IT1306162B1 - Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico. - Google Patents
Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.Info
- Publication number
- IT1306162B1 IT1306162B1 IT1999RM000418A ITRM990418A IT1306162B1 IT 1306162 B1 IT1306162 B1 IT 1306162B1 IT 1999RM000418 A IT1999RM000418 A IT 1999RM000418A IT RM990418 A ITRM990418 A IT RM990418A IT 1306162 B1 IT1306162 B1 IT 1306162B1
- Authority
- IT
- Italy
- Prior art keywords
- aminocarnitine
- derivatives
- aspartic acid
- solvents
- possibility
- Prior art date
Links
- DAWBGYHPBBDHMQ-ZCFIWIBFSA-N (3r)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](N)CC([O-])=O DAWBGYHPBBDHMQ-ZCFIWIBFSA-N 0.000 title abstract 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 title abstract 2
- DAWBGYHPBBDHMQ-LURJTMIESA-N (3s)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@@H](N)CC([O-])=O DAWBGYHPBBDHMQ-LURJTMIESA-N 0.000 title 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 title 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 title 1
- 229960005261 aspartic acid Drugs 0.000 title 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999RM000418A IT1306162B1 (it) | 1999-06-30 | 1999-06-30 | Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico. |
| US10/018,794 US6528684B1 (en) | 1999-06-30 | 2000-06-23 | Synthesis of (R) and (S) -aminocarnitine and their derivatives starting from D- and L-aspartic acid |
| DK00944218T DK1194398T3 (da) | 1999-06-30 | 2000-06-23 | Syntese af (R)- og (S)-aminocarnitin og dets derivater med udgangspunkt i D- og L-asparginsyre |
| ES00944218T ES2204644T3 (es) | 1999-06-30 | 2000-06-23 | Sintesis de (r) y (s)-aminocarnitina y sus derivados comenzando apartir de acido d-aspartico y l-aspartico. |
| AT00944218T ATE248141T1 (de) | 1999-06-30 | 2000-06-23 | Verfahren zur herstellung von (r) und (s)- aminocarnitin und deren derivative aus d- und l- aspargin säure |
| DE60004850T DE60004850T2 (de) | 1999-06-30 | 2000-06-23 | Verfahren zur herstellung von (r) und (s)-aminocarnitin und deren derivative aus d- und l-aspargin säure |
| PCT/IT2000/000258 WO2001002341A1 (en) | 1999-06-30 | 2000-06-23 | Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid |
| PT00944218T PT1194398E (pt) | 1999-06-30 | 2000-06-23 | Sintese de aminocarnitina (s) e (r) e dos seus derivados, a partir de acido aspartico l e d |
| EP00944218A EP1194398B1 (en) | 1999-06-30 | 2000-06-23 | Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid |
| AU58448/00A AU5844800A (en) | 1999-06-30 | 2000-06-23 | Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid |
| US10/338,045 US20030153783A1 (en) | 1999-06-30 | 2003-01-08 | Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid |
| US10/372,627 US6822115B2 (en) | 1999-06-30 | 2003-02-25 | Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999RM000418A IT1306162B1 (it) | 1999-06-30 | 1999-06-30 | Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM990418A0 ITRM990418A0 (it) | 1999-06-30 |
| ITRM990418A1 ITRM990418A1 (it) | 2000-12-30 |
| IT1306162B1 true IT1306162B1 (it) | 2001-05-30 |
Family
ID=11406859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1999RM000418A IT1306162B1 (it) | 1999-06-30 | 1999-06-30 | Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6528684B1 (it) |
| EP (1) | EP1194398B1 (it) |
| AT (1) | ATE248141T1 (it) |
| AU (1) | AU5844800A (it) |
| DE (1) | DE60004850T2 (it) |
| DK (1) | DK1194398T3 (it) |
| ES (1) | ES2204644T3 (it) |
| IT (1) | IT1306162B1 (it) |
| PT (1) | PT1194398E (it) |
| WO (1) | WO2001002341A1 (it) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1299266B1 (it) * | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Inibitori reversibili della carnitina palmitoil trasferasi |
| US6822115B2 (en) * | 1999-06-30 | 2004-11-23 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid |
| US20030153783A1 (en) * | 1999-06-30 | 2003-08-14 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid |
| US7776915B2 (en) * | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
| WO2008109991A1 (en) * | 2007-03-09 | 2008-09-18 | University Health Network | Inhibitors of carnitine palmitoyltransferase and treating cancer |
| CA2677049A1 (en) * | 2007-08-01 | 2009-02-05 | Sionex Corporation | Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1136945B (it) * | 1981-03-18 | 1986-09-03 | Anic Spa | Processo per la preparazione di l-carnitina |
| IT1261489B (it) | 1993-07-29 | 1996-05-23 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r amminocarnitina e s amminocarnitina. |
-
1999
- 1999-06-30 IT IT1999RM000418A patent/IT1306162B1/it active
-
2000
- 2000-06-23 US US10/018,794 patent/US6528684B1/en not_active Expired - Fee Related
- 2000-06-23 EP EP00944218A patent/EP1194398B1/en not_active Expired - Lifetime
- 2000-06-23 ES ES00944218T patent/ES2204644T3/es not_active Expired - Lifetime
- 2000-06-23 PT PT00944218T patent/PT1194398E/pt unknown
- 2000-06-23 AT AT00944218T patent/ATE248141T1/de not_active IP Right Cessation
- 2000-06-23 DK DK00944218T patent/DK1194398T3/da active
- 2000-06-23 WO PCT/IT2000/000258 patent/WO2001002341A1/en not_active Ceased
- 2000-06-23 AU AU58448/00A patent/AU5844800A/en not_active Abandoned
- 2000-06-23 DE DE60004850T patent/DE60004850T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60004850T2 (de) | 2004-05-27 |
| US6528684B1 (en) | 2003-03-04 |
| DE60004850D1 (de) | 2003-10-02 |
| EP1194398B1 (en) | 2003-08-27 |
| ITRM990418A0 (it) | 1999-06-30 |
| AU5844800A (en) | 2001-01-22 |
| PT1194398E (pt) | 2004-01-30 |
| DK1194398T3 (da) | 2003-12-22 |
| WO2001002341A1 (en) | 2001-01-11 |
| EP1194398A1 (en) | 2002-04-10 |
| ES2204644T3 (es) | 2004-05-01 |
| ATE248141T1 (de) | 2003-09-15 |
| ITRM990418A1 (it) | 2000-12-30 |
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