IL87858A - Pharmaceutical compositions for treatment of glaucoma containing renin inhibiting amide analogs - Google Patents

Pharmaceutical compositions for treatment of glaucoma containing renin inhibiting amide analogs

Info

Publication number: IL87858A
Authority: IL; Israel
Prior art keywords: methyl; loweralkyl; inhibiting compound; renin inhibiting; treatment
Prior art date: 1987-10-06

Application number

IL87858A

Other languages

English (en)

Other versions

IL87858A0 (en

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-06

Filing date

1988-09-27

Publication date

1993-04-04

1988-09-27 Application filed by Abbott Lab filed Critical Abbott Lab

1989-03-31 Publication of IL87858A0 publication Critical patent/IL87858A0/xx

1993-04-04 Publication of IL87858A publication Critical patent/IL87858A/xx

Links

230000002401 inhibitory effect Effects 0.000 title abstract 4
102100028255 Renin Human genes 0.000 title abstract 3
108090000783 Renin Proteins 0.000 title abstract 3
208000010412 Glaucoma Diseases 0.000 title abstract 2
150000001408 amides Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
-1 (2-naphthyl)methyl Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
230000004410 intraocular pressure Effects 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
PHRABVHYUHIYGY-UHFFFAOYSA-N 1-methylnaphthalene Chemical group C1=CC=C2C([CH2])=CC=CC2=C1 PHRABVHYUHIYGY-UHFFFAOYSA-N 0.000 abstract 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
239000002876 beta blocker Substances 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000006277 halobenzyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002294 steroidal antiinflammatory agent Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000005309 thioalkoxy group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/553—Renin inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL87858A 1987-10-06 1988-09-27 Pharmaceutical compositions for treatment of glaucoma containing renin inhibiting amide analogs IL87858A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10563687A	1987-10-06	1987-10-06
US07/240,567 US4927807A (en)	1987-10-06	1988-09-08	Glaucoma treatment

Publications (2)

Publication Number	Publication Date
IL87858A0 IL87858A0 (en)	1989-03-31
IL87858A true IL87858A (en)	1993-04-04

Family

ID=26802775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL87858A IL87858A (en)	1987-10-06	1988-09-27	Pharmaceutical compositions for treatment of glaucoma containing renin inhibiting amide analogs

Country Status (11)

Country	Link
US (1)	US4927807A (fr)
EP (1)	EP0311012B1 (fr)
JP (1)	JPH0381257A (fr)
KR (1)	KR890006229A (fr)
AT (1)	ATE120370T1 (fr)
AU (1)	AU611953B2 (fr)
CA (1)	CA1328608C (fr)
DE (1)	DE3853459T2 (fr)
DK (1)	DK560688A (fr)
IL (1)	IL87858A (fr)
NZ (1)	NZ226479A (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0326364B1 (fr) *	1988-01-26	1994-06-22	Sankyo Company Limited	Polypeptide inhibant la rénine, sa fabrication et son utilisation
US5268374A (en) *	1988-10-04	1993-12-07	Abbott Laboratories	Non-peptide renin inhibitors
US5164388A (en) *	1988-10-19	1992-11-17	Abbott Laboratories	Heterocyclic peptide renin inhibitors
FR2647675B1 (fr) *	1989-06-05	1994-05-20	Sanofi	Utilisation d'un derive de la statine dans le traitement des affections oculaires
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
US5114937A (en) *	1989-11-28	1992-05-19	Warner-Lambert Company	Renin inhibiting nonpeptides
DK167813B1 (da) *	1989-12-07	1993-12-20	Carlbiotech Ltd As	Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5332742A (en) *	1990-05-11	1994-07-26	Abbott Laboratories	Renin inhibitors
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors
JPH04243835A (ja) *	1990-08-29	1992-08-31	Pfizer Inc	高眼圧症又は緑内障治療用薬剤組成物及び治療方法
US5442044A (en) *	1991-01-04	1995-08-15	Pfizer Inc.	Orally active renin inhibitors
GB9127041D0 (en) *	1991-12-20	1992-02-19	Fujisawa Pharmaceutical Co	New use
DK0708085T3 (da) *	1994-10-19	2002-11-11	Novartis Ag	Antivirale ethere af aspartatproteasesubstrat-isostere
AU4093799A (en)	1998-05-22	1999-12-13	Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
US6867203B2 (en)	1998-12-29	2005-03-15	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
AU1891399A (en)	1999-01-19	2000-08-07	Hamamatsu Photonics K.K.	Photomultiplier
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CA2789262C (fr)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Systeme pharma-informatique
EP1945240B1 (fr)	2005-09-16	2016-12-28	Raptor Pharmaceutical Inc	Compositions de proteines rap specifiques des proteines contenant du cr, et leurs utilisations
TR201908314T4 (tr)	2009-02-20	2019-06-21	2 Bbb Medicines B V	Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
UA108742C2 (uk)	2009-09-23	2015-06-10		Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA817261B (en) *	1980-10-23	1982-09-29	Schering Corp	Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4442089A (en) *	1982-07-06	1984-04-10	E. R. Squibb & Sons, Inc.	Method for treating glaucoma with topical or systemic ACE inhibitor compositions
DE3381850D1 (de) *	1982-12-27	1990-10-04	Schering Corp	Pharmazeutische zusammensetzung.
GB8422165D0 (en) *	1984-09-01	1984-10-03	Wellcome Found	Compounds
US4845079A (en) *	1985-01-23	1989-07-04	Luly Jay R	Peptidylaminodiols
DE3686706T2 (de) *	1985-07-03	1993-01-28	Schering Corp	Glaukomhemmende zusammensetzungen und verfahren zu ihrer herstellung.
US4914090A (en) *	1985-11-01	1990-04-03	Schering Corporation	Ophthalmic compositions
US4906613A (en) *	1985-11-05	1990-03-06	Schering Corporation	Antiglaucoma compositions and methods
IL81234A (en) *	1986-01-16	1992-09-06	Abbott Lab	Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
MY103189A (en) *	1986-10-31	1993-05-29	Pfizer	Nor-statine and nor-cyclostatine polypeptides

1988
- 1988-09-08 US US07/240,567 patent/US4927807A/en not_active Expired - Fee Related
- 1988-09-27 IL IL87858A patent/IL87858A/xx not_active IP Right Cessation
- 1988-09-30 AU AU23308/88A patent/AU611953B2/en not_active Ceased
- 1988-10-04 EP EP88116399A patent/EP0311012B1/fr not_active Expired - Lifetime
- 1988-10-04 CA CA000579269A patent/CA1328608C/fr not_active Expired - Fee Related
- 1988-10-04 DE DE3853459T patent/DE3853459T2/de not_active Expired - Fee Related
- 1988-10-04 AT AT88116399T patent/ATE120370T1/de not_active IP Right Cessation
- 1988-10-05 KR KR1019880012965A patent/KR890006229A/ko not_active Ceased
- 1988-10-06 DK DK560688A patent/DK560688A/da not_active Application Discontinuation
- 1988-10-06 NZ NZ226479A patent/NZ226479A/en unknown
- 1988-10-06 JP JP63252887A patent/JPH0381257A/ja active Pending

Also Published As

Publication number	Publication date
JPH0381257A (ja)	1991-04-05
DK560688D0 (da)	1988-10-06
US4927807A (en)	1990-05-22
CA1328608C (fr)	1994-04-19
EP0311012B1 (fr)	1995-03-29
AU2330888A (en)	1989-04-06
EP0311012A2 (fr)	1989-04-12
EP0311012A3 (en)	1990-07-11
NZ226479A (en)	1991-04-26
KR890006229A (ko)	1989-06-12
DK560688A (da)	1989-04-07
IL87858A0 (en)	1989-03-31
DE3853459D1 (de)	1995-05-04
AU611953B2 (en)	1991-06-27
DE3853459T2 (de)	1995-11-09
ATE120370T1 (de)	1995-04-15

Legal Events

Date	Code	Title	Description
1999-09-22	RH	Patent void

Publication	Publication Date	Title
IL87858A (en)	1993-04-04	Pharmaceutical compositions for treatment of glaucoma containing renin inhibiting amide analogs
NZ218936A (en)	1989-10-27	Peptidylaminodiols and pharmaceutical compositions
IE873548L (en)	1988-06-30	Peptidylaminodiols
IL111288A (en)	1999-05-09	Uses of 2-phenyl-3-aroylbenzothiophenes and 3-phenyl-4-aroyl-1,2-dihydronaphthalenes for the preparation of a medicament for inhibiting smooth muscle cell proliferation and restinosis
MY132056A (en)	2007-09-28	Methods of inhibiting physiological conditions associated with an excess of neuropeptide y.
KR890005147A (ko)	1989-05-13	펩티딜헤테로사이클
WO2001012169A3 (fr)	2002-02-14	Traitement anticancereux
KR870007204A (ko)	1987-08-17	작용화 펩티딜 아미노디올 및-트리올
WO2002009702A3 (fr)	2002-12-27	Methode de reduction de la pression intraoculaire avec des derives d'indole
KR880007538A (ko)	1988-08-27	피리다조 디아제핀 유도체
GEP20012389B (en)	2001-03-25	Benzoxazinone Dopamine D4 Receptor Antagonists, Pharmaceutical Composition Containing the Same and Method for Treatment of Psychosis or Schizophrenia
NO931980D0 (no)	1993-06-01	Angiotensin ii antagonistimidazolderivater samt fremstilling og terapeutisk anvendelse av slike
NZ293691A (en)	1999-07-29	Use of a medicament containing an anilide compound for treatment of type i allergic diseases
KR940701407A (ko)	1994-05-28	레닌 억제제로서의 하이드록시아지도 유도체 및 관련 화합물
EA199800665A1 (ru)	1999-08-26	Способы лечения и предупреждения неблагоприятного воздействия активных форм кислорода
US4424228A (en)	1984-01-03	Antihypertensive agent comprising a thiazolidine carboxylic acid and probenecid
KR910006322A (ko)	1991-04-29	펩티딜 디플루오로디올 레닌 억제제
MY108455A (en)	1996-09-30	Therapeutic benzazapine compounds.
MX9709189A (es)	1998-03-31	Metodos para inhibir la migracion de celulas de musculo liso vascular.