IS7271A - Piperdine og piperazine afleiður 2,4-disubstituted, 3,5-disubstituded and 3,4,5-sumstituted piperadines and piperazines - Google Patents
Piperdine og piperazine afleiður 2,4-disubstituted, 3,5-disubstituded and 3,4,5-sumstituted piperadines and piperazinesInfo
- Publication number
- IS7271A IS7271A IS7271A IS7271A IS7271A IS 7271 A IS7271 A IS 7271A IS 7271 A IS7271 A IS 7271A IS 7271 A IS7271 A IS 7271A IS 7271 A IS7271 A IS 7271A
- Authority
- IS
- Iceland
- Prior art keywords
- disubstituted
- sumstituted
- piperadines
- piperdine
- piperazines
- Prior art date
Links
- 150000004885 piperazines Chemical class 0.000 title 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33270801P | 2001-11-19 | 2001-11-19 | |
| US38316702P | 2002-05-24 | 2002-05-24 | |
| PCT/US2002/037037 WO2003043987A2 (en) | 2001-11-19 | 2002-11-19 | (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS7271A true IS7271A (is) | 2004-05-19 |
Family
ID=26988352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS7271A IS7271A (is) | 2001-11-19 | 2004-05-19 | Piperdine og piperazine afleiður 2,4-disubstituted, 3,5-disubstituded and 3,4,5-sumstituted piperadines and piperazines |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7338965B2 (is) |
| EP (1) | EP1448200A2 (is) |
| JP (1) | JP2005514362A (is) |
| KR (1) | KR20050044533A (is) |
| AP (1) | AP2004003052A0 (is) |
| AU (1) | AU2002360403A1 (is) |
| BR (1) | BR0214295A (is) |
| CA (1) | CA2467749A1 (is) |
| CO (1) | CO5580743A2 (is) |
| EA (1) | EA200400699A1 (is) |
| GE (1) | GEP20074045B (is) |
| HR (1) | HRP20040550A2 (is) |
| IL (1) | IL162079A0 (is) |
| IS (1) | IS7271A (is) |
| MX (1) | MXPA04004772A (is) |
| NO (1) | NO20042580L (is) |
| NZ (1) | NZ533158A (is) |
| OA (1) | OA12812A (is) |
| RS (1) | RS54204A (is) |
| TN (1) | TNSN04088A1 (is) |
| WO (1) | WO2003043987A2 (is) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| JP2008535863A (ja) | 2005-04-08 | 2008-09-04 | コメンティス，インコーポレーテッド | β−セクレターゼ活性を阻害する化合物およびその使用方法 |
| EP1816122A3 (en) * | 2006-01-19 | 2007-09-19 | Speedel Experimenta AG | 3,4,5-substituted piperidines as therapeutic compounds |
| JP5564249B2 (ja) | 2006-06-23 | 2014-07-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌に関与するポリヌクレオチド配列およびポリペプチド配列 |
| KR100679869B1 (ko) * | 2006-10-27 | 2007-02-07 | 한국기계연구원 | Ｄｐｆ시스템용 플라즈마 반응기와 이를 이용한 입자상물질의 저감 장치 |
| CA2664130A1 (en) | 2006-09-21 | 2008-03-27 | Merck & Co., Inc. | Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| KR100838645B1 (ko) * | 2006-09-28 | 2008-06-16 | 한국화학연구원 | 베타-세크리테아제 활성을 억제하는 피페리딘 화합물 |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| CA2679446C (en) | 2007-03-01 | 2016-05-17 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| KR100894713B1 (ko) * | 2007-10-08 | 2009-04-24 | 한국화학연구원 | 베타-세크리테아제의 활성을 저해하는 아릴피페라진이 치환된 피페리딘 유도체 또는 이의 약제학적으로 허용 가능한 염 및 이를 유효성분으로 함유하는 신경퇴행성 질환의 예방 또는 치료용 조성물 |
| WO2010060186A1 (en) | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| BR112012008346B1 (pt) | 2009-09-11 | 2021-12-21 | Vivoryon Therapeutics N.V. | Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| JP6294221B2 (ja) | 2011-03-31 | 2018-03-14 | アー・デー・ツェー・セラピューティクス・エス・アー | 腎臓関連抗原１に対する抗体およびその抗原結合性フラグメント |
| TR201908872T4 (tr) | 2012-01-09 | 2019-07-22 | Adc Therapeutics Sa | Üçlü negatif meme kanserini tedavi etmek için ajanlar. |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3992441A (en) * | 1972-12-26 | 1976-11-16 | Pfizer Inc. | Sulfamylbenzoic acids |
| US4248876A (en) | 1977-01-08 | 1981-02-03 | John Wyeth & Brother Ltd. | Piperidine derivatives |
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| GB8430581D0 (en) | 1984-12-04 | 1985-01-09 | Ferrosan As | Treatment |
| DE3640475A1 (de) * | 1986-11-27 | 1988-06-09 | Hoechst Sa Lab | Arzneimittel auf basis von derivaten des 3,4-diphenylpiperidins, die verwendung der derivate als arzneimittel sowie neue 3,4-diphenylpiperidinderivate und verfahren zu ihrer herstellung |
| GB8714789D0 (en) * | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
| IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
| US4997836A (en) * | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
| US5708004A (en) | 1990-11-19 | 1998-01-13 | Monsanto Company | Retroviral protease inhibitors |
| DK0810209T3 (da) | 1992-08-25 | 2002-08-12 | Monsanto Co | Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
| US5475138A (en) | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
| TR199800409T1 (xx) * | 1995-09-07 | 1998-05-21 | F.Hoffmann-La Roche Ag | Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler |
| AU749281B2 (en) | 1997-02-04 | 2002-06-20 | Regents Of The University Of California, The | Nanomolar, non-peptide inhibitors of cathepsin D |
| WO1999012532A2 (en) * | 1997-09-08 | 1999-03-18 | F.Hoffmann-La Roche Ag | Piperidine derivatives against malaria |
| JP2001522846A (ja) * | 1997-11-05 | 2001-11-20 | ニューロサーチ、アクティーゼルスカブ | アザ環−エーテル誘導体及びこれをニコチン性ａｃｈレセプターモジュレーターとして使用する方法 |
| CN1289336A (zh) * | 1998-01-21 | 2001-03-28 | 千禧药品公司 | 趋化因子受体拮抗剂和其使用方法 |
| GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| US6365602B1 (en) * | 1998-07-10 | 2002-04-02 | Astra Zeneca Ab | N-substituted naphthalene carboxamides as neurokinin-receptor antagonists |
| US6274735B1 (en) | 1998-08-10 | 2001-08-14 | Hoffmann-La Roche Inc. | Process and intermediates for preparation of substituted piperidines |
| US6440996B1 (en) * | 1998-10-07 | 2002-08-27 | Georgetown University | Monomeric and dimeric heterocycles, and therapeutic uses thereof |
| GB9904786D0 (en) | 1999-03-02 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
| EP1688412A3 (en) | 2001-02-16 | 2006-08-16 | Aventis Pharmaceuticals, Inc. | Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands |
| WO2002076440A2 (en) | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| WO2002088101A2 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
-
2002
- 2002-11-19 OA OA1200400289A patent/OA12812A/en unknown
- 2002-11-19 CA CA002467749A patent/CA2467749A1/en not_active Abandoned
- 2002-11-19 BR BR0214295-3A patent/BR0214295A/pt not_active IP Right Cessation
- 2002-11-19 WO PCT/US2002/037037 patent/WO2003043987A2/en not_active Ceased
- 2002-11-19 EA EA200400699A patent/EA200400699A1/ru unknown
- 2002-11-19 US US10/299,746 patent/US7338965B2/en not_active Expired - Fee Related
- 2002-11-19 IL IL16207902A patent/IL162079A0/xx unknown
- 2002-11-19 HR HR20040550A patent/HRP20040550A2/xx not_active Application Discontinuation
- 2002-11-19 AP APAP/P/2004/003052A patent/AP2004003052A0/en unknown
- 2002-11-19 KR KR1020047007631A patent/KR20050044533A/ko not_active Withdrawn
- 2002-11-19 JP JP2003545624A patent/JP2005514362A/ja active Pending
- 2002-11-19 AU AU2002360403A patent/AU2002360403A1/en not_active Abandoned
- 2002-11-19 RS YU54204A patent/RS54204A/sr unknown
- 2002-11-19 NZ NZ533158A patent/NZ533158A/en unknown
- 2002-11-19 GE GE5634A patent/GEP20074045B/en unknown
- 2002-11-19 MX MXPA04004772A patent/MXPA04004772A/es not_active Application Discontinuation
- 2002-11-19 EP EP02795653A patent/EP1448200A2/en not_active Withdrawn
-
2004
- 2004-05-19 IS IS7271A patent/IS7271A/is unknown
- 2004-05-19 TN TNP2004000088A patent/TNSN04088A1/en unknown
- 2004-05-26 CO CO04048699A patent/CO5580743A2/es not_active Application Discontinuation
- 2004-06-18 NO NO20042580A patent/NO20042580L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005514362A (ja) | 2005-05-19 |
| IL162079A0 (en) | 2005-11-20 |
| CA2467749A1 (en) | 2003-05-30 |
| AP2004003052A0 (en) | 2004-06-30 |
| WO2003043987A3 (en) | 2003-07-10 |
| TNSN04088A1 (en) | 2006-06-01 |
| RS54204A (sr) | 2006-12-15 |
| EA200400699A1 (ru) | 2004-12-30 |
| OA12812A (en) | 2006-07-10 |
| NO20042580L (no) | 2004-08-09 |
| US7338965B2 (en) | 2008-03-04 |
| WO2003043987A2 (en) | 2003-05-30 |
| EP1448200A2 (en) | 2004-08-25 |
| KR20050044533A (ko) | 2005-05-12 |
| NZ533158A (en) | 2006-09-29 |
| AU2002360403A1 (en) | 2003-06-10 |
| MXPA04004772A (es) | 2005-06-06 |
| HRP20040550A2 (en) | 2006-11-30 |
| US20040034031A1 (en) | 2004-02-19 |
| CO5580743A2 (es) | 2005-11-30 |
| BR0214295A (pt) | 2004-11-09 |
| GEP20074045B (en) | 2007-02-26 |
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