IT1120561B - Derivati alfa-aril-alfa alfa-bis omega-ammino bisostituiti alchilacetammidici ditati di proprieta' farmacologiche antiaritmia - Google Patents

Derivati alfa-aril-alfa alfa-bis omega-ammino bisostituiti alchilacetammidici ditati di proprieta' farmacologiche antiaritmia

Info

Publication number: IT1120561B
Authority: IT; Italy
Prior art keywords: alpha; acetamidic; arrhythmia; facts; omega
Prior art date: 1978-09-08

Application number

IT50202/79A

Other languages

English (en)

Other versions

IT7950202A0 (it

Inventor

Peter K Yonan

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-09-08

Filing date

1979-09-07

Publication date

1986-03-26

1979-09-07 Application filed by Searle & Co filed Critical Searle & Co

1979-09-07 Publication of IT7950202A0 publication Critical patent/IT7950202A0/it

1986-03-26 Application granted granted Critical

1986-03-26 Publication of IT1120561B publication Critical patent/IT1120561B/it

Links

230000003288 anthiarrhythmic effect Effects 0.000 title 1
230000000144 pharmacologic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IT50202/79A 1978-09-08 1979-09-07 Derivati alfa-aril-alfa alfa-bis omega-ammino bisostituiti alchilacetammidici ditati di proprieta' farmacologiche antiaritmia IT1120561B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/940,527 US4217306A (en)	1978-05-01	1978-09-08	α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]-acetamides

Publications (2)

Publication Number	Publication Date
IT7950202A0 IT7950202A0 (it)	1979-09-07
IT1120561B true IT1120561B (it)	1986-03-26

Family

ID=25474978

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT50202/79A IT1120561B (it)	1978-09-08	1979-09-07	Derivati alfa-aril-alfa alfa-bis omega-ammino bisostituiti alchilacetammidici ditati di proprieta' farmacologiche antiaritmia

Country Status (20)

Country	Link
US (1)	US4217306A (it)
JP (1)	JPS5592350A (it)
AT (3)	AT364813B (it)
AU (1)	AU5068679A (it)
BE (1)	BE878662A (it)
CA (1)	CA1136622A (it)
DE (1)	DE2936287A1 (it)
DK (1)	DK374879A (it)
ES (1)	ES483985A1 (it)
FR (1)	FR2435462A1 (it)
GB (1)	GB2030984B (it)
GR (1)	GR72494B (it)
IL (1)	IL58200A (it)
IT (1)	IT1120561B (it)
NL (1)	NL7906745A (it)
NO (1)	NO792901L (it)
NZ (1)	NZ191505A (it)
PT (1)	PT70151B (it)
SE (1)	SE7907432L (it)
ZA (1)	ZA794764B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4639524A (en) *	1984-07-09	1987-01-27	G. D. Searle & Co.	Monobasic disobutamide derivatives
US5097035A (en) *	1984-07-09	1992-03-17	G. D. Searle & Co.	Monobasic disobutamide derivatives
US4791199A (en) *	1985-09-19	1988-12-13	G. D. Searle & Co.	Process for antiarrhythmic 1,3-diazabicyclo[4.4.0]dec-2-en-4-ones
EP0370712A3 (en) *	1988-11-18	1991-10-02	Ajinomoto Co., Inc.	Ethylamine derivatives and hypotensives containing the same
FR2686339B1 (fr) *	1992-01-22	1994-03-11	Adir Cie	Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5432284A (en) *	1993-09-08	1995-07-11	G. D. Searle & Co.	Process for the preparation of heterocyclic alkylamide derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2884436A (en) *	1954-08-28	1959-04-28	Nl Combinatie Chem Ind	Parasympathicolytically active alpha, alpha-diphenyl-gamma-dialkylaminobutyramide compounds and manufacture thereof
US3022314A (en) *	1955-06-20	1962-02-20	Upjohn Co	Alpha-phenyl-omega-amino-alkanamides
US3022302A (en) *	1956-03-15	1962-02-20	Pharmacia Ab	Manufacture of nu, nu-disubstituted amides of aryl acetic acids
US3078275A (en) *	1956-05-28	1963-02-19	Upjohn Co	N, n-disubstituted-alpha-(tertiaryaminoalkyl)-alpha, alpha-diphenylacetamides
US2894955A (en) *	1956-11-19	1959-07-14	Upjohn Co	Organic compounds
US3225091A (en) *	1962-02-01	1965-12-21	Lilly Co Eli	Anticholinergic substituted butyramides
NL124729C (it) *	1963-05-14
BE673495A (fr)	1965-12-09	1966-04-01	Madan Ag	Amides et N-hydroxyamides dérivés d'acides para-alkyloxyarylacétiques substitués et leur préparation
BE689347A (it)	1965-12-09	1967-04-14	Madan Ag
US4107205A (en) *	1977-03-11	1978-08-15	G. D. Searle & Co.	α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides and related compounds

1978
- 1978-09-08 US US05/940,527 patent/US4217306A/en not_active Expired - Lifetime
1979
- 1979-09-07 ZA ZA00794764A patent/ZA794764B/xx unknown
- 1979-09-07 PT PT70151A patent/PT70151B/pt unknown
- 1979-09-07 GB GB7931218A patent/GB2030984B/en not_active Expired
- 1979-09-07 JP JP11508979A patent/JPS5592350A/ja active Pending
- 1979-09-07 CA CA000335200A patent/CA1136622A/en not_active Expired
- 1979-09-07 NZ NZ191505A patent/NZ191505A/xx unknown
- 1979-09-07 IL IL58200A patent/IL58200A/xx unknown
- 1979-09-07 FR FR7922468A patent/FR2435462A1/fr active Pending
- 1979-09-07 AT AT0592679A patent/AT364813B/de not_active IP Right Cessation
- 1979-09-07 IT IT50202/79A patent/IT1120561B/it active
- 1979-09-07 GR GR59993A patent/GR72494B/el unknown
- 1979-09-07 DE DE19792936287 patent/DE2936287A1/de not_active Withdrawn
- 1979-09-07 DK DK374879A patent/DK374879A/da not_active Application Discontinuation
- 1979-09-07 ES ES483985A patent/ES483985A1/es not_active Expired
- 1979-09-07 BE BE0/197051A patent/BE878662A/fr unknown
- 1979-09-07 AU AU50686/79A patent/AU5068679A/en not_active Abandoned
- 1979-09-07 NO NO792901A patent/NO792901L/no unknown
- 1979-09-07 SE SE7907432A patent/SE7907432L/xx not_active Application Discontinuation
- 1979-09-10 NL NL7906745A patent/NL7906745A/nl not_active Application Discontinuation
1980
- 1980-12-10 AT AT0600280A patent/AT370088B/de not_active IP Right Cessation
- 1980-12-10 AT AT0600180A patent/AT370087B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATA600180A (de)	1982-07-15
PT70151A (en)	1979-09-01
AT370088B (de)	1983-02-25
AT364813B (de)	1981-11-25
PT70151B (pt)	1981-12-11
DK374879A (da)	1980-03-09
SE7907432L (sv)	1980-03-09
IL58200A (en)	1982-12-31
BE878662A (fr)	1980-03-07
IT7950202A0 (it)	1979-09-07
IL58200A0 (en)	1979-12-30
GR72494B (it)	1983-11-15
CA1136622A (en)	1982-11-30
NZ191505A (en)	1982-03-30
ATA600280A (de)	1982-07-15
JPS5592350A (en)	1980-07-12
FR2435462A1 (fr)	1980-04-04
AT370087B (de)	1983-02-25
ATA592679A (de)	1981-04-15
AU5068679A (en)	1980-03-27
GB2030984A (en)	1980-04-16
ES483985A1 (es)	1980-04-16
DE2936287A1 (de)	1980-03-20
NL7906745A (nl)	1980-03-11
NO792901L (no)	1980-03-11
ZA794764B (en)	1981-04-29
US4217306A (en)	1980-08-12
GB2030984B (en)	1983-07-27

Publication	Publication Date	Title
IT1116820B (it)	1986-02-10	Derivati di moranolina con proprieta'farmacologiche
IT1121238B (it)	1986-03-26	Derivati di amminotiazoli ad azione farmaceutica
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IT7948802A0 (it)	1979-04-20	Derivati di n-alchenilmoranolina aventi attivita' farmacologica
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IT1085538B (it)	1985-05-28	Derivati di i 125 immidazol-steroidi
IT7950523A0 (it)	1979-10-10	Derivati carbamoil-piperazinici dotati di attivita' farmacologica
IT1113377B (it)	1986-01-20	Derivati di n-ciano-azometini
BE857512A (fr)	1978-02-06	Nouveaux derives de l'imidazole
IT1162424B (it)	1987-04-01	Derivati di 7 alfa-metossicefalosporina e procedimento per produrli
IT1102516B (it)	1985-10-07	Derivati dell'acido 2-triclorometil 4-nitrobenzolsolfenico
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