IL91930A - Quinolinone derivatives, their preparation and their application in therapy - Google Patents

Quinolinone derivatives, their preparation and their application in therapy

Info

Publication number: IL91930A
Authority: IL; Israel
Prior art keywords: therapy; application; preparation; quinolinone derivatives; alkyl radical
Prior art date: 1988-10-11

Application number

IL91930A

Other languages

English (en)

Other versions

IL91930A0 (en

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-11

Filing date

1989-10-10

Publication date

1993-08-18

1989-10-10 Application filed by Synthelabo filed Critical Synthelabo

1990-06-10 Publication of IL91930A0 publication Critical patent/IL91930A0/xx

1993-08-18 Publication of IL91930A publication Critical patent/IL91930A/xx

Links

LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title abstract 2
238000002560 therapeutic procedure Methods 0.000 title abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229910052731 fluorine Chemical group 0.000 abstract 1
239000011737 fluorine Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000005956 isoquinolyl group Chemical group 0.000 abstract 1
UCFFGYASXIPWPD-UHFFFAOYSA-N methyl hypochlorite Chemical group COCl UCFFGYASXIPWPD-UHFFFAOYSA-N 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical group O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL91930A 1988-10-11 1989-10-10 Quinolinone derivatives, their preparation and their application in therapy IL91930A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8813324A FR2637591B1 (fr)	1988-10-11	1988-10-11	Derives de quinoleinone, leur preparation et leur application en therapeutique

Publications (2)

Publication Number	Publication Date
IL91930A0 IL91930A0 (en)	1990-06-10
IL91930A true IL91930A (en)	1993-08-18

Family

ID=9370884

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL91930A IL91930A (en)	1988-10-11	1989-10-10	Quinolinone derivatives, their preparation and their application in therapy

Country Status (20)

Country	Link
US (1)	US4983607A (cs)
EP (1)	EP0364327B1 (cs)
JP (1)	JPH02157267A (cs)
KR (1)	KR900006317A (cs)
AT (1)	ATE71617T1 (cs)
AU (1)	AU619349B2 (cs)
CS (1)	CS404891A3 (cs)
DE (1)	DE68900717D1 (cs)
DK (1)	DK500189A (cs)
ES (1)	ES2037980T3 (cs)
FI (1)	FI91748C (cs)
FR (1)	FR2637591B1 (cs)
GR (1)	GR3003921T3 (cs)
HU (1)	HU204813B (cs)
IE (1)	IE61830B1 (cs)
IL (1)	IL91930A (cs)
NO (1)	NO173058C (cs)
NZ (1)	NZ230959A (cs)
PT (1)	PT91939B (cs)
ZA (1)	ZA897672B (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2635105B1 (fr) *	1988-08-03	1991-01-25	Synthelabo	Derives de piperazine et leur procede de preparation
US5457099A (en) *	1992-07-02	1995-10-10	Sawai Pharmaceutical Co., Ltd.	Carbostyril derivatives and antiallergic agent
DK148392D0 (da) *	1992-12-09	1992-12-09	Lundbeck & Co As H	Heterocykliske forbindelser
AU679042B2 (en) *	1993-03-05	1997-06-19	Merck Sharp & Dohme Limited	Quinolone derivatives as dopamine D4 ligands
WO1994021619A1 (en) *	1993-03-16	1994-09-29	Pfizer Inc.	Naphthalene derivatives
FR2737723B1 (fr) *	1995-08-09	1997-09-05	Synthelabo	Derives de 1-(2-(1h-inden-3-yl)ethyl)-4-(naphtalen-1-yl)- piperazine, leur preparation et leur application en therapeutique
FR2738823B1 (fr) *	1995-09-15	1997-10-31	Synthelabo	Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
FR2761071B1 (fr) *	1997-03-20	1999-12-03	Synthelabo	Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
FR2761067B1 (fr) *	1997-03-20	1999-04-23	Synthelabo	Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
US6562837B1 (en) *	1998-10-21	2003-05-13	Korea Institute Of Science & Technology	Use of tetrahydroisoquinoline compounds for the treatment of septicemia
CN1253449C (zh)	2000-11-07	2006-04-26	诺瓦提斯公司	作为蛋白激酶c抑制剂的吲哚基马来酰亚胺衍生物
US7053092B2 (en) *	2001-01-29	2006-05-30	Otsuka Pharmaceutical Co., Ltd.	5-HT1a receptor subtype agonist
AR033485A1 (es) *	2001-09-25	2003-12-26	Otsuka Pharma Co Ltd	Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en)	2001-09-25	2014-04-22	Otsuka Pharmaceutical Co., Ltd.	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
TW200803855A (en) *	2006-02-24	2008-01-16	Kalypsys Inc	Quinolones useful as inducible nitric oxide synthase inhibitors
EA201001644A1 (ru) *	2008-05-20	2011-06-30	Астразенека Аб	Способ лечения тревожного большого депрессивного расстройства
MA41168A (fr) *	2014-12-17	2017-10-24	Acraf	Nouveaux composés antibactériens

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54128588A (en) *	1978-03-29	1979-10-05	Dainippon Pharmaceut Co Ltd	Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline
JPS54130587A (en) *	1978-03-30	1979-10-09	Otsuka Pharmaceut Co Ltd	Carbostyryl derivative
PH17194A (en) *	1980-03-06	1984-06-19	Otsuka Pharma Co Ltd	Novel carbostyril derivatives,and pharmaceutical composition containing the same
US4284768A (en) *	1980-07-02	1981-08-18	American Home Products Corporation	1,2-Dihydro-4-amino-2-oxo-3-quinoline-carboxylic acid derivatives
GB8827189D0 (en) *	1988-11-21	1988-12-29	Fujisawa Pharmaceutical Co	2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same

1988
- 1988-10-11 FR FR8813324A patent/FR2637591B1/fr not_active Expired - Fee Related
1989
- 1989-10-02 ES ES198989402700T patent/ES2037980T3/es not_active Expired - Lifetime
- 1989-10-02 DE DE8989402700T patent/DE68900717D1/de not_active Expired - Lifetime
- 1989-10-02 EP EP89402700A patent/EP0364327B1/fr not_active Expired - Lifetime
- 1989-10-02 AT AT89402700T patent/ATE71617T1/de not_active IP Right Cessation
- 1989-10-09 ZA ZA897672A patent/ZA897672B/xx unknown
- 1989-10-10 US US07/417,970 patent/US4983607A/en not_active Expired - Lifetime
- 1989-10-10 KR KR1019890014520A patent/KR900006317A/ko not_active Withdrawn
- 1989-10-10 HU HU895268A patent/HU204813B/hu not_active IP Right Cessation
- 1989-10-10 AU AU42750/89A patent/AU619349B2/en not_active Ceased
- 1989-10-10 IL IL91930A patent/IL91930A/xx not_active IP Right Cessation
- 1989-10-10 NO NO894036A patent/NO173058C/no not_active IP Right Cessation
- 1989-10-10 DK DK500189A patent/DK500189A/da not_active Application Discontinuation
- 1989-10-10 NZ NZ230959A patent/NZ230959A/en unknown
- 1989-10-10 FI FI894803A patent/FI91748C/fi not_active IP Right Cessation
- 1989-10-10 PT PT91939A patent/PT91939B/pt not_active IP Right Cessation
- 1989-10-10 IE IE326589A patent/IE61830B1/en not_active IP Right Cessation
- 1989-10-11 JP JP1266051A patent/JPH02157267A/ja active Pending
1991
- 1991-12-23 CS CS914048A patent/CS404891A3/cs unknown
1992
- 1992-02-27 GR GR920400344T patent/GR3003921T3/el unknown

Also Published As

Publication number	Publication date
PT91939A (pt)	1990-04-30
FI894803L (fi)	1990-04-12
EP0364327A1 (fr)	1990-04-18
DK500189A (da)	1990-04-12
FI91748B (fi)	1994-04-29
HU895268D0 (en)	1990-01-28
AU4275089A (en)	1990-04-26
IL91930A0 (en)	1990-06-10
AU619349B2 (en)	1992-01-23
NO173058B (no)	1993-07-12
NO894036L (no)	1990-04-17
ZA897672B (en)	1990-07-25
NZ230959A (en)	1990-12-21
DE68900717D1 (de)	1992-02-27
JPH02157267A (ja)	1990-06-18
EP0364327B1 (fr)	1992-01-15
NO894036D0 (no)	1989-10-10
KR900006317A (ko)	1990-05-07
CS404891A3 (en)	1992-04-15
IE61830B1 (en)	1994-11-30
IE893265L (en)	1990-04-11
DK500189D0 (da)	1989-10-10
ES2037980T3 (es)	1993-07-01
HU204813B (en)	1992-02-28
NO173058C (no)	1993-10-20
FI91748C (fi)	1994-08-10
FR2637591B1 (fr)	1992-10-23
ATE71617T1 (de)	1992-02-15
FI894803A0 (fi)	1989-10-10
US4983607A (en)	1991-01-08
GR3003921T3 (cs)	1993-03-16
FR2637591A1 (fr)	1990-04-13
HUT51612A (en)	1990-05-28
PT91939B (pt)	1995-05-31

Legal Events

Date	Code	Title	Description
2000-06-01	KB	Patent renewed
2004-06-20	RH1	Patent not in force

Publication	Publication Date	Title
AU619349B2 (en)	1992-01-23	Quinolinone derivatives, their preparation and their application in therapy
IE891816L (en)	1989-12-10	Pyrimidine derivatives
AU2201088A (en)	1989-03-23	1-((2-pyrimidinyl)aminoalkyl)piperidines, their preparation and their application in therapy
ATE21900T1 (de)	1986-09-15	Pyrimidinonderivate und diese enthaltende pharmazeutische zusammenstellungen.
NO840526L (no)	1984-08-16	Derivater av n-iminopyridiniumbetainer, fremgangsmaate til deres fremstilling og deres anvendelse i medikamenter
DK627584A (da)	1985-06-28	Benzothiazinderivater og fysiologisk acceptable salte deraf, fremgangsmaade og mellemprodukt til deres fremstilling samt deres anvendelse
FR2618436B1 (fr)	1989-10-27	Derives de piperidine, leur preparation et leur application en therapeutique
FR2596760B1 (fr)	1988-12-09	Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
DK12584A (da)	1984-07-15	Bicyclo(4.2.0)1,3,5-octatrienderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende disse
HUT44500A (en)	1988-03-28	Process for producing methionin-substituted new 1,4-dihydro-pyridine derivatives and pharmaceutical compositions containing them
ES509194A0 (es)	1983-01-16	Procedimiento para la preparacion de una nueva tiovinil-3 cefalosporina.
DK0461012T3 (da)	1994-09-12	Derivater af ((1-arylpyrrolidin-2-yl)methyl)piperazin, fremstillingen heraf og deres terapeutiske anvendelse
CA2049440A1 (en)	1992-03-01	Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
FI921298A7 (fi)	1992-03-25	Menetelmä lääkeaineena käyttökelpoisen 5-(6-imidatso/1,2-a/pyridyyli)pyridiini-johdannaisen valmistamiseksi
IL66208A (en)	1984-11-30	Phenethyl derivatives of imidazothiazolols and thiazolopyrimidinols,their preparation and pharmaceutical compositions containing them