IL88118A - Ion-exchange chromatographic method of purifying proteins - Google Patents
Ion-exchange chromatographic method of purifying proteinsInfo
- Publication number
- IL88118A IL88118A IL88118A IL8811888A IL88118A IL 88118 A IL88118 A IL 88118A IL 88118 A IL88118 A IL 88118A IL 8811888 A IL8811888 A IL 8811888A IL 88118 A IL88118 A IL 88118A
- Authority
- IL
- Israel
- Prior art keywords
- ion
- chromatographic method
- exchange chromatographic
- purifying proteins
- disclosed
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000004587 chromatography analysis Methods 0.000 title 1
- 238000005342 ion exchange Methods 0.000 title 1
- 239000012535 impurity Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 235000019750 Crude protein Nutrition 0.000 abstract 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 239000003729 cation exchange resin Substances 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11188687A | 1987-10-23 | 1987-10-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL88118A0 IL88118A0 (en) | 1989-06-30 |
| IL88118A true IL88118A (en) | 1993-06-10 |
Family
ID=22340970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL88118A IL88118A (en) | 1987-10-23 | 1988-10-21 | Ion-exchange chromatographic method of purifying proteins |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP0313343B2 (da) |
| JP (1) | JPH0788395B2 (da) |
| KR (1) | KR930008447B1 (da) |
| CN (1) | CN1031943C (da) |
| AT (1) | ATE121418T1 (da) |
| AU (1) | AU626008B2 (da) |
| DE (1) | DE3853610T3 (da) |
| DK (1) | DK99690A (da) |
| ES (1) | ES2070855T5 (da) |
| FI (1) | FI103974B1 (da) |
| HU (1) | HU204537B (da) |
| IE (1) | IE72219B1 (da) |
| IL (1) | IL88118A (da) |
| MY (1) | MY108512A (da) |
| NO (1) | NO303451B1 (da) |
| NZ (1) | NZ226651A (da) |
| OA (1) | OA09787A (da) |
| PT (1) | PT88813B (da) |
| TN (1) | TNSN88111A1 (da) |
| WO (1) | WO1989003840A1 (da) |
| ZA (1) | ZA887862B (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0133561B1 (ko) * | 1988-05-13 | 1998-04-21 | 스티븐 엠. 오드레 | 과립구 군체 자극인자의 정제방법 |
| US7217689B1 (en) | 1989-10-13 | 2007-05-15 | Amgen Inc. | Glycosylation analogs of erythropoietin |
| US5110913A (en) * | 1990-05-25 | 1992-05-05 | Miles Inc. | Antibody purification method |
| US5463029A (en) * | 1992-11-23 | 1995-10-31 | Immunex Corporation | Purification of fusion proteins comprising GM-CSF and IL-3 |
| CA2171832C (en) * | 1993-09-15 | 2001-01-02 | Harutyun Eran | Alpha1-acid glycoprotein purification process and product |
| US5808011A (en) * | 1996-07-01 | 1998-09-15 | Biopure Corporation | Method for chromatographic removal of prions |
| US7304150B1 (en) | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
| AU763039B2 (en) | 1999-04-08 | 2003-07-10 | Genentech Inc. | Composition based on oppositely-charged polypeptides |
| EP3225625A1 (en) * | 2002-09-11 | 2017-10-04 | Chugai Seiyaku Kabushiki Kaisha | Protein purification method |
| DE10360841A1 (de) * | 2003-12-20 | 2005-07-14 | Henkel Kgaa | Helle, stabile, staub- und geruchsarme Enzymgranulate |
| EP1869065B1 (en) * | 2005-03-11 | 2020-05-06 | Wyeth LLC | A method of weak partitioning chromatography |
| SE529259C2 (sv) * | 2005-08-31 | 2007-06-12 | Ge Healthcare Bio Sciences Ab | Tillverkning av kromarografimatriser, en kromarografimatris, en vätskekromatografikolonn, prcess för att isolera målföreningar och användning av en kromarografimatris för vätskekromatografi |
| CA2702645C (en) * | 2006-11-10 | 2018-01-02 | Agriculture Victoria Services Pty Ltd | Process for the preparation of angiogenin |
| CN101556261B (zh) * | 2009-05-25 | 2012-01-11 | 北京理工大学 | 微管内等电聚焦和剪断吹出培养测定微生物等电点的方法 |
| CN101556260B (zh) * | 2009-05-25 | 2012-01-11 | 北京理工大学 | 固定化pH梯度毛细管等电聚焦测定微生物等电点的方法 |
| WO2013075740A1 (en) * | 2011-11-23 | 2013-05-30 | Sanofi | Antibody purification method |
| RU2648999C2 (ru) * | 2011-12-22 | 2018-03-29 | Дженентек, Инк. | Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии |
| EP3301115B1 (en) | 2013-05-06 | 2021-11-10 | Sanofi | Continuous multistep process for purifying antibodies |
| EP3546475A1 (en) | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4658018A (en) * | 1984-03-13 | 1987-04-14 | Immunex Corporation | Process for producing homogeneous colony stimulating factor |
| IL76360A0 (en) * | 1984-09-26 | 1986-01-31 | Takeda Chemical Industries Ltd | Mutual separation of proteins |
| ZA872781B (en) * | 1986-05-19 | 1987-10-05 | Immunology Ventures | B-cell stimulating factor |
-
1988
- 1988-10-19 EP EP88309824A patent/EP0313343B2/en not_active Expired - Lifetime
- 1988-10-19 DE DE3853610T patent/DE3853610T3/de not_active Expired - Fee Related
- 1988-10-19 AT AT88309824T patent/ATE121418T1/de not_active IP Right Cessation
- 1988-10-19 WO PCT/US1988/003589 patent/WO1989003840A1/en not_active Ceased
- 1988-10-19 HU HU886264A patent/HU204537B/hu not_active IP Right Cessation
- 1988-10-19 AU AU26247/88A patent/AU626008B2/en not_active Ceased
- 1988-10-19 KR KR1019890701131A patent/KR930008447B1/ko not_active Expired - Fee Related
- 1988-10-19 JP JP63508950A patent/JPH0788395B2/ja not_active Expired - Lifetime
- 1988-10-19 EP EP88909648A patent/EP0391934A1/en active Pending
- 1988-10-19 ES ES88309824T patent/ES2070855T5/es not_active Expired - Lifetime
- 1988-10-20 PT PT88813A patent/PT88813B/pt not_active IP Right Cessation
- 1988-10-20 IE IE316888A patent/IE72219B1/en not_active IP Right Cessation
- 1988-10-20 ZA ZA887862A patent/ZA887862B/xx unknown
- 1988-10-20 TN TNTNSN88111A patent/TNSN88111A1/fr unknown
- 1988-10-20 MY MYPI88001190A patent/MY108512A/en unknown
- 1988-10-20 NZ NZ226651A patent/NZ226651A/xx unknown
- 1988-10-21 IL IL88118A patent/IL88118A/xx not_active IP Right Cessation
- 1988-10-21 CN CN88107266A patent/CN1031943C/zh not_active Expired - Fee Related
-
1990
- 1990-04-17 OA OA59777A patent/OA09787A/en unknown
- 1990-04-20 NO NO901769A patent/NO303451B1/no not_active IP Right Cessation
- 1990-04-23 DK DK099690A patent/DK99690A/da unknown
- 1990-04-23 FI FI902017A patent/FI103974B1/fi not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH1 | Patent not in force |