IL95090A - Enzyme oxidation of C HPEC to glutril-7-amino-cephalosporin - Google Patents

Enzyme oxidation of C HPEC to glutril-7-amino-cephalosporin

Info

Publication number: IL95090A
Authority: IL; Israel
Prior art keywords: glutaryl; aca; catalase; cell; ceph
Prior art date: 1989-07-19

Application number

IL9509090A

Other languages

English (en)

Hebrew (he)

Other versions

IL95090A0 (en

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-19

Filing date

1990-07-16

Publication date

1995-08-31

1990-07-16 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1991-06-10 Publication of IL95090A0 publication Critical patent/IL95090A0/xx

1995-08-31 Publication of IL95090A publication Critical patent/IL95090A/en

Links

IXUSDMGLUJZNFO-BXUZGUMPSA-N (7R)-7-(4-carboxybutanamido)cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCCC(O)=O)[C@@H]12 IXUSDMGLUJZNFO-BXUZGUMPSA-N 0.000 title claims abstract description 24
230000002255 enzymatic effect Effects 0.000 title claims abstract description 17
230000003647 oxidation Effects 0.000 title claims abstract description 13
238000007254 oxidation reaction Methods 0.000 title claims abstract description 13
238000000034 method Methods 0.000 claims abstract description 22
HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 claims abstract description 20
230000008569 process Effects 0.000 claims abstract description 10
102000016938 Catalase Human genes 0.000 claims description 17
108010053835 Catalase Proteins 0.000 claims description 17
239000000284 extract Substances 0.000 claims description 9
102000004316 Oxidoreductases Human genes 0.000 claims description 7
108090000854 Oxidoreductases Proteins 0.000 claims description 7
238000006243 chemical reaction Methods 0.000 claims description 7
102000004674 D-amino-acid oxidase Human genes 0.000 claims description 6
108010003989 D-amino-acid oxidase Proteins 0.000 claims description 6
239000002585 base Substances 0.000 claims description 4
102000004190 Enzymes Human genes 0.000 claims description 2
108090000790 Enzymes Proteins 0.000 claims description 2
239000003637 basic solution Substances 0.000 claims 1
108090000371 Esterases Proteins 0.000 abstract description 10
230000009849 deactivation Effects 0.000 abstract description 4
210000004027 cell Anatomy 0.000 description 24
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
230000000694 effects Effects 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
239000011541 reaction mixture Substances 0.000 description 9
239000000203 mixture Substances 0.000 description 8
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 6
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
239000002002 slurry Substances 0.000 description 5
HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 description 4
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
239000002518 antifoaming agent Substances 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
239000000356 contaminant Substances 0.000 description 3
238000011065 in-situ storage Methods 0.000 description 3
GRQXHIBWEUNUHL-BXKDBHETSA-N (6r,7r)-7-(4-carboxybutanoylamino)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(CO)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCCC(O)=O)[C@@H]12 GRQXHIBWEUNUHL-BXKDBHETSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
WGZDBVOTUVNQFP-UHFFFAOYSA-N N-(1-phthalazinylamino)carbamic acid ethyl ester Chemical compound C1=CC=C2C(NNC(=O)OCC)=NN=CC2=C1 WGZDBVOTUVNQFP-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
-1 adipoyl 7-ACA Chemical compound 0.000 description 2
230000005587 bubbling Effects 0.000 description 2
239000000919 ceramic Substances 0.000 description 2
238000011026 diafiltration Methods 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
239000003112 inhibitor Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
KLSJWNVTNUYHDU-UHFFFAOYSA-N Amitrole Chemical compound NC1=NC=NN1 KLSJWNVTNUYHDU-UHFFFAOYSA-N 0.000 description 1
IVRMZWNICZWHMI-UHFFFAOYSA-N Azide Chemical compound [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
239000004280 Sodium formate Substances 0.000 description 1
241001480015 Trigonopsis variabilis Species 0.000 description 1
108010092464 Urate Oxidase Proteins 0.000 description 1
NKVMUTMFKVQTCM-SSDOTTSWSA-N [N-]=[N+]=NCC1=CN2[C@@H](CC2=O)SC1 Chemical compound [N-]=[N+]=NCC1=CN2[C@@H](CC2=O)SC1 NKVMUTMFKVQTCM-SSDOTTSWSA-N 0.000 description 1
150000008044 alkali metal hydroxides Chemical class 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
125000000852 azido group Chemical class *N=[N+]=[N-] 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 description 1
KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000002920 hazardous waste Substances 0.000 description 1
238000002955 isolation Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
230000008823 permeabilization Effects 0.000 description 1
239000012466 permeate Substances 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000013341 scale-up Methods 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
239000011775 sodium fluoride Substances 0.000 description 1
235000013024 sodium fluoride Nutrition 0.000 description 1
HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
235000019254 sodium formate Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1
210000005253 yeast cell Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
- C12N9/0024—D-Amino acid oxidase (1.4.3.3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cephalosporin Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

IL9509090A 1989-07-19 1990-07-16 Enzyme oxidation of C HPEC to glutril-7-amino-cephalosporin IL95090A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US38250589A	1989-07-19	1989-07-19

Publications (2)

Publication Number	Publication Date
IL95090A0 IL95090A0 (en)	1991-06-10
IL95090A true IL95090A (en)	1995-08-31

Family

ID=23509253

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9509090A IL95090A (en)	1989-07-19	1990-07-16	Enzyme oxidation of C HPEC to glutril-7-amino-cephalosporin

Country Status (13)

Country	Link
US (2)	US5424203A (fr)
EP (2)	EP0409521B1 (fr)
JP (1)	JP2883173B2 (fr)
KR (1)	KR0163175B1 (fr)
AT (1)	ATE129012T1 (fr)
CA (2)	CA2268710C (fr)
DE (1)	DE69022909T2 (fr)
DK (1)	DK0409521T3 (fr)
ES (1)	ES2079442T3 (fr)
GR (1)	GR3017731T3 (fr)
HU (1)	HU212587B (fr)
IE (1)	IE71523B1 (fr)
IL (1)	IL95090A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0409521B1 (fr) *	1989-07-19	1995-10-11	Eli Lilly And Company	Oxydation enzymatique améliorée de la céphalosporine C en acide glutaryl-7-aminocéphalosporanique
DE4028119C1 (fr) *	1990-09-05	1991-12-05	Hoechst Ag, 6230 Frankfurt, De
CA2100987C (fr) *	1992-07-27	1999-06-15	Kaoru Furuya	Un transformant pouvant produire une d-amino-acide oxydase
EP0600247A3 (fr) *	1992-11-05	1995-05-10	Hoechst Ag	Méthode de désactivation sélective de protéine non désirable dans un mélange, protéinique, par les radiations d'un four à microondes.
ES2097080B1 (es) *	1993-03-08	1997-11-16	Asahi Chemical Ind	Procedimiento para la conversion de cefalosporina c en acido glutaril-7-aminocefalosporanico.
AU1092297A (en) *	1995-12-07	1997-06-27	Novo Nordisk A/S	Selective inactivation of enzyme activities
KR100481138B1 (ko)	1997-09-09	2005-04-11	바이오케미 게젤샤프트 엠베하	효소 활성을 갖는 미생물을 함유하는 구형 입자 및 구형 입자의 제조방법
WO2002061068A2 (fr) *	2001-01-31	2002-08-08	Novozymes A/S	Oxydase exempte d'activite laterale de la catalase
KR100512774B1 (ko) *	2001-10-06	2005-09-07	종근당바이오 주식회사	7-아미노세팔로스포란산의 제조를 위한 세팔로스포린ｃ배양액의 전처리방법
US20090208543A1 (en) *	2008-01-22	2009-08-20	Oral Health Clinical Services	Method and apparatus for applying a protective oral care composition
WO2017221944A1 (fr) *	2016-06-21	2017-12-28	パナソニックヘルスケアホールディングス株式会社	Inhibiteur de catalase et procédé de mesure d'analyte utilisant un inhibiteur de catalase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1272769A (en) *	1968-08-02	1972-05-03	Glaxo Lab Ltd	Improvements in or relating to cephalosporin derivatives
GB1385685A (en) *	1971-04-21	1975-02-26	Glaxo Lab Ltd	Cephalosporin derivatives
GB1474519A (fr) *	1973-05-14	1977-05-25
US3976546A (en) *	1974-11-08	1976-08-24	Glaxo Laboratories Limited	Cephalosporins
US4079180A (en) *	1975-01-22	1978-03-14	Asahi Kasei Kogyo Kabushiki Kaisha	Process for preparing 7-aminocephalosporanic acid derivatives
US4394450A (en) *	1982-03-01	1983-07-19	Miles Laboratories, Inc.	Method for purification of uricase
DE3447023A1 (de) *	1984-12-22	1986-06-26	Hoechst Ag, 6230 Frankfurt	Neue d-aminosaeure-transaminase und ihre verwendung
EP0409521B1 (fr) *	1989-07-19	1995-10-11	Eli Lilly And Company	Oxydation enzymatique améliorée de la céphalosporine C en acide glutaryl-7-aminocéphalosporanique

1990
- 1990-07-16 EP EP90307738A patent/EP0409521B1/fr not_active Expired - Lifetime
- 1990-07-16 IL IL9509090A patent/IL95090A/en not_active IP Right Cessation
- 1990-07-16 AT AT90307738T patent/ATE129012T1/de not_active IP Right Cessation
- 1990-07-16 DE DE69022909T patent/DE69022909T2/de not_active Expired - Fee Related
- 1990-07-16 EP EP94100223A patent/EP0601996A1/fr not_active Withdrawn
- 1990-07-16 CA CA002268710A patent/CA2268710C/fr not_active Expired - Fee Related
- 1990-07-16 ES ES90307738T patent/ES2079442T3/es not_active Expired - Lifetime
- 1990-07-16 CA CA002021299A patent/CA2021299C/fr not_active Expired - Fee Related
- 1990-07-16 DK DK90307738.6T patent/DK0409521T3/da active
- 1990-07-18 JP JP2192858A patent/JP2883173B2/ja not_active Expired - Lifetime
- 1990-07-18 IE IE262390A patent/IE71523B1/en not_active IP Right Cessation
- 1990-07-18 HU HU904539A patent/HU212587B/hu not_active IP Right Cessation
- 1990-07-18 KR KR1019900010913A patent/KR0163175B1/ko not_active Expired - Fee Related
1994
- 1994-03-11 US US08/212,656 patent/US5424203A/en not_active Expired - Fee Related
1995
- 1995-02-22 US US08/392,438 patent/US5559006A/en not_active Expired - Fee Related
- 1995-10-12 GR GR950402684T patent/GR3017731T3/el unknown

Also Published As

Publication number	Publication date
CA2268710C (fr)	2000-09-26
JPH0353879A (ja)	1991-03-07
EP0409521B1 (fr)	1995-10-11
EP0409521A3 (en)	1991-09-11
US5424203A (en)	1995-06-13
ATE129012T1 (de)	1995-10-15
IE902623A1 (en)	1991-02-27
EP0409521A2 (fr)	1991-01-23
IE71523B1 (en)	1997-02-12
DE69022909T2 (de)	1996-04-11
DK0409521T3 (da)	1996-02-05
KR0163175B1 (ko)	1998-11-16
JP2883173B2 (ja)	1999-04-19
HUT59727A (en)	1992-06-29
HU904539D0 (en)	1990-12-28
ES2079442T3 (es)	1996-01-16
CA2021299A1 (fr)	1991-01-20
EP0601996A1 (fr)	1994-06-15
DE69022909D1 (de)	1995-11-16
KR910003114A (ko)	1991-02-26
US5559006A (en)	1996-09-24
HU212587B (en)	1996-08-29
GR3017731T3 (en)	1996-01-31
CA2021299C (fr)	1999-08-17
IL95090A0 (en)	1991-06-10

Legal Events

Date	Code	Title
1996-10-16	KB	Patent renewed
2000-10-31	KB	Patent renewed
2005-07-25	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
EP0409521B1 (fr)	1995-10-11	Oxydation enzymatique améliorée de la céphalosporine C en acide glutaryl-7-aminocéphalosporanique
Conlon et al.	1995	Two‐step immobilized enzyme conversion of cephalosporin C to 7‐aminocephalosporanic acid
KR0180934B1 (ko)	1999-04-01	7-아미노세팔로스포란 산 및 이의 유도체를 제조하는 효소적 방법
JP3910213B2 (ja)	2007-04-25	グルコン酸及びその塩の酵素的生産方法
EP0465600B1 (fr)	1995-06-07	Production enzymatique d'acide 7-aminocephalosporanique
US3658649A (en)	1972-04-25	Cephalosporin derivatives
CA2165940A1 (fr)	1995-01-05	Methode de preparation d'acide pyruvique
Vicenzi et al.	1993	Enzymatic oxidation of cephalosporin C using whole cells of the yeast Triginopsis variabilis within a “cross-flow filter-reactor”
WO1987007639A1 (fr)	1987-12-17	Procede pour preparer une oxydase exempte de catalase et une levure contenant une oxydase exempte de catalase, et utilisation
EP0517200B1 (fr)	1996-08-14	Procédé pour la préparation enzymatique de dérivés de céphalosporine
EP0242007A1 (fr)	1987-10-21	Procédé de préparation de levure contenant une oxidase exempte de catalase et son utilisation
JPS6111591B2 (fr)	1986-04-03
Bianchi et al.	1998	Enzymatic transformation of cephalosporin C to 7-ACA by simultaneous action of immobilized d-amino acid oxidase and glutaryl-7-ACA acylase
GB2275925A (en)	1994-09-14	Converting cephalosporin C to glutaryl-7-aminocephalosporanic acid
Chen et al.	1991	Enzymic and chemical conversions of cephalosporin C to 7-(glutarylamido) cephalosporanic acid
JPS58201985A (ja)	1983-11-25	グルコ−ス脱水素酵素の生産方法
JP3063800B2 (ja)	2000-07-12	耐熱性カタラーゼ
D'acunzo et al.	1996	d-Amino acid oxidase from Trigonopsis variabilis: Immobilization of whole cells in natural polymeric gels for glutaryl-7-aminocephalosporanic acid production
US4661448A (en)	1987-04-28	Method for producing reduced-form coenzyme
US5919684A (en)	1999-07-06	Process for the reduction of catalase activity in alcohol oxidase
JP3601846B2 (ja)	2004-12-15	グルタリル−７−アミノセファロスポラン酸の製造方法
JPS5915635B2 (ja)	1984-04-10	７−（４−カルボキシブタンアミド）−３−セフェム−４−カルボン酸化合物の製法
JP2005348743A (ja)	2005-12-22	エステラーゼ非含有酵素
IT9022512A1 (it)	1992-06-21	Procedimento enzimatico per la produzione di acido 7b- (4carbossibutanamido) cefalosporanici.