ITTO910907A1 - Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. - Google Patents

Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.

Info

Publication number: ITTO910907A1
Authority: IT; Italy
Prior art keywords: pct; transdermal; acrylic; extradiol; release
Prior art date: 1991-11-25

Application number

IT000907A

Other languages

English (en)

Inventor

Francesco Makovec

Lucio Rovati

Luigi Rovati

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-25

Filing date

1991-11-25

Publication date

1993-05-25

1991-11-25 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

1991-11-25 Publication of ITTO910907A0 publication Critical patent/ITTO910907A0/it

1991-11-25 Priority to ITTO910907A priority Critical patent/IT1253265B/it

1992-11-24 Priority to EP92923782A priority patent/EP0614356B1/en

1992-11-24 Priority to AT92923782T priority patent/ATE128029T1/de

1992-11-24 Priority to JP5509788A priority patent/JPH07501335A/ja

1992-11-24 Priority to DK92923782.4T priority patent/DK0614356T3/da

1992-11-24 Priority to DE69205010T priority patent/DE69205010T2/de

1992-11-24 Priority to AU29451/92A priority patent/AU666151B2/en

1992-11-24 Priority to US08/244,132 priority patent/US6156335A/en

1992-11-24 Priority to ES92923782T priority patent/ES2078066T3/es

1992-11-24 Priority to CA002124209A priority patent/CA2124209A1/en

1992-11-24 Priority to PCT/EP1992/002704 priority patent/WO1993010772A1/en

1993-05-25 Publication of ITTO910907A1 publication Critical patent/ITTO910907A1/it

1995-07-14 Application granted granted Critical

1995-07-14 Publication of IT1253265B publication Critical patent/IT1253265B/it

1995-12-05 Priority to GR950403422T priority patent/GR3018303T3/el

Links

239000011159 matrix material Substances 0.000 title abstract 3
239000000853 adhesive Substances 0.000 title 1
230000001070 adhesive effect Effects 0.000 title 1
229920001577 copolymer Polymers 0.000 title 1
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 4
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 abstract 2
229920006243 acrylic copolymer Polymers 0.000 abstract 2
229960005309 estradiol Drugs 0.000 abstract 2
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 abstract 1
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 abstract 1
239000004820 Pressure-sensitive adhesive Substances 0.000 abstract 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
238000007334 copolymerization reaction Methods 0.000 abstract 1
238000013265 extended release Methods 0.000 abstract 1
229940066974 medicated patch Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000001681 protective effect Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

ITTO910907A 1991-11-25 1991-11-25 Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. IT1253265B (it)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
ITTO910907A IT1253265B (it)	1991-11-25	1991-11-25	Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.
AU29451/92A AU666151B2 (en)	1991-11-25	1992-11-24	Transdermal estradiol delivery system
ES92923782T ES2078066T3 (es)	1991-11-25	1992-11-24	Sistema de suministro transdermico de estradiol.
JP5509788A JPH07501335A (ja)	1991-11-25	1992-11-24	エストラジオール経皮投与用のアクリル系接着性共重合マトリックスを備えた新規な調合物
DK92923782.4T DK0614356T3 (da)	1991-11-25	1992-11-24	Transdermalt estradiolafgivelsessystem
DE69205010T DE69205010T2 (de)	1991-11-25	1992-11-24	Transdermales estradiol als therapeutisches system.
EP92923782A EP0614356B1 (en)	1991-11-25	1992-11-24	Transdermal estradiol delivery system
US08/244,132 US6156335A (en)	1991-11-25	1992-11-24	Preparation with an acrylic-based, adhesive copolymeric matrix for the transdermal delivery of estradiol
AT92923782T ATE128029T1 (de)	1991-11-25	1992-11-24	Transdermales estradiol als therapeutisches system.
CA002124209A CA2124209A1 (en)	1991-11-25	1992-11-24	A new preparation with an acrylic-based adhesive copolymeric matrix for the transdermal delivery of estradiol
PCT/EP1992/002704 WO1993010772A1 (en)	1991-11-25	1992-11-24	Transdermal estradiol delivery system
GR950403422T GR3018303T3 (en)	1991-11-25	1995-12-05	Transdermal estradiol delivery system.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITTO910907A IT1253265B (it)	1991-11-25	1991-11-25	Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.

Publications (3)

Publication Number	Publication Date
ITTO910907A0 ITTO910907A0 (it)	1991-11-25
ITTO910907A1 true ITTO910907A1 (it)	1993-05-25
IT1253265B IT1253265B (it)	1995-07-14

Family

ID=11409742

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITTO910907A IT1253265B (it)	1991-11-25	1991-11-25	Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.

Country Status (12)

Country	Link
US (1)	US6156335A (it)
EP (1)	EP0614356B1 (it)
JP (1)	JPH07501335A (it)
AT (1)	ATE128029T1 (it)
AU (1)	AU666151B2 (it)
CA (1)	CA2124209A1 (it)
DE (1)	DE69205010T2 (it)
DK (1)	DK0614356T3 (it)
ES (1)	ES2078066T3 (it)
GR (1)	GR3018303T3 (it)
IT (1)	IT1253265B (it)
WO (1)	WO1993010772A1 (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5554381A (en) *	1993-08-09	1996-09-10	Cygnus, Inc.	Low flux matrix system for delivering potent drugs transdermally
DE4333595A1 (de) *	1993-10-01	1995-04-06	Labtec Gmbh	Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut
GR1002079B (en) *	1994-07-26	1995-12-05	Lavipharm A E	System of a special structure and composition for the rapid transdermal administration of oestrogens.
DE19526864A1 (de) *	1995-07-22	1997-01-23	Labtec Gmbh	Hormonpflaster
US6623763B2 (en)	1996-01-08	2003-09-23	Lts Lohmann Therape-System Ag	Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism
DE19600347A1 (de) *	1996-01-08	1997-07-10	Lohmann Therapie Syst Lts	Hauthaftende pharmazeutische Zubereitung, insbesondere TTS zur Abgabe von 17-beta-Estradiol an den menschlichen Organismus
DE19830649C2 (de) *	1998-07-09	2003-04-10	Lohmann Therapie Syst Lts	Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe
GB0019745D0 (en) *	2000-08-10	2000-09-27	Univ Surrey	Gene expression element
WO2002045701A2 (en) *	2000-12-05	2002-06-13	Noven Pharmaceuticals, Inc.	Crystallization inhibition of drugs in transdermal drug delivery systems
DE10141652B4 (de)	2001-08-24	2011-04-07	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung
US6927267B1 (en)	2002-03-07	2005-08-09	Basf Ag	High solids dispersion for wide temperature, pressure sensitive adhesive applications
DE10229733A1 (de) *	2002-07-02	2004-01-22	Basf Ag	Haftklebstoffe für Träger aus Weich-PVC
CA2494915C (en)	2002-08-09	2012-07-10	Teikoku Seiyaku Co., Ltd.	Female hormone-containing patch
MX2007004135A (es) *	2004-10-04	2007-06-15	Oreal	Composicion cosmetica y/o dermatologica para pieles sensibles.
FR2889057B1 (fr) *	2005-08-01	2008-07-18	Oreal	Composition cosmetique et/ou dermatologique pour la prevention et/ou le traitement des peaux sensibles ou seches
US7754256B2 (en) *	2007-03-07	2010-07-13	Stan Dennison	Nutritional composition
US20080226698A1 (en)	2007-03-16	2008-09-18	Mylan Technologies, Inc.	Amorphous drug transdermal systems, manufacturing methods, and stabilization
FR2919501B1 (fr) *	2007-08-02	2010-12-31	Oreal	Utilisation d'hesperidine ou de l'un de ses derives pour la prevention et/ou le traitement des peaux relachees
FR2920304B1 (fr)	2007-09-04	2010-06-25	Oreal	Utilisation cosmetique de lysat bifidobacterium species pour le traitement de la secheresse.
CA2697735C (en) *	2007-09-04	2014-02-18	L'oreal	Use of a combination of hesperidin and of a microorganism for influencing the barrier function of the skin
DE102008013701A1 (de)	2008-03-11	2009-09-17	Lts Lohmann Therapie-Systeme Ag	Transdermales Therapeutisches System mit stabilisierter Membran
BRPI0913214B1 (pt) *	2008-05-30	2022-05-17	Mylan Laboratories Inc	Dispositivo de fornecimento de drogas transdérmico e método de fabricação do mesmo
US8231906B2 (en) *	2008-07-10	2012-07-31	Noven Pharmaceuticals, Inc.	Transdermal estrogen device and delivery
CA2739380C (en) *	2008-10-06	2014-12-09	Mylan Technologies, Inc.	Amorphous rotigotine transdermal system
DE102008059054A1 (de)	2008-11-26	2010-05-27	Otto Bock Pur Life Science Gmbh	Polyurethanpflaster für die transdermale Applikation von Wirkstoffen und Verfahren zu dessen Herstellung
WO2011009800A1 (en) *	2009-07-21	2011-01-27	Basf Se	Film-to-film laminate, made by using an aqueous polymer dispersion as adhesive agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4906475A (en) *	1988-02-16	1990-03-06	Paco Pharmaceutical Services	Estradiol transdermal delivery system
DE68917292T2 (de) *	1988-02-26	1995-02-02	Riker Laboratories Inc	Transdermales estradiol als therapeutisches sytem.
US4994267A (en) *	1988-03-04	1991-02-19	Noven Pharmaceuticals, Inc.	Transdermal acrylic multipolymer drug delivery system
AU637496B2 (en) *	1990-04-24	1993-05-27	Teijin Limited	Plaster

1991
- 1991-11-25 IT ITTO910907A patent/IT1253265B/it active IP Right Grant
1992
- 1992-11-24 WO PCT/EP1992/002704 patent/WO1993010772A1/en not_active Ceased
- 1992-11-24 CA CA002124209A patent/CA2124209A1/en not_active Abandoned
- 1992-11-24 US US08/244,132 patent/US6156335A/en not_active Expired - Fee Related
- 1992-11-24 AU AU29451/92A patent/AU666151B2/en not_active Ceased
- 1992-11-24 AT AT92923782T patent/ATE128029T1/de not_active IP Right Cessation
- 1992-11-24 JP JP5509788A patent/JPH07501335A/ja active Pending
- 1992-11-24 DK DK92923782.4T patent/DK0614356T3/da active
- 1992-11-24 ES ES92923782T patent/ES2078066T3/es not_active Expired - Lifetime
- 1992-11-24 EP EP92923782A patent/EP0614356B1/en not_active Expired - Lifetime
- 1992-11-24 DE DE69205010T patent/DE69205010T2/de not_active Expired - Lifetime
1995
- 1995-12-05 GR GR950403422T patent/GR3018303T3/el unknown

Also Published As

Publication number	Publication date
ITTO910907A0 (it)	1991-11-25
AU2945192A (en)	1993-06-28
JPH07501335A (ja)	1995-02-09
ES2078066T3 (es)	1995-12-01
EP0614356B1 (en)	1995-09-20
AU666151B2 (en)	1996-02-01
DE69205010T2 (de)	1996-02-22
WO1993010772A1 (en)	1993-06-10
DK0614356T3 (da)	1995-11-13
US6156335A (en)	2000-12-05
GR3018303T3 (en)	1996-03-31
CA2124209A1 (en)	1993-06-10
EP0614356A1 (en)	1994-09-14
ATE128029T1 (de)	1995-10-15
DE69205010D1 (en)	1995-10-26
IT1253265B (it)	1995-07-14

Legal Events

Date	Code	Title	Description
1995-07-14	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971129

Publication	Publication Date	Title
DK0614356T3 (da)	1995-11-13	Transdermalt estradiolafgivelsessystem
RU2176499C2 (ru)	2001-12-10	Композиция для чрескожного введения стероидных лекарственных средств и содержащий ее препарат
TW464511B (en)	2001-11-21	Pressure-sensitive adhesive composition suitable for use in a transdermal drug delivery system and preparation method therefor
MY106628A (en)	1995-06-30	Estrogen-containing active substance plaster
US5725876A (en)	1998-03-10	Compositions and methods for using low-swell clays in nicotine containing dermal compositions
AU651234B2 (en)	1994-07-14	Transdermal estradiol delivery system
JPH09504537A (ja)	1997-05-06	爪真菌症の処置用硬膏剤
US20040247656A1 (en)	2004-12-09	Matrix controlled transdermal therapeutic system for the use of pramipexole and ropinirole
WO1997044018A9 (en)	1998-04-16	Dermal compositions comprising acrylate polymers, nicotine and low-swell clay
DK0588839T3 (da)	1995-12-27	Nitroglycerol-plaster og fremgangsmåde til dets fremstilling
FI960556A0 (fi)	1996-02-07	Transdermaalinen aktiivisten lääkeaineiden hitaan virtauksen antojärjestelmä
JP3361674B2 (ja)	2003-01-07	医療用粘着剤組成物
KR900009084A (ko)	1990-07-02	1-이소부틸-1H-이미다조[4,5-c] 퀴놀린-4-아민을 함유하는 국소제제 및 경피 투여시스템
JPH02255611A (ja)	1990-10-16	疾患治療用テープ製剤
JPH04150865A (ja)	1992-05-25	医療用粘着テープおよび疾患治療用テープ製剤
ATE149829T1 (de)	1997-03-15	Nitroglycerinhaltiges pflaster, verfahren zu seiner herstellung und verwendung
JPH0339488B2 (it)	1991-06-14
JP3130350B2 (ja)	2001-01-31	経皮吸収製剤
JPH08104627A (ja)	1996-04-23	眠気よけ貼付剤
JPH0137375B2 (it)	1989-08-07
JPH05229962A (ja)	1993-09-07	経皮吸収製剤
JPH08291068A (ja)	1996-11-05	エペリゾン外用貼付剤
JPH08291069A (ja)	1996-11-05	エペリゾン外用貼付剤
JPH08291067A (ja)	1996-11-05	エペリゾン外用貼付剤
JPH037217A (ja)	1991-01-14	メトプロロール含有テープ製剤