IS5336A - 2-(4-Arýl eða heteróarýl-píperazín-1-ýlmetýl)-1H-indól afleiður - Google Patents

2-(4-Arýl eða heteróarýl-píperazín-1-ýlmetýl)-1H-indól afleiður

Info

Publication number: IS5336A
Authority: IS; Iceland
Prior art keywords: ylmethyl; piperazine; heteroaryl; aryl; indole derivatives
Prior art date: 1997-08-15

Application number

IS5336A

Other languages

English (en)

Icelandic (is)

Inventor

Franz Josef Fliri Anton

Jerome Majchrzak Mark

Ann Seymour Patricia

Howard Zorn Stevin

Rollema Hans

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

2000-01-11

Publication date

2000-01-11

2000-01-11 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2000-01-11 Publication of IS5336A publication Critical patent/IS5336A/is

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

IS5336A 1997-08-15 2000-01-11 2-(4-Arýl eða heteróarýl-píperazín-1-ýlmetýl)-1H-indól afleiður IS5336A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5576497P	1997-08-15	1997-08-15
PCT/IB1998/001198 WO1999009025A2 (fr)	1997-08-15	1998-08-05	Derives de 2-(4-aryl- ou heteroaryl-piperazin-1-ylmethyl)-1h-indole

Publications (1)

Publication Number	Publication Date
IS5336A true IS5336A (is)	2000-01-11

Family

ID=22000003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS5336A IS5336A (is)	1997-08-15	2000-01-11	2-(4-Arýl eða heteróarýl-píperazín-1-ýlmetýl)-1H-indól afleiður

Country Status (30)

Country	Link
EP (1)	EP1003739A2 (fr)
JP (1)	JP2002536291A (fr)
KR (1)	KR20010022507A (fr)
CN (1)	CN1265660A (fr)
AP (1)	AP9801321A0 (fr)
AR (1)	AR017019A1 (fr)
AU (1)	AU8457298A (fr)
BG (1)	BG104069A (fr)
BR (1)	BR9811557A (fr)
CA (1)	CA2297486C (fr)
CO (1)	CO4960656A1 (fr)
DZ (1)	DZ2583A1 (fr)
EA (1)	EA200000023A1 (fr)
HR (1)	HRP980441A2 (fr)
HU (1)	HUP0003425A3 (fr)
ID (1)	ID23803A (fr)
IL (1)	IL133960A0 (fr)
IS (1)	IS5336A (fr)
MA (1)	MA24632A1 (fr)
NO (1)	NO20000722D0 (fr)
OA (1)	OA11286A (fr)
PA (1)	PA8457001A1 (fr)
PE (1)	PE106299A1 (fr)
PL (1)	PL338947A1 (fr)
SK (1)	SK1352000A3 (fr)
TN (1)	TNSN98151A1 (fr)
TR (1)	TR200000414T2 (fr)
UY (1)	UY25144A1 (fr)
WO (1)	WO1999009025A2 (fr)
ZA (1)	ZA987304B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4570773B2 (ja) *	1997-10-27	2010-10-27	ニューロサーチ、アクティーゼルスカブ	ニコチン性アセチルコリンレセプターに於けるコリン作動性リガンドとしてのヘテロアリールジアザシクロアルカン
EP0953567A3 (fr) *	1998-04-29	2003-04-02	Pfizer Products Inc.	Dérivés de piperazin-, piperidine- et tetrahydropyridine bicyclique substitués, leur préparation et leur utilisation comme agents a activité dopaminergique (recepteur D4 de la dopamine) centrale
DE60011817T2 (de) *	1999-12-30	2005-07-14	H. Lundbeck A/S	4-phenyl-1-piperazinyl, -piperidinyl und -tetrahydropyridyl-derivate
GB0017952D0 (en) *	2000-07-22	2000-09-13	Univ Manchester	Treatment of dyskinesia
EP1177792A3 (fr)	2000-07-27	2002-10-23	Pfizer Products Inc.	Ligands dopamine d4 destines au traitement des troubles associees a la cherche de la nouveaute
US6803362B2 (en)	2001-03-09	2004-10-12	Ortho-Mcneil Pharmaceutical Inc.	Heterocyclic compounds
PL377087A1 (pl)	2002-09-06	2006-01-23	Janssen Pharmaceutica, N.V.	Związki heterocykliczne
WO2004108671A1 (fr) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant
EP1731505B1 (fr)	2004-03-30	2015-01-14	Takeda Pharmaceutical Company Limited	Dérivés de l'acide alkoxyphénylpropanoïque
US7572805B2 (en)	2004-07-14	2009-08-11	Bristol-Myers Squibb Company	Pyrrolo(oxo)isoquinolines as 5HT ligands
US7618980B2 (en)	2004-07-14	2009-11-17	Bristol-Myers Squibb Company	Pyrrolo(oxo)quinolines as 5HT ligands
JO2769B1 (en) *	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en)	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) *	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
CA2683111A1 (fr)	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	Derives de 4-alkoxypyridazine en tant qu'antagonistes du recepteur 2 de la dopamine a dissociation rapide
MX2009011416A (es)	2007-04-23	2009-11-05	Janssen Pharmaceutica Nv	Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
JP5417439B2 (ja)	2008-07-03	2014-02-12	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類
CN102171189B (zh)	2008-07-31	2013-11-20	詹森药业有限公司	作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶
WO2019057123A1 (fr) *	2017-09-20	2019-03-28	杭州英创医药科技有限公司	Composé polycyclique agissant en tant qu'inhibiteur de l'ido et/ou en tant qu'inhibiteur double de l'ido-hdac
WO2021216665A1 (fr) *	2020-04-22	2021-10-28	Anima Biotech Inc.	Inhibiteurs de traduction de collagène 1 et leurs procédés d'utilisation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (fr) *	1959-09-25	1900-01-01
ES2097341T3 (es) *	1991-07-03	1997-04-01	Upjohn Co	Indoles sustituidos como farmacos para el tratamiento del sida.
JPH05255089A (ja) *	1991-12-18	1993-10-05	Sanwa Kagaku Kenkyusho Co Ltd	抗ウイルス剤
CA2146018A1 (fr) *	1992-10-23	1994-05-11	Paul David Leeson	Ligands de sous-types de recepteurs dopaminergiques
GB9305644D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
AU6215594A (en) *	1993-03-18	1994-10-11	Merck Sharp & Dohme Limited	Indole derivatives as dopamine d4 antagonists
WO1994024105A1 (fr) *	1993-04-15	1994-10-27	Merck Sharp & Dohme Limited	Derives d'indole utiles comme antagonistes de la dopamine d4
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
TW406075B (en) *	1994-12-13	2000-09-21	Upjohn Co	Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) *	1995-11-17	1998-04-14	Upjohn Co	Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) *	1996-05-10	2002-10-01	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives

1998
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 CA CA002297486A patent/CA2297486C/fr not_active Expired - Fee Related
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Ceased
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/fr not_active Ceased
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/fr not_active Withdrawn
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/fr active
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0003425A2 (hu)	2001-10-28
JP2002536291A (ja)	2002-10-29
PE106299A1 (es)	1999-11-02
HUP0003425A3 (en)	2002-02-28
EA200000023A1 (ru)	2000-08-28
TR200000414T2 (tr)	2000-08-21
AP9801321A0 (en)	2000-02-14
BR9811557A (pt)	2000-08-22
DZ2583A1 (fr)	2003-02-22
AR017019A1 (es)	2001-08-22
CA2297486C (fr)	2005-05-03
PL338947A1 (en)	2000-12-04
UY25144A1 (es)	2000-12-29
CN1265660A (zh)	2000-09-06
WO1999009025A3 (fr)	1999-04-15
ID23803A (id)	2000-05-11
WO1999009025A2 (fr)	1999-02-25
BG104069A (en)	2001-05-31
CO4960656A1 (es)	2000-09-25
TNSN98151A1 (fr)	2005-03-15
IL133960A0 (en)	2001-04-30
NO20000722L (no)	2000-02-14
MA24632A1 (fr)	1999-04-01
HRP980441A2 (en)	1999-04-30
CA2297486A1 (fr)	1999-02-25
KR20010022507A (ko)	2001-03-15
OA11286A (en)	2003-10-22
SK1352000A3 (en)	2000-08-14
EP1003739A2 (fr)	2000-05-31
ZA987304B (en)	2000-02-14
AU8457298A (en)	1999-03-08
PA8457001A1 (es)	2000-09-29
NO20000722D0 (no)	2000-02-14

Publication	Publication Date	Title
ATE260243T1 (de)	2004-03-15	N-aroylphenylalaninderivate
ATE235220T1 (de)	2003-04-15	Resorcinderivate
ID22781A (id)	1999-12-09	Turunan-turunan nikotinamida
ATE426598T1 (de)	2009-04-15	Epothilonderivate
IS5336A (is)	2000-01-11	2-(4-Arýl eða heteróarýl-píperazín-1-ýlmetýl)-1H-indól afleiður
PT994890E (pt)	2003-11-28	Derivados de benzimidazole
DE69817186D1 (de)	2003-09-18	Diaminorhodamin-derivate
NO20010193D0 (no)	2001-01-12	Tiobenzimidazol-derivater
ATE236136T1 (de)	2003-04-15	Benzosulfonderivate
PT1037892E (pt)	2005-01-31	Derivados de piperidina
ATE259810T1 (de)	2004-03-15	Phenyl-xanthinderivate
ATE255098T1 (de)	2003-12-15	Substituierte chromanderivate
DE69841086D1 (de)	2009-10-08	5-Deoxy-Cytidin-Derivate
PT869121E (pt)	2004-10-29	Derivados de propanolamina hipolipidemicos
ATE255099T1 (de)	2003-12-15	Substituierte chromanderivate
DK1115716T3 (da)	2003-02-24	2-phenylpyran-4-on-derivater
DK0966437T3 (da)	2002-10-07	5-Aroylnaphthalenderivater
DK1134219T3 (da)	2005-10-17	Cucloalkylsubstituerede aminomethylpyrrolidinderivater
ATE233253T1 (de)	2003-03-15	Chromanderivate
DE69829682D1 (de)	2005-05-12	Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate
DE69828780D1 (de)	2005-03-03	Amidinocamptpthecin-derivate
NO981495D0 (no)	1998-04-02	Phenoxymetylpiperidin-derivater
DK1060183T3 (da)	2003-08-11	5-deoxycytidinderivater
ATE372989T1 (de)	2007-09-15	Azolinderivate
FI974001A0 (fi)	1997-10-20	Nya metylenbisfosfonsyraderivat