NO20000722L - 2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater - Google Patents

2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater

Info

Publication number: NO20000722L
Authority: NO; Norway
Prior art keywords: piperazin; ylmethyl; heteroaryl; aryl; indole derivatives
Prior art date: 1997-08-15

Application number

NO20000722A

Other languages

English (en)

Norwegian (no)

Other versions

NO20000722D0 (no

Inventor

Anton Franz Josef Fliri

Marc J Majchrzak

Patricia Ann Seymour

Stevin Howard Zorn

Hans Rollema

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

2000-02-14

Publication date

2000-02-14

2000-02-14 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2000-02-14 Publication of NO20000722D0 publication Critical patent/NO20000722D0/no

2000-02-14 Publication of NO20000722L publication Critical patent/NO20000722L/no

Links

150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Ophthalmology & Optometry (AREA)
Addiction (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20000722A 1997-08-15 2000-02-14 2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater NO20000722L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5576497P	1997-08-15	1997-08-15
PCT/IB1998/001198 WO1999009025A2 (fr)	1997-08-15	1998-08-05	Derives de 2-(4-aryl- ou heteroaryl-piperazin-1-ylmethyl)-1h-indole

Publications (2)

Publication Number	Publication Date
NO20000722D0 NO20000722D0 (no)	2000-02-14
NO20000722L true NO20000722L (no)	2000-02-14

Family

ID=22000003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20000722A NO20000722L (no)	1997-08-15	2000-02-14	2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater

Country Status (30)

Country	Link
EP (1)	EP1003739A2 (fr)
JP (1)	JP2002536291A (fr)
KR (1)	KR20010022507A (fr)
CN (1)	CN1265660A (fr)
AP (1)	AP9801321A0 (fr)
AR (1)	AR017019A1 (fr)
AU (1)	AU8457298A (fr)
BG (1)	BG104069A (fr)
BR (1)	BR9811557A (fr)
CA (1)	CA2297486C (fr)
CO (1)	CO4960656A1 (fr)
DZ (1)	DZ2583A1 (fr)
EA (1)	EA200000023A1 (fr)
HR (1)	HRP980441A2 (fr)
HU (1)	HUP0003425A3 (fr)
ID (1)	ID23803A (fr)
IL (1)	IL133960A0 (fr)
IS (1)	IS5336A (fr)
MA (1)	MA24632A1 (fr)
NO (1)	NO20000722L (fr)
OA (1)	OA11286A (fr)
PA (1)	PA8457001A1 (fr)
PE (1)	PE106299A1 (fr)
PL (1)	PL338947A1 (fr)
SK (1)	SK1352000A3 (fr)
TN (1)	TNSN98151A1 (fr)
TR (1)	TR200000414T2 (fr)
UY (1)	UY25144A1 (fr)
WO (1)	WO1999009025A2 (fr)
ZA (1)	ZA987304B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU744539B2 (en) *	1997-10-27	2002-02-28	Neurosearch A/S	Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
EP0953567A3 (fr) *	1998-04-29	2003-04-02	Pfizer Products Inc.	Dérivés de piperazin-, piperidine- et tetrahydropyridine bicyclique substitués, leur préparation et leur utilisation comme agents a activité dopaminergique (recepteur D4 de la dopamine) centrale
EP1246817B1 (fr)	1999-12-30	2004-06-23	H. Lundbeck A/S	Derives de 4-phenyle-1-piperazinyle, -piperidinyle et -tetrahydropyridyle
GB0017952D0 (en) *	2000-07-22	2000-09-13	Univ Manchester	Treatment of dyskinesia
EP1177792A3 (fr)	2000-07-27	2002-10-23	Pfizer Products Inc.	Ligands dopamine d4 destines au traitement des troubles associees a la cherche de la nouveaute
AU2002336273A1 (en) *	2001-03-09	2002-09-24	Ortho-Mcneil Pharmaceutical, Inc.	Heterocyclic compounds and their use as histamine h4 ligands.
CA2497827A1 (fr)	2002-09-06	2004-03-18	Janssen Pharmaceutica, N.V.	Composes heterocycliques
WO2004108671A1 (fr) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant
EP2253315A1 (fr)	2004-03-30	2010-11-24	Takeda Pharmaceutical Company Limited	Dérivés d'acide alkoxypropanoique
US7572805B2 (en)	2004-07-14	2009-08-11	Bristol-Myers Squibb Company	Pyrrolo(oxo)isoquinolines as 5HT ligands
US7618980B2 (en)	2004-07-14	2009-11-17	Bristol-Myers Squibb Company	Pyrrolo(oxo)quinolines as 5HT ligands
JO2769B1 (en)	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en)	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) *	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JP5431305B2 (ja)	2007-04-23	2014-03-05	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
WO2008128996A1 (fr)	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	Thia(dia)zoles en tant qu'antagonistes du récepteur de la dopamine à dissociation rapide
EP2310374B1 (fr)	2008-07-03	2012-10-31	Janssen Pharmaceutica N.V.	6-(1-pipérazinyl)-pyridazines substituées comme antagonistes du récepteur 5-ht6
EP2307374B1 (fr)	2008-07-31	2017-01-25	Janssen Pharmaceutica NV	Pyridines à substitution pipérazin-1-yl-trifluorométhyle en tant qu'antagonistes du récepteur de la dopamine 2 à dissociation rapide
US11266640B2 (en) *	2017-09-20	2022-03-08	Hangzhou Innogate Pharma Co., Ltd.	Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor
US20230150980A1 (en) *	2020-04-22	2023-05-18	Anima Biotech Inc.	Collagen 1 translation inhibitors and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (fr) *	1959-09-25	1900-01-01
ES2097341T3 (es) *	1991-07-03	1997-04-01	Upjohn Co	Indoles sustituidos como farmacos para el tratamiento del sida.
JPH05255089A (ja) *	1991-12-18	1993-10-05	Sanwa Kagaku Kenkyusho Co Ltd	抗ウイルス剤
JPH08502958A (ja) *	1992-10-23	1996-04-02	メルクシヤープエンドドームリミテツド	ドーパミンレセプターサブタイプリガンド
AU6215594A (en) *	1993-03-18	1994-10-11	Merck Sharp & Dohme Limited	Indole derivatives as dopamine d4 antagonists
GB9305644D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
WO1994024105A1 (fr) *	1993-04-15	1994-10-27	Merck Sharp & Dohme Limited	Derives d'indole utiles comme antagonistes de la dopamine d4
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
TW406075B (en) *	1994-12-13	2000-09-21	Upjohn Co	Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) *	1995-11-17	1998-04-14	Upjohn Co	Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) *	1996-05-10	2002-10-01	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives

1998
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-05 EP EP98935229A patent/EP1003739A2/fr not_active Withdrawn
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/fr not_active Expired - Fee Related
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/fr not_active Ceased
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Ceased
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/fr active
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DZ2583A1 (fr)	2003-02-22
AR017019A1 (es)	2001-08-22
TR200000414T2 (tr)	2000-08-21
WO1999009025A3 (fr)	1999-04-15
CO4960656A1 (es)	2000-09-25
OA11286A (en)	2003-10-22
KR20010022507A (ko)	2001-03-15
SK1352000A3 (en)	2000-08-14
BG104069A (en)	2001-05-31
IL133960A0 (en)	2001-04-30
ID23803A (id)	2000-05-11
PL338947A1 (en)	2000-12-04
JP2002536291A (ja)	2002-10-29
HUP0003425A3 (en)	2002-02-28
EP1003739A2 (fr)	2000-05-31
CA2297486C (fr)	2005-05-03
UY25144A1 (es)	2000-12-29
ZA987304B (en)	2000-02-14
PE106299A1 (es)	1999-11-02
NO20000722D0 (no)	2000-02-14
HRP980441A2 (en)	1999-04-30
AP9801321A0 (en)	2000-02-14
CA2297486A1 (fr)	1999-02-25
TNSN98151A1 (fr)	2005-03-15
MA24632A1 (fr)	1999-04-01
HUP0003425A2 (hu)	2001-10-28
PA8457001A1 (es)	2000-09-29
WO1999009025A2 (fr)	1999-02-25
CN1265660A (zh)	2000-09-06
IS5336A (is)	2000-01-11
EA200000023A1 (ru)	2000-08-28
AU8457298A (en)	1999-03-08
BR9811557A (pt)	2000-08-22

Legal Events

Date	Code	Title	Description
2002-05-06	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
AP9801321A0 (en)	2000-02-14	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-h-indole derivatives.
NO986055D0 (no)	1998-12-22	Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat
TR200100439T2 (tr)	2001-05-21	1H-İmidazopiridin türevleri
DK0928788T3 (da)	2003-03-24	Imidazolidin-4-on-derivater, der er nyttige som anticancer-midler
AU4264396A (en)	1996-06-19	Cosmetic or pharmaceutical compositions containing mangiferin or derivatives thereof
NO996108L (no)	2000-02-10	9-oksinerytromycinderivater
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
DK0734383T3 (da)	2002-10-14	Cykliske amidderivater som neurokinin-A-antagonister
NO20024177L (no)	2002-10-29	Farmasöytiske preparater inneholdende azetidinderivater, de nye azetidinderivater og deres fremstilling
IL124537A0 (en)	1998-12-06	Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
NO20015172L (no)	2002-01-23	1-metyl-erytromycin-derivater
TR200100693T2 (tr)	2001-07-23	Azetidin türevleri, hazırlanmaları ve bunları içeren ilaçlar
NO970349D0 (no)	1997-01-27	Forbindelser som er anvendbare som antiproliferative midler og GARFT inhibitorer
TW333527B (en)	1998-06-11	Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
NO20052683L (no)	2005-06-03	Nye pyridopyrimidinonforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
NO20040881L (no)	2004-04-19	Orale antidiabetes midler.
DK0992509T3 (da)	2004-12-20	Nye makrolid-derivater
NO971625L (no)	1997-05-30	Nye peptider med immunomodulatoriske effekter
NZ516100A (en)	2004-01-30	Streptogramin derivatives, preparation and compositions containing them
NO20050666L (no)	2005-03-11	2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer
NO20070157L (no)	2007-01-23	Substituerte diketopiperaziner som oksytocinantagonister
NO20022552L (no)	2002-07-11	Nye benzotiadiazinderivater, deres fremstilling og farmasöytiske sammensetninger inneholdende det samme
NO961797L (no)	1996-11-06	Anvendelse av benzopyranderivater for fremstilling av farmasöytiske sammensetninger beregnet for behandling av patologier forbundet med den Na+-uavhengige C1-HCO3-utbytter
AR027035A1 (es)	2003-03-12	Pirroles sustituidos
DK0798298T3 (da)	2001-10-22	Thiazolidinon- eller oxazolidonderivater til behandling af angina pectoris eller sammensætninger indeholdende samme som aktiv bestanddel