IT1252944B - Polilattide purificato e relativo metodo di produzione - Google Patents

Polilattide purificato e relativo metodo di produzione

Info

Publication number
IT1252944B
IT1252944B ITRM910553A ITRM910553A IT1252944B IT 1252944 B IT1252944 B IT 1252944B IT RM910553 A ITRM910553 A IT RM910553A IT RM910553 A ITRM910553 A IT RM910553A IT 1252944 B IT1252944 B IT 1252944B
Authority
IT
Italy
Prior art keywords
polylactide
production method
related production
purified
purified polylactide
Prior art date
Application number
ITRM910553A
Other languages
English (en)
Inventor
Walter Prikoszovich
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016840A external-priority patent/GB9016840D0/en
Priority claimed from GB909016882A external-priority patent/GB9016882D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of ITRM910553A0 publication Critical patent/ITRM910553A0/it
Publication of ITRM910553A1 publication Critical patent/ITRM910553A1/it
Application granted granted Critical
Publication of IT1252944B publication Critical patent/IT1252944B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un polilattide in stato purificato, che soddisfa i requisiti di - le intensità di colorazione delle soluzioni di riferimento B2-B9 della prova di colorazione marrone della European Pharmacopoeia, II edizione (1980) parte I, Sezione V, 6.2 e - contenere uno o più metalli in forma cationica, lo ione o gli ioni metallici avendo una concentrazione al massimo di 10 ppm.Il polilattide è particolarmente adatto per l'impiego come microparticelle o impianti, e contiene di preferenza un medicamento idrofilo come octreotide ovvero un medicamento lipofilo come bromocriptine.
ITRM910553A 1990-08-01 1991-07-23 Polilattide purificato e relativo metodo di produzione IT1252944B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016840A GB9016840D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB909016882A GB9016882D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds

Publications (3)

Publication Number Publication Date
ITRM910553A0 ITRM910553A0 (it) 1991-07-23
ITRM910553A1 ITRM910553A1 (it) 1993-01-23
IT1252944B true IT1252944B (it) 1995-07-05

Family

ID=26297417

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910553A IT1252944B (it) 1990-08-01 1991-07-23 Polilattide purificato e relativo metodo di produzione

Country Status (27)

Country Link
EP (2) EP0469520B1 (it)
JP (1) JP3137368B2 (it)
KR (1) KR100255904B1 (it)
AT (1) AT402503B (it)
AU (1) AU650277B2 (it)
CA (1) CA2048200C (it)
CH (1) CH683772A5 (it)
CY (1) CY1986A (it)
DE (1) DE4124468B4 (it)
DK (2) DK0816413T3 (it)
ES (2) ES2112259T3 (it)
FI (2) FI108040B (it)
FR (1) FR2665453B1 (it)
GB (1) GB2246573B (it)
GR (1) GR3026322T3 (it)
HK (1) HK11797A (it)
HU (1) HUT59837A (it)
IE (1) IE66185B1 (it)
IL (1) IL99007A (it)
IT (1) IT1252944B (it)
LU (1) LU87985A1 (it)
MY (1) MY108621A (it)
NO (1) NO912960D0 (it)
NZ (1) NZ239184A (it)
PH (1) PH31047A (it)
PT (1) PT98491B (it)
TW (2) TW282477B (it)

Families Citing this family (34)

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US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
JPH06116381A (ja) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc ポリヒドロキシカルボン酸の精製方法
DE4412317A1 (de) * 1993-04-21 1994-10-27 Basf Ag Polylactid mit verbreiterter Molmassenverteilung
US5359026A (en) * 1993-07-30 1994-10-25 Cargill, Incorporated Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) * 1993-09-20 1996-03-05 Mitsui Toatsu Chemicals, Inc. Purification process of aliphatic polyester
ATE288270T1 (de) * 1993-11-19 2005-02-15 Janssen Pharmaceutica Nv Mikroverkapselte 1,2-benzazole
MX9504664A (es) * 1994-03-07 1997-05-31 Dow Chemical Co Conjugados de dendrimeros bioactivos y/o dirigidos.
DE59903490D1 (de) 1998-09-11 2003-01-02 Schmidmaier Gerhard Biologisch aktive implantate
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
KR100880140B1 (ko) * 2001-07-10 2009-01-23 가부시끼가이샤 구레하 폴리히드록시카르복실산 및 이의 제조 방법
FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
ES2541908T3 (es) 2001-10-10 2015-07-28 Pierre Fabre Medicament Microesferas biodegradables de liberación prolongada y su procedimiento de preparación
GB0226993D0 (en) * 2002-11-19 2002-12-24 Novartis Ag Organic compounds
AU2013204972B2 (en) * 2002-11-19 2016-04-21 Novartis Ag Pharmaceutical composition comprising octreotide microparticles
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
SI1787658T1 (sl) 2005-11-10 2012-07-31 Chemi Spa Formulacije z trajnim sproščanjem somatostatin analognih inhibitorjev rastnega hormona
CN101193531B (zh) 2006-11-29 2010-12-01 富准精密工业(深圳)有限公司 散热装置
EP2229417B1 (en) * 2007-12-31 2014-07-30 Samyang Biopharmaceuticals Corporation Process for the preparation of highly pure amphiphilic copolymer comprising hydrophobic block from alpha-hydroxy acid
WO2010111238A2 (en) * 2009-03-23 2010-09-30 Micell Technologies, Inc. Improved biodegradable polymers
JP5594996B2 (ja) 2009-09-14 2014-09-24 三菱重工業株式会社 航空機の操縦システム
EP2583990B2 (en) 2010-06-21 2020-08-19 LG Chem, Ltd. Outstandingly heat resistant polylactide resin and a production method for the same
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
CN105820332B (zh) * 2015-01-09 2018-06-29 北京化工大学 一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法
EP3408305B1 (en) 2016-01-29 2024-03-06 Tolmar Inc. Purification and decolorization of polymers
KR102688314B1 (ko) * 2017-08-31 2024-07-26 에보닉 코포레이션 개선된 재흡수성 중합체 정제 방법
GR1009392B (el) * 2017-09-19 2018-10-25 Φαρματεν Αβεε Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467970A (en) * 1975-05-02 1977-03-23 Ici Ltd Purification of polyethers
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
DE3583988D1 (de) * 1984-11-13 1991-10-10 Asahi Chemical Ind Verfahren zur reinigung von polyalkylenaethern.
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
JPH0610252B2 (ja) * 1985-08-21 1994-02-09 和光純薬工業株式会社 重合体の製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
ATE168391T1 (de) * 1990-04-13 1998-08-15 Takeda Chemical Industries Ltd Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung

Also Published As

Publication number Publication date
HU912452D0 (en) 1991-12-30
PH31047A (en) 1998-02-03
IL99007A (en) 1994-12-29
EP0816413B1 (en) 2005-06-08
ITRM910553A0 (it) 1991-07-23
GB2246573B (en) 1994-05-11
EP0816413A3 (en) 1998-11-11
ES2243966T3 (es) 2005-12-01
DK0469520T3 (da) 1998-09-23
LU87985A1 (fr) 1993-02-15
HUT59837A (en) 1992-07-28
GB9116396D0 (en) 1991-09-11
FI20011189L (fi) 2001-06-05
TW218025B (it) 1993-12-21
CA2048200A1 (en) 1992-02-02
FI108040B (fi) 2001-11-15
FI111268B (fi) 2003-06-30
EP0469520A2 (en) 1992-02-05
AU8143091A (en) 1992-02-27
DE4124468B4 (de) 2010-10-28
GB2246573A (en) 1992-02-05
PT98491B (pt) 1997-12-31
FR2665453A1 (fr) 1992-02-07
FI913641L (fi) 1992-02-02
TW282477B (it) 1996-08-01
NZ239184A (en) 1994-09-27
IE912697A1 (en) 1992-02-12
FR2665453B1 (fr) 1995-01-27
AU650277B2 (en) 1994-06-16
DK0816413T3 (da) 2005-08-29
IE66185B1 (en) 1995-12-13
DE4124468A1 (de) 1992-02-06
KR100255904B1 (ko) 2000-05-01
KR920003990A (ko) 1992-03-27
JP3137368B2 (ja) 2001-02-19
CH683772A5 (de) 1994-05-13
MY108621A (en) 1996-10-31
ITRM910553A1 (it) 1993-01-23
GR3026322T3 (en) 1998-06-30
EP0816413A2 (en) 1998-01-07
HK11797A (en) 1997-02-14
AT402503B (de) 1997-06-25
ATA151591A (de) 1996-10-15
NO912960D0 (no) 1991-07-30
CA2048200C (en) 1999-06-29
ES2112259T3 (es) 1998-04-01
IL99007A0 (en) 1992-07-15
PT98491A (pt) 1992-06-30
CY1986A (en) 1997-09-05
EP0469520B1 (en) 1998-02-25
EP0469520A3 (en) 1992-10-07
JPH0641279A (ja) 1994-02-15
FI913641A0 (fi) 1991-07-30

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970623