IT1277113B1 - Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita - Google Patents

Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita

Info

Publication number: IT1277113B1
Authority: IT; Italy
Prior art keywords: mrp; release; growth hormone; hydrogen; alkyltryptophane
Prior art date: 1995-12-20

Application number

IT95MI002681A

Other languages

English (en)

Inventor

Romano Deghenghi

Original Assignee

Romano Deghenghi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-20

Filing date

1995-12-20

Publication date

1997-11-04

1995-12-20 Application filed by Romano Deghenghi filed Critical Romano Deghenghi

1995-12-20 Publication of ITMI952681A0 publication Critical patent/ITMI952681A0/it

1995-12-20 Priority to IT95MI002681A priority Critical patent/IT1277113B1/it

1996-12-04 Priority to ES96942326T priority patent/ES2186810T3/es

1996-12-04 Priority to JP9522460A priority patent/JP2000502089A/ja

1996-12-04 Priority to BR9612146A priority patent/BR9612146A/pt

1996-12-04 Priority to AT96942326T priority patent/ATE226214T1/de

1996-12-04 Priority to CN96199086A priority patent/CN1126759C/zh

1996-12-04 Priority to HK99101182.8A priority patent/HK1016193B/en

1996-12-04 Priority to RU98113920/04A priority patent/RU2182156C2/ru

1996-12-04 Priority to DK96942326T priority patent/DK0868429T3/da

1996-12-04 Priority to PT96942326T priority patent/PT868429E/pt

1996-12-04 Priority to KR10-1998-0704587A priority patent/KR100369104B1/ko

1996-12-04 Priority to PCT/EP1996/005393 priority patent/WO1997022620A1/en

1996-12-04 Priority to IL12450796A priority patent/IL124507A/xx

1996-12-04 Priority to DE69624371T priority patent/DE69624371T2/de

1996-12-04 Priority to AU11759/97A priority patent/AU1175997A/en

1996-12-04 Priority to EP96942326A priority patent/EP0868429B1/en

1996-12-04 Priority to CA002239702A priority patent/CA2239702C/en

1996-12-17 Priority to ZA9610591A priority patent/ZA9610591B/xx

1997-06-20 Publication of ITMI952681A1 publication Critical patent/ITMI952681A1/it

1997-11-04 Application granted granted Critical

1997-11-04 Publication of IT1277113B1 publication Critical patent/IT1277113B1/it

1998-06-17 Priority to MX9804868A priority patent/MX9804868A/es

Links

102000018997 Growth Hormone Human genes 0.000 title abstract 2
108010051696 Growth Hormone Proteins 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
239000000122 growth hormone Substances 0.000 title abstract 2
102000015636 Oligopeptides Human genes 0.000 title 1
108010038807 Oligopeptides Proteins 0.000 title 1
-1 2-aminoisobutyryl Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 abstract 1
125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

IT95MI002681A 1995-12-20 1995-12-20 Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita IT1277113B1 (it)

Priority Applications (19)

Application Number	Priority Date	Filing Date	Title
IT95MI002681A IT1277113B1 (it)	1995-12-20	1995-12-20	Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
KR10-1998-0704587A KR100369104B1 (ko)	1995-12-20	1996-12-04	성장호르몬의유리를촉진하는2-알킬트립토판함유-올리고펩티드화합물
IL12450796A IL124507A (en)	1995-12-20	1996-12-04	Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
BR9612146A BR9612146A (pt)	1995-12-20	1996-12-04	Compsostos de oligopeptídeo contendo d-2alquiltriptofano capazes de promover a liberação de hormônio de crescimento
AT96942326T ATE226214T1 (de)	1995-12-20	1996-12-04	D-2-alkyltryptophan-enthaltende oligopeptidverbindungen, die die freisetzung von wachstumshormon fördern
CN96199086A CN1126759C (zh)	1995-12-20	1996-12-04	含d－2－烷基色氨酸、能促进生长激素释放的寡肽化合物
HK99101182.8A HK1016193B (en)	1995-12-20	1996-12-04	Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
RU98113920/04A RU2182156C2 (ru)	1995-12-20	1996-12-04	Производные олигопептидов, содержащие d-алкилтриптофан и способные активировать высвобождение гормона роста
DK96942326T DK0868429T3 (da)	1995-12-20	1996-12-04	Oligopeptidforbindelser indeholdende D-2-alkyltryptophan hvilke er i stand til at fremme frigivelsen af væksthormon
PT96942326T PT868429E (pt)	1995-12-20	1996-12-04	Compostos oligopeptidicos que contem d-2-alquiltriptofano susceptiveis de promover a libertacao da hormona do crescimento
ES96942326T ES2186810T3 (es)	1995-12-20	1996-12-04	Compuestos oligopeptidicos que contienen aminoacido d-2-alquiltriptofano y que son capaces de liberar hormona del crecimiento.
PCT/EP1996/005393 WO1997022620A1 (en)	1995-12-20	1996-12-04	Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
JP9522460A JP2000502089A (ja)	1995-12-20	1996-12-04	成長ホルモンの放出を促進できるｄ―２―アルキルトリプトファンを含有するオリゴペプチド化合物
DE69624371T DE69624371T2 (de)	1995-12-20	1996-12-04	D-2-alkyltryptophan-enthaltende oligopeptidverbindungen, die die freisetzung von wachstumshormon fördern
AU11759/97A AU1175997A (en)	1995-12-20	1996-12-04	Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
EP96942326A EP0868429B1 (en)	1995-12-20	1996-12-04	Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
CA002239702A CA2239702C (en)	1995-12-20	1996-12-04	Oligopeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
ZA9610591A ZA9610591B (en)	1995-12-20	1996-12-17	Oligopeptide compounds conaining d-2-alkyltryptophOligopeptide compounds containing D-2-alkyltryptopphan capable of promoting the release of growth hoan capable of promoting the release of growth hormone rmone
MX9804868A MX9804868A (es)	1995-12-20	1998-06-17	Compuestos oligopeptidicos que contienen d-2-alquiltriptofano capaz de promover la liberacion de hormona del crecimiento.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT95MI002681A IT1277113B1 (it)	1995-12-20	1995-12-20	Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita

Publications (3)

Publication Number	Publication Date
ITMI952681A0 ITMI952681A0 (it)	1995-12-20
ITMI952681A1 ITMI952681A1 (it)	1997-06-20
IT1277113B1 true IT1277113B1 (it)	1997-11-04

Family

ID=11372755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT95MI002681A IT1277113B1 (it)	1995-12-20	1995-12-20	Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita

Country Status (18)

Country	Link
EP (1)	EP0868429B1 (it)
JP (1)	JP2000502089A (it)
KR (1)	KR100369104B1 (it)
CN (1)	CN1126759C (it)
AT (1)	ATE226214T1 (it)
AU (1)	AU1175997A (it)
BR (1)	BR9612146A (it)
CA (1)	CA2239702C (it)
DE (1)	DE69624371T2 (it)
DK (1)	DK0868429T3 (it)
ES (1)	ES2186810T3 (it)
IL (1)	IL124507A (it)
IT (1)	IT1277113B1 (it)
MX (1)	MX9804868A (it)
PT (1)	PT868429E (it)
RU (1)	RU2182156C2 (it)
WO (1)	WO1997022620A1 (it)
ZA (1)	ZA9610591B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL137007A0 (en)	1998-01-16	2001-06-14	Novo Nordisk As	Compounds with growth hormone releasing properties
US5932548A (en) *	1998-06-03	1999-08-03	Deghenghi; Romano	Lysine containing peptides for treatment of heart disease
US6919315B1 (en)	1998-06-30	2005-07-19	Novo Nordisk A/S	Compounds with growth hormone releasing properties
EP1158996A4 (en)	1999-02-18	2005-01-12	Kaken Pharma Co Ltd	NEW AMIDE SECRETAGOGUES OF GROWTH HORMONE DERIVATIVES
US6417397B1 (en)	1999-10-04	2002-07-09	The Regents Of The University Of California, San Diego	N-substituted alkylamino acids for use as amino-protecting groups
US6211156B1 (en) *	1999-11-10	2001-04-03	Asta Medica A.G.	Peptides for treatment of erectile dysfunction
ATE446758T1 (de)	2000-05-31	2009-11-15	Pfizer Prod Inc	Verwendung von wachstumshormonsekretagoga zur förderung der beweglichkeit des verdauungstrakts
US7476653B2 (en)	2003-06-18	2009-01-13	Tranzyme Pharma, Inc.	Macrocyclic modulators of the ghrelin receptor
PL1756142T3 (pl) *	2004-04-28	2008-12-31	Mediolanum Farm S P A	Pseudopeptydy pobudzające wydzielanie hormonu wzrostu
GB0603295D0 (en)	2006-02-18	2006-03-29	Ardana Bioscience Ltd	Methods and kits
CU23558A1 (es)	2006-02-28	2010-07-20	Ct Ingenieria Genetica Biotech	Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
KR20090107088A (ko)	2007-02-09	2009-10-12	트랜자임 파르마 인크	거대고리 그렐린 수용체 조절제 및 이의 사용 방법
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
WO2017075535A1 (en)	2015-10-28	2017-05-04	Oxeia Biopharmaceuticals, Inc.	Methods of treating neurodegenerative conditions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1175810A (en) *	1979-03-30	1984-10-09	Frank A. Momany	Synthetic peptides having pituitary growth hormone releasing activity
SU1316565A3 (ru) *	1979-09-20	1987-06-07	Фармиталия Карло Эрба С.П.А. (Фирма)	Способ получени пептидов
SU1341970A1 (ru) *	1985-10-04	1990-03-23	Институт Органического Синтеза Ан Латвсср	Аналог энкефалина, обладающий анальгетической активностью
IT1240643B (it) *	1990-05-11	1993-12-17	Mediolanum Farmaceutici Spa	Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
JP3810083B2 (ja) *	1994-09-27	2006-08-16	アーダナ・バイオサイエンス・リミテツド	成長因子の放出を促進し得る２−アルキルトリプトファン含有ペプチド化合物

1995
- 1995-12-20 IT IT95MI002681A patent/IT1277113B1/it active IP Right Grant
1996
- 1996-12-04 IL IL12450796A patent/IL124507A/xx not_active IP Right Cessation
- 1996-12-04 CA CA002239702A patent/CA2239702C/en not_active Expired - Fee Related
- 1996-12-04 WO PCT/EP1996/005393 patent/WO1997022620A1/en not_active Ceased
- 1996-12-04 AU AU11759/97A patent/AU1175997A/en not_active Abandoned
- 1996-12-04 PT PT96942326T patent/PT868429E/pt unknown
- 1996-12-04 EP EP96942326A patent/EP0868429B1/en not_active Expired - Lifetime
- 1996-12-04 CN CN96199086A patent/CN1126759C/zh not_active Expired - Fee Related
- 1996-12-04 BR BR9612146A patent/BR9612146A/pt not_active IP Right Cessation
- 1996-12-04 KR KR10-1998-0704587A patent/KR100369104B1/ko not_active Expired - Fee Related
- 1996-12-04 DE DE69624371T patent/DE69624371T2/de not_active Expired - Fee Related
- 1996-12-04 ES ES96942326T patent/ES2186810T3/es not_active Expired - Lifetime
- 1996-12-04 RU RU98113920/04A patent/RU2182156C2/ru not_active IP Right Cessation
- 1996-12-04 JP JP9522460A patent/JP2000502089A/ja active Pending
- 1996-12-04 AT AT96942326T patent/ATE226214T1/de not_active IP Right Cessation
- 1996-12-04 DK DK96942326T patent/DK0868429T3/da active
- 1996-12-17 ZA ZA9610591A patent/ZA9610591B/xx unknown
1998
- 1998-06-17 MX MX9804868A patent/MX9804868A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
ITMI952681A1 (it)	1997-06-20
KR100369104B1 (ko)	2003-06-12
HK1016193A1 (en)	1999-10-29
IL124507A (en)	2001-03-19
BR9612146A (pt)	1999-07-13
ZA9610591B (en)	1997-06-24
IL124507A0 (en)	1998-12-06
ITMI952681A0 (it)	1995-12-20
KR20000064444A (ko)	2000-11-06
EP0868429B1 (en)	2002-10-16
ES2186810T3 (es)	2003-05-16
PT868429E (pt)	2003-02-28
DK0868429T3 (da)	2003-02-10
DE69624371D1 (de)	2002-11-21
CN1204341A (zh)	1999-01-06
JP2000502089A (ja)	2000-02-22
CA2239702C (en)	2007-08-07
CN1126759C (zh)	2003-11-05
AU1175997A (en)	1997-07-14
ATE226214T1 (de)	2002-11-15
EP0868429A1 (en)	1998-10-07
CA2239702A1 (en)	1997-06-26
MX9804868A (es)	1998-10-31
WO1997022620A1 (en)	1997-06-26
DE69624371T2 (de)	2003-06-18
RU2182156C2 (ru)	2002-05-10

Legal Events

Date	Code	Title	Description
1997-11-04	0001	Granted

Publication	Publication Date	Title
IT1277113B1 (it)	1997-11-04	Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
HUP0100669A2 (hu)	2001-08-28	Szerin proteázokat gátló peptidszármazékok és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
MX9304970A (es)	1994-05-31	ACIDOS ß-AMINOALQUIL- Y ß-N-PEPTIDILAMINOALQUIL-BORONICOS.
SE9604341D0 (sv)	1996-11-26	Hepta-peptide oxytocin analogue
AR012588A1 (es)	2000-11-08	UN INHIBIDOR DE SERINA PROTEASA, UNA COMPOSICIoN FARMACEUTICA QUE LO COMPRENDE Y UN PROCEDIMIENTO PARA PREPARAR UNA COMPOSICIoN FARMACEUTICA
IL144483A0 (en)	2002-05-23	Chemical compounds
MY119155A (en)	2005-04-30	New peptide derivatives
ATE99698T1 (de)	1994-01-15	Peptide.
MX9702275A (es)	1997-06-28	Compuestos polipectidicos que contienen d-2 alquiltriptofano capaces de promover la liberacion de hormona del crecimiento.
DK0406119T3 (da)	1994-03-21	Hidtil ukendte peptidderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
NO175310C (no)	1994-09-28	Analogifremgangsmåte til fremstilling av terapeutisk aktive pyrrolo(2,3-b)indolderivater
RU98113920A (ru)	2000-05-20	Производные олигопептидов, содержащие d-алкилтриптофан и способные активировать высвобождение гормона роста
IT1209644B (it)	1989-08-30	Composti farmacologicamente attivi.
HU9200069D0 (en)	1992-03-30	Process for producing 1,4-dihydro-pyridines and for producing pharmaceutical preparatives containing said compounds as active substance
MX9804828A (es)	1998-09-30	Benzotiazolona etanaminas biologicamente activas.
NO167286C (no)	1991-10-23	Fremgangsmaate for fremstilling av terapeutisk aktive benzotiazepin-derivater.
ES8606882A1 (es)	1986-05-01	Procedimiento de obtencion de nuevos derivados gonadoliberi-nos y de sus sales de adicion formadas con acidos terapeuti-camente utilizables y complejos de los mismos
DK0904270T3 (da)	2003-12-01	Dihydrobenzofuran og beslægtede forbindelser anvendelige som antiinflammatoriske midler
DE3886656D1 (de)	1994-02-10	Lösungssynthese eines Oktapeptids.
ATE46347T1 (de)	1989-09-15	Immunostimulierende peptide.
YU40492A (sh)	1994-06-10	Prekursorski oblik faktora oslobađanja goveđeg hormona rasta i srodna dna jedinjenja
IT1270021B (it)	1997-04-16	"composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"
ITMI921151A1 (it)	1993-11-14	Composti terapeuticamente attivi, particolarmente ad attivita' nootropica e procedimento per la loro preparazione
JO1871B1 (en)	1995-12-27	Innovative substituted benzimidazole compounds