IL98998A - 4-amino- delta4,6-steroids process for their preparation and their use as 5alpha-reductase inhibitors - Google Patents

4-amino- delta4,6-steroids process for their preparation and their use as 5alpha-reductase inhibitors

Info

Publication number
IL98998A
IL98998A IL9899891A IL9899891A IL98998A IL 98998 A IL98998 A IL 98998A IL 9899891 A IL9899891 A IL 9899891A IL 9899891 A IL9899891 A IL 9899891A IL 98998 A IL98998 A IL 98998A
Authority
IL
Israel
Prior art keywords
alkyl
hydrogen
amino
double bond
give
Prior art date
Application number
IL9899891A
Other languages
English (en)
Other versions
IL98998A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/671,555 external-priority patent/US5143909A/en
Priority claimed from US07/720,899 external-priority patent/US5130424A/en
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL98998A0 publication Critical patent/IL98998A0/xx
Publication of IL98998A publication Critical patent/IL98998A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL9899891A 1990-08-01 1991-07-29 4-amino- delta4,6-steroids process for their preparation and their use as 5alpha-reductase inhibitors IL98998A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56141090A 1990-08-01 1990-08-01
US07/671,555 US5143909A (en) 1991-03-19 1991-03-19 Aminosteroids in a method for inhibiting c17-20 lyase
US07/720,899 US5130424A (en) 1990-08-01 1991-07-02 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors

Publications (2)

Publication Number Publication Date
IL98998A0 IL98998A0 (en) 1992-07-15
IL98998A true IL98998A (en) 1996-01-19

Family

ID=27415853

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9899891A IL98998A (en) 1990-08-01 1991-07-29 4-amino- delta4,6-steroids process for their preparation and their use as 5alpha-reductase inhibitors

Country Status (17)

Country Link
EP (1) EP0469547B1 (fr)
JP (1) JP3021818B2 (fr)
CN (1) CN1031574C (fr)
AT (1) ATE138073T1 (fr)
AU (1) AU642757B2 (fr)
CA (1) CA2048243C (fr)
DE (1) DE69119502T2 (fr)
DK (1) DK0469547T3 (fr)
ES (1) ES2089063T3 (fr)
FI (1) FI102378B (fr)
GR (1) GR3020268T3 (fr)
HU (1) HU210042B (fr)
IE (1) IE75199B1 (fr)
IL (1) IL98998A (fr)
NO (1) NO180197C (fr)
NZ (1) NZ239141A (fr)
PT (1) PT98519B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543406A (en) * 1991-12-20 1996-08-06 Glaxo Wellcome, Inc. Inhibitors of 5-α-testosterone reductase
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5356935A (en) * 1993-12-13 1994-10-18 Eli Lilly And Company Reduced phenanthrenes
AU686793B2 (en) * 1994-05-02 1998-02-12 Merrell Pharmaceuticals Inc. Process for the preparation of 4-amino- 4-3-ketosteroids via 4-nitro-delta 4-3-ketosteroids
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
WO2001005364A1 (fr) * 1999-07-15 2001-01-25 The Procter & Gamble Company Composes steroides a base d'azote et leur utilisation pour reguler la pousse des cheveux
JP6353939B1 (ja) * 2017-02-15 2018-07-04 横関油脂工業株式会社 油状組成物、その製法、油性基剤および皮膚外用剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1154008A (fr) * 1979-05-02 1983-09-20 Thomas R. Blohm INHIBITEURS DE STEROIDE 5.alpha.-REDUCTASE
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives

Also Published As

Publication number Publication date
EP0469547A2 (fr) 1992-02-05
FI102378B1 (fi) 1998-11-30
NZ239141A (en) 1994-04-27
HUT59157A (en) 1992-04-28
FI913658A0 (fi) 1991-07-31
DE69119502D1 (de) 1996-06-20
IE912706A1 (en) 1992-02-12
FI913658L (fi) 1992-02-02
JPH05320189A (ja) 1993-12-03
AU642757B2 (en) 1993-10-28
PT98519B (pt) 1999-01-29
NO180197B (no) 1996-11-25
EP0469547A3 (en) 1992-06-03
AU8135691A (en) 1992-02-06
CA2048243C (fr) 2003-04-08
CA2048243A1 (fr) 1992-02-02
JP3021818B2 (ja) 2000-03-15
FI102378B (fi) 1998-11-30
HU912559D0 (en) 1992-01-28
NO912982L (no) 1992-02-03
ES2089063T3 (es) 1996-10-01
CN1031574C (zh) 1996-04-17
IE75199B1 (en) 1997-08-27
NO912982D0 (no) 1991-07-31
CN1059150A (zh) 1992-03-04
PT98519A (pt) 1992-06-30
GR3020268T3 (en) 1996-09-30
DE69119502T2 (de) 1996-09-26
DK0469547T3 (da) 1996-06-10
NO180197C (no) 1997-03-05
EP0469547B1 (fr) 1996-05-15
ATE138073T1 (de) 1996-06-15
IL98998A0 (en) 1992-07-15
HU210042B (en) 1995-01-30

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
HC Change of name of proprietor(s)