IL94665A - n-heteroaryl-9h-purin-6-amines, a process for their preparation and pharmaceutical compositions containing them - Google Patents

n-heteroaryl-9h-purin-6-amines, a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL94665A
IL94665A IL9466590A IL9466590A IL94665A IL 94665 A IL94665 A IL 94665A IL 9466590 A IL9466590 A IL 9466590A IL 9466590 A IL9466590 A IL 9466590A IL 94665 A IL94665 A IL 94665A
Authority
IL
Israel
Prior art keywords
compound
purin
amine
hydrogen
pyrrol
Prior art date
Application number
IL9466590A
Other languages
English (en)
Other versions
IL94665A0 (en
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of IL94665A0 publication Critical patent/IL94665A0/xx
Publication of IL94665A publication Critical patent/IL94665A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Television Signal Processing For Recording (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
IL9466590A 1989-06-09 1990-06-07 n-heteroaryl-9h-purin-6-amines, a process for their preparation and pharmaceutical compositions containing them IL94665A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/363,837 US5017578A (en) 1989-06-09 1989-06-09 N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents

Publications (2)

Publication Number Publication Date
IL94665A0 IL94665A0 (en) 1991-04-15
IL94665A true IL94665A (en) 1994-06-24

Family

ID=23431950

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9466590A IL94665A (en) 1989-06-09 1990-06-07 n-heteroaryl-9h-purin-6-amines, a process for their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US5017578A (fr)
EP (1) EP0402752B1 (fr)
JP (1) JPH06102663B2 (fr)
KR (2) KR100199524B1 (fr)
CN (1) CN1029968C (fr)
AT (1) ATE127807T1 (fr)
AU (1) AU636351B2 (fr)
CA (1) CA2018563C (fr)
DE (1) DE69022294T2 (fr)
DK (1) DK0402752T3 (fr)
ES (1) ES2078267T3 (fr)
FI (1) FI902850A7 (fr)
GR (1) GR3017743T3 (fr)
HU (1) HU207320B (fr)
IE (1) IE68433B1 (fr)
IL (1) IL94665A (fr)
MX (1) MX21088A (fr)
NO (1) NO902555L (fr)
NZ (1) NZ233970A (fr)
PT (1) PT94297B (fr)
ZA (1) ZA904443B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432164A (en) * 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
JP3355237B2 (ja) * 1993-10-15 2002-12-09 呉羽化学工業株式会社 Ｎ−（置換アミノ）ピロール誘導体、その製造方法及び除草剤
FI964468A0 (fi) * 1994-05-10 1996-11-06 Sandoz Ltd Adenosiinijohdannaisia
RU2172320C2 (ru) * 1996-08-27 2001-08-20 Си Ви Терапьютикс, Инк. Производные аденозина, фармацевтическая композиция и способ коррекции электрических нарушений в сердце млекопитающего
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
EP2147679B1 (fr) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions pour le transport de barrière hématoencéphalique
CN100447143C (zh) * 2003-08-15 2008-12-31 Irm责任有限公司 作为rtk抑制剂的6-取代的苯胺基嘌呤
US20050124637A1 (en) * 2003-08-15 2005-06-09 Irm Llc Compounds and compositions as inhibitors of receptor tyrosine kinase activity
EP2392258B1 (fr) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Systeme pharma-informatique
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN104744470A (zh) * 2014-10-31 2015-07-01 合肥平光制药有限公司 一种茶碱的合成方法
WO2017160922A1 (fr) 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Composés analgésiques
CN106632339B (zh) * 2016-12-16 2018-11-27 温州医科大学 一种6-取代-9h-嘌呤类衍生物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016378A (en) * 1959-07-01 1962-01-09 Thomae Gmbh Dr K Amino-substituted purine derivatives
BE768925A (fr) * 1970-06-30 1971-11-03 Takeda Chemical Industries Ltd Derives d'adenosine et procede de preparation
JPS4935635B1 (fr) * 1970-12-28 1974-09-25
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
US3936454A (en) * 1973-08-14 1976-02-03 Warner-Lambert Company 5-Amino-4-chloro-6-(substituted amino)-pyrimidines
JPS57171998A (en) * 1981-04-15 1982-10-22 Fujisawa Pharmaceut Co Ltd Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
US4514405A (en) * 1981-09-17 1985-04-30 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of adenosine derivatives as anticonvulsants
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
DE3587717T2 (de) * 1984-04-18 1994-04-28 Whitby Research Inc N-6-thienyl-substituierte Adenosinderivate als herzgefässerweiternde Mittel.
US4657897A (en) * 1984-06-22 1987-04-14 Warner-Lambert Company N6 -substituted adenosines for treating pain
CA1254888A (fr) * 1984-10-26 1989-05-30 Bharat Trivedi N.sup.6-bicyclo-adenosines
US4752610A (en) * 1985-12-04 1988-06-21 Hoechst-Roussel Pharmaceuticals Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
US4780452A (en) * 1986-09-08 1988-10-25 Burroughs Wellcome Co. F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
DE69022294D1 (de) 1995-10-19
FI902850A0 (fi) 1990-06-07
CA2018563A1 (fr) 1990-12-09
KR910000730A (ko) 1991-01-30
JPH0324080A (ja) 1991-02-01
IE68433B1 (en) 1996-06-12
NZ233970A (en) 1993-02-25
ES2078267T3 (es) 1995-12-16
EP0402752A1 (fr) 1990-12-19
DE69022294T2 (de) 1996-03-14
JPH06102663B2 (ja) 1994-12-14
HUT54156A (en) 1991-01-28
PT94297B (pt) 1997-01-31
PT94297A (pt) 1991-02-08
AU5691990A (en) 1990-12-13
DK0402752T3 (da) 1996-01-15
HU903768D0 (en) 1990-11-28
KR100210179B1 (ko) 1999-07-15
EP0402752B1 (fr) 1995-09-13
CN1047866A (zh) 1990-12-19
IE902077L (en) 1990-12-09
US5017578A (en) 1991-05-21
HU207320B (en) 1993-03-29
CA2018563C (fr) 2000-09-19
GR3017743T3 (en) 1996-01-31
CN1029968C (zh) 1995-10-11
KR100199524B1 (ko) 1999-06-15
IL94665A0 (en) 1991-04-15
FI902850A7 (fi) 1990-12-10
ZA904443B (en) 1991-03-27
NO902555L (no) 1990-12-10
AU636351B2 (en) 1993-04-29
NO902555D0 (no) 1990-06-08
ATE127807T1 (de) 1995-09-15
MX21088A (es) 1993-11-01

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Legal Events

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KB Patent renewed
HC Change of name of proprietor(s)
RH Patent void