ATE128029T1 - Transdermales estradiol als therapeutisches system. - Google Patents

Transdermales estradiol als therapeutisches system.

Info

Publication number: ATE128029T1
Authority: AT; Austria
Prior art keywords: pct; estradiol; beta; sec; transdermal
Prior art date: 1991-11-25

Application number

AT92923782T

Other languages

English (en)

Inventor

Luigi Rovati

Lucio Rovati

Francesco Makovec

Guenter Cordes

Wilfried Fischer

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-25

Filing date

1992-11-24

Publication date

1995-10-15

1992-11-24 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

1995-10-15 Application granted granted Critical

1995-10-15 Publication of ATE128029T1 publication Critical patent/ATE128029T1/de

Links

VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title abstract 5
229960005309 estradiol Drugs 0.000 title abstract 3
229930182833 estradiol Natural products 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 abstract 2
229920006243 acrylic copolymer Polymers 0.000 abstract 2
239000011159 matrix material Substances 0.000 abstract 2
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 abstract 1
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 abstract 1
239000004820 Pressure-sensitive adhesive Substances 0.000 abstract 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
238000007334 copolymerization reaction Methods 0.000 abstract 1
238000013265 extended release Methods 0.000 abstract 1
229940066974 medicated patch Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000001681 protective effect Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

AT92923782T 1991-11-25 1992-11-24 Transdermales estradiol als therapeutisches system. ATE128029T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITTO910907A IT1253265B (it)	1991-11-25	1991-11-25	Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.

Publications (1)

Publication Number	Publication Date
ATE128029T1 true ATE128029T1 (de)	1995-10-15

Family

ID=11409742

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92923782T ATE128029T1 (de)	1991-11-25	1992-11-24	Transdermales estradiol als therapeutisches system.

Country Status (12)

Country	Link
US (1)	US6156335A (de)
EP (1)	EP0614356B1 (de)
JP (1)	JPH07501335A (de)
AT (1)	ATE128029T1 (de)
AU (1)	AU666151B2 (de)
CA (1)	CA2124209A1 (de)
DE (1)	DE69205010T2 (de)
DK (1)	DK0614356T3 (de)
ES (1)	ES2078066T3 (de)
GR (1)	GR3018303T3 (de)
IT (1)	IT1253265B (de)
WO (1)	WO1993010772A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5554381A (en) *	1993-08-09	1996-09-10	Cygnus, Inc.	Low flux matrix system for delivering potent drugs transdermally
DE4333595A1 (de) *	1993-10-01	1995-04-06	Labtec Gmbh	Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut
GR1002079B (en) *	1994-07-26	1995-12-05	Lavipharm A E	System of a special structure and composition for the rapid transdermal administration of oestrogens.
DE19526864A1 (de) *	1995-07-22	1997-01-23	Labtec Gmbh	Hormonpflaster
US6623763B2 (en)	1996-01-08	2003-09-23	Lts Lohmann Therape-System Ag	Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism
DE19600347A1 (de) *	1996-01-08	1997-07-10	Lohmann Therapie Syst Lts	Hauthaftende pharmazeutische Zubereitung, insbesondere TTS zur Abgabe von 17-beta-Estradiol an den menschlichen Organismus
DE19830649C2 (de) *	1998-07-09	2003-04-10	Lohmann Therapie Syst Lts	Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe
GB0019745D0 (en) *	2000-08-10	2000-09-27	Univ Surrey	Gene expression element
TWI287455B (en) *	2000-12-05	2007-10-01	Noven Pharma	Crystallization inhibition of drugs in transdermal drug delivery systems and methods of use
DE10141652B4 (de) *	2001-08-24	2011-04-07	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung
US6927267B1 (en)	2002-03-07	2005-08-09	Basf Ag	High solids dispersion for wide temperature, pressure sensitive adhesive applications
DE10229733A1 (de) *	2002-07-02	2004-01-22	Basf Ag	Haftklebstoffe für Träger aus Weich-PVC
US8124122B2 (en)	2002-08-09	2012-02-28	Teikoku Seiyaku Co., Ltd.	Female hormone-containing patch
AU2005291098B2 (en) *	2004-10-04	2011-11-24	L'oreal	Cosmetic and/or dermatological composition for sensitive skins
FR2889057B1 (fr) *	2005-08-01	2008-07-18	Oreal	Composition cosmetique et/ou dermatologique pour la prevention et/ou le traitement des peaux sensibles ou seches
US7754256B2 (en) *	2007-03-07	2010-07-13	Stan Dennison	Nutritional composition
US20080226698A1 (en) *	2007-03-16	2008-09-18	Mylan Technologies, Inc.	Amorphous drug transdermal systems, manufacturing methods, and stabilization
FR2919501B1 (fr) *	2007-08-02	2010-12-31	Oreal	Utilisation d'hesperidine ou de l'un de ses derives pour la prevention et/ou le traitement des peaux relachees
FR2920304B1 (fr) *	2007-09-04	2010-06-25	Oreal	Utilisation cosmetique de lysat bifidobacterium species pour le traitement de la secheresse.
ES2461791T3 (es) *	2007-09-04	2014-05-21	L'oréal	Utilización de una combinación de hesperidina y de un microorganismo para actuar sobre la función de barrera de la piel
DE102008013701A1 (de)	2008-03-11	2009-09-17	Lts Lohmann Therapie-Systeme Ag	Transdermales Therapeutisches System mit stabilisierter Membran
KR101590209B1 (ko) *	2008-05-30	2016-02-01	밀란 인크.	안정화 경피 약물 전달 시스템
US8231906B2 (en)	2008-07-10	2012-07-31	Noven Pharmaceuticals, Inc.	Transdermal estrogen device and delivery
KR20110082142A (ko) *	2008-10-06	2011-07-18	밀란 테크놀로지즈 인코포레이티드	비정질 로티고틴 경피 시스템
DE102008059054A1 (de)	2008-11-26	2010-05-27	Otto Bock Pur Life Science Gmbh	Polyurethanpflaster für die transdermale Applikation von Wirkstoffen und Verfahren zu dessen Herstellung
WO2011009800A1 (en) *	2009-07-21	2011-01-27	Basf Se	Film-to-film laminate, made by using an aqueous polymer dispersion as adhesive agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4906475A (en) *	1988-02-16	1990-03-06	Paco Pharmaceutical Services	Estradiol transdermal delivery system
JP2931002B2 (ja) *	1988-02-26	1999-08-09	ライカーラボラトリースインコーポレーテッド	皮膚透過エストラジオールデリバリーシステム
US4994267A (en) *	1988-03-04	1991-02-19	Noven Pharmaceuticals, Inc.	Transdermal acrylic multipolymer drug delivery system
EP0484543B1 (de) *	1990-04-24	1995-12-13	Teijin Limited	Pflaster

1991
- 1991-11-25 IT ITTO910907A patent/IT1253265B/it active IP Right Grant
1992
- 1992-11-24 DE DE69205010T patent/DE69205010T2/de not_active Expired - Lifetime
- 1992-11-24 JP JP5509788A patent/JPH07501335A/ja active Pending
- 1992-11-24 US US08/244,132 patent/US6156335A/en not_active Expired - Fee Related
- 1992-11-24 AT AT92923782T patent/ATE128029T1/de not_active IP Right Cessation
- 1992-11-24 ES ES92923782T patent/ES2078066T3/es not_active Expired - Lifetime
- 1992-11-24 CA CA002124209A patent/CA2124209A1/en not_active Abandoned
- 1992-11-24 DK DK92923782.4T patent/DK0614356T3/da active
- 1992-11-24 AU AU29451/92A patent/AU666151B2/en not_active Ceased
- 1992-11-24 WO PCT/EP1992/002704 patent/WO1993010772A1/en not_active Ceased
- 1992-11-24 EP EP92923782A patent/EP0614356B1/de not_active Expired - Lifetime
1995
- 1995-12-05 GR GR950403422T patent/GR3018303T3/el unknown

Also Published As

Publication number	Publication date
DK0614356T3 (da)	1995-11-13
EP0614356B1 (de)	1995-09-20
EP0614356A1 (de)	1994-09-14
GR3018303T3 (en)	1996-03-31
CA2124209A1 (en)	1993-06-10
ITTO910907A0 (it)	1991-11-25
JPH07501335A (ja)	1995-02-09
ES2078066T3 (es)	1995-12-01
AU2945192A (en)	1993-06-28
DE69205010T2 (de)	1996-02-22
IT1253265B (it)	1995-07-14
ITTO910907A1 (it)	1993-05-25
DE69205010D1 (en)	1995-10-26
WO1993010772A1 (en)	1993-06-10
US6156335A (en)	2000-12-05
AU666151B2 (en)	1996-02-01

Legal Events

Date	Code	Title	Description
1996-03-15	UEP	Publication of translation of european patent specification
2005-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE128029T1 (de)	1995-10-15	Transdermales estradiol als therapeutisches system.
RU2176499C2 (ru)	2001-12-10	Композиция для чрескожного введения стероидных лекарственных средств и содержащий ее препарат
MY106628A (en)	1995-06-30	Estrogen-containing active substance plaster
JP2655983B2 (ja)	1997-09-24	チロシナーゼ抑制活性を有する薬物の安定性を改善する方法、及び、皮膚美白用貼付剤
TW464511B (en)	2001-11-21	Pressure-sensitive adhesive composition suitable for use in a transdermal drug delivery system and preparation method therefor
CA2227538A1 (en)	1997-02-06	Hormone patch
EP1423102A1 (de)	2004-06-02	Pflaster zur behandlung von funktionsstörungen und störungen des nagelwachstums
AU2002361825A1 (en)	2003-06-05	Plaster for the treatment of dysfunctions and disorders of nail growth
US20040247656A1 (en)	2004-12-09	Matrix controlled transdermal therapeutic system for the use of pramipexole and ropinirole
WO1997044018A9 (en)	1998-04-16	Dermal compositions comprising acrylate polymers, nicotine and low-swell clay
Czech et al.	2007	Acrylic pressure‐sensitive adhesive for transdermal drug delivery systems
DK0588839T3 (da)	1995-12-27	Nitroglycerol-plaster og fremgangsmåde til dets fremstilling
KR900009084A (ko)	1990-07-02	1-이소부틸-1H-이미다조[4,5-c] 퀴놀린-4-아민을 함유하는 국소제제 및 경피 투여시스템
DK0689458T3 (da)	1999-08-09	Plaster med aktiv bestanddel til afgivelse af estradiol på huden
JP3361674B2 (ja)	2003-01-07	医療用粘着剤組成物
ATE149829T1 (de)	1997-03-15	Nitroglycerinhaltiges pflaster, verfahren zu seiner herstellung und verwendung
JPH11199521A (ja)	1999-07-27	皮膚外用剤
JPH0339488B2 (de)	1991-06-14
KR950703948A (ko)	1995-11-17	피부를 통해 피소스티그민을 투여하기 위한 경피치료계, 및 이러한 계의 제조방법(transdermal therapeutic system for administering physostigmin through the skin〈 and a method of producing the system)
WO2021007584A1 (en)	2021-01-14	Acrylic polymer and adhesive compositions
JPH08104627A (ja)	1996-04-23	眠気よけ貼付剤
JPS59184122A (ja)	1984-10-19	アクリル系膏体
JPH0137375B2 (de)	1989-08-07
JPH05229962A (ja)	1993-09-07	経皮吸収製剤
JPH08291068A (ja)	1996-11-05	エペリゾン外用貼付剤