IL99981A - The result of reliable dictation and its preparation - Google Patents

The result of reliable dictation and its preparation

Info

Publication number: IL99981A
Authority: IL; Israel
Prior art keywords: formula; compound; nitro; furyl; dimethylaminomethyl
Prior art date: 1990-11-09

Application number

IL9998191A

Other languages

English (en)

Hebrew (he)

Other versions

IL99981A0 (en

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-09

Filing date

1991-11-07

Publication date

1996-01-19

1991-11-07 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1992-08-18 Publication of IL99981A0 publication Critical patent/IL99981A0/xx

1996-01-19 Publication of IL99981A publication Critical patent/IL99981A/en

Links

238000002360 preparation method Methods 0.000 title claims abstract description 7
-1 Diketene imine Chemical class 0.000 title abstract description 10
238000000034 method Methods 0.000 claims abstract description 12
150000001875 compounds Chemical class 0.000 claims abstract description 9
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 6
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 9
150000003751 zinc Chemical class 0.000 claims description 7
150000002828 nitro derivatives Chemical class 0.000 claims description 6
239000011541 reaction mixture Substances 0.000 claims description 6
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 6
AMBKPYJJYUKNFI-UHFFFAOYSA-N methylsulfanylethene Chemical compound CSC=C AMBKPYJJYUKNFI-UHFFFAOYSA-N 0.000 claims description 4
229910052757 nitrogen Inorganic materials 0.000 claims description 4
150000003512 tertiary amines Chemical class 0.000 claims description 4
OGMADIBCHLQMIP-UHFFFAOYSA-N 2-aminoethanethiol;hydron;chloride Chemical compound Cl.NCCS OGMADIBCHLQMIP-UHFFFAOYSA-N 0.000 claims description 3
238000006243 chemical reaction Methods 0.000 claims description 3
229940097265 cysteamine hydrochloride Drugs 0.000 claims description 3
XPFVYQJUAUNWIW-UHFFFAOYSA-N furfuryl alcohol Chemical class OCC1=CC=CO1 XPFVYQJUAUNWIW-UHFFFAOYSA-N 0.000 claims description 3
239000011592 zinc chloride Substances 0.000 claims description 3
235000005074 zinc chloride Nutrition 0.000 claims description 3
150000007529 inorganic bases Chemical class 0.000 claims description 2
150000007530 organic bases Chemical class 0.000 claims description 2
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
229960001763 zinc sulfate Drugs 0.000 claims description 2
229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 abstract description 7
229960000620 ranitidine Drugs 0.000 abstract description 7
230000015572 biosynthetic process Effects 0.000 abstract description 3
239000003485 histamine H2 receptor antagonist Substances 0.000 abstract description 3
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract description 3
238000003786 synthesis reaction Methods 0.000 abstract description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
239000000203 mixture Substances 0.000 description 5
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
239000000047 product Substances 0.000 description 3
238000004809 thin layer chromatography Methods 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000001914 filtration Methods 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 1
238000009835 boiling Methods 0.000 description 1
238000011109 contamination Methods 0.000 description 1
239000002274 desiccant Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
239000000401 methanolic extract Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/36—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Indole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

IL9998191A 1990-11-09 1991-11-07 The result of reliable dictation and its preparation IL99981A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU907073A HU210849B (en)	1990-11-09	1990-11-09	Process for preparing furil derivatives

Publications (2)

Publication Number	Publication Date
IL99981A0 IL99981A0 (en)	1992-08-18
IL99981A true IL99981A (en)	1996-01-19

Family

ID=10972141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9998191A IL99981A (en)	1990-11-09	1991-11-07	The result of reliable dictation and its preparation

Country Status (14)

Country	Link
EP (1)	EP0486461B1 (cs)
JP (1)	JPH04273872A (cs)
KR (1)	KR920009812A (cs)
CN (1)	CN1032857C (cs)
AT (1)	ATE133171T1 (cs)
AU (1)	AU644698B2 (cs)
CA (1)	CA2055165A1 (cs)
CZ (1)	CZ280449B6 (cs)
DE (1)	DE69116520T2 (cs)
HU (1)	HU210849B (cs)
IL (1)	IL99981A (cs)
PL (1)	PL166485B1 (cs)
RU (1)	RU2042671C1 (cs)
ZA (1)	ZA918874B (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106986847B (zh) *	2017-05-27	2019-01-22	河北海力香料股份有限公司	一种2-[[[5-(二甲氨基)甲基-2-呋喃基]甲基]硫代]乙胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1565966A (en) *	1976-08-04	1980-04-23	Allen & Hanburys Ltd	Aminoalkyl furan derivatives
YU42819B (en) *	1982-11-22	1988-12-31	Lek Tovarna Farmacevtskih	Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
HU196979B (en) *	1985-01-11	1989-02-28	Gyogyszerkutato Intezet	Process for producing basic thioether and salt
JPH0725745B2 (ja) *	1986-11-11	1995-03-22	株式会社日本触媒	アミン化合物の製造方法

1990
- 1990-11-09 HU HU907073A patent/HU210849B/hu not_active IP Right Cessation
1991
- 1991-11-06 RU SU915010207A patent/RU2042671C1/ru active
- 1991-11-06 AT AT91890268T patent/ATE133171T1/de not_active IP Right Cessation
- 1991-11-06 DE DE69116520T patent/DE69116520T2/de not_active Expired - Fee Related
- 1991-11-06 EP EP91890268A patent/EP0486461B1/en not_active Expired - Lifetime
- 1991-11-07 IL IL9998191A patent/IL99981A/en not_active IP Right Cessation
- 1991-11-08 CA CA002055165A patent/CA2055165A1/en not_active Abandoned
- 1991-11-08 CZ CS913402A patent/CZ280449B6/cs unknown
- 1991-11-08 PL PL91292326A patent/PL166485B1/pl unknown
- 1991-11-08 AU AU87710/91A patent/AU644698B2/en not_active Ceased
- 1991-11-08 ZA ZA918874A patent/ZA918874B/xx unknown
- 1991-11-09 CN CN91110543A patent/CN1032857C/zh not_active Expired - Fee Related
- 1991-11-09 KR KR1019910019913A patent/KR920009812A/ko not_active Withdrawn
- 1991-11-11 JP JP3294507A patent/JPH04273872A/ja active Pending

Also Published As

Publication number	Publication date
EP0486461A1 (en)	1992-05-20
EP0486461B1 (en)	1996-01-17
AU644698B2 (en)	1993-12-16
CZ280449B6 (cs)	1996-01-17
HUT61014A (en)	1992-11-30
HU210849B (en)	1995-08-28
PL166485B1 (pl)	1995-05-31
RU2042671C1 (ru)	1995-08-27
DE69116520T2 (de)	1996-09-19
HU907073D0 (en)	1991-05-28
CA2055165A1 (en)	1992-05-10
CS340291A3 (en)	1992-05-13
ATE133171T1 (de)	1996-02-15
IL99981A0 (en)	1992-08-18
AU8771091A (en)	1992-05-14
ZA918874B (en)	1992-08-26
CN1061599A (zh)	1992-06-03
JPH04273872A (ja)	1992-09-30
DE69116520D1 (de)	1996-02-29
CN1032857C (zh)	1996-09-25
PL292326A1 (cs)	1992-10-19
KR920009812A (ko)	1992-06-25

Legal Events

Date	Code	Title	Description
1996-06-18	FF	Patent granted
1998-11-26	RH	Patent void

Publication	Publication Date	Title
EP1361876A2 (en)	2003-11-19	Novel cannabimimetic ligands
CA1321594C (en)	1993-08-24	Process for the preparation of nitroethene derivatives
US4031111A (en)	1977-06-21	Macrocyclic hetero imine complexing agents
IL99981A (en)	1996-01-19	The result of reliable dictation and its preparation
RU2007402C1 (ru)	1994-02-15	Способ получения производных 2-азабицикло(2,2,1)гепт-5-ен-2-уксусной кислоты
CA1164876A (en)	1984-04-03	Process for the preparation of cimetidine
KR100708581B1 (ko)	2007-04-18	리토나비르의 합성 방법
US4166184A (en)	1979-08-28	2h-imidazole-2-thione derivatives
RU2032681C1 (ru)	1995-04-10	Способ получения 1-(2-[(5-диметиламинометил-2-фурил) -метилтио]-этил)-амино-1- метиламино-2-нитроэтилена
DK170067B1 (da)	1995-05-15	Fremgangsmåde til fremstilling af aminderivater
EP0393109B1 (en)	1994-03-23	Novel 2,3-thiomorpholinedione-2-oxime derivatives, pharmaceutical compositions containing them and process for preparing same
US4087609A (en)	1978-05-02	Azido-triazines
US3948915A (en)	1976-04-06	2-Halopyrimidine derivatives and a method for their preparation
EP0230127A1 (en)	1987-07-29	Synthesis of nizatidine
KR960008246B1 (ko)	1996-06-21	우레아 유도체
US4565874A (en)	1986-01-21	Synthesis of parabactin and homologs thereof
US4945161A (en)	1990-07-31	Process for the preparation of N,N'-bis-(2-hydroxy-ethyl) piperazine
Elkafrawy et al.	1991	Synthesis and reactions of some 4-aryl-2-benzylmercapto-1, 6-dihydro-6-thiono-1, 3, 5-triazines
JPH013177A (ja)	1989-01-06	アミン誘導体の製造方法
JPH0528708B2 (cs)	1993-04-27
JPH0469156B2 (cs)	1992-11-05
JPS622588B2 (cs)	1987-01-20
SU525684A1 (ru)	1976-08-25	Способ получени 4-аминохроманов
HU194160B (en)	1988-01-28	Process for producing 9-carbamoyl-fluorene derivatives
CS210394B1 (cs)	1982-01-29	Deriváty formamidinu a způsoby jejich výroby