IL98447A - 3-aryl-2- hydroxypropionic acid derivatives their preparation and pharmaceutical compositions containing them useful as hypoglycemic agents - Google Patents

3-aryl-2- hydroxypropionic acid derivatives their preparation and pharmaceutical compositions containing them useful as hypoglycemic agents

Info

Publication number
IL98447A
IL98447A IL9844791A IL9844791A IL98447A IL 98447 A IL98447 A IL 98447A IL 9844791 A IL9844791 A IL 9844791A IL 9844791 A IL9844791 A IL 9844791A IL 98447 A IL98447 A IL 98447A
Authority
IL
Israel
Prior art keywords
phenyl
formula
methyl
compound
mmol
Prior art date
Application number
IL9844791A
Other languages
English (en)
Other versions
IL98447A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL98447A0 publication Critical patent/IL98447A0/xx
Publication of IL98447A publication Critical patent/IL98447A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL9844791A 1990-06-14 1991-06-11 3-aryl-2- hydroxypropionic acid derivatives their preparation and pharmaceutical compositions containing them useful as hypoglycemic agents IL98447A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/537,673 US5089514A (en) 1990-06-14 1990-06-14 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents

Publications (2)

Publication Number Publication Date
IL98447A0 IL98447A0 (en) 1992-07-15
IL98447A true IL98447A (en) 1995-12-31

Family

ID=24143633

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9844791A IL98447A (en) 1990-06-14 1991-06-11 3-aryl-2- hydroxypropionic acid derivatives their preparation and pharmaceutical compositions containing them useful as hypoglycemic agents

Country Status (21)

Country Link
US (3) US5089514A (de)
EP (1) EP0533781B1 (de)
JP (2) JPH075513B2 (de)
KR (1) KR930700492A (de)
AT (1) ATE149156T1 (de)
AU (1) AU646052B2 (de)
CA (1) CA2084898A1 (de)
DE (1) DE69124798T2 (de)
DK (1) DK0533781T3 (de)
ES (1) ES2098356T3 (de)
FI (1) FI925640A7 (de)
GR (1) GR3022714T3 (de)
HU (1) HUT65603A (de)
IE (1) IE912003A1 (de)
IL (1) IL98447A (de)
MY (1) MY106380A (de)
NO (1) NO924799L (de)
NZ (1) NZ238528A (de)
PT (1) PT97950B (de)
WO (1) WO1991019702A1 (de)
ZA (1) ZA914519B (de)

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IE912003A1 (en) 1991-12-18
CA2084898A1 (en) 1991-12-15
NZ238528A (en) 1993-07-27
EP0533781A1 (de) 1993-03-31
ES2098356T3 (es) 1997-05-01
GR3022714T3 (en) 1997-06-30
JP2581523B2 (ja) 1997-02-12
US5089514A (en) 1992-02-18
JPH05507920A (ja) 1993-11-11
EP0533781B1 (de) 1997-02-26
HU9203943D0 (en) 1993-03-29
FI925640A0 (fi) 1992-12-11
DK0533781T3 (da) 1997-07-07
US5306726A (en) 1994-04-26
KR930700492A (ko) 1993-03-15
ZA914519B (en) 1993-01-27
PT97950B (pt) 1998-11-30
ATE149156T1 (de) 1997-03-15
FI925640L (fi) 1992-12-11
NO924799D0 (no) 1992-12-11
HUT65603A (en) 1994-07-28
PT97950A (pt) 1992-03-31
NO924799L (no) 1992-12-14
WO1991019702A1 (en) 1991-12-26
JPH075513B2 (ja) 1995-01-25
AU7995691A (en) 1992-01-07
DE69124798D1 (de) 1997-04-03
IL98447A0 (en) 1992-07-15
MY106380A (en) 1995-05-30
JPH07149636A (ja) 1995-06-13
US5438074A (en) 1995-08-01
DE69124798T2 (de) 1997-06-12
FI925640A7 (fi) 1992-12-11
AU646052B2 (en) 1994-02-03

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