PL338947A1 - Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole - Google Patents

Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole

Info

Publication number: PL338947A1
Authority: PL; Poland
Prior art keywords: piperazin; ylmethyl; indole; heteroaryl; aryl
Prior art date: 1997-08-15

Application number

PL98338947A

Other languages

English (en)

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

1998-08-05

Publication date

2000-12-04

1998-08-05 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2000-12-04 Publication of PL338947A1 publication Critical patent/PL338947A1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL98338947A 1997-08-15 1998-08-05 Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole PL338947A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5576497P	1997-08-15	1997-08-15
PCT/IB1998/001198 WO1999009025A2 (fr)	1997-08-15	1998-08-05	Derives de 2-(4-aryl- ou heteroaryl-piperazin-1-ylmethyl)-1h-indole

Publications (1)

Publication Number	Publication Date
PL338947A1 true PL338947A1 (en)	2000-12-04

Family

ID=22000003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL98338947A PL338947A1 (en)	1997-08-15	1998-08-05	Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole

Country Status (30)

Country	Link
EP (1)	EP1003739A2 (fr)
JP (1)	JP2002536291A (fr)
KR (1)	KR20010022507A (fr)
CN (1)	CN1265660A (fr)
AP (1)	AP9801321A0 (fr)
AR (1)	AR017019A1 (fr)
AU (1)	AU8457298A (fr)
BG (1)	BG104069A (fr)
BR (1)	BR9811557A (fr)
CA (1)	CA2297486C (fr)
CO (1)	CO4960656A1 (fr)
DZ (1)	DZ2583A1 (fr)
EA (1)	EA200000023A1 (fr)
HR (1)	HRP980441A2 (fr)
HU (1)	HUP0003425A3 (fr)
ID (1)	ID23803A (fr)
IL (1)	IL133960A0 (fr)
IS (1)	IS5336A (fr)
MA (1)	MA24632A1 (fr)
NO (1)	NO20000722L (fr)
OA (1)	OA11286A (fr)
PA (1)	PA8457001A1 (fr)
PE (1)	PE106299A1 (fr)
PL (1)	PL338947A1 (fr)
SK (1)	SK1352000A3 (fr)
TN (1)	TNSN98151A1 (fr)
TR (1)	TR200000414T2 (fr)
UY (1)	UY25144A1 (fr)
WO (1)	WO1999009025A2 (fr)
ZA (1)	ZA987304B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100607838B1 (ko) *	1997-10-27	2006-08-04	뉴로서치 에이/에스	니코틴 작용성 아세틸콜린 수용체상의 콜린 작용성 리간드로서의 호모피페라진 유도체 및 이를 포함하는 약제학적 조성물
EP0953567A3 (fr)	1998-04-29	2003-04-02	Pfizer Products Inc.	Dérivés de piperazin-, piperidine- et tetrahydropyridine bicyclique substitués, leur préparation et leur utilisation comme agents a activité dopaminergique (recepteur D4 de la dopamine) centrale
CZ20022603A3 (cs)	1999-12-30	2002-10-16	H. Lundbeck A/S	4-fenyl-1-piperazinylové deriváty
GB0017952D0 (en) *	2000-07-22	2000-09-13	Univ Manchester	Treatment of dyskinesia
EP1177792A3 (fr)	2000-07-27	2002-10-23	Pfizer Products Inc.	Ligands dopamine d4 destines au traitement des troubles associees a la cherche de la nouveaute
WO2002072548A2 (fr) *	2001-03-09	2002-09-19	Ortho-Mcneil Pharmaceutical, Inc.	Composes heterocycliques
MXPA05002575A (es)	2002-09-06	2005-09-08	Johnson & Johnson	Compuestos heterociclicos.
WO2004108671A1 (fr) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant
JP4859665B2 (ja)	2004-03-30	2012-01-25	武田薬品工業株式会社	アルコキシフェニルプロパン酸誘導体
US7618980B2 (en)	2004-07-14	2009-11-17	Bristol-Myers Squibb Company	Pyrrolo(oxo)quinolines as 5HT ligands
US7572805B2 (en)	2004-07-14	2009-08-11	Bristol-Myers Squibb Company	Pyrrolo(oxo)isoquinolines as 5HT ligands
JO2769B1 (en) *	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en) *	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en)	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JP5431305B2 (ja)	2007-04-23	2014-03-05	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
RU2489431C2 (ru)	2007-04-23	2013-08-10	Янссен Фармацевтика Н.В.	Тиа(диа)золы как быстро диссоциирующие антагонисты рецептора допамина 2
JP5417439B2 (ja)	2008-07-03	2014-02-12	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類
EA019048B1 (ru)	2008-07-31	2013-12-30	Янссен Фармацевтика Нв	Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина
WO2019057123A1 (fr) *	2017-09-20	2019-03-28	杭州英创医药科技有限公司	Composé polycyclique agissant en tant qu'inhibiteur de l'ido et/ou en tant qu'inhibiteur double de l'ido-hdac
CA3171950A1 (fr) *	2020-04-22	2021-10-28	David William Sheppard	Inhibiteurs de traduction de collagene 1 et leurs procedes d'utilisation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (fr) *	1959-09-25	1900-01-01
KR100236808B1 (ko) *	1991-07-03	2000-02-01	로렌스 티. 마이젠헬더	에이즈 치료약제로서의 치환된 인돌
JPH05255089A (ja) *	1991-12-18	1993-10-05	Sanwa Kagaku Kenkyusho Co Ltd	抗ウイルス剤
EP0665840A1 (fr) *	1992-10-23	1995-08-09	MERCK SHARP & DOHME LTD.	Ligands pour les sous-types de recepteurs de dopamine
US5576336A (en) *	1993-03-18	1996-11-19	Merck Sharp & Dohme Limited	Indole derivatives as dopamine D4 antagonists
GB9305644D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
AU6435594A (en) *	1993-04-15	1994-11-08	Merck Sharp & Dohme Limited	Indole derivatives as dopamine d4 antagonists
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
TW406075B (en) *	1994-12-13	2000-09-21	Upjohn Co	Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) *	1995-11-17	1998-04-14	Upjohn Co	Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) *	1996-05-10	2002-10-01	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives

1998
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/fr not_active Expired - Fee Related
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/fr not_active Withdrawn
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Ceased
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/fr not_active Ceased
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/fr active
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EA200000023A1 (ru)	2000-08-28
TNSN98151A1 (fr)	2005-03-15
BG104069A (en)	2001-05-31
BR9811557A (pt)	2000-08-22
AR017019A1 (es)	2001-08-22
HUP0003425A2 (hu)	2001-10-28
IL133960A0 (en)	2001-04-30
SK1352000A3 (en)	2000-08-14
WO1999009025A2 (fr)	1999-02-25
NO20000722D0 (no)	2000-02-14
ID23803A (id)	2000-05-11
ZA987304B (en)	2000-02-14
CO4960656A1 (es)	2000-09-25
MA24632A1 (fr)	1999-04-01
EP1003739A2 (fr)	2000-05-31
UY25144A1 (es)	2000-12-29
PA8457001A1 (es)	2000-09-29
PE106299A1 (es)	1999-11-02
NO20000722L (no)	2000-02-14
OA11286A (en)	2003-10-22
HUP0003425A3 (en)	2002-02-28
DZ2583A1 (fr)	2003-02-22
KR20010022507A (ko)	2001-03-15
AP9801321A0 (en)	2000-02-14
HRP980441A2 (en)	1999-04-30
CN1265660A (zh)	2000-09-06
AU8457298A (en)	1999-03-08
WO1999009025A3 (fr)	1999-04-15
CA2297486C (fr)	2005-05-03
JP2002536291A (ja)	2002-10-29
IS5336A (is)	2000-01-11
TR200000414T2 (tr)	2000-08-21
CA2297486A1 (fr)	1999-02-25

Publication	Publication Date	Title
ZA975675B (en)	1998-01-28	Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one
AU6000900A (en)	2001-02-13	Carbazole derivatives and their use as neuropeptide y5 receptor ligands
IL145428A0 (en)	2002-06-30	Alkanoyl-substituted heterocyclic derivatives and pharmaceutical compositions containing the same
IL144717A0 (en)	2002-06-30	Phenyl-and pyridinyl derivatives
IL143979A0 (en)	2002-04-21	Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
AU5108000A (en)	2001-01-02	Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
IL133960A0 (en)	2001-04-30	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives
AU2055201A (en)	2001-06-12	N6 heterocyclic 5' modified adenosine derivatives
AU3039995A (en)	1996-03-14	Heterocyclic derivatives of N-phenylamides
GB9515412D0 (en)	1995-09-27	2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
AU3075595A (en)	1996-02-09	Anti-helicobacter heterocyclic derivatives of azolones
IL121461A0 (en)	1998-02-08	Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]butyl]-1H-azole derivatives
IL130169A0 (en)	2000-06-01	Indole derivatives
HUP0202479A3 (en)	2003-12-29	Indole derivatives
PL352409A1 (en)	2003-08-25	Derivatives of 1-trifluorometyl-4-hydroxy-7-piperidinyl-aminomethylochromane
ZA9810039B (en)	1999-05-04	Azoline derivatives
AU8179198A (en)	1999-01-19	Nucleobase heterocyclic combinatorialization
IL150010A0 (en)	2002-12-01	Heterocyclic derivatives
IL141602A0 (en)	2002-03-10	Bridged heterocyclic derivatives
AU5570900A (en)	2001-01-22	Indoline or tetrahydroquinoline derivatives
AU1691799A (en)	1999-07-26	4-(3-indolyl)imidazole derivatives
AU4616200A (en)	2000-12-12	Hydrazide derivatives
PL340294A1 (en)	2001-01-29	Antipsychoic substituted derivatives of piperidine
GB9715893D0 (en)	1997-10-01	Heterocyclic derivatives
AU6030000A (en)	2001-01-22	5-nitrofurfural derivatives