ATE328882T1 - Tropanderivative als ccr5-modulatoren - Google Patents

Tropanderivative als ccr5-modulatoren

Info

Publication number: ATE328882T1
Authority: AT; Austria
Prior art keywords: tropane derivatives; ccr5 modulators; ccr5; modulators; tropane
Prior art date: 2002-04-08

Application number

AT03710080T

Other languages

English (en)

Inventor

Patricia Ann Basford

Peter Thomas Stephenson

Stefan Colin John Taylor

Anthony Wood

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-08

Filing date

2003-03-31

Publication date

2006-06-15

2002-04-08 Priority claimed from GBGB0208071.1A external-priority patent/GB0208071D0/en

2003-01-23 Priority claimed from GB0301575A external-priority patent/GB0301575D0/en

2003-03-31 Application filed by Pfizer filed Critical Pfizer

2006-06-15 Application granted granted Critical

2006-06-15 Publication of ATE328882T1 publication Critical patent/ATE328882T1/de

Links

102100035875 C-C chemokine receptor type 5 Human genes 0.000 title 1
101710149870 C-C chemokine receptor type 5 Proteins 0.000 title 1
150000003813 tropane derivatives Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P37/02—Immunomodulators
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)

AT03710080T 2002-04-08 2003-03-31 Tropanderivative als ccr5-modulatoren ATE328882T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0208071.1A GB0208071D0 (en)	2002-04-08	2002-04-08	Tropane derivatives useful in therapy
GB0301575A GB0301575D0 (en)	2003-01-23	2003-01-23	Tropane derivatives useful in therapy

Publications (1)

Publication Number	Publication Date
ATE328882T1 true ATE328882T1 (de)	2006-06-15

Family

ID=28793308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03710080T ATE328882T1 (de)	2002-04-08	2003-03-31	Tropanderivative als ccr5-modulatoren

Country Status (40)

Country	Link
EP (1)	EP1492789B1 (de)
JP (2)	JP3793200B2 (de)
KR (1)	KR100734685B1 (de)
CN (1)	CN1324025C (de)
AP (1)	AP1789A (de)
AR (1)	AR039383A1 (de)
AT (1)	ATE328882T1 (de)
AU (1)	AU2003214503B2 (de)
BR (1)	BR0309118A (de)
CA (1)	CA2481482C (de)
CR (1)	CR7514A (de)
CU (1)	CU23282A3 (de)
CY (1)	CY1106114T1 (de)
DE (1)	DE60305903T2 (de)
DK (1)	DK1492789T3 (de)
DO (1)	DOP2003000624A (de)
EA (1)	EA007590B1 (de)
ES (1)	ES2263960T3 (de)
GE (1)	GEP20074210B (de)
HN (1)	HN2003000114A (de)
HR (1)	HRP20040940A2 (de)
IL (1)	IL164261A0 (de)
IS (1)	IS2577B (de)
MA (1)	MA27190A1 (de)
MX (1)	MXPA04009220A (de)
MY (1)	MY134223A (de)
NI (1)	NI200300053A (de)
NO (1)	NO329674B1 (de)
NZ (1)	NZ535452A (de)
OA (1)	OA12798A (de)
PA (1)	PA8570801A1 (de)
PE (1)	PE20040082A1 (de)
PL (1)	PL372968A1 (de)
PT (1)	PT1492789E (de)
RS (1)	RS51550B (de)
SI (1)	SI1492789T1 (de)
TN (1)	TNSN04194A1 (de)
TW (1)	TWI280130B (de)
UY (1)	UY27752A1 (de)
WO (1)	WO2003084954A1 (de)

Families Citing this family (31)

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HRP20040940A2 (en) *	2002-04-08	2005-04-30	Pfizer Inc.	Tropane derivatives as ccr5 modulators
US6855724B2 (en)	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy
EP1786816A4 (de)	2003-09-10	2009-11-04	Virochem Pharma Inc	Spirohydantoinverbindungen und -verfahren zur modulation von chemokin-rezeptoraktivität
GB0323236D0 (en) *	2003-10-03	2003-11-05	Pfizer Ltd	Chemical compounds
HRP20080052T3 (hr) *	2003-10-03	2008-02-29	Pfizer Inc.	Derivati tropana supstituirani imidazopiridinom santagonističkim djelovanjem na ccr5 receptor za liječenje hiv-a i upala
TW200533348A (en)	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8131026B2 (en)	2004-04-16	2012-03-06	Validity Sensors, Inc.	Method and apparatus for fingerprint image reconstruction
EP1800243B1 (de)	2004-10-04	2010-08-11	Validity Sensors, Inc.	Fingerabdruckerfassende konstruktionen mit einem substrat
WO2006064340A2 (en) *	2004-12-13	2006-06-22	Pfizer Limited	Process for the preparation of n-acyl beta-aminoaldehydes
US7932235B2 (en)	2006-11-17	2011-04-26	Concert Pharmaceuticals, Inc.	Triazolyl tropane derivatives
CA2683939C (en)	2007-04-13	2012-06-19	Dong Wha Pharmaceutical Co. Ltd.	Aspartate of 1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3.4]oct-6-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid, method for preparing the same, and antimicrobial pharmaceutical composition comprising the same
WO2009029257A1 (en) *	2007-08-27	2009-03-05	Theravance, Inc.	Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists
CN101712679B (zh)	2008-10-08	2013-04-10	中国科学院上海药物研究所	一种酰胺类化合物、其药物组合物及其制备方法和用途
BR112012012085A2 (pt) *	2009-11-21	2016-05-17	Hoffmann La Roche	compostos antivirais heterocíclicos
CN102822163B (zh)	2009-12-23	2016-01-20	艾恩伍德医药品股份有限公司	Crth2调节剂
US20130023496A1 (en)	2010-04-02	2013-01-24	Randy Tressler	Combination Therapy Comprising A CCR5 Antagonist, A HIV-1 Protease Inhibtior and a Pharmacokinetic Enhancer
WO2012009137A1 (en)	2010-07-12	2012-01-19	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
US20130259830A1 (en)	2010-07-12	2013-10-03	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
HUE047354T2 (hu)	2011-05-18	2020-04-28	Vertex Pharmaceuticals Europe Ltd	Ivacaftor deuterizált származékai
US20140271680A1 (en)	2011-08-12	2014-09-18	Universite Paris-Est Creteil Val De Marne	Methods and pharmaceutical compositions for treatment of pulmonary hypertension
CN106977511B (zh) *	2011-12-19	2019-04-12	中国科学院上海药物研究所	一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途
JP6146990B2 (ja) *	2012-11-16	2017-06-14	コンサートファーマシューティカルズインコーポレイテッド	重水素化されたｃｆｔｒ増強物質
GB201321748D0 (en)	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
GB201321749D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
WO2016160945A1 (en)	2015-03-31	2016-10-06	Concert Pharmaceuticals, Inc.	Deuterated vx-661
MA42954A (fr)	2015-09-25	2018-08-01	Vertex Pharmaceuticals Europe Ltd	Potentialisateurs cftr deutérés
JP2017105824A (ja) *	2017-02-10	2017-06-15	コンサートファーマシューティカルズインコーポレイテッド	重水素化されたｃｆｔｒ増強物質
SG11202004264VA (en)	2017-12-01	2020-06-29	Vertex Pharma	Processes for making modulators of cystic fibrosis transmembrane conductance regulator
WO2019183133A1 (en)	2018-03-19	2019-09-26	Emory University	Pan-Tropic Entry Inhibitors
JP6654223B2 (ja) *	2018-08-13	2020-02-26	バーテックスファーマシューティカルズ（ヨーロッパ）リミテッド	重水素化されたｃｆｔｒ増強物質
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

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Publication number	Priority date	Publication date	Assignee	Title
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
WO2001080106A1 (en) *	2000-04-19	2001-10-25	Satoshi Yamazaki	Advertising-tool distribution method and magnetic recorded medium for the software
CZ299102B6 (cs) *	2000-05-26	2008-04-23	Pfizer Inc.	Tropanový derivát, zpusoby a meziprodukty pro jeho výrobu, léciva a lécivové kombinace s jeho obsahem
HRP20040940A2 (en) *	2002-04-08	2005-04-30	Pfizer Inc.	Tropane derivatives as ccr5 modulators

2003
- 2003-03-31 HR HR20040940A patent/HRP20040940A2/hr not_active Application Discontinuation
- 2003-03-31 MX MXPA04009220A patent/MXPA04009220A/es active IP Right Grant
- 2003-03-31 OA OA1200400262A patent/OA12798A/en unknown
- 2003-03-31 CN CNB03807639XA patent/CN1324025C/zh not_active Expired - Fee Related
- 2003-03-31 AP APAP/P/2004/003147A patent/AP1789A/en active
- 2003-03-31 DK DK03710080T patent/DK1492789T3/da active
- 2003-03-31 JP JP2003582151A patent/JP3793200B2/ja not_active Expired - Lifetime
- 2003-03-31 PT PT03710080T patent/PT1492789E/pt unknown
- 2003-03-31 SI SI200330319T patent/SI1492789T1/sl unknown
- 2003-03-31 CA CA002481482A patent/CA2481482C/en not_active Expired - Lifetime
- 2003-03-31 KR KR1020047016104A patent/KR100734685B1/ko not_active Expired - Fee Related
- 2003-03-31 IL IL16426103A patent/IL164261A0/xx unknown
- 2003-03-31 BR BR0309118-0A patent/BR0309118A/pt not_active IP Right Cessation
- 2003-03-31 GE GEAP8437A patent/GEP20074210B/en unknown
- 2003-03-31 RS YUP-888/04A patent/RS51550B/sr unknown
- 2003-03-31 AU AU2003214503A patent/AU2003214503B2/en not_active Ceased
- 2003-03-31 ES ES03710080T patent/ES2263960T3/es not_active Expired - Lifetime
- 2003-03-31 NZ NZ535452A patent/NZ535452A/en not_active IP Right Cessation
- 2003-03-31 DE DE60305903T patent/DE60305903T2/de not_active Expired - Lifetime
- 2003-03-31 AT AT03710080T patent/ATE328882T1/de active
- 2003-03-31 WO PCT/IB2003/001220 patent/WO2003084954A1/en not_active Ceased
- 2003-03-31 EP EP03710080A patent/EP1492789B1/de not_active Expired - Lifetime
- 2003-03-31 EA EA200401167A patent/EA007590B1/ru not_active IP Right Cessation
- 2003-03-31 PL PL03372968A patent/PL372968A1/xx unknown
- 2003-04-04 PE PE2003000346A patent/PE20040082A1/es not_active Application Discontinuation
- 2003-04-04 MY MYPI20031257A patent/MY134223A/en unknown
- 2003-04-04 NI NI200300053A patent/NI200300053A/es unknown
- 2003-04-04 DO DO2003000624A patent/DOP2003000624A/es unknown
- 2003-04-07 UY UY27752A patent/UY27752A1/es unknown
- 2003-04-07 HN HN2003000114A patent/HN2003000114A/es unknown
- 2003-04-07 TW TW092107880A patent/TWI280130B/zh not_active IP Right Cessation
- 2003-04-07 AR ARP030101205A patent/AR039383A1/es unknown
- 2003-04-08 PA PA20038570801A patent/PA8570801A1/es unknown
2004
- 2004-09-16 IS IS7453A patent/IS2577B/is unknown
- 2004-09-29 MA MA27883A patent/MA27190A1/fr unknown
- 2004-10-06 TN TNP2004000194A patent/TNSN04194A1/fr unknown
- 2004-10-07 CU CU20040219A patent/CU23282A3/es unknown
- 2004-10-07 CR CR7514A patent/CR7514A/es unknown
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PA8570801A1 (es)	2004-11-26
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CY1106114T1 (el)	2011-06-08
DE60305903D1 (de)	2006-07-20
NO20044615L (no)	2004-10-26
OA12798A (en)	2006-07-10
PT1492789E (pt)	2006-09-29
EA200401167A1 (ru)	2005-04-28
KR20040099420A (ko)	2004-11-26
AP1789A (en)	2007-10-05
CN1324025C (zh)	2007-07-04
MXPA04009220A (es)	2005-09-30
TNSN04194A1 (fr)	2007-03-12
AP2004003147A0 (en)	2004-09-30
JP4571078B2 (ja)	2010-10-27
NI200300053A (es)	2005-11-01
AU2003214503B2 (en)	2008-08-07
DE60305903T2 (de)	2007-03-08
EP1492789B1 (de)	2006-06-07
CA2481482A1 (en)	2003-10-16
DK1492789T3 (da)	2006-09-11
SI1492789T1 (sl)	2006-10-31
HRP20040940A2 (en)	2005-04-30
CR7514A (es)	2004-11-08
CN1646526A (zh)	2005-07-27
CU23282A3 (es)	2008-06-30
RS88804A (sr)	2006-12-15
BR0309118A (pt)	2005-02-01
TWI280130B (en)	2007-05-01
AR039383A1 (es)	2005-02-16
KR100734685B1 (ko)	2007-07-02
EP1492789A1 (de)	2005-01-05
PL372968A1 (en)	2005-08-08
NO329674B1 (no)	2010-11-29
IL164261A0 (en)	2005-12-18
CA2481482C (en)	2009-11-10
JP2005532285A (ja)	2005-10-27
TW200403242A (en)	2004-03-01
GEP20074210B (en)	2007-10-10
MY134223A (en)	2007-11-30
JP3793200B2 (ja)	2006-07-05
IS7453A (is)	2004-09-16
MA27190A1 (fr)	2005-01-03
WO2003084954A1 (en)	2003-10-16
HN2003000114A (es)	2004-05-05
JP2006182784A (ja)	2006-07-13
PE20040082A1 (es)	2004-03-20
UY27752A1 (es)	2003-11-28
ES2263960T3 (es)	2006-12-16
EA007590B1 (ru)	2006-12-29
HK1076102A1 (en)	2006-01-06
IS2577B (is)	2010-02-15
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