IL85295A - Tricyclic imidazole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

Tricyclic imidazole derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL85295A
Authority: IL; Israel
Prior art keywords: alkyl; preparation; pharmaceutical compositions; compositions containing; imidazole derivatives
Prior art date: 1987-03-18

Application number

IL85295A

Other languages

English (en)

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-18

Filing date

1988-02-02

Publication date

1991-12-12

1988-02-02 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1991-12-12 Publication of IL85295A publication Critical patent/IL85295A/xx

Links

238000002360 preparation method Methods 0.000 title abstract 2
150000002460 imidazoles Chemical class 0.000 title 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 2
125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000003326 hypnotic agent Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000002664 nootropic agent Substances 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Anesthesiology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)
Luminescent Compositions (AREA)

IL85295A 1987-03-18 1988-02-02 Tricyclic imidazole derivatives,their preparation and pharmaceutical compositions containing them IL85295A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK137487A DK155524C (da)	1987-03-18	1987-03-18	Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse

Publications (1)

Publication Number	Publication Date
IL85295A true IL85295A (en)	1991-12-12

Family

ID=8104158

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL85295A IL85295A (en)	1987-03-18	1988-02-02	Tricyclic imidazole derivatives,their preparation and pharmaceutical compositions containing them

Country Status (18)

Country	Link
US (2)	US4873244A (de)
EP (1)	EP0283162B1 (de)
JP (1)	JPS6463581A (de)
KR (1)	KR960010455B1 (de)
AT (1)	ATE92926T1 (de)
AU (1)	AU607469B2 (de)
CA (1)	CA1308712C (de)
DE (1)	DE3883033T2 (de)
DK (1)	DK155524C (de)
ES (1)	ES2058251T3 (de)
FI (1)	FI92700C (de)
IE (1)	IE62320B1 (de)
IL (1)	IL85295A (de)
NO (1)	NO169340C (de)
NZ (1)	NZ223777A (de)
PH (2)	PH24076A (de)
PT (1)	PT87013B (de)
ZA (1)	ZA881140B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) *	1988-06-01	1989-12-15	Ferrosan As	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK161148C (da) *	1988-06-14	1991-11-18	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne
DK626288D0 (da) *	1988-11-10	1988-11-10	Ferrosan As	Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
DK588489D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588389D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
FR2659329B1 (fr) *	1990-03-09	1994-06-03	Adir	Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DK151890D0 (da) *	1990-06-22	1990-06-22	Ferrosan As	Heterocykliske forbindelser deres fremstilling og brug
US5276028A (en) *	1990-06-22	1994-01-04	Nordisk A/S	Imidazoquinoxaline compounds
DK204291D0 (da) *	1991-12-20	1991-12-20	Novo Nordisk As	Heterocykliske forbindelser deres fremstilling og anvendelse
US5371080A (en) *	1990-06-22	1994-12-06	Novo Nordisk A/S	Imidazoquinazoline compounds and their use
WO1992004350A1 (en) *	1990-09-04	1992-03-19	The Upjohn Company	Oxygenated quinoxalines
EP0590022A1 (de) *	1991-06-14	1994-04-06	PHARMACIA & UPJOHN COMPANY	Imidazo(1,5-a)chinoxaline
WO1993012113A1 (en) *	1991-12-17	1993-06-24	The Upjohn Company	3-SUBSTITUTED IMIDAZO (1,5-a) AND IMIDAZO (1,5-a)-TRIAZOLO (1,5-c) QUINOXALINES AND QUINAZOLINES WITH CNS ACTIVITY
EP0625982B1 (de) *	1992-02-13	2002-06-12	PHARMACIA & UPJOHN COMPANY	4-oxo-und 4h-imidazo(5,1-c)(1,4)benzoxazine nützlich als benzodiazepinrezeptor-bindemittel.
JPH07503970A (ja) *	1992-02-19	1995-04-27	ジ・アップジョン・カンパニー	ＣＮＳ活性を有する３−置換イミダゾ（１，５−ａ）−キノキサリン類およびキナゾリン類
US5367077A (en) *	1992-04-08	1994-11-22	Neurogen Corporation	Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
USRE35840E (en) *	1993-11-19	1998-07-07	Pharmacia & Upjohn Company	Imidazo 1,5-a!quinolines for treatment of anxiety and sleep disorders
IL112235A (en) *	1994-01-03	2000-06-29	Acea Pharm Inc	1,4-dihydro-pyrido¬2,3-b¾pyrazine-2,3-dione (5 or 8) oxide derivatives and pharmaceutical compositions containing them
FR2799757B1 (fr) *	1999-10-15	2001-12-14	Adir	Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6888004B2 (en) *	2001-01-26	2005-05-03	Bristol-Myers Squibb Company	Imidazolyl derivatives as corticotropin releasing factor inhibitors
WO2017149469A1 (en)	2016-03-03	2017-09-08	Emcure Pharmaceuticals Limited	Heterocyclic compounds useful as ido and/or tdo modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4440929A (en) *	1981-07-16	1984-04-03	Usv Pharmaceutical Corporation	Imidazoquinoxaline compounds
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DE202441T1 (de) *	1985-05-17	1987-03-19	Aktieselskabet Ferrosan, Soeborg	Oxadiazolylimidazobenzodiazepine, verfahren zu ihrer herstellung und pharmazeutische zubereitungen.
US4771051A (en) *	1985-05-17	1988-09-13	A/S Ferrosan	3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
EP0226282B1 (de) *	1985-10-17	1989-07-05	A/S Ferrosan	Heterocyclische Verbindungen und ihre Herstellung und Verwendung
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) *	1988-06-01	1989-12-15	Ferrosan As	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them

1987
- 1987-03-18 DK DK137487A patent/DK155524C/da not_active IP Right Cessation
1988
- 1988-02-02 IL IL85295A patent/IL85295A/xx not_active IP Right Cessation
- 1988-02-10 PH PH36480A patent/PH24076A/en unknown
- 1988-02-16 US US07/156,363 patent/US4873244A/en not_active Expired - Fee Related
- 1988-02-18 IE IE43888A patent/IE62320B1/en not_active IP Right Cessation
- 1988-02-18 ZA ZA881140A patent/ZA881140B/xx unknown
- 1988-02-22 FI FI880815A patent/FI92700C/fi not_active IP Right Cessation
- 1988-03-01 DE DE88301783T patent/DE3883033T2/de not_active Expired - Fee Related
- 1988-03-01 EP EP88301783A patent/EP0283162B1/de not_active Expired - Lifetime
- 1988-03-01 ES ES88301783T patent/ES2058251T3/es not_active Expired - Lifetime
- 1988-03-01 AT AT88301783T patent/ATE92926T1/de not_active IP Right Cessation
- 1988-03-07 NZ NZ223777A patent/NZ223777A/xx unknown
- 1988-03-16 KR KR1019880002727A patent/KR960010455B1/ko not_active Expired - Fee Related
- 1988-03-17 JP JP63062068A patent/JPS6463581A/ja active Pending
- 1988-03-17 CA CA000561758A patent/CA1308712C/en not_active Expired - Lifetime
- 1988-03-17 NO NO881191A patent/NO169340C/no unknown
- 1988-03-18 PT PT87013A patent/PT87013B/pt not_active IP Right Cessation
- 1988-03-18 AU AU13259/88A patent/AU607469B2/en not_active Ceased
- 1988-07-18 PH PH37235A patent/PH24165A/en unknown
1989
- 1989-04-20 US US07/340,901 patent/US4902686A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR880011157A (ko)	1988-10-26
NO169340C (no)	1992-06-10
DE3883033T2 (de)	1993-12-16
IE62320B1 (en)	1995-01-25
KR960010455B1 (ko)	1996-08-01
DK155524C (da)	1989-09-11
EP0283162B1 (de)	1993-08-11
ES2058251T3 (es)	1994-11-01
JPS6463581A (en)	1989-03-09
DK137487D0 (da)	1987-03-18
NO881191D0 (no)	1988-03-17
AU1325988A (en)	1988-09-22
US4902686A (en)	1990-02-20
ATE92926T1 (de)	1993-08-15
NZ223777A (en)	1989-09-27
PT87013B (pt)	1995-03-01
PT87013A (pt)	1989-03-30
FI92700C (fi)	1994-12-27
DK137487A (da)	1988-09-19
PH24076A (en)	1990-03-05
NO881191L (no)	1988-09-19
ZA881140B (en)	1988-08-15
EP0283162A3 (en)	1990-05-30
US4873244A (en)	1989-10-10
PH24165A (en)	1990-03-22
DK155524B (da)	1989-04-17
AU607469B2 (en)	1991-03-07
EP0283162A2 (de)	1988-09-21
DE3883033D1 (de)	1993-09-16
FI92700B (fi)	1994-09-15
FI880815A7 (fi)	1988-09-19
FI880815A0 (fi)	1988-02-22
IE880438L (en)	1988-09-18
CA1308712C (en)	1992-10-13
NO169340B (no)	1992-03-02

Legal Events

Date	Code	Title	Description
1999-01-26	RH	Patent void

Publication	Publication Date	Title
NZ223777A (en)	1989-09-27	Heterocyclic derivatives and pharmaceutical compositions
AU588994B2 (en)	1989-09-28	Novel benzodiazepine derivatives and their preparation and use
AU586043B2 (en)	1989-06-29	Imidazo``1,5-a``quinazoline derivatives, their preparation and use.
AU567163B2 (en)	1987-11-12	B-carbolin-3-carboxylic acid derivatives
NZ229300A (en)	1991-04-26	Substituted-2-ethenyl-3,4,5,6-tetrahydrothieno (4,3,2-cf)(3)benzazepine derivatives and pharmaceutical compositions
TW228524B (de)	1994-08-21
ZA875345B (en)	1988-03-30	Tetracyclic indole derivatives
IL99782A0 (en)	1992-08-18	Ergoline derivatives,their production and pharmaceutical compositions containing them