IT1223391B - Prostacicline - Google Patents

Prostacicline

Info

Publication number: IT1223391B
Authority: IT; Italy
Prior art keywords: prostacyclin
Prior art date: 1986-12-01

Application number

IT22815/87A

Other languages

English (en)

Other versions

IT8722815A0 (it

Inventor

Georg William Holland

Ferdinand Lee

Hans Maag

Perry Rosen

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-01

Filing date

1987-11-30

Publication date

1990-09-19

1987-11-30 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1987-11-30 Publication of IT8722815A0 publication Critical patent/IT8722815A0/it

1990-09-19 Application granted granted Critical

1990-09-19 Publication of IT1223391B publication Critical patent/IT1223391B/it

Links

KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title 1
229960001123 epoprostenol Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)

IT22815/87A 1986-12-01 1987-11-30 Prostacicline IT1223391B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/936,569 US4808734A (en)	1986-12-01	1986-12-01	16-cycloalkyl-7-fluoro-prostacyclins

Publications (2)

Publication Number	Publication Date
IT8722815A0 IT8722815A0 (it)	1987-11-30
IT1223391B true IT1223391B (it)	1990-09-19

Family

ID=25468824

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT22815/87A IT1223391B (it)	1986-12-01	1987-11-30	Prostacicline

Country Status (15)

Country	Link
US (1)	US4808734A (it)
JP (1)	JPS63145276A (it)
AT (1)	AT392071B (it)
AU (1)	AU604792B2 (it)
BE (1)	BE1001109A3 (it)
CH (1)	CH673650A5 (it)
DE (1)	DE3740596A1 (it)
DK (1)	DK627887A (it)
FR (1)	FR2607500A1 (it)
GB (1)	GB2198131B (it)
IT (1)	IT1223391B (it)
NL (1)	NL8702881A (it)
NZ (1)	NZ222724A (it)
SE (1)	SE8704771L (it)
ZA (1)	ZA878946B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW208001B (it) *	1990-09-07	1993-06-21	Asahi Glass Co Ltd

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1513913A (en) *	1975-06-20	1978-06-14	Ici Ltd	Prostane derivatives
US4565827A (en) *	1980-10-27	1986-01-21	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T.	7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
DE3176313D1 (en) *	1980-12-09	1987-08-20	Teijin Ltd	Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
US4558142A (en) *	1981-03-11	1985-12-10	Hoffmann-La Roche Inc.	7-Fluoro-prostacyclin analogs
CH648556A5 (de) *	1981-03-11	1985-03-29	Hoffmann La Roche	Fluorprostacycline.
JPS58150583A (ja) *	1982-03-04	1983-09-07	Teijin Ltd	新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
JPS59227888A (ja) *	1983-06-10	1984-12-21	Asahi Glass Co Ltd	７−フルオロプロスタグランジン類の製造方法
HU191264B (en) *	1984-01-13	1987-01-28	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu	Process for production of derivatives of 7-oxo-prostacyclin with selective biological effect
JPS60243079A (ja) *	1984-05-18	1985-12-03	Asahi Glass Co Ltd	７―フルオロプロスタグランジンｉ↓２類を有効成分とする薬剤
US4616034A (en) *	1985-02-28	1986-10-07	G. D. Searle & Co.	15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof
JPS61289034A (ja) *	1985-06-17	1986-12-19	Teijin Ltd	イソカルバサイクリン類脂肪乳剤
FR2583828B1 (fr) *	1985-06-21	1987-08-14	Kley France Sa	Appareil moteur fonctionnant par reprises successives
US4634782A (en) *	1985-06-24	1987-01-06	Hoffmann-La Roche Inc.	7-fluoro-dihydro PGI compounds

1986
- 1986-12-01 US US06/936,569 patent/US4808734A/en not_active Expired - Fee Related
1987
- 1987-11-13 CH CH4429/87A patent/CH673650A5/de not_active IP Right Cessation
- 1987-11-27 ZA ZA878946A patent/ZA878946B/xx unknown
- 1987-11-27 FR FR8716486A patent/FR2607500A1/fr not_active Withdrawn
- 1987-11-27 JP JP62297861A patent/JPS63145276A/ja active Pending
- 1987-11-27 NZ NZ222724A patent/NZ222724A/en unknown
- 1987-11-30 AU AU81908/87A patent/AU604792B2/en not_active Expired - Fee Related
- 1987-11-30 GB GB8727992A patent/GB2198131B/en not_active Expired - Lifetime
- 1987-11-30 DE DE19873740596 patent/DE3740596A1/de not_active Withdrawn
- 1987-11-30 BE BE8701357A patent/BE1001109A3/fr not_active IP Right Cessation
- 1987-11-30 IT IT22815/87A patent/IT1223391B/it active
- 1987-11-30 AT AT0313787A patent/AT392071B/de not_active IP Right Cessation
- 1987-11-30 SE SE8704771A patent/SE8704771L/xx not_active Application Discontinuation
- 1987-11-30 DK DK627887A patent/DK627887A/da not_active Application Discontinuation
- 1987-12-01 NL NL8702881A patent/NL8702881A/nl not_active Application Discontinuation

Also Published As

Publication number	Publication date
DK627887D0 (da)	1987-11-30
CH673650A5 (it)	1990-03-30
GB2198131B (en)	1990-08-08
ATA313787A (de)	1990-07-15
NL8702881A (nl)	1988-07-01
ZA878946B (en)	1988-06-01
US4808734A (en)	1989-02-28
DE3740596A1 (de)	1988-06-16
GB8727992D0 (en)	1988-01-06
AU604792B2 (en)	1991-01-03
GB2198131A (en)	1988-06-08
AU8190887A (en)	1988-06-02
BE1001109A3 (fr)	1989-07-18
DK627887A (da)	1988-06-02
SE8704771D0 (sv)	1987-11-30
SE8704771L (sv)	1988-06-02
NZ222724A (en)	1990-11-27
FR2607500A1 (fr)	1988-06-03
AT392071B (de)	1991-01-25
IT8722815A0 (it)	1987-11-30
JPS63145276A (ja)	1988-06-17

Publication	Publication Date	Title
DK409187A (da)	1988-02-16	Loefteslynge
DK83687A (da)	1987-08-21	Aeltemaskine
DK492587A (da)	1987-09-18	Substituerede indolquinoxaliner
DK157746C (da)	1990-07-23	Loeftekrog
FI90608C (fi)	1994-02-25	Taajuussyntesointilaite
FR2608909B1 (fr)	1992-03-27	Amnioscope
DK438087A (da)	1988-02-23	Schistosomprotein
DK290487A (da)	1987-12-10	Substituerede 3-amino-2-benzoylcyklohex-2-enoner
DK134688D0 (da)	1988-03-11	Fluidumpudeindretning
DK477187D0 (da)	1987-09-11	Klaebekomposition
BR8605161A (pt)	1988-04-26	Palmilha
DK479988D0 (da)	1988-08-26	Carbamoyloxylabdaner
DK406888A (da)	1988-09-13	Stige
FI875615A0 (fi)	1987-12-21	Segmenttimäärittelijäyksikkö
DK249087A (da)	1987-11-17	Alfa-halogenpyruvatoxim
ATA246886A (de)	1988-01-15	Schachtsystem
FR2599154B1 (fr)	1990-05-11	Altimetre-radar
DK178786A (da)	1987-10-19	Vaeskecontainer
DK145387A (da)	1987-09-25	Naphthalenderivater
DK521787D0 (da)	1987-10-05	Skotrendeplade-emne
IT1223390B (it)	1990-09-19	Prostacicline
DK627887D0 (da)	1987-11-30	Prostacycliner
ES292764Y (es)	1987-03-01	Carrito transportador-expositor
DK595087A (da)	1988-05-14	Hjultaellevaerk
IS3238A7 (is)	1987-10-02	Keðjulás