IN2014MN00258A - - Google Patents
Info
- Publication number
- IN2014MN00258A IN2014MN00258A IN258MUN2014A IN2014MN00258A IN 2014MN00258 A IN2014MN00258 A IN 2014MN00258A IN 258MUN2014 A IN258MUN2014 A IN 258MUN2014A IN 2014MN00258 A IN2014MN00258 A IN 2014MN00258A
- Authority
- IN
- India
- Prior art keywords
- compounds
- present
- novel
- medicament
- concerned
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- VHNYOQKVZQVBLC-RTCGXNAVSA-N (4r,7e,9as)-7-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorophenyl)-1,3,4,8,9,9a-hexahydropyrido[2,1-c][1,4]oxazin-6-one Chemical compound C1([C@@H]2COC[C@@H]3CC\C(C(N32)=O)=C/C=2C=C(C(=CC=2)N2C=C(C)N=C2)OC)=CC(F)=C(F)C(F)=C1 VHNYOQKVZQVBLC-RTCGXNAVSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124648 γ-Secretase Modulator Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11174120 | 2011-07-15 | ||
| PCT/EP2012/063667 WO2013010904A1 (fr) | 2011-07-15 | 2012-07-12 | Nouveaux dérivés d'indole substitués utilisés en tant que modulateurs de la gamma-sécrétase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN00258A true IN2014MN00258A (fr) | 2015-09-25 |
Family
ID=46506432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN258MUN2014 IN2014MN00258A (fr) | 2011-07-15 | 2012-07-12 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9115143B2 (fr) |
| EP (1) | EP2731948B1 (fr) |
| JP (1) | JP6068464B2 (fr) |
| KR (1) | KR101913135B1 (fr) |
| CN (1) | CN103874702B (fr) |
| AR (1) | AR087182A1 (fr) |
| AU (1) | AU2012285931B2 (fr) |
| BR (1) | BR112014000713A2 (fr) |
| CA (1) | CA2841102C (fr) |
| EA (1) | EA023045B1 (fr) |
| ES (1) | ES2555167T3 (fr) |
| IL (1) | IL230422B (fr) |
| IN (1) | IN2014MN00258A (fr) |
| MX (1) | MX2014000626A (fr) |
| TW (1) | TWI567079B (fr) |
| WO (1) | WO2013010904A1 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102325765B (zh) | 2009-02-06 | 2014-12-24 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的双环杂环化合物 |
| CA2755467A1 (fr) | 2009-05-07 | 2010-12-23 | Janssen Pharmaceuticals, Inc. | Nouveaux derives substitues d'indazole et d'aza-indazole utilises comme modulateurs de la gamma secretase |
| BR112012000915A2 (pt) | 2009-07-15 | 2019-09-24 | Janssen Pharmaceuticals Inc | derivados de triazol e imidazol substituídos como moduladores de gama secretase. |
| AU2011206635B2 (en) | 2010-01-15 | 2015-01-22 | Cellzome Limited | Novel substituted triazole derivatives as gamma secretase modulators |
| AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
| ES2555167T3 (es) | 2011-07-15 | 2015-12-29 | Janssen Pharmaceuticals, Inc. | Nuevos derivados de indol sustituidos como moduladores de gamma secretasa |
| CN104583208B (zh) | 2012-05-16 | 2016-09-28 | 杨森制药公司 | 可用于治疗(尤其是)阿尔茨海默病的取代的3,4-二氢-2H-吡啶并[1,2-a]吡嗪-1,6-二酮衍生物 |
| EP2738172A1 (fr) * | 2012-11-28 | 2014-06-04 | Almirall, S.A. | Nouveaux composés bicycliques utilisés comme modulateurs du canal crac |
| AU2013366668B2 (en) | 2012-12-20 | 2017-07-20 | Janssen Pharmaceutica Nv | Novel tricyclic 3,4-dihydro-2H-pyrido[1,2-alpha]pyrazine -1,6-dione derivatives as gamma secretase modulators |
| AU2014206834B2 (en) | 2013-01-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| MX391344B (es) | 2016-07-30 | 2025-03-21 | Bristol Myers Squibb Co | Compuestos indol sustituidos con dimetoxifenilo como inhibidores de receptores tipo toll 7, 8 o 9 (tlr7, tlr8 o tlr9). |
| JP7028861B2 (ja) | 2016-09-09 | 2022-03-02 | ブリストル－マイヤーズ スクイブ カンパニー | ピリジル置換のインドール化合物 |
| JOP20190060A1 (ar) | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| ES2921020T3 (es) | 2017-08-04 | 2022-08-16 | Bristol Myers Squibb Co | Compuestos de indol sustituidos con [1,2,4]triazolo[4,3-a]piridinilo |
| CN110997656B (zh) | 2017-08-04 | 2023-04-14 | 百时美施贵宝公司 | 用作tlr7/8/9抑制剂的取代的吲哚化合物 |
| CR20200151A (es) | 2017-10-11 | 2020-05-23 | Hoffmann La Roche | Compuestos bicíclicos y métodos de utilización de los mismos |
| WO2019099336A1 (fr) * | 2017-11-14 | 2019-05-23 | Bristol-Myers Squibb Company | Composés d'indole substitués |
| AU2018386201A1 (en) | 2017-12-15 | 2020-07-30 | Bristol-Myers Squibb Company | Substituted indole ether compounds |
| JP7289301B2 (ja) | 2017-12-18 | 2023-06-09 | ブリストル－マイヤーズ スクイブ カンパニー | ４－アザインドール化合物 |
| CN111511730B (zh) | 2017-12-19 | 2023-07-25 | 百时美施贵宝公司 | 可用作tlr抑制剂的被酰胺取代的吲哚化合物 |
| US11878975B2 (en) | 2017-12-19 | 2024-01-23 | Bristol-Myers Squibb Company | Substituted indole compounds useful as TLR inhibitors |
| SG11202005704RA (en) | 2017-12-19 | 2020-07-29 | Bristol Myers Squibb Co | 6-azaindole compounds |
| SG11202005694RA (en) | 2017-12-20 | 2020-07-29 | Bristol Myers Squibb Co | Amino indole compounds useful as tlr inhibitors |
| KR102730859B1 (ko) | 2017-12-20 | 2024-11-15 | 브리스톨-마이어스 스큅 컴퍼니 | 아릴 및 헤테로아릴 치환된 인돌 화합물 |
| CA3085937A1 (fr) | 2017-12-20 | 2019-06-27 | Bristol-Myers Squibb Company | Composes de diazaindole |
| TWI841592B (zh) | 2018-09-03 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 雙環雜芳基衍生物 |
| EP3628669A1 (fr) * | 2018-09-28 | 2020-04-01 | GenKyoTex Suisse SA | Nouveaux composés en tant qu'inhibiteurs de la nadph oxydase |
| US11998537B2 (en) | 2018-10-24 | 2024-06-04 | Bristol-Myers Squibb Company | Substituted indole dimer compounds |
| WO2020086503A1 (fr) | 2018-10-24 | 2020-04-30 | Bristol-Myers Squibb Company | Composés d'indole et d'indazole substitués |
| LT3894411T (lt) | 2018-12-13 | 2024-08-26 | F. Hoffmann-La Roche Ag | 7-fenoksi-n-(3-azabiciklo[3.2.1]oktan-8-il)-6,7-dihidro-5h-pirolo [1,2-b][1,2,4]triazol-2-amino dariniai ir susiję junginiai kaip gama sekretazės moduliatoriai alzheimerio ligai gydyti |
| KR102904576B1 (ko) | 2019-05-09 | 2025-12-24 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 벤즈이미다졸론 화합물 |
| WO2021067326A1 (fr) | 2019-10-01 | 2021-04-08 | Bristol-Myers Squibb Company | Composés hétéroaryle bicycliques substitués |
| ES2965164T3 (es) | 2019-10-04 | 2024-04-11 | Bristol Myers Squibb Co | Compuestos de carbazol sustituidos |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0571253T3 (da) * | 1992-05-19 | 1999-07-19 | Adir | Benzimidazolderivater med antidiabetisk og antiblodpladekoagulerende virkning |
| US5767144A (en) | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
| DE69615376T2 (de) | 1995-07-13 | 2002-09-05 | Knoll Gmbh | Piperazin-derivate als heilmittel |
| YU86801A (sh) | 1999-06-10 | 2004-07-15 | Warner-Lambert Company | Izoindol derivati korisni u inhibiciji agregacije amiloidnih proteina i snimanju amiloidnih naslaga |
| AU5702201A (en) | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
| WO2001087845A2 (fr) | 2000-05-15 | 2001-11-22 | Fujisawa Pharmaceutical Co., Ltd. | Composes heterocycliques contenant de l'azote |
| DE10109867A1 (de) | 2001-03-01 | 2002-09-05 | Abbott Gmbh & Co Kg | Verwendung von Triazolverbindungen zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie |
| DE10238002A1 (de) | 2002-08-20 | 2004-03-04 | Merck Patent Gmbh | Benzimidazolderivate |
| CA2516634A1 (fr) | 2003-02-27 | 2004-09-10 | F. Hoffmann-La Roche Ag | Antagonistes du recepteur ccr-3 |
| EP1628666B1 (fr) | 2003-05-14 | 2015-09-23 | NeuroGenetic Pharmaceuticals, Inc. | Composes et leurs utilisations pour la modulation de l'amyloide-beta |
| DE602004025354D1 (de) | 2003-08-14 | 2010-03-18 | Hoffmann La Roche | Gabanerge modulatoren |
| ES2353309T3 (es) | 2004-03-08 | 2011-03-01 | Prosidion Ltd. | Hidrazidas del ácido pirrolopiridin-2-carboxílico como inhibidores de glucógeno fosforilasa. |
| BRPI0511504A (pt) | 2004-05-26 | 2008-01-22 | Eisai R&D Man Co Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, e, agente preventivo ou terapêutico para uma doença resultante de beta-amilóides |
| ATE458729T1 (de) | 2004-10-26 | 2010-03-15 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
| MX2007011234A (es) | 2005-03-14 | 2007-11-12 | Transtech Pharma Inc | Derivados de benzazol, composiciones y metodos de uso en la forma de inhibidores de b-secretasa. |
| US7572807B2 (en) | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| AU2006293635A1 (en) | 2005-09-22 | 2007-03-29 | Sanofi-Aventis | Amino-alkyl-amide derivatives as CCR3 receptor liquids |
| WO2007043786A1 (fr) | 2005-10-10 | 2007-04-19 | Seiyang Yang | Appareil de verification a base dynamique permettant une verification a partir d'un niveau de systeme electronique au niveau grille, et procede de verification utilisant cet appareil |
| CN101283031B (zh) | 2005-10-11 | 2012-10-10 | 科聚亚公司 | 二芳基胺 |
| CA2628455A1 (fr) | 2005-11-10 | 2007-05-24 | Merck Sharp & Dohme Corp. | Imidazopyrazines inhibant la proteine kinase |
| US20090163482A1 (en) | 2006-03-13 | 2009-06-25 | Mchardy Stanton Furst | Tetralines antagonists of the h-3 receptor |
| GB0606774D0 (en) | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
| US7893058B2 (en) | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| US7951818B2 (en) | 2006-12-01 | 2011-05-31 | Galapagos Nv | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases |
| KR20090090364A (ko) | 2006-12-12 | 2009-08-25 | 쉐링 코포레이션 | 트리사이클릭 환 시스템을 함유하는 아스파르틸 프로테아제 억제제 |
| WO2008082490A2 (fr) | 2006-12-20 | 2008-07-10 | Schering Corporation | Nouveaux inhibiteurs de jnk |
| JP2010518080A (ja) | 2007-02-08 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | 治療薬 |
| EP2121633A2 (fr) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Dérivés de pipérazine pour le traitement de la maladie d'alzheimer et des conditions apparentées |
| US8252803B2 (en) | 2007-02-12 | 2012-08-28 | Merck Sharp & Dohme Corp. | Piperidine derivatives |
| CA2686589A1 (fr) | 2007-05-07 | 2008-11-13 | Schering Corporation | Modulateurs de gamma secretase |
| AU2008250436B2 (en) | 2007-05-11 | 2013-03-28 | F. Hoffmann-La Roche Ag | Hetarylanilines as modulators for amyloid beta |
| WO2008156580A1 (fr) | 2007-06-13 | 2008-12-24 | Merck & Co., Inc. | Dérivés du triazole destinés au traitement de la maladie d'alzheimer et d'états associés |
| EP2178857A1 (fr) | 2007-06-29 | 2010-04-28 | Schering Corporation | Modulateurs de la gamma-sécrétase |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| JP2010538068A (ja) | 2007-09-06 | 2010-12-09 | シェーリング コーポレイション | ガンマセクレターゼモジュレーター |
| GB0720444D0 (en) | 2007-10-18 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
| JP2011506335A (ja) | 2007-12-06 | 2011-03-03 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
| US8426595B2 (en) | 2007-12-11 | 2013-04-23 | Xianhai Huang | Gamma secretase modulators |
| AU2009216851B2 (en) | 2008-02-22 | 2013-11-07 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| US20100137320A1 (en) | 2008-02-29 | 2010-06-03 | Schering Corporation | Gamma secretase modulators |
| WO2010010188A1 (fr) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Nouveaux composés utiles pour le traitement de maladies dégénératives et inflammatoires |
| US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
| CA2742317A1 (fr) | 2008-11-06 | 2010-05-14 | Schering Corporation | Modulateurs de secretase gamma |
| AU2009312856A1 (en) | 2008-11-10 | 2010-05-14 | F. Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
| WO2010065310A1 (fr) | 2008-12-03 | 2010-06-10 | Via Pharmaceuticals, Inc | Inhibiteurs de l'enzyme diacylglycérol acyltransférase |
| PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| CN102325765B (zh) | 2009-02-06 | 2014-12-24 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的双环杂环化合物 |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| JP2012051806A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| TW201035101A (en) * | 2009-02-26 | 2010-10-01 | Eisai R&D Man Co Ltd | Nitrogen-containing fused heterocyclic compound |
| JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
| JP2012519682A (ja) | 2009-03-03 | 2012-08-30 | ファイザー・インク | ガンマ−セクレターゼモジュレーターとしての新規フェニルイミダゾールおよびフェニルトリアゾール |
| EP2410529A1 (fr) | 2009-03-16 | 2012-01-25 | Panasonic Corporation | Dispositif de lancement d'application |
| US20120029190A1 (en) * | 2009-04-03 | 2012-02-02 | Douglas Burdi | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| CN102414210A (zh) * | 2009-04-27 | 2012-04-11 | 高点制药有限责任公司 | 作为β-分泌酶抑制剂的取代的咪唑并[1，2-a]吡啶衍生物、药物组合物和使用方法 |
| CA2755467A1 (fr) | 2009-05-07 | 2010-12-23 | Janssen Pharmaceuticals, Inc. | Nouveaux derives substitues d'indazole et d'aza-indazole utilises comme modulateurs de la gamma secretase |
| JP2010274429A (ja) | 2009-05-26 | 2010-12-09 | Ihi Corp | アライメントステージ |
| BR112012000915A2 (pt) | 2009-07-15 | 2019-09-24 | Janssen Pharmaceuticals Inc | derivados de triazol e imidazol substituídos como moduladores de gama secretase. |
| AU2011206635B2 (en) | 2010-01-15 | 2015-01-22 | Cellzome Limited | Novel substituted triazole derivatives as gamma secretase modulators |
| WO2012061342A2 (fr) * | 2010-11-01 | 2012-05-10 | Arqule, Inc. | Composés de benzo-imidazo-pyrido-diazépine substitués |
| AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
| WO2012131539A1 (fr) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Nouvelles pyridones bicycliques |
| ES2555167T3 (es) | 2011-07-15 | 2015-12-29 | Janssen Pharmaceuticals, Inc. | Nuevos derivados de indol sustituidos como moduladores de gamma secretasa |
-
2012
- 2012-07-12 ES ES12733754.1T patent/ES2555167T3/es active Active
- 2012-07-12 CN CN201280034912.XA patent/CN103874702B/zh not_active Expired - Fee Related
- 2012-07-12 IN IN258MUN2014 patent/IN2014MN00258A/en unknown
- 2012-07-12 EP EP12733754.1A patent/EP2731948B1/fr active Active
- 2012-07-12 KR KR1020147003465A patent/KR101913135B1/ko not_active Expired - Fee Related
- 2012-07-12 BR BR112014000713A patent/BR112014000713A2/pt active Search and Examination
- 2012-07-12 WO PCT/EP2012/063667 patent/WO2013010904A1/fr not_active Ceased
- 2012-07-12 TW TW101125035A patent/TWI567079B/zh not_active IP Right Cessation
- 2012-07-12 US US14/233,078 patent/US9115143B2/en not_active Expired - Fee Related
- 2012-07-12 MX MX2014000626A patent/MX2014000626A/es unknown
- 2012-07-12 EA EA201490287A patent/EA023045B1/ru not_active IP Right Cessation
- 2012-07-12 AU AU2012285931A patent/AU2012285931B2/en not_active Ceased
- 2012-07-12 JP JP2014519557A patent/JP6068464B2/ja not_active Expired - Fee Related
- 2012-07-12 CA CA2841102A patent/CA2841102C/fr not_active Expired - Fee Related
- 2012-07-13 AR ARP120102548A patent/AR087182A1/es not_active Application Discontinuation
-
2014
- 2014-01-13 IL IL230422A patent/IL230422B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EA023045B1 (ru) | 2016-04-29 |
| MX2014000626A (es) | 2014-04-30 |
| JP6068464B2 (ja) | 2017-01-25 |
| TWI567079B (zh) | 2017-01-21 |
| AR087182A1 (es) | 2014-02-26 |
| CA2841102C (fr) | 2019-08-13 |
| AU2012285931B2 (en) | 2017-01-12 |
| EA201490287A1 (ru) | 2014-05-30 |
| TW201315736A (zh) | 2013-04-16 |
| US20140148450A1 (en) | 2014-05-29 |
| NZ619683A (en) | 2015-01-30 |
| IL230422B (en) | 2018-03-29 |
| JP2014518286A (ja) | 2014-07-28 |
| CN103874702B (zh) | 2015-12-09 |
| WO2013010904A1 (fr) | 2013-01-24 |
| KR101913135B1 (ko) | 2018-10-30 |
| ES2555167T3 (es) | 2015-12-29 |
| EP2731948B1 (fr) | 2015-09-09 |
| US9115143B2 (en) | 2015-08-25 |
| CA2841102A1 (fr) | 2013-01-24 |
| EP2731948A1 (fr) | 2014-05-21 |
| KR20140063595A (ko) | 2014-05-27 |
| BR112014000713A2 (pt) | 2017-01-10 |
| CN103874702A (zh) | 2014-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2014000626A (es) | Nuevos derivados de indol sustituidos como moduladores de gamma secretasa. | |
| PH12012501381A1 (en) | Novel substituted bicyclic triazole derivatives as gamma secretase modulators | |
| MX2011008335A (es) | Novedosos compuestos heterociclicos biciclicos sustituidos como moduladores de la gamma secretasa. | |
| MX2011011753A (es) | Nuevos derivados sustitutos de indazol y aza-indazol como moduladores de la gamma secretasa. | |
| MX2012000763A (es) | Derivados sustituidos de triazol e imidazol como moduladores de la gamma secretasa. | |
| UA104151C2 (ru) | Замещенные бициклические производные имидазола как модуляторы гамма-секретазы | |
| EA201171066A1 (ru) | Новые замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина в качестве модуляторов гамма-секретазы | |
| IN2014MN02598A (fr) | ||
| MX355164B (es) | Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia). | |
| CA2875877C (fr) | Inhibiteurs syk | |
| IN2014CN04530A (fr) | ||
| MY169986A (en) | Benzimidazole-proline derivatives | |
| GEP20146146B (en) | Pyrrolopyrimidine compounds as inhibitors of cdk4/6 | |
| NZ703162A (en) | Heterocyclic modulators of lipid synthesis | |
| PH12014501514A1 (en) | New azetidine derivatives, pharmaceutical compositions and uses thereof | |
| PH12014501542B1 (en) | Substituted pyrrolidine -2- carboxamides | |
| MX2015014025A (es) | Derivados de n-(2,3-dihidro-1h-pirrolo[2,3,b]piridin-5-il)-4-quina zolinamina y n-(2,3-dihidro-1h-indol-5-il)-4-quinazolinamina novedosos como inhibidores de perk. | |
| MX364610B (es) | Derivados de 1- [m-carboxamido (hetero) aril-metil]-heterociclil-c arboxamida. | |
| MX2014008918A (es) | Nuevos derivados de pirrolidina. | |
| MX2014009084A (es) | Derivados de pirimidooxazocina como inhibidores de mtor. | |
| MX2013005966A (es) | Nuevos compuestos de benzofurano. | |
| CA2818993A1 (fr) | Modulateurs de recepteurs de la s1p | |
| GEP20156247B (en) | Novel dihydrobenzoxathiazepine derivatives, preparation thereof, and pharmaceutical compositions containing them | |
| UA108365C2 (ru) | Производные замещенного бициклического триазола как модуляторы гамма-секретазы | |
| UA108740C2 (ru) | Замещенные производные триазола и имидазола в качестве модулятора гамма-секретазы |