MA27190A1 - Derives de tropane servant de modulateurs de ccr5 - Google Patents

Derives de tropane servant de modulateurs de ccr5

Info

Publication number
MA27190A1
MA27190A1 MA27883A MA27883A MA27190A1 MA 27190 A1 MA27190 A1 MA 27190A1 MA 27883 A MA27883 A MA 27883A MA 27883 A MA27883 A MA 27883A MA 27190 A1 MA27190 A1 MA 27190A1
Authority
MA
Morocco
Prior art keywords
modulators
ccr5
treatment
present
tropane derivatives
Prior art date
Application number
MA27883A
Other languages
English (en)
Inventor
Patricia Ann Basford
Stefan Colin John Taylor
Peter Thomas Stephenson
Anthony Wood
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0208071.1A external-priority patent/GB0208071D0/en
Priority claimed from GB0301575A external-priority patent/GB0301575D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of MA27190A1 publication Critical patent/MA27190A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)

Abstract

DEPOSANT Société dite : PFIZER INC. REVENDICATION DE PRIORITES GB 8 Avril 2002 0208071.1 GB 23 Janvier 2003 0301575.7 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés de tropane servant de modulateurs de CCR5 La présente invention propose des composés de formule (I) dans laquelle X, Y, R1, R2 et R3 répondent aux définitions indiquées. Les composés de la présente invention sont des modulateurs, notamment des antagonistes, de l'activité des récepteurs de chimiokines CCR5. Des modulateurs du récepteur CCR5 peuvent être utiles dans le traitement de diverses maladies et affections inflammatoires, et dans le traitement de l'infection par le VIH et par des rétrovirus génétiquement apparentés.
MA27883A 2002-04-08 2004-09-29 Derives de tropane servant de modulateurs de ccr5 MA27190A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0208071.1A GB0208071D0 (en) 2002-04-08 2002-04-08 Tropane derivatives useful in therapy
GB0301575A GB0301575D0 (en) 2003-01-23 2003-01-23 Tropane derivatives useful in therapy

Publications (1)

Publication Number Publication Date
MA27190A1 true MA27190A1 (fr) 2005-01-03

Family

ID=28793308

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27883A MA27190A1 (fr) 2002-04-08 2004-09-29 Derives de tropane servant de modulateurs de ccr5

Country Status (40)

Country Link
EP (1) EP1492789B1 (fr)
JP (2) JP3793200B2 (fr)
KR (1) KR100734685B1 (fr)
CN (1) CN1324025C (fr)
AP (1) AP1789A (fr)
AR (1) AR039383A1 (fr)
AT (1) ATE328882T1 (fr)
AU (1) AU2003214503B2 (fr)
BR (1) BR0309118A (fr)
CA (1) CA2481482C (fr)
CR (1) CR7514A (fr)
CU (1) CU23282A3 (fr)
CY (1) CY1106114T1 (fr)
DE (1) DE60305903T2 (fr)
DK (1) DK1492789T3 (fr)
DO (1) DOP2003000624A (fr)
EA (1) EA007590B1 (fr)
ES (1) ES2263960T3 (fr)
GE (1) GEP20074210B (fr)
HN (1) HN2003000114A (fr)
HR (1) HRP20040940A2 (fr)
IL (1) IL164261A0 (fr)
IS (1) IS2577B (fr)
MA (1) MA27190A1 (fr)
MX (1) MXPA04009220A (fr)
MY (1) MY134223A (fr)
NI (1) NI200300053A (fr)
NO (1) NO329674B1 (fr)
NZ (1) NZ535452A (fr)
OA (1) OA12798A (fr)
PA (1) PA8570801A1 (fr)
PE (1) PE20040082A1 (fr)
PL (1) PL372968A1 (fr)
PT (1) PT1492789E (fr)
RS (1) RS51550B (fr)
SI (1) SI1492789T1 (fr)
TN (1) TNSN04194A1 (fr)
TW (1) TWI280130B (fr)
UY (1) UY27752A1 (fr)
WO (1) WO2003084954A1 (fr)

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US6855724B2 (en) 2002-04-08 2005-02-15 Agouron Pharmaceuticals, Inc. Tropane derivatives useful in therapy
PL372968A1 (en) * 2002-04-08 2005-08-08 Pfizer Inc. Tropane derivatives as ccr5 modulators
WO2005023810A1 (fr) 2003-09-10 2005-03-17 Virochem Pharma Inc. Composes de spirohydantoine et procedes de modulation de l'activite des recepteurs de chimiokine
KR100777885B1 (ko) * 2003-10-03 2007-11-28 화이자 인코포레이티드 Ｈｉｖ 및 염증 치료를 위한 ｃｃｒ5 수용체 길항제 활성을갖는 이미다조피리딘 치환된 트로판 유도체
GB0323236D0 (en) * 2003-10-03 2003-11-05 Pfizer Ltd Chemical compounds
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8131026B2 (en) 2004-04-16 2012-03-06 Validity Sensors, Inc. Method and apparatus for fingerprint image reconstruction
WO2006041780A1 (fr) 2004-10-04 2006-04-20 Validity Sensors, Inc. Groupes de detection d'empreintes digitales comprenant un substrat
WO2006064340A2 (fr) * 2004-12-13 2006-06-22 Pfizer Limited Elaboration de n-acyl beta-aminoaldehydes
WO2008063600A2 (fr) * 2006-11-17 2008-05-29 Concert Pharmaceuticals Inc. Dérivés de triazolyle tropane
WO2008127060A1 (fr) 2007-04-13 2008-10-23 Dong Wha Pharmaceutical Co. Ltd. Aspartate de l'acide 1-cyclopropyl-6-fluoro-7-(8-méthoxyimino-2,6-diaza- spiro[3.4]oct-6-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylique, leurs méthodes de préparation, et préparations pharmaceutiques antimicrobiennes les contenant
ATE502939T1 (de) 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
CN101712679B (zh) * 2008-10-08 2013-04-10 中国科学院上海药物研究所 一种酰胺类化合物、其药物组合物及其制备方法和用途
CN102639504A (zh) * 2009-11-21 2012-08-15 弗·哈夫曼-拉罗切有限公司 杂环抗病毒化合物
JP5731538B2 (ja) 2009-12-23 2015-06-10 アイアンウッド ファーマシューティカルズ インコーポレイテッド Ｃｒｔｈ２モジュレーター
MA34215B1 (fr) 2010-04-02 2013-05-02 Phivco 1 Llc Traitement d'association comprenant un antagoniste du récepteur ccr5, un inhibiteur de la protéase du vih-1 et un accélérateur pharmacocinétique
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012009137A1 (fr) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Modulateurs de crth2
HUE047354T2 (hu) 2011-05-18 2020-04-28 Vertex Pharmaceuticals Europe Ltd Ivacaftor deuterizált származékai
WO2013024022A1 (fr) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter l'hypertension pulmonaire
CN106977511B (zh) * 2011-12-19 2019-04-12 中国科学院上海药物研究所 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途
JP6146990B2 (ja) * 2012-11-16 2017-06-14 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
GB201321748D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
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HK1249893A1 (zh) 2015-03-31 2018-11-16 Vertex Pharmaceuticals (Europe) Limited 氘代vx-661
HK1258473A1 (zh) 2015-09-25 2019-11-15 Vertex Pharmaceuticals (Europe) Limited 氘代cftr增效剂
JP2017105824A (ja) * 2017-02-10 2017-06-15 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
CA3082444A1 (fr) 2017-12-01 2019-06-06 Vertex Pharmaceuticals Incorporated Procedes pour preparer des modulateurs de regulateur de conductance transmembranaire de mucoviscidose
US11649235B2 (en) 2018-03-19 2023-05-16 Emory University Pan-tropic entry inhibitors
JP6654223B2 (ja) * 2018-08-13 2020-02-26 バーテックス ファーマシューティカルズ （ヨーロッパ） リミテッド 重水素化されたｃｆｔｒ増強物質
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PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
WO2001080106A1 (fr) * 2000-04-19 2001-10-25 Satoshi Yamazaki Procede de diffusion d'outil publicitaire et support magnetique pour le logiciel
CN100355753C (zh) * 2000-05-26 2007-12-19 辉瑞大药厂 用于制备具有治疗作用的莨菪烷衍生物的中间体
PL372968A1 (en) * 2002-04-08 2005-08-08 Pfizer Inc. Tropane derivatives as ccr5 modulators

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CA2481482C (fr) 2009-11-10
AP2004003147A0 (en) 2004-09-30
MXPA04009220A (es) 2005-09-30
JP2005532285A (ja) 2005-10-27
MY134223A (en) 2007-11-30
CY1106114T1 (el) 2011-06-08
WO2003084954A1 (fr) 2003-10-16
PL372968A1 (en) 2005-08-08
HN2003000114A (es) 2004-05-05
BR0309118A (pt) 2005-02-01
AU2003214503A1 (en) 2003-10-20
EA200401167A1 (ru) 2005-04-28
NI200300053A (es) 2005-11-01
SI1492789T1 (sl) 2006-10-31
EA007590B1 (ru) 2006-12-29
NO329674B1 (no) 2010-11-29
DE60305903T2 (de) 2007-03-08
NZ535452A (en) 2006-11-30
CR7514A (es) 2004-11-08
ES2263960T3 (es) 2006-12-16
AU2003214503B2 (en) 2008-08-07
PA8570801A1 (es) 2004-11-26
OA12798A (en) 2006-07-10
CN1646526A (zh) 2005-07-27
KR100734685B1 (ko) 2007-07-02
NO20044615L (no) 2004-10-26
TW200403242A (en) 2004-03-01
IS7453A (is) 2004-09-16
DK1492789T3 (da) 2006-09-11
HRP20040940A2 (en) 2005-04-30
RS51550B (sr) 2011-06-30
PE20040082A1 (es) 2004-03-20
DE60305903D1 (de) 2006-07-20
TNSN04194A1 (fr) 2007-03-12
JP4571078B2 (ja) 2010-10-27
ATE328882T1 (de) 2006-06-15
IS2577B (is) 2010-02-15
GEP20074210B (en) 2007-10-10
CN1324025C (zh) 2007-07-04
HK1076102A1 (en) 2006-01-06
CU23282A3 (es) 2008-06-30
EP1492789A1 (fr) 2005-01-05
IL164261A0 (en) 2005-12-18
CA2481482A1 (fr) 2003-10-16
DOP2003000624A (es) 2003-10-15
UY27752A1 (es) 2003-11-28
EP1492789B1 (fr) 2006-06-07
AR039383A1 (es) 2005-02-16
KR20040099420A (ko) 2004-11-26
TWI280130B (en) 2007-05-01
AP1789A (en) 2007-10-05
JP3793200B2 (ja) 2006-07-05
JP2006182784A (ja) 2006-07-13
RS88804A (sr) 2006-12-15
PT1492789E (pt) 2006-09-29

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