ES2061956T3 - Procedimiento para la preparacion de peptidos retro-inversos y nuevos compuestos intermedios de los mismos. - Google Patents

Procedimiento para la preparacion de peptidos retro-inversos y nuevos compuestos intermedios de los mismos.

Info

Publication number
ES2061956T3
ES2061956T3 ES89203194T ES89203194T ES2061956T3 ES 2061956 T3 ES2061956 T3 ES 2061956T3 ES 89203194 T ES89203194 T ES 89203194T ES 89203194 T ES89203194 T ES 89203194T ES 2061956 T3 ES2061956 T3 ES 2061956T3
Authority
ES
Spain
Prior art keywords
retro
preparation
formula
side chain
waste
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89203194T
Other languages
English (en)
Inventor
Massimo Pinori
Felice Centini
Antonio Silvio Verdini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sclavo SpA
Original Assignee
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo SpA filed Critical Sclavo SpA
Application granted granted Critical
Publication of ES2061956T3 publication Critical patent/ES2061956T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN METODO DE SINTESIS DE UN PEPTIDO RETRO-INVERSO PARCIALMENTE QUE INCORPORA AL MENOS UN RESIDUO MALONIL DE FORMULA (III) EN DONDE R REPRESENTA LA CADENA LATERAL DE UN ACIDO AMINO-A, ES DESCRITA QUE SE CARACTERIZA EN QUE DICHO RESIDUO MALONIL ES INCORPORADO POR CONDENSAR UN DIONE-4,6-DIOXANO-1,3-DIMETIL-2,2-SUSTITUIDO-5 DE FORMULA (VI) EN DONDE R'' ES LA CADENA LATERAL R EN DONDE LOS GRUPOS FUNCIONALES, SI ALGUNO, ES CONVENIENTEMENTE PROTEGIDO, CON UN ACIDO AMINO, AMIDA DE ACIDO AMINO, FRAGMENTO PEPTIDO, O FRAGMENTO PSEUDO-PEPTIDO EN DONDE EL GRUPO TERMINAL CARBOXIL, SI ESTA PRESENTE,, Y LAS POSIBLES FUNCIONALIDADES DE LA CADENA LATERAL SON CONVENIENTEMENTE PROTEGIDAS Y EL GRUPO AMINO REACTIVO ES TRI-ALQUIL-SILILATADO. LOS NUEVOS COMPONENTES DE FORMULA (VI) Y UN PROCESO PARA LA PREPARACION DE UN TERMINO TUFTSIN PARCIALMENTE RETRO-INVERSO QUE ATAÑE AL USO DE DICHO METODO Y TAMBIEN SON DESCRITOS Y RECLAMADOS DICHOS INTERMEDIARIOS.
ES89203194T 1988-12-23 1989-12-14 Procedimiento para la preparacion de peptidos retro-inversos y nuevos compuestos intermedios de los mismos. Expired - Lifetime ES2061956T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8823098A IT1227907B (it) 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Publications (1)

Publication Number Publication Date
ES2061956T3 true ES2061956T3 (es) 1994-12-16

Family

ID=11203765

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89203194T Expired - Lifetime ES2061956T3 (es) 1988-12-23 1989-12-14 Procedimiento para la preparacion de peptidos retro-inversos y nuevos compuestos intermedios de los mismos.

Country Status (8)

Country Link
US (2) US5061811A (es)
EP (1) EP0375040B1 (es)
JP (1) JPH02221294A (es)
AT (1) ATE102949T1 (es)
CA (1) CA2006560A1 (es)
DE (1) DE68913935T2 (es)
ES (1) ES2061956T3 (es)
IT (1) IT1227907B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200506A (en) * 1987-03-19 1993-04-06 Eniricerche S.P.A. Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
IT1227907B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
US5218089A (en) * 1988-12-23 1993-06-08 Sclavo S.P.A. Retro-inverso analogues of thymopentin and the method for their synthesis
WO1992013958A1 (en) * 1991-02-06 1992-08-20 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
CN1091138A (zh) 1992-08-27 1994-08-24 迪金研究有限公司 疫苗
AU766219B2 (en) * 1998-02-02 2003-10-09 1149336 Ontario Inc. Method of regulating glucose metabolism, and reagents related thereto
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US6610820B1 (en) * 1999-10-12 2003-08-26 University Of Lausanne Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
EP1469873A4 (en) * 2001-11-26 2007-10-03 Tufts College PEPTIDOMIMETIC INHIBITORS FROM BEHIND PROLIN SPLENDING ENZYMES
WO2003045228A2 (en) 2001-11-26 2003-06-05 Trustees Of Tufts College Methods for treating autoimmune disorders, and reagents related thereto
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
DE60234713D1 (de) * 2001-12-18 2010-01-21 Endocube Sas Neue mit dem zelltod assoziierte proteine aus der thap familie und par4 verwandte signalwege, die bei der kontrolle von apoptosis involviert sind
EP2078727A1 (en) 2002-03-13 2009-07-15 Bayer CropScience SA Mutagenesis of aspergillus fungi and identification of genes essential for growth
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
AU2010362444B2 (en) 2010-10-14 2015-08-06 Xigen Inflammation Ltd. Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
ES2870085T3 (es) 2013-06-26 2021-10-26 Xigen Inflammation Ltd Inhibidores peptídicos permeables a células de la ruta de transducción de señales de JNK para el tratamiento de la cistitis
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052517T3 (es) * 1986-07-16 1994-07-16 Eniricerche Spa Analogos de tuftsina parcialmente retroinversos, metodo de preparacion de los mismos y composiciones farmaceuticas que los contienen.
IT1227907B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Also Published As

Publication number Publication date
EP0375040A3 (en) 1991-07-03
ATE102949T1 (de) 1994-04-15
IT8823098A0 (it) 1988-12-23
EP0375040B1 (en) 1994-03-16
JPH02221294A (ja) 1990-09-04
US5061811A (en) 1991-10-29
US5116947A (en) 1992-05-26
CA2006560A1 (en) 1990-06-23
DE68913935D1 (de) 1994-04-21
EP0375040A2 (en) 1990-06-27
DE68913935T2 (de) 1994-07-07
IT1227907B (it) 1991-05-14

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