IT1270021B - "composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare" - Google Patents

"composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"

Info

Publication number
IT1270021B
IT1270021B ITMI941954A ITMI941954A IT1270021B IT 1270021 B IT1270021 B IT 1270021B IT MI941954 A ITMI941954 A IT MI941954A IT MI941954 A ITMI941954 A IT MI941954A IT 1270021 B IT1270021 B IT 1270021B
Authority
IT
Italy
Prior art keywords
phe
tyr
ala
methyltryptophan
trp
Prior art date
Application number
ITMI941954A
Other languages
English (en)
Inventor
Romano Deghenghi
Original Assignee
Europ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europ filed Critical Europ
Publication of ITMI941954A0 publication Critical patent/ITMI941954A0/it
Priority to ITMI941954A priority Critical patent/IT1270021B/it
Priority to KR1019970701987A priority patent/KR100369105B1/ko
Priority to AT95932735T priority patent/ATE225806T1/de
Priority to CN95195323A priority patent/CN1121413C/zh
Priority to JP51131596A priority patent/JP3810083B2/ja
Priority to AU35668/95A priority patent/AU700066B2/en
Priority to DK95932735T priority patent/DK0783521T3/da
Priority to RU97107089/04A priority patent/RU2157378C2/ru
Priority to HU9800136A priority patent/HU221481B/hu
Priority to HK98100002.9A priority patent/HK1001207B/en
Priority to CZ1997914A priority patent/CZ291798B6/cs
Priority to PCT/EP1995/003601 priority patent/WO1996010040A1/en
Priority to DE69528531T priority patent/DE69528531T2/de
Priority to ES95932735T priority patent/ES2186730T3/es
Priority to SK399-97A priority patent/SK284550B6/sk
Priority to PL95319382A priority patent/PL181588B1/pl
Priority to EP95932735A priority patent/EP0783521B8/en
Priority to CA002201122A priority patent/CA2201122A1/en
Priority to PT95932735T priority patent/PT783521E/pt
Priority to MX9702275A priority patent/MX9702275A/es
Priority to US08/530,853 priority patent/US5795957A/en
Priority to ZA957977A priority patent/ZA957977B/xx
Priority to IL11538195A priority patent/IL115381A/xx
Publication of ITMI941954A1 publication Critical patent/ITMI941954A1/it
Application granted granted Critical
Publication of IT1270021B publication Critical patent/IT1270021B/it
Priority to US08/871,418 priority patent/US5872100A/en
Priority to US08/971,032 priority patent/US5955421A/en

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un peptide di formula: A-D-Mrp-Ala-B-C dove A è un qualsiasi L-amminoacido presente in natura o il suo isomero D con l'eccezione che non è His se B è Trp e C è D-Phe-Lys-NH2, imidazolacetile, Glu-Tyr-Ala-His, Tyr-Ala-His, Tyr-His, D-Thr-His e più preferibilmente A è D-Ala, D-Thr, Tyr; D si riferisce all'isomero destrogiro, Mrp è 2-alchiltriptofano; B è Trp o Phe, C è NH2, D-Phe-LysNH2, D-Trp-Lys-NH2, D-Phe-Lys-ThrNH2, D-Phe-Lys-D-ThrNH2, e i sali di addizione con acidi organici o inorganici farmaceuticamente accettabili di uno qualsiasi di detti polipeptidi, questi composti sono in grado di promuovere la liberazione dell'ormone della crescita, e sono attivi per via orale.
ITMI941954A 1990-05-11 1994-09-27 "composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare" IT1270021B (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ITMI941954A IT1270021B (it) 1994-09-27 1994-09-27 "composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"
DE69528531T DE69528531T2 (de) 1994-09-27 1995-09-13 D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
SK399-97A SK284550B6 (sk) 1994-09-27 1995-09-13 Peptidy, farmaceutický prostriedok s ich obsahom a ich použitie
CN95195323A CN1121413C (zh) 1994-09-27 1995-09-13 含d－2－烷基色氨酸的能促进生长激素释放的多肽化合物
JP51131596A JP3810083B2 (ja) 1994-09-27 1995-09-13 成長因子の放出を促進し得る２−アルキルトリプトファン含有ペプチド化合物
AU35668/95A AU700066B2 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
DK95932735T DK0783521T3 (da) 1994-09-27 1995-09-13 Polypeptidforbindelser indeholdende D-2-alkyltryptophan, hvilke er i stand til at fremme frigivelsen af væksthormon
RU97107089/04A RU2157378C2 (ru) 1994-09-27 1995-09-13 Полипептидные соединения, содержащие d-2-алкилтриптофан, стимулирующий высвобождение гормона роста
HU9800136A HU221481B (en) 1994-09-27 1995-09-13 Oligopeptides containing d-2-alkyltryptophan capable of promoting the release of growth hormone, their use and pharmaceutical compositions comprising thereof
HK98100002.9A HK1001207B (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
CZ1997914A CZ291798B6 (cs) 1994-09-27 1995-09-13 Peptidy, jejich použití a farmaceutický prostředek s jejich obsahem
PCT/EP1995/003601 WO1996010040A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
KR1019970701987A KR100369105B1 (ko) 1994-09-27 1995-09-13 성장호르몬의분비를촉진할수있는d-2-알킬트립토판을함유하는폴리펩티드화합물
ES95932735T ES2186730T3 (es) 1994-09-27 1995-09-13 Compuestos oligoppeptidicos que contienen un aminoacido d-2-alquiltriptofano y que son capaces de liberar hormona de crecimiento.
AT95932735T ATE225806T1 (de) 1994-09-27 1995-09-13 D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
PL95319382A PL181588B1 (pl) 1994-09-27 1995-09-13 Zwiazki polipeptydowe zawierajace D-2-alkilotryptofan wspomagajace uwalnianie hormonu wzrostu oraz kompozycje farmaceutyczne je zawierajace PL PL PL
EP95932735A EP0783521B8 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
CA002201122A CA2201122A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
PT95932735T PT783521E (pt) 1994-09-27 1995-09-13 Compostos polipeptidos que contem d-2-alquiltriptofano capazes de promover a libertacao da hormona do crescimento
MX9702275A MX9702275A (es) 1994-09-27 1995-09-13 Compuestos polipectidicos que contienen d-2 alquiltriptofano capaces de promover la liberacion de hormona del crecimiento.
US08/530,853 US5795957A (en) 1994-09-27 1995-09-20 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
ZA957977A ZA957977B (en) 1994-09-27 1995-09-21 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
IL11538195A IL115381A (en) 1994-09-27 1995-09-21 Polypeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
US08/871,418 US5872100A (en) 1990-05-11 1997-06-09 Peptides containing D-2-Alkyl-Tryptophan
US08/971,032 US5955421A (en) 1990-05-11 1997-11-14 Peptides containing D-2-alkyl-Tryptophan

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941954A IT1270021B (it) 1994-09-27 1994-09-27 "composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"

Publications (3)

Publication Number Publication Date
ITMI941954A0 ITMI941954A0 (it) 1994-09-27
ITMI941954A1 ITMI941954A1 (it) 1996-03-27
IT1270021B true IT1270021B (it) 1997-04-16

Family

ID=11369598

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941954A IT1270021B (it) 1990-05-11 1994-09-27 "composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"

Country Status (2)

Country Link
IT (1) IT1270021B (it)
ZA (1) ZA957977B (it)

Also Published As

Publication number Publication date
ITMI941954A1 (it) 1996-03-27
ZA957977B (en) 1996-03-15
ITMI941954A0 (it) 1994-09-27

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970926