710A (en)	1992-01-15

Family

ID=10598692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL82710A IL82710A (en)	1986-05-30	1987-05-29	3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it

Country Status (18)

Country	Link
US (1)	US4847249A (de)
EP (1)	EP0247892B1 (de)
JP (1)	JPH0751571B2 (de)
KR (1)	KR910002254B1 (de)
AT (1)	ATE62902T1 (de)
AU (1)	AU597982B2 (de)
CA (1)	CA1286670C (de)
DE (1)	DE3769516D1 (de)
DK (1)	DK166278C (de)
ES (1)	ES2021709B3 (de)
FI (1)	FI90770C (de)
GB (1)	GB8613183D0 (de)
GR (1)	GR3001942T3 (de)
HU (1)	HU196769B (de)
IE (1)	IE60626B1 (de)
IL (1)	IL82710A (de)
NZ (1)	NZ220497A (de)
ZA (1)	ZA873896B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9012312D0 (en) *	1990-06-01	1990-07-18	Wellcome Found	Pharmacologically active cns compounds
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
GB9124807D0 (en) *	1991-11-22	1992-01-15	Wellcome Found	Pharmaceutical formulations
SK282072B6 (sk) *	1991-01-30	2001-10-08	The Wellcome Foundation Limited	Tableta s obsahom lamotrigínu dispergovateľná vo vode a spôsob jej prípravy
GB9203483D0 (en) *	1992-02-19	1992-04-08	Wellcome Found	Anti-inflammatory compounds
HRP930964B1 (en) *	1992-06-12	2000-06-30	Wellcome Found	Therapeutic triazine compounds and the use thereof
GB9215908D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Water dispersible tablets
FR2699078B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application de la lamotrigine dans le traitement de lésions neurologiques liées à des traumatismes.
FR2699077B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
FR2700117B1 (fr) *	1993-01-07	1995-02-03	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.
FR2702148B1 (fr) *	1993-03-05	1995-04-07	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement du neuro-sida.
US5866597A (en) *	1993-03-19	1999-02-02	Glaxo Wellcome Inc.	Use of triazine compounds for the treatment of memory and learning disorders
GB9305693D0 (en) *	1993-03-19	1993-05-05	Wellcome Found	Therapeutic triazine compounds and use
GB9306639D0 (en) *	1993-03-30	1993-05-26	Tocris Neuramin Limited	Organic compounds
FR2702149B1 (fr) *	1993-06-03	1995-04-07	Rhone Poulenc Rorer Sa	Application de la lamotrigine dans le traitement du neuro-sida.
US5698226A (en) *	1993-07-13	1997-12-16	Glaxo Wellcome Inc.	Water-dispersible tablets
EP0800520B1 (de) *	1994-12-30	2002-06-19	The Wellcome Foundation Limited	Verfahren zur herstellung von lamotrigine
GB9426448D0 (en) *	1994-12-30	1995-03-01	Wellcome Found	Process
GB9512854D0 (en) *	1995-06-23	1995-08-23	Wellcome Found	Novel formulation
GB9812413D0 (en)	1998-06-10	1998-08-05	Glaxo Group Ltd	Compound and its use
EP1140872B1 (de) *	1998-12-14	2003-09-17	Torrent Pharmaceuticals Ltd	Ein verbessertes verfahren zur herstellung von 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazin
GB2372988B (en) *	2000-01-03	2004-04-07	Rpg Life Sciences Ltd	A process for the preparation of 6-(2,3-Dichlorophenyl)-1,2,4- Triazine-3,5-Diamine, commonly known as Lamotrigine
IL134730A (en) *	2000-02-25	2003-10-31	Chemagis Ltd	Process for preparing substituted benzoyl cyanide amidinohydrazones
WO2002068398A1 (en) *	2001-02-27	2002-09-06	Teva Pharmaceutical Industries Ltd.	New crystal forms of lamotrigine and processes for their preparations
WO2003090693A2 (en) *	2002-04-23	2003-11-06	Teva Pharmaceutical Industries Ltd.	Pharmaceutical composition containing lamotrigine particles of defined morphology
HU225667B1 (en)	2002-09-20	2007-05-29	Richter Gedeon Nyrt	Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es)	2002-10-31	2005-08-01	Vita Cientifica, S.L.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
GB2395483A (en) *	2003-07-03	2004-05-26	Jubilant Organosys Ltd	Crystalline lamotrigine and its monohydrate
US8486927B2 (en) *	2007-11-09	2013-07-16	Thar Pharmaceuticals	Crystalline forms of lamotrigine
US12605388B2 (en)	2024-09-25	2026-04-21	Azurity Pharmaceuticals Ireland Limited	Lamotrigine salts, co-crystals, and compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD151309A5 (de) *	1979-06-01	1981-10-14	Wellcome Found	Verfahren zur herstellung von substituierten aminotriazinen
DE3069556D1 (en) *	1979-08-16	1984-12-06	Wellcome Found	Solid pharmaceutical formulation containing substitued phenyl-triazines
EP0093186B1 (de) *	1982-05-03	1986-07-09	Richardson Vicks Limited	Pharmazeutisches Präparat zur topischen Behandlung von Akne
GB8328757D0 (en) *	1983-10-27	1983-11-30	Wellcome Found	Chemical compounds

1986
- 1986-05-30 GB GB868613183A patent/GB8613183D0/en active Pending
1987
- 1987-05-29 IE IE141587A patent/IE60626B1/en not_active IP Right Cessation
- 1987-05-29 DE DE8787304776T patent/DE3769516D1/de not_active Expired - Fee Related
- 1987-05-29 JP JP62134772A patent/JPH0751571B2/ja not_active Expired - Fee Related
- 1987-05-29 DK DK275987A patent/DK166278C/da active
- 1987-05-29 ES ES87304776T patent/ES2021709B3/es not_active Expired - Lifetime
- 1987-05-29 ZA ZA873896A patent/ZA873896B/xx unknown
- 1987-05-29 US US07/056,136 patent/US4847249A/en not_active Expired - Lifetime
- 1987-05-29 NZ NZ220497A patent/NZ220497A/xx unknown
- 1987-05-29 KR KR1019870005364A patent/KR910002254B1/ko not_active Expired
- 1987-05-29 AT AT87304776T patent/ATE62902T1/de not_active IP Right Cessation
- 1987-05-29 IL IL82710A patent/IL82710A/xx unknown
- 1987-05-29 EP EP87304776A patent/EP0247892B1/de not_active Expired - Lifetime
- 1987-05-29 AU AU73684/87A patent/AU597982B2/en not_active Ceased
- 1987-05-29 CA CA000538395A patent/CA1286670C/en not_active Expired - Fee Related
- 1987-05-29 FI FI872406A patent/FI90770C/fi not_active IP Right Cessation
- 1987-05-29 HU HU872487A patent/HU196769B/hu not_active IP Right Cessation
1991
- 1991-05-13 GR GR91400613T patent/GR3001942T3/el unknown

Also Published As

Publication number	Publication date
EP0247892B1 (de)	1991-04-24
GB8613183D0 (en)	1986-07-02
GR3001942T3 (en)	1992-11-23
ATE62902T1 (de)	1991-05-15
HUT45978A (en)	1988-09-28
JPH0751571B2 (ja)	1995-06-05
IE871415L (en)	1987-11-30
FI90770C (fi)	1994-03-25
ZA873896B (en)	1989-01-25
KR910002254B1 (ko)	1991-04-08
DK166278C (da)	1993-08-23
JPS62289570A (ja)	1987-12-16
FI90770B (fi)	1993-12-15
HU196769B (en)	1989-01-30
DK166278B (da)	1993-03-29
DK275987D0 (da)	1987-05-29
KR870011112A (ko)	1987-12-21
IL82710A0 (en)	1987-11-30
FI872406A0 (fi)	1987-05-29
US4847249A (en)	1989-07-11
AU597982B2 (en)	1990-06-14
EP0247892A1 (de)	1987-12-02
CA1286670C (en)	1991-07-23
DE3769516D1 (de)	1991-05-29
FI872406L (fi)	1987-12-01
NZ220497A (en)	1990-05-28
AU7368487A (en)	1987-12-03
IE60626B1 (en)	1994-07-27
ES2021709B3 (es)	1991-11-16
DK275987A (da)	1987-12-01

Legal Events

Date	Code	Title	Description
1997-09-30	KB	Patent renewed

Publication	Publication Date	Title
IL82710A (en)	1992-01-15	3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate,its production and pharmaceutical compositions containing it
KR0156747B1 (en)	1998-11-16	Use of 1,3-oxathiolan nucleoside analogues in the treatment of hepatitis-b
DE3668892D1 (en)	1990-03-15	Hypoglycemische thiazolidinedione.
HU908076D0 (en)	1991-06-28	Process for producing amino acid derivatives
ZA94748B (en)	1994-09-29	Cytotoxic and antiviral compound.
CY1870A (en)	1996-04-05	Derivatives of penciclovir for the treatment of hepatitis-B infections
IL104775A0 (en)	1993-06-10	Pharmaceutical compositions containing triazine derivatives
GR3001691T3 (en)	1992-11-23	Novel crystalline salts of aryloxy-propanolamines, their preparation and their use
FI900145L (fi)	1990-01-11	Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
PT86285A (en)	1988-01-01	Process for the preparation of injectable anthracycline glycoside solutions
EP0276151A3 (en)	1988-12-14	Dissolved composition of ûbenzo-1,2,4-thiadiazine¨-1,1-dioxide
NZ229300A (en)	1991-04-26	Substituted-2-ethenyl-3,4,5,6-tetrahydrothieno (4,3,2-cf)(3)benzazepine derivatives and pharmaceutical compositions
PT86006A (en)	1987-11-01	Process for the preparation of 2-aminomethyl-5-(2-biphenylyl)-1,3,4-thiadiazole
IL85856A0 (en)	1988-09-30	Tert.-butylamino-3-(phenyl-2'-phenoxy)-1-propanol-2,its acid addition salts and pharmaceutical compositions containing them
DE3363560D1 (en)	1986-06-26	Finely pulverized 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine and pharmaceutically acceptable acid addition salts thereof
HU9201483D0 (en)	1992-07-28	Process for the production of 1h-rh-analogues'acid additive salts, and for the production of medical preparations containing them
YU48086A (en)	1988-02-29	Process for preparing derivatives of penicilan acid 1,1-dioxide
CS170786A1 (en)	1987-02-12	Prumyslovy kmen houby claviceps purpurea (fr.) tul. 59 cc 5 86
EP0221032A3 (en)	1988-10-05	Sodium salt of etodolic acid and process for its preparation