IT1228209B - Procedimento per la preparazione di fluoxetina cloridrato. - Google Patents

Procedimento per la preparazione di fluoxetina cloridrato.

Info

Publication number: IT1228209B
Authority: IT; Italy
Prior art keywords: preparation; fluoxetine hydrochloride; compound; procedure; phenyl
Prior art date: 1989-01-10

Application number

IT8919049A

Other languages

English (en)

Other versions

IT8919049A0 (it

Inventor

Grato Magnone

Original Assignee

Grato Magnone

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-10

Filing date

1989-01-10

Publication date

1991-06-05

1989-01-10 Application filed by Grato Magnone filed Critical Grato Magnone

1989-01-10 Priority to IT8919049A priority Critical patent/IT1228209B/it

1989-01-10 Publication of IT8919049A0 publication Critical patent/IT8919049A0/it

1990-01-08 Priority to ES90100314T priority patent/ES2057187T3/es

1990-01-08 Priority to DE69010017T priority patent/DE69010017T2/de

1990-01-08 Priority to AT90100314T priority patent/ATE107623T1/de

1990-01-08 Priority to EP90100314A priority patent/EP0380924B1/en

1991-06-05 Application granted granted Critical

1991-06-05 Publication of IT1228209B publication Critical patent/IT1228209B/it

Links

GIYXAJPCNFJEHY-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine hydrochloride (1:1) Chemical compound Cl.C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 GIYXAJPCNFJEHY-UHFFFAOYSA-N 0.000 title abstract 3
229960000389 fluoxetine hydrochloride Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
BSTQFFNIYBSGEL-UHFFFAOYSA-N n-methylpropanamide Chemical compound C[CH]C(=O)NC BSTQFFNIYBSGEL-UHFFFAOYSA-N 0.000 abstract 3
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 abstract 1
LIUQUIPHRFFOIE-UHFFFAOYSA-N 3-hydroxy-n-methyl-3-phenylpropanamide Chemical compound CNC(=O)CC(O)C1=CC=CC=C1 LIUQUIPHRFFOIE-UHFFFAOYSA-N 0.000 abstract 1
BAYGVMXZJBFEMB-UHFFFAOYSA-N 4-(trifluoromethyl)phenol Chemical compound OC1=CC=C(C(F)(F)F)C=C1 BAYGVMXZJBFEMB-UHFFFAOYSA-N 0.000 abstract 1
GKKZMYDNDDMXSE-UHFFFAOYSA-N Ethyl 3-oxo-3-phenylpropanoate Chemical compound CCOC(=O)CC(=O)C1=CC=CC=C1 GKKZMYDNDDMXSE-UHFFFAOYSA-N 0.000 abstract 1
DVIBDQWVFHDBOP-UHFFFAOYSA-N ethyl 3-hydroxy-3-phenylpropanoate Chemical compound CCOC(=O)CC(O)C1=CC=CC=C1 DVIBDQWVFHDBOP-UHFFFAOYSA-N 0.000 abstract 1
229960002464 fluoxetine Drugs 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IT8919049A 1989-01-10 1989-01-10 Procedimento per la preparazione di fluoxetina cloridrato. IT1228209B (it)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
IT8919049A IT1228209B (it)	1989-01-10	1989-01-10	Procedimento per la preparazione di fluoxetina cloridrato.
ES90100314T ES2057187T3 (es)	1989-01-10	1990-01-08	Procedimiento para la preparacion de clorhidrato de fluoxetina.
DE69010017T DE69010017T2 (de)	1989-01-10	1990-01-08	Verfahren zur Herstellung von Fluoxetinhydrochlorid.
AT90100314T ATE107623T1 (de)	1989-01-10	1990-01-08	Verfahren zur herstellung von fluoxetinhydrochlorid.
EP90100314A EP0380924B1 (en)	1989-01-10	1990-01-08	Process for the preparation of fluoxetine hydrochloride

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8919049A IT1228209B (it)	1989-01-10	1989-01-10	Procedimento per la preparazione di fluoxetina cloridrato.

Publications (2)

Publication Number	Publication Date
IT8919049A0 IT8919049A0 (it)	1989-01-10
IT1228209B true IT1228209B (it)	1991-06-05

Family

ID=11154121

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8919049A IT1228209B (it)	1989-01-10	1989-01-10	Procedimento per la preparazione di fluoxetina cloridrato.

Country Status (5)

Country	Link
EP (1)	EP0380924B1 (it)
AT (1)	ATE107623T1 (it)
DE (1)	DE69010017T2 (it)
ES (1)	ES2057187T3 (it)
IT (1)	IT1228209B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99316A (en)	1991-08-27	1995-03-15	Teva Pharma	Production of fluoxetine and new intermediates
US5618968A (en) *	1993-02-05	1997-04-08	Pliva Farmaceutska Kemijska, Prehrambena I Kozmeticka Industrija, Dionicko Drustvo	N-substituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation
ES2101650B1 (es) *	1995-06-29	1998-01-16	Lilly Sa	Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfenoxi) propilamina.
ES2101654B1 (es) *	1995-07-24	1998-01-16	Lilly Sa	Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina.
ES2101655B1 (es) *	1995-07-28	1998-01-16	Lilly Sa	Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina.
ES2103680B1 (es) *	1995-08-03	1998-04-01	Lilly Sa	Procedimiento de preparacion de n-metil-3-fenil-3- (p-trifluorometilfenoxi)propilamina.
ES2103681B1 (es) *	1995-09-19	1998-04-01	Lilly Sa	Procedimiento de preparacion de n-metil-3-fenil - (p-trifluorometilfenoxi) propilamina.
US5936124A (en) *	1998-06-22	1999-08-10	Sepacor Inc.	Fluoxetine process from benzoylpropionic acid
US6025517A (en) *	1998-08-03	2000-02-15	Sepracor Inc.	Fluoxetine process from benzoylacetonitrile
US6846957B2 (en)	2002-11-22	2005-01-25	Board Of Regents, The University Of Texas System	Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4314081A (en) *	1974-01-10	1982-02-02	Eli Lilly And Company	Arloxyphenylpropylamines
GB2060618A (en) *	1979-09-14	1981-05-07	Wyeth John & Brother Ltd	3-Aryl-3-Aryloxypropylamines

1989
- 1989-01-10 IT IT8919049A patent/IT1228209B/it active
1990
- 1990-01-08 AT AT90100314T patent/ATE107623T1/de not_active IP Right Cessation
- 1990-01-08 DE DE69010017T patent/DE69010017T2/de not_active Expired - Fee Related
- 1990-01-08 EP EP90100314A patent/EP0380924B1/en not_active Expired - Lifetime
- 1990-01-08 ES ES90100314T patent/ES2057187T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69010017T2 (de)	1994-10-06
DE69010017D1 (de)	1994-07-28
EP0380924B1 (en)	1994-06-22
IT8919049A0 (it)	1989-01-10
ES2057187T3 (es)	1994-10-16
EP0380924A1 (en)	1990-08-08
ATE107623T1 (de)	1994-07-15

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Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19940203