IT1231425B - Procedimento per la sintesi di un derivato dell'acido benzo (ij) chinolizin-2-carbossilico - Google Patents

Procedimento per la sintesi di un derivato dell'acido benzo (ij) chinolizin-2-carbossilico

Info

Publication number: IT1231425B
Authority: IT; Italy
Prior art keywords: benzo; fluoro; methyl; alkyl; quinolizin
Prior art date: 1987-10-05

Application number

IT8722142A

Other languages

English (en)

Other versions

IT8722142A0 (it

Inventor

Tiberio Bruzzese

Massimo Signorini

Marco Rognoni

Original Assignee

Prodotti Antibiotici Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-05

Filing date

1987-10-05

Publication date

1991-12-04

1987-10-05 Application filed by Prodotti Antibiotici Spa filed Critical Prodotti Antibiotici Spa

1987-10-05 Priority to IT8722142A priority Critical patent/IT1231425B/it

1987-10-05 Publication of IT8722142A0 publication Critical patent/IT8722142A0/it

1988-09-19 Priority to EP88115302A priority patent/EP0310849B1/en

1988-09-19 Priority to DE8888115302T priority patent/DE3878814T2/de

1988-09-19 Priority to AT88115302T priority patent/ATE86254T1/de

1988-10-04 Priority to JP63249176A priority patent/JPH01128982A/ja

1991-12-04 Application granted granted Critical

1991-12-04 Publication of IT1231425B publication Critical patent/IT1231425B/it

Links

IAKNLKLKKBPMHN-UHFFFAOYSA-N 4h-quinolizine-2-carboxylic acid Chemical class C1=CC=CC2=CC(C(=O)O)=CCN21 IAKNLKLKKBPMHN-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
-1 2,2-disubstituted 1,3-dioxan-4,6-dione Chemical class 0.000 abstract 2
DPSPPJIUMHPXMA-UHFFFAOYSA-N 9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid Chemical compound C1CC(C)N2C=C(C(O)=O)C(=O)C3=C2C1=CC(F)=C3 DPSPPJIUMHPXMA-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
GOCWCDOCXBSXIT-UHFFFAOYSA-N 2-methylidene-1,3-dioxane-4,6-dione Chemical compound C=C1OC(=O)CC(=O)O1 GOCWCDOCXBSXIT-UHFFFAOYSA-N 0.000 abstract 1
BDCCXYVTXRUGAN-UHFFFAOYSA-N 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline Chemical compound FC1=CC=C2NC(C)CCC2=C1 BDCCXYVTXRUGAN-UHFFFAOYSA-N 0.000 abstract 1
229920000388 Polyphosphate Polymers 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000007796 conventional method Methods 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229960000702 flumequine Drugs 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000001205 polyphosphate Substances 0.000 abstract 1
235000011176 polyphosphates Nutrition 0.000 abstract 1
229920000137 polyphosphoric acid Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

IT8722142A 1987-10-05 1987-10-05 Procedimento per la sintesi di un derivato dell'acido benzo (ij) chinolizin-2-carbossilico IT1231425B (it)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
IT8722142A IT1231425B (it)	1987-10-05	1987-10-05	Procedimento per la sintesi di un derivato dell'acido benzo (ij) chinolizin-2-carbossilico
EP88115302A EP0310849B1 (en)	1987-10-05	1988-09-19	Process for the synthesis of a benzo [ij] quinolizine-2-carboxylic acid derivative
DE8888115302T DE3878814T2 (de)	1987-10-05	1988-09-19	Verfahren zur synthese eines benzo(ij)chinolizin-2-carbonsaeure-derivates.
AT88115302T ATE86254T1 (de)	1987-10-05	1988-09-19	Verfahren zur synthese eines benzo(ij>chinolizin- 2-carbonsaeure-derivates.
JP63249176A JPH01128982A (ja)	1987-10-05	1988-10-04	ベンゾ〔ｉｊ〕キノリジン−２−カルボン酸誘導体の合成方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8722142A IT1231425B (it)	1987-10-05	1987-10-05	Procedimento per la sintesi di un derivato dell'acido benzo (ij) chinolizin-2-carbossilico

Publications (2)

Publication Number	Publication Date
IT8722142A0 IT8722142A0 (it)	1987-10-05
IT1231425B true IT1231425B (it)	1991-12-04

Family

ID=11192115

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8722142A IT1231425B (it)	1987-10-05	1987-10-05	Procedimento per la sintesi di un derivato dell'acido benzo (ij) chinolizin-2-carbossilico

Country Status (5)

Country	Link
EP (1)	EP0310849B1 (it)
JP (1)	JPH01128982A (it)
AT (1)	ATE86254T1 (it)
DE (1)	DE3878814T2 (it)
IT (1)	IT1231425B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2655545B1 (fr) *	1989-12-11	1994-06-10	Rhone Poulenc Sante	Nouvelle application therapeutique des derives des fluoroquinolones.
US5532239A (en) *	1993-08-02	1996-07-02	Assistance Publique - Hopitaux De Paris	Therapeutic application of fluoroquinolone derivatives
US7973022B2 (en)	2006-02-17	2011-07-05	Idexx Laboratories, Inc.	Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en)	2006-02-17	2007-08-23	Murthy Yerramilli V S	Fluoroquinolone compositions
US8485403B2 (en)	2008-03-27	2013-07-16	GM Global Technology Operations LLC	Roof rack assembly with stowable cross members

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ196293A (en) *	1980-02-19	1983-09-02	Riker Laboratories Inc	Preparation of 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1h 5h-benzo(ij)quinolizine-2-carboxylic acid and intermediates therefor

1987
- 1987-10-05 IT IT8722142A patent/IT1231425B/it active
1988
- 1988-09-19 EP EP88115302A patent/EP0310849B1/en not_active Expired - Lifetime
- 1988-09-19 DE DE8888115302T patent/DE3878814T2/de not_active Expired - Fee Related
- 1988-09-19 AT AT88115302T patent/ATE86254T1/de not_active IP Right Cessation
- 1988-10-04 JP JP63249176A patent/JPH01128982A/ja active Pending

Also Published As

Publication number	Publication date
JPH01128982A (ja)	1989-05-22
DE3878814T2 (de)	1993-06-09
IT8722142A0 (it)	1987-10-05
ATE86254T1 (de)	1993-03-15
EP0310849A1 (en)	1989-04-12
DE3878814D1 (de)	1993-04-08
EP0310849B1 (en)	1993-03-03

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19931026

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ATE242241T1 (de)	2003-06-15	Imidazopyridinderivate und verfahren zu ihrer herstellung
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ATE75737T1 (de)	1992-05-15	Indenothiazolderivate und verfahren zu ihrer herstellung.
US4736029A (en)	1988-04-05	Process for preparing 2-amino-6-chloropurine
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KR860002450A (ko)	1986-04-26	아미노-알콜유도체의 제조방법
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GB2231570B (en)	1992-05-20	Naphthalenepropionic acid salts
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ES514256A0 (es)	1983-04-16	"procedimiento de preparar compuestos 6,7-dietoxi-1-(4-etoxi-3-hidroxibencil)-384-dihidroisoquinolinicos".
DE3884518D1 (de)	1993-11-04	Naphthothiazepin-derivate und verfahren zu ihrer herstellung.
EP0206765A3 (en)	1987-08-26	Process for preparation of rooperol, hypoxoside and derivatives thereof
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ES8706716A1 (es)	1987-07-01	Un procedimiento para la preparacion de derivados del acido griseolico.
JPS55139379A (en)	1980-10-31	Production of 1-(5'-hexynyl)-3,7-dimethylxanthine
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ES2076995T3 (es)	1995-11-16	Procedimiento para preparar derivados de carbamato de lankacidina.
JP4001388B1 (it)	2007-10-31