IL83841A - 5-membered heterocyclic ring compounds substituted by phenyl and pyrrolidin-2-yl,their preparation and pharmaceutical compositions containing them - Google Patents
5-membered heterocyclic ring compounds substituted by phenyl and pyrrolidin-2-yl,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL83841A IL83841A IL83841A IL8384187A IL83841A IL 83841 A IL83841 A IL 83841A IL 83841 A IL83841 A IL 83841A IL 8384187 A IL8384187 A IL 8384187A IL 83841 A IL83841 A IL 83841A
- Authority
- IL
- Israel
- Prior art keywords
- phenyl
- pyrrolidin
- preparation
- pharmaceutical compositions
- heterocyclic ring
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 3
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 title abstract 2
- 150000001875 compounds Chemical group 0.000 title abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8602305 | 1986-09-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL83841A0 IL83841A0 (en) | 1988-02-29 |
| IL83841A true IL83841A (en) | 1991-11-21 |
Family
ID=19848538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL83841A IL83841A (en) | 1986-09-12 | 1987-09-09 | 5-membered heterocyclic ring compounds substituted by phenyl and pyrrolidin-2-yl,their preparation and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4791132A (de) |
| EP (1) | EP0259930B1 (de) |
| JP (1) | JPH0794432B2 (de) |
| AT (1) | ATE72435T1 (de) |
| AU (1) | AU609415B2 (de) |
| DE (1) | DE3776611D1 (de) |
| DK (1) | DK166275C (de) |
| ES (1) | ES2033297T3 (de) |
| GR (1) | GR3004436T3 (de) |
| IE (1) | IE60294B1 (de) |
| IL (1) | IL83841A (de) |
| NZ (1) | NZ221731A (de) |
| PH (1) | PH23898A (de) |
| ZA (1) | ZA876749B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
| EP0654023B1 (de) * | 1992-08-06 | 1998-09-16 | Smithkline Beecham Plc | 5-(2-oxyphenyl)-pyrrol-derivate als dopamin-d3-rezeptor-antagonisten |
| GB9307400D0 (en) * | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
| GB9309573D0 (en) * | 1993-05-10 | 1993-06-23 | Merck Sharp & Dohme | Therapeutic agents |
| JPH08511789A (ja) * | 1993-06-25 | 1996-12-10 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | フェニルピロール誘導体およびドーパミンｄ３拮抗薬としてのそれらの使用 |
| GB9315801D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
| GB9315800D0 (en) * | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
| GB9320855D0 (en) * | 1993-10-09 | 1993-12-01 | Smithkline Beecham Plc | Compounds |
| GB9402197D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
| GB9403199D0 (en) * | 1994-02-19 | 1994-04-13 | Smithkline Beecham Plc | Compounds |
| GB9512129D0 (en) * | 1995-06-15 | 1995-08-16 | Smithkline Beecham Plc | Compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219560A (en) * | 1978-04-17 | 1980-08-26 | Sandoz, Inc. | Piperidine and pyrrolidine alcohols |
| DE2835439A1 (de) * | 1978-08-12 | 1980-02-28 | Basf Ag | 2-(o-hydroxyphenyl)-pyrrol |
| US4321385A (en) * | 1980-02-04 | 1982-03-23 | Hoechst Roussel Pharmaceuticals Inc. | [(Aryl-1-pyrryl) methyl]-piperidinols and pyrrolidinols |
| US4539332A (en) * | 1983-11-14 | 1985-09-03 | Merck & Co., Inc. | 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists |
-
1987
- 1987-09-08 PH PH35780A patent/PH23898A/en unknown
- 1987-09-09 IL IL83841A patent/IL83841A/xx not_active IP Right Cessation
- 1987-09-09 NZ NZ221731A patent/NZ221731A/xx unknown
- 1987-09-09 IE IE240987A patent/IE60294B1/en not_active IP Right Cessation
- 1987-09-09 DE DE8787201706T patent/DE3776611D1/de not_active Expired - Fee Related
- 1987-09-09 EP EP87201706A patent/EP0259930B1/de not_active Expired - Lifetime
- 1987-09-09 AU AU78191/87A patent/AU609415B2/en not_active Ceased
- 1987-09-09 US US07/094,746 patent/US4791132A/en not_active Expired - Fee Related
- 1987-09-09 ZA ZA876749A patent/ZA876749B/xx unknown
- 1987-09-09 ES ES198787201706T patent/ES2033297T3/es not_active Expired - Lifetime
- 1987-09-09 AT AT87201706T patent/ATE72435T1/de not_active IP Right Cessation
- 1987-09-09 DK DK470687A patent/DK166275C/da active
- 1987-09-10 JP JP62225427A patent/JPH0794432B2/ja not_active Expired - Lifetime
-
1992
- 1992-04-22 GR GR920400808T patent/GR3004436T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK470687A (da) | 1988-03-13 |
| GR3004436T3 (de) | 1993-03-31 |
| DE3776611D1 (de) | 1992-03-19 |
| JPS6377856A (ja) | 1988-04-08 |
| AU7819187A (en) | 1988-03-17 |
| NZ221731A (en) | 1990-07-26 |
| IE872409L (en) | 1988-03-12 |
| DK166275C (da) | 1993-08-23 |
| AU609415B2 (en) | 1991-05-02 |
| PH23898A (en) | 1989-12-18 |
| IE60294B1 (en) | 1994-06-29 |
| DK470687D0 (da) | 1987-09-09 |
| DK166275B (da) | 1993-03-29 |
| IL83841A0 (en) | 1988-02-29 |
| US4791132A (en) | 1988-12-13 |
| EP0259930A1 (de) | 1988-03-16 |
| ATE72435T1 (de) | 1992-02-15 |
| ES2033297T3 (es) | 1993-03-16 |
| ZA876749B (en) | 1988-03-14 |
| EP0259930B1 (de) | 1992-02-05 |
| JPH0794432B2 (ja) | 1995-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE10199003I2 (de) | ||
| GB8919434D0 (en) | Novel compounds | |
| JPS57146777A (en) | Manufacture of 2-penem compounds, novel compounds manufactured thereby and pharmaceutic compositions containing them | |
| PT88603A (pt) | Immunomodulatory azapiranes | |
| HUT54357A (en) | Process for producing benzilidene-(azolylmethyl)-cycloalkane and -cycloalkene derivatives, fungicidal compositions comprising such compounds as active ingredient and intermediates usable for the production of the active ingredients | |
| KR900700494A (ko) | 마크로시클릭 화합물 | |
| GR3004902T3 (de) | ||
| GB8919417D0 (en) | Novel compounds | |
| IL83841A (en) | 5-membered heterocyclic ring compounds substituted by phenyl and pyrrolidin-2-yl,their preparation and pharmaceutical compositions containing them | |
| ES8507090A1 (es) | Procedimiento para la obtencion de nuevas 1, 5-benzotiacepinas | |
| NZ218243A (en) | B-carboline derivatives and pharmaceutical compositions | |
| DE3875295D1 (de) | Bakterizide pharmazeutische zusammensetzung. | |
| IL77124A (en) | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compoundds,their preparation and pharmaceutical compositions containing them | |
| NZ230128A (en) | Dibenzooxepine-pyridinium and -pyrrolo derivatives and pharmaceutical compositions | |
| IL75987A0 (en) | 1,6-naphthyridine derivatives,their preparation and pharmaceutical compositions containing them | |
| GR3019076T3 (en) | 1-alkyl-3-(acylamino)-epsilon-caprolactames as enhancers of learning and memory and pharmaceutical compositions containing same. | |
| NZ229300A (en) | Substituted-2-ethenyl-3,4,5,6-tetrahydrothieno (4,3,2-cf)(3)benzazepine derivatives and pharmaceutical compositions | |
| GR3005900T3 (de) | ||
| EP0294828A3 (en) | Mitomycin analogs, a process for preparing them and pharmaceutical compositions | |
| PH12683A (en) | 3-amino-1-phenyl-1h,5h-benzo-2,4-thiazepines and pharmaceutical compositions thereof | |
| GR3004321T3 (de) | ||
| EP0273357A3 (en) | Fluorine-containing macrolide compounds, pharmaceutical compositions comprising the same and their use for the manufacture of medicaments | |
| GB8610369D0 (en) | Heterocyclic compounds | |
| ES8104224A1 (es) | Un procedimiento para la preparacion de derivados de tetra- hidrobenzo c pirrol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |