IL85159A - Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them - Google Patents

Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them

Info

Publication number: IL85159A
Authority: IL; Israel
Prior art keywords: hirudin; region; pharmaceutical compositions; compositions containing; peptides corresponding
Prior art date: 1987-01-23

Application number

IL85159A

Other languages

English (en)

Other versions

IL85159A0 (en

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-23

Filing date

1988-01-21

Publication date

1993-04-04

1988-01-21 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1988-06-30 Publication of IL85159A0 publication Critical patent/IL85159A0/xx

1993-04-04 Publication of IL85159A publication Critical patent/IL85159A/xx

Links

102000007625 Hirudins Human genes 0.000 title 1
108010007267 Hirudins Proteins 0.000 title 1
239000003146 anticoagulant agent Substances 0.000 title 1
229940127219 anticoagulant drug Drugs 0.000 title 1
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title 1
229940006607 hirudin Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

IL85159A 1987-01-23 1988-01-21 Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them IL85159A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US641787A	1987-01-23	1987-01-23
US5316287A	1987-05-21	1987-05-21

Publications (2)

Publication Number	Publication Date
IL85159A0 IL85159A0 (en)	1988-06-30
IL85159A true IL85159A (en)	1993-04-04

Family

ID=26675603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL85159A IL85159A (en)	1987-01-23	1988-01-21	Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them

Country Status (19)

Country	Link
EP (1)	EP0276014B1 (fr)
JP (1)	JP2709817B2 (fr)
KR (1)	KR960014105B1 (fr)
CN (1)	CN88100260A (fr)
AR (1)	AR245140A1 (fr)
AT (1)	ATE110743T1 (fr)
AU (1)	AU601801B2 (fr)
CA (1)	CA1341032C (fr)
DE (1)	DE3851238T2 (fr)
DK (1)	DK173757B1 (fr)
ES (1)	ES2063740T3 (fr)
FI (1)	FI89060C (fr)
HU (1)	HU199159B (fr)
IE (1)	IE63547B1 (fr)
IL (1)	IL85159A (fr)
NO (1)	NO174105C (fr)
NZ (1)	NZ223236A (fr)
PH (1)	PH26263A (fr)
PT (1)	PT86600B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6005071A (en) *	1987-01-23	1999-12-21	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5789540A (en) *	1987-01-23	1998-08-04	Merrell Pharmaceuticals Inc.	Anticoagulant peptides
US5192745A (en) *	1987-05-21	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5236898A (en) *	1987-05-21	1993-08-17	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
NZ228995A (en) *	1988-05-10	1992-03-26	Merrell Dow Pharma	Hirudin peptide derivatives and pharmaceutical compositions
FI904329A0 (fi) *	1988-12-05	1990-09-03	Biogen Inc	Foerfaranden och kompositioner foer inhibering av tronbocytaggregation.
ZA899247B (en) *	1988-12-07	1990-09-26	Merrell Dow Pharma	Anticoagulant peptides
US5232912A (en) *	1988-12-07	1993-08-03	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
ZA907742B (en) *	1989-10-03	1991-07-31	Merrell Dow Pharma	Anticoagulant peptides
CA2026377A1 (fr) *	1989-10-03	1991-04-04	John L. Krstenansky	Peptides anticoagulants avec marqueur radioactif
US5192747A (en) *	1989-10-03	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
CA2035917C (fr) *	1990-02-13	2001-10-02	John L. Krstenansky	Derives sulfonate, sulfate, phosphonate et phosphate stabilises de hirudine
DE4005591A1 (de) *	1990-02-22	1991-09-05	Behringwerke Ag	Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
US6060451A (en) *	1990-06-15	2000-05-09	The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin
ZA915658B (en) *	1990-07-24	1992-05-27	Merrell Dow Pharma	Analogs of hirudin having antiplatelet activity
US5574012A (en) *	1990-07-24	1996-11-12	Merrell Pharmaceuticals Inc.	Analogs of hirudin having anti-platelet activity
ATE142648T1 (de) *	1990-07-24	1996-09-15	Merrell Pharma Inc	Antigerinnungspeptide
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation
DE4103649A1 (de) *	1991-02-07	1992-08-13	Basf Ag	Neue antikoagulatorisch wirksame peptide
DE69213628T2 (de) *	1991-03-05	1997-04-24	Fuji Yakuhin Kogyo Kk	Hirudinanalog oder dessen salz, dessen herstellung und das als aktiven bestandteil enthaltende antikoagulanz
US5767235A (en) *	1991-03-05	1998-06-16	Nippon Mining Company Limited	Anticoagulant hirudin variants and methods for their production
IT1250689B (it) *	1991-07-22	1995-04-21	Marco Gerna	Analoghi dell'irudina e procedimento per la loro preparazione
WO1993003057A1 (fr) *	1991-07-31	1993-02-18	Institut Pasteur	Polypeptides aptes a induire in vivo des anticorps eux-memes capables d'inhiber l'invasion de globules rouges par des merozoites de p.falciparum, produits apparentes et leur application a la production de compositions vaccinantes
PT702696E (pt) *	1993-06-11	2003-12-31	Merrell Pharma Inc	Peptidos trifuncionais antitrombina e antiplaquetas
GB9426038D0 (en)	1994-12-22	1995-02-22	Iaf Biochem Int	Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) *	1995-12-21	2000-05-02	Biochem Pharma Inc.	Low molecular weight bicyclic thrombin inhibitors
US5831003A (en) *	1996-06-28	1998-11-03	Bayer Corporation	Peptides which bind to prothrombin and thrombin
GB0209249D0 (en) *	2002-04-23	2002-06-05	Evolutec Ltd	Anticoagulants
GB0711779D0 (en) *	2007-06-18	2007-07-25	Univ Singapore	Thrombin inhibitor
CN102757479B (zh) *	2012-05-09	2014-04-30	北京林业大学	高活性降血压肽及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3506992A1 (de) *	1985-02-27	1986-08-28	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.

1988
- 1988-01-15 CA CA000556652A patent/CA1341032C/fr not_active Expired - Fee Related
- 1988-01-19 NZ NZ223236A patent/NZ223236A/xx unknown
- 1988-01-19 JP JP63007651A patent/JP2709817B2/ja not_active Expired - Fee Related
- 1988-01-21 KR KR1019880000432A patent/KR960014105B1/ko not_active Expired - Fee Related
- 1988-01-21 AR AR88309880A patent/AR245140A1/es active
- 1988-01-21 IL IL85159A patent/IL85159A/xx not_active IP Right Cessation
- 1988-01-22 PH PH36388A patent/PH26263A/en unknown
- 1988-01-22 DK DK198800310A patent/DK173757B1/da not_active IP Right Cessation
- 1988-01-22 AT AT88100934T patent/ATE110743T1/de not_active IP Right Cessation
- 1988-01-22 ES ES88100934T patent/ES2063740T3/es not_active Expired - Lifetime
- 1988-01-22 PT PT86600A patent/PT86600B/pt not_active IP Right Cessation
- 1988-01-22 EP EP88100934A patent/EP0276014B1/fr not_active Expired - Lifetime
- 1988-01-22 DE DE3851238T patent/DE3851238T2/de not_active Expired - Fee Related
- 1988-01-22 AU AU10729/88A patent/AU601801B2/en not_active Ceased
- 1988-01-22 NO NO880268A patent/NO174105C/no unknown
- 1988-01-22 IE IE16788A patent/IE63547B1/en not_active IP Right Cessation
- 1988-01-22 FI FI880286A patent/FI89060C/fi not_active IP Right Cessation
- 1988-01-22 HU HU88258A patent/HU199159B/hu unknown
- 1988-01-23 CN CN198888100260A patent/CN88100260A/zh active Pending

Also Published As

Publication number	Publication date
EP0276014B1 (fr)	1994-08-31
PT86600B (pt)	1991-12-31
KR960014105B1 (ko)	1996-10-14
CA1341032C (fr)	2000-06-20
DK173757B1 (da)	2001-09-10
PH26263A (en)	1992-04-01
DE3851238D1 (de)	1994-10-06
NO880268L (no)	1988-07-25
IE63547B1 (en)	1995-05-17
JP2709817B2 (ja)	1998-02-04
PT86600A (pt)	1988-02-01
AR245140A1 (es)	1993-12-30
AU1072988A (en)	1988-07-28
CN88100260A (zh)	1988-11-09
FI89060C (fi)	1993-08-10
EP0276014A3 (en)	1990-05-16
NZ223236A (en)	1989-11-28
FI880286A7 (fi)	1988-07-24
FI880286A0 (fi)	1988-01-22
NO174105B (no)	1993-12-06
ES2063740T3 (es)	1995-01-16
JPS63215698A (ja)	1988-09-08
HU199159B (en)	1990-01-29
DK31088D0 (da)	1988-01-22
IL85159A0 (en)	1988-06-30
AU601801B2 (en)	1990-09-20
EP0276014A2 (fr)	1988-07-27
ATE110743T1 (de)	1994-09-15
KR880009045A (ko)	1988-09-13
DK31088A (da)	1988-07-24
DE3851238T2 (de)	1995-03-16
NO174105C (no)	1994-03-16
HUT46339A (en)	1988-10-28
IE880167L (en)	1988-07-23
NO880268D0 (no)	1988-01-22
FI89060B (fi)	1993-04-30

Legal Events

Date

Code

Title

Description

1998-06-15

KB

Patent renewed

2002-09-12

MM9K

Patent not in force due to non-payment of renewal fees

2006-09-05

HC

Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.

Publication	Publication Date	Title
IL85159A (en)	1993-04-04	Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them
NZ213563A (en)	1991-08-27	Anticoagulant proteins and pharmaceutical compositions
NZ224903A (en)	1990-02-26	C-terminal alpha aminoboronic acid derivatives and pharmaceutical compositions
IL88156A (en)	1997-02-18	Azacyclic compounds their preparation and pharmaceutical compositions containing them
IL82221A0 (en)	1987-10-30	Phenyl-piperazines and pharmaceutical compositions containing them
IL74384A (en)	1988-11-30	Crf antagonist peptides and pharmaceutical compositions containing them
IL90067A0 (en)	1989-12-15	1alpha-hydroxyvitamin-d compounds and pharmaceutical compositions containing them
IL85896A (en)	1993-01-14	Substituted di-tert.- butylphenols and pharmaceutical compositions containing them
IL88670A0 (en)	1989-07-31	2,5-diaryl-tetrahydrofurans and analogs thereof and pharmaceutical compositions containing them
NZ220365A (en)	1990-06-26	Antiviral peptides and pharmaceutical compositions
IL86086A0 (en)	1988-09-30	Bifunctional proteins and pharmaceutical compositions containing them
GB2207922B (en)	1991-02-20	Tripeptides and pharmaceutical compositions containing them
NZ226450A (en)	1990-05-28	Crystalline-1-carbacephalosporin and pharmaceutical compositions
IL88433A0 (en)	1989-06-30	Diarylstyrylquinoline diacids and pharmaceutical compositions containing them
IL84268A (en)	1992-09-06	Amino-cyclohexyl-hydroxyalkanoic acid peptide derivatives and pharmaceutical compositions containing them
NZ218749A (en)	1990-06-26	5 to 8-membered azacyclic derivatives and pharmaceutical compositions
IL85969A0 (en)	1988-09-30	Ribofuranuronic acid derivatives and pharmaceutical compositions containing them
IL88776A0 (en)	1989-07-31	Linear analogs of atrial natriuretic peptides,their preparation and pharmaceutical compositions containing them
GB2167746B (en)	1989-01-11	A process for the preparation of isosilybin-free silibinin and pharmaceutical compositions containing it
IL86166A0 (en)	1988-11-15	Synthetic grf analogs and pharmaceutical compositions containing them
NZ216971A (en)	1989-05-29	Phosphonate esters and pharmaceutical compositions
GB2207916B (en)	1992-03-25	Nitromethane compounds and pharmaceutical compositions containing them
EP0285550A3 (en)	1989-07-19	A percutaneous-administration-type pharmaceutical preparation of nitroglycerin
GR870093B (en)	1987-05-25	8a- acylaminoergolines their production and pharmaceutical compositions containing them
IL91663A0 (en)	1990-04-29	Crf analogs and pharmaceutical compositions containing them