IL92167A - Preparation containing activin and / or inhibin - Google Patents

Preparation containing activin and / or inhibin

Info

Publication number: IL92167A
Authority: IL; Israel
Prior art keywords: inhibin; chain; activin; globin; composition according
Prior art date: 1988-11-01

Application number

IL9216789A

Other languages

English (en)

Hebrew (he)

Other versions

IL92167A0 (en

Original Assignee

Perrine Susan P

Albers Norbert

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-01

Filing date

1989-10-31

Publication date

1994-07-31

1989-10-31 Application filed by Perrine Susan P, Albers Norbert filed Critical Perrine Susan P

1990-07-12 Publication of IL92167A0 publication Critical patent/IL92167A0/xx

1994-07-31 Publication of IL92167A publication Critical patent/IL92167A/en

Links

ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title claims abstract description 63
239000000893 inhibin Substances 0.000 title claims abstract description 57
108010059616 Activins Proteins 0.000 title claims abstract description 37
102000005606 Activins Human genes 0.000 title claims abstract description 37
239000000488 activin Substances 0.000 title claims abstract description 37
239000000203 mixture Substances 0.000 title claims abstract description 34
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
208000035475 disorder Diseases 0.000 claims abstract description 11
208000007056 sickle cell anemia Diseases 0.000 claims abstract description 11
102100021519 Hemoglobin subunit beta Human genes 0.000 claims abstract description 8
108091005904 Hemoglobin subunit beta Proteins 0.000 claims abstract description 8
150000001875 compounds Chemical class 0.000 claims description 20
241000124008 Mammalia Species 0.000 claims description 11
230000001605 fetal effect Effects 0.000 claims description 7
239000002243 precursor Substances 0.000 claims description 6
150000001413 amino acids Chemical group 0.000 claims description 5
208000005980 beta thalassemia Diseases 0.000 claims description 4
230000002441 reversible effect Effects 0.000 claims description 4
239000003937 drug carrier Substances 0.000 claims description 2
101710107057 Inhibin beta chain Proteins 0.000 claims 4
239000004480 active ingredient Substances 0.000 claims 1
238000000034 method Methods 0.000 abstract description 22
230000002401 inhibitory effect Effects 0.000 abstract description 4
208000024891 symptom Diseases 0.000 abstract description 3
239000003814 drug Substances 0.000 abstract description 2
108091005886 Hemoglobin subunit gamma Proteins 0.000 abstract 1
102100038617 Hemoglobin subunit gamma-2 Human genes 0.000 abstract 1
208000018020 Sickle cell-beta-thalassemia disease syndrome Diseases 0.000 abstract 1
206010043391 Thalassaemia beta Diseases 0.000 abstract 1
102000002746 Inhibins Human genes 0.000 description 45
108010004250 Inhibins Proteins 0.000 description 45
210000003754 fetus Anatomy 0.000 description 14
108010044495 Fetal Hemoglobin Proteins 0.000 description 10
102000012673 Follicle Stimulating Hormone Human genes 0.000 description 10
108010079345 Follicle Stimulating Hormone Proteins 0.000 description 10
102000004169 proteins and genes Human genes 0.000 description 10
108090000623 proteins and genes Proteins 0.000 description 10
230000015572 biosynthetic process Effects 0.000 description 9
102000018146 globin Human genes 0.000 description 9
108060003196 globin Proteins 0.000 description 9
238000003786 synthesis reaction Methods 0.000 description 9
229940028334 follicle stimulating hormone Drugs 0.000 description 8
238000009472 formulation Methods 0.000 description 8
229920001184 polypeptide Polymers 0.000 description 8
230000035935 pregnancy Effects 0.000 description 8
102000004196 processed proteins & peptides Human genes 0.000 description 8
108090000765 processed proteins & peptides Proteins 0.000 description 8
238000004519 manufacturing process Methods 0.000 description 7
210000004027 cell Anatomy 0.000 description 6
238000004113 cell culture Methods 0.000 description 6
230000000694 effects Effects 0.000 description 6
241000282412 Homo Species 0.000 description 5
125000003275 alpha amino acid group Chemical group 0.000 description 5
230000000925 erythroid effect Effects 0.000 description 5
238000000338 in vitro Methods 0.000 description 5
108010054147 Hemoglobins Proteins 0.000 description 4
102000001554 Hemoglobins Human genes 0.000 description 4
108010023082 activin A Proteins 0.000 description 4
229940024606 amino acid Drugs 0.000 description 4
238000000376 autoradiography Methods 0.000 description 4
239000000969 carrier Substances 0.000 description 4
230000003247 decreasing effect Effects 0.000 description 4
210000004700 fetal blood Anatomy 0.000 description 4
238000001727 in vivo Methods 0.000 description 4
230000035772 mutation Effects 0.000 description 4
238000013268 sustained release Methods 0.000 description 4
239000012730 sustained-release form Substances 0.000 description 4
208000011580 syndromic disease Diseases 0.000 description 4
238000002560 therapeutic procedure Methods 0.000 description 4
208000002903 Thalassemia Diseases 0.000 description 3
108010023079 activin B Proteins 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000008280 blood Substances 0.000 description 3
230000037396 body weight Effects 0.000 description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
201000010099 disease Diseases 0.000 description 3
210000003743 erythrocyte Anatomy 0.000 description 3
210000001733 follicular fluid Anatomy 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
238000002703 mutagenesis Methods 0.000 description 3
231100000350 mutagenesis Toxicity 0.000 description 3
238000007911 parenteral administration Methods 0.000 description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
239000000243 solution Substances 0.000 description 3
241000894007 species Species 0.000 description 3
239000000126 substance Substances 0.000 description 3
238000006467 substitution reaction Methods 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
125000000539 amino acid group Chemical group 0.000 description 2
-1 aspartyl residues Chemical group 0.000 description 2
239000012472 biological sample Substances 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
230000007012 clinical effect Effects 0.000 description 2
230000002939 deleterious effect Effects 0.000 description 2
238000012217 deletion Methods 0.000 description 2
230000037430 deletion Effects 0.000 description 2
238000002405 diagnostic procedure Methods 0.000 description 2
230000008175 fetal development Effects 0.000 description 2
239000012634 fragment Substances 0.000 description 2
230000013595 glycosylation Effects 0.000 description 2
238000006206 glycosylation reaction Methods 0.000 description 2
229940088597 hormone Drugs 0.000 description 2
239000005556 hormone Substances 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000003780 insertion Methods 0.000 description 2
230000037431 insertion Effects 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
239000002502 liposome Substances 0.000 description 2
230000007774 longterm Effects 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
102000005962 receptors Human genes 0.000 description 2
108020003175 receptors Proteins 0.000 description 2
238000012360 testing method Methods 0.000 description 2
239000003981 vehicle Substances 0.000 description 2
LLXVXPPXELIDGQ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate Chemical compound C=1C=CC(N2C(C=CC2=O)=O)=CC=1C(=O)ON1C(=O)CCC1=O LLXVXPPXELIDGQ-UHFFFAOYSA-N 0.000 description 1
XMQUEQJCYRFIQS-YFKPBYRVSA-N (2s)-2-amino-5-ethoxy-5-oxopentanoic acid Chemical compound CCOC(=O)CC[C@H](N)C(O)=O XMQUEQJCYRFIQS-YFKPBYRVSA-N 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
108010001857 Cell Surface Receptors Proteins 0.000 description 1
108020004705 Codon Proteins 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
102000008100 Human Serum Albumin Human genes 0.000 description 1
108091006905 Human Serum Albumin Proteins 0.000 description 1
206010062767 Hypophysitis Diseases 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
208000036830 Normal foetus Diseases 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
229940099408 Oxidizing agent Drugs 0.000 description 1
241001494479 Pecora Species 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
206010043395 Thalassaemia sickle cell Diseases 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
125000002252 acyl group Chemical group 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
125000003435 aroyl group Chemical group 0.000 description 1
230000003190 augmentative effect Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
210000002960 bfu-e Anatomy 0.000 description 1
229920001222 biopolymer Polymers 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
239000000872 buffer Substances 0.000 description 1
DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
125000001589 carboacyl group Chemical group 0.000 description 1
150000001717 carbocyclic compounds Chemical class 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
239000013068 control sample Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
230000009260 cross reactivity Effects 0.000 description 1
238000012258 culturing Methods 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
238000001212 derivatisation Methods 0.000 description 1
239000000539 dimer Substances 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
210000003013 erythroid precursor cell Anatomy 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
239000005038 ethylene vinyl acetate Substances 0.000 description 1
239000013604 expression vector Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229960002989 glutamic acid Drugs 0.000 description 1
230000002710 gonadal effect Effects 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
208000020451 hereditary persistence of fetal hemoglobin Diseases 0.000 description 1
150000002391 heterocyclic compounds Chemical class 0.000 description 1
125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
239000000710 homodimer Substances 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
208000000509 infertility Diseases 0.000 description 1
230000036512 infertility Effects 0.000 description 1
208000021267 infertility disease Diseases 0.000 description 1
238000001802 infusion Methods 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000002372 labelling Methods 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
102000006240 membrane receptors Human genes 0.000 description 1
108020004999 messenger RNA Proteins 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
210000005087 mononuclear cell Anatomy 0.000 description 1
239000002687 nonaqueous vehicle Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000000346 nonvolatile oil Substances 0.000 description 1
230000001151 other effect Effects 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
210000003635 pituitary gland Anatomy 0.000 description 1
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000000541 pulsatile effect Effects 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
239000002287 radioligand Substances 0.000 description 1
238000002708 random mutagenesis Methods 0.000 description 1
210000001995 reticulocyte Anatomy 0.000 description 1
230000007017 scission Effects 0.000 description 1
230000028327 secretion Effects 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000011146 sterile filtration Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Food Science & Technology (AREA)
Biochemistry (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Zoology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Reproductive Health (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL9216789A 1988-11-01 1989-10-31 Preparation containing activin and / or inhibin IL92167A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/266,421 US4997815A (en)	1988-11-01	1988-11-01	Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin

Publications (2)

Publication Number	Publication Date
IL92167A0 IL92167A0 (en)	1990-07-12
IL92167A true IL92167A (en)	1994-07-31

Family

ID=23014518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9216789A IL92167A (en)	1988-11-01	1989-10-31	Preparation containing activin and / or inhibin

Country Status (9)

Country	Link
US (1)	US4997815A (fr)
EP (2)	EP0617966A1 (fr)
JP (1)	JPH02256622A (fr)
AT (1)	ATE119396T1 (fr)
CA (1)	CA2001897A1 (fr)
DE (1)	DE68921546T2 (fr)
IL (1)	IL92167A (fr)
MA (1)	MA21667A1 (fr)
PT (1)	PT92174B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03173805A (ja) *	1989-09-11	1991-07-29	Ajinomoto Co Inc	卵分割促進剤
US5166190A (en) *	1990-01-08	1992-11-24	Genentech, Inc.	Method for increasing fertility in males
US5102868A (en) *	1990-01-08	1992-04-07	Genentech, Inc.	Method for inhibiting follicular maturation
US5942220A (en) *	1990-03-16	1999-08-24	Chiron Corporation	Inhibitor of cytokine activity and applications thereof
WO1991012334A1 (fr) *	1990-02-15	1991-08-22	Cetus Corporation	Inhibiteur de l'activite des cytokines et applications de celui-ci
EP0548276A4 (en) *	1990-09-13	1993-12-29	Children's Hospital Medical Center Of Northern California	Method for increasing red blood cell production by treatment with activin or activin-related peptides
US7910624B1 (en)	1995-03-03	2011-03-22	The Trustees Of Boston University	Compositions for the treatment of blood disorders
USD354971S (en)	1993-07-26	1995-01-31	Mugnier Design	Eyeglasses
US5487895A (en) *	1993-08-13	1996-01-30	Vitaphore Corporation	Method for forming controlled release polymeric substrate
AU7668894A (en) *	1993-08-13	1995-03-14	Vitaphore Corporation	Hydrogel-based microsphere drug delivery systems
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1988
- 1988-11-01 US US07/266,421 patent/US4997815A/en not_active Expired - Fee Related
1989
- 1989-10-31 MA MA21919A patent/MA21667A1/fr unknown
- 1989-10-31 IL IL9216789A patent/IL92167A/en not_active IP Right Cessation
- 1989-10-31 CA CA002001897A patent/CA2001897A1/fr not_active Abandoned
- 1989-11-01 AT AT89311297T patent/ATE119396T1/de active
- 1989-11-01 JP JP1286002A patent/JPH02256622A/ja active Pending
- 1989-11-01 DE DE68921546T patent/DE68921546T2/de not_active Expired - Fee Related
- 1989-11-01 EP EP94200748A patent/EP0617966A1/fr not_active Withdrawn
- 1989-11-01 EP EP89311297A patent/EP0367590B1/fr not_active Expired - Lifetime
- 1989-11-02 PT PT92174A patent/PT92174B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT92174B (pt)	1995-09-12
DE68921546T2 (de)	1995-07-06
DE68921546D1 (de)	1995-04-13
EP0367590A2 (fr)	1990-05-09
MA21667A1 (fr)	1990-07-01
PT92174A (pt)	1990-05-31
EP0367590B1 (fr)	1995-03-08
EP0367590A3 (fr)	1992-01-02
IL92167A0 (en)	1990-07-12
CA2001897A1 (fr)	1990-05-01
JPH02256622A (ja)	1990-10-17
ATE119396T1 (de)	1995-03-15
EP0617966A1 (fr)	1994-10-05
US4997815A (en)	1991-03-05

Legal Events

Date	Code	Title	Description
1996-08-04	RH	Patent void

Publication	Publication Date	Title
US4997815A (en)	1991-03-05	Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin
US5216004A (en)	1993-06-01	Method for preventing malaria
EP0548276A4 (en)	1993-12-29	Method for increasing red blood cell production by treatment with activin or activin-related peptides
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EP0602050B1 (fr)	1997-05-07	Procede de stimulation de la reponse immunitaire
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Baumann	1987	Molecular heterogeneity of circulating growth hormone in acromegaly
MXPA98009140A (en)	2000-06-05	Treatment of the partial insensitivity syndrome to the growth hormone
JPH03505088A (ja)	1991-11-07	ホルモン類の作用
MXPA96004802A (en)	1998-02-01	Treatment of cardiac failure congest
HK1062395A (en)	2004-11-05	Treatment of partial growth hormone insensitivity syndrome