UA98311C2 - Соединение 2-алкилиндазола для лечения определенных расстройств, связанных с цнс, способ его получения (варианты) и фармацевтическая композиция на его основе - Google Patents

Соединение 2-алкилиндазола для лечения определенных расстройств, связанных с цнс, способ его получения (варианты) и фармацевтическая композиция на его основе

Info

Publication number
UA98311C2
UA98311C2 UAA200905092A UAA200905092A UA98311C2 UA 98311 C2 UA98311 C2 UA 98311C2 UA A200905092 A UAA200905092 A UA A200905092A UA A200905092 A UAA200905092 A UA A200905092A UA 98311 C2 UA98311 C2 UA 98311C2
Authority
UA
Ukraine
Prior art keywords
alkyl
pharmaceutical composition
indazole compound
processes
preparation
Prior art date
Application number
UAA200905092A
Other languages
English (en)
Ukrainian (uk)
Inventor
Мария Алессандра Алиси
Никола Каццолла
Гвидо Фурлотти
Катерина Мауджери
Розелла Омбрато
Лоренцо Поленцани
Original Assignee
Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А.
Publication of UA98311C2 publication Critical patent/UA98311C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Соединение 2-алкилиндазола и его фармацевтически приемлемые соли присоединения кислоты, способов и промежуточные соединения для их получения, фармацевтическая композиция, которая содержит их, и применение последней. Соединение 2-алкилиндазола имеет следующую общую формулу (I), в которой R1, R2, R3, R4, R6, R7, X, Y, W, n, р и m принимают значения, представленные в описании.
UAA200905092A 2006-11-22 2007-11-19 Соединение 2-алкилиндазола для лечения определенных расстройств, связанных с цнс, способ его получения (варианты) и фармацевтическая композиция на его основе UA98311C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002230A ITMI20062230A1 (it) 2006-11-22 2006-11-22 Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
PCT/EP2007/010000 WO2008061688A1 (en) 2006-11-22 2007-11-19 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders

Publications (1)

Publication Number Publication Date
UA98311C2 true UA98311C2 (ru) 2012-05-10

Family

ID=38474157

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200905092A UA98311C2 (ru) 2006-11-22 2007-11-19 Соединение 2-алкилиндазола для лечения определенных расстройств, связанных с цнс, способ его получения (варианты) и фармацевтическая композиция на его основе

Country Status (22)

Country Link
US (1) US8507528B2 (ru)
EP (1) EP2099780B1 (ru)
JP (1) JP5551443B2 (ru)
KR (1) KR101471987B1 (ru)
CN (1) CN101558057B (ru)
AR (1) AR063881A1 (ru)
AU (1) AU2007323368B2 (ru)
BR (1) BRPI0718976A2 (ru)
CA (1) CA2668205C (ru)
DK (1) DK2099780T3 (ru)
EA (1) EA019217B1 (ru)
ES (1) ES2401199T3 (ru)
GE (1) GEP20125414B (ru)
IL (1) IL198432A (ru)
IT (1) ITMI20062230A1 (ru)
MX (1) MX2009005250A (ru)
PL (1) PL2099780T3 (ru)
PT (1) PT2099780E (ru)
SG (1) SG176504A1 (ru)
SI (1) SI2099780T1 (ru)
UA (1) UA98311C2 (ru)
WO (1) WO2008061688A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20150325T1 (hr) * 2010-04-08 2015-04-24 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. Tricikliäśki spoj indazola, postupak njegove priprave i farmaceutski sastav koji ga sadrži
KR101834362B1 (ko) 2011-03-18 2018-03-05 바이엘 인텔렉쳐 프로퍼티 게엠베하 N-(3-카바모일페닐)-1h-피라졸-5-카복사미드 유도체 및 동물 해충을 구제하기 위한 그의 용도

Family Cites Families (21)

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JPS57501378A (ru) * 1980-09-05 1982-08-05
DE3687080T2 (de) * 1985-04-27 1993-03-25 Beecham Group Plc Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
JPH02215779A (ja) * 1989-02-14 1990-08-28 Kuraray Co Ltd カルボン酸アミド誘導体類及びその医薬用途
US5246947A (en) * 1991-09-23 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
WO1994005642A1 (en) 1992-08-28 1994-03-17 Ciba-Geigy Ag Indazole derivatives
JPH08277287A (ja) * 1995-02-09 1996-10-22 Mitsubishi Chem Corp インダゾール類およびその用途
EP0829474B1 (en) * 1995-05-31 2003-04-09 Nisshin Seifun Group Inc. Indazole derivatives having monocyclic amino group
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6218390B1 (en) * 1998-12-17 2001-04-17 Synaptic Pharmaceutical Corporation Morpholinone and morpholine derivatives and uses thereof
DE60321958D1 (de) * 2002-12-02 2008-08-14 Hoffmann La Roche Indazolderivate und ihre verwendung als crf antagonisten
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
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BRPI0418351A (pt) * 2004-01-05 2007-05-08 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, métodos de limitar a proliferação celular em um humano ou animal, de tratamento de um humano ou animal sofrendo de cáncer, de tratamento de profilaxia de cáncer, de tratamento de um humano ou animal sofrendo de uma doença neoplásica, de tratamento de um humano ou animal sofrendo de uma doença prolifetativa de tratamento de cáncer, para o tratamento de infecções associadas com cáncer, para o tratamento profilático de infecções associadas com cáncer, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, método de inibir a chk1 quinase, e, processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo
JP2008509138A (ja) * 2004-08-03 2008-03-27 ワイス 心臓血管疾患の治療に有用なインダゾール類
TW200621237A (en) * 2004-11-01 2006-07-01 Wyeth Corp [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones
SA05260357B1 (ar) * 2004-11-19 2008-09-08 ارينا فارماسيتو تيكالز ، أنك مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به
WO2008054748A2 (en) * 2006-10-31 2008-05-08 Arena Pharmaceuticals, Inc. Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

Also Published As

Publication number Publication date
EA200970496A1 (ru) 2009-10-30
JP2010510265A (ja) 2010-04-02
KR20090089880A (ko) 2009-08-24
CA2668205C (en) 2014-10-21
IL198432A0 (en) 2010-02-17
CN101558057A (zh) 2009-10-14
CN101558057B (zh) 2013-05-01
EA019217B1 (ru) 2014-02-28
EP2099780B1 (en) 2013-01-09
EP2099780A1 (en) 2009-09-16
ES2401199T3 (es) 2013-04-17
IL198432A (en) 2013-03-24
MX2009005250A (es) 2009-05-28
AU2007323368B2 (en) 2013-02-07
US20100056573A1 (en) 2010-03-04
US8507528B2 (en) 2013-08-13
AU2007323368A1 (en) 2008-05-29
DK2099780T3 (da) 2013-04-15
SG176504A1 (en) 2011-12-29
GEP20125414B (en) 2012-03-12
CA2668205A1 (en) 2008-05-29
JP5551443B2 (ja) 2014-07-16
WO2008061688A1 (en) 2008-05-29
KR101471987B1 (ko) 2014-12-12
SI2099780T1 (sl) 2013-03-29
AR063881A1 (es) 2009-02-25
BRPI0718976A2 (pt) 2014-02-04
ITMI20062230A1 (it) 2008-05-23
PL2099780T3 (pl) 2013-05-31
HK1129112A1 (en) 2009-11-20
PT2099780E (pt) 2013-03-11

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UA98311C2 (ru) Соединение 2-алкилиндазола для лечения определенных расстройств, связанных с цнс, способ его получения (варианты) и фармацевтическая композиция на его основе