ITRM20000570A0 - Derivati triciclici dell'indolo ad attivita' antiagiogenica. - Google Patents

Derivati triciclici dell'indolo ad attivita' antiagiogenica.

Info

Publication number
ITRM20000570A0
ITRM20000570A0 IT2000RM000570A ITRM20000570A ITRM20000570A0 IT RM20000570 A0 ITRM20000570 A0 IT RM20000570A0 IT 2000RM000570 A IT2000RM000570 A IT 2000RM000570A IT RM20000570 A ITRM20000570 A IT RM20000570A IT RM20000570 A0 ITRM20000570 A0 IT RM20000570A0
Authority
IT
Italy
Prior art keywords
antiagiogenic
indel
tricyclic
derivatives
activity
Prior art date
Application number
IT2000RM000570A
Other languages
English (en)
Inventor
Mauro Marzi
Giuseppe Giannini
Maria Ornella Tinti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM20000570A0 publication Critical patent/ITRM20000570A0/it
Priority to IT2000RM000570A priority Critical patent/IT1317926B1/it
Priority to DK01983768T priority patent/DK1343789T3/da
Priority to MXPA03003798A priority patent/MXPA03003798A/es
Priority to ES01983768T priority patent/ES2247182T3/es
Priority to KR10-2003-7005651A priority patent/KR20030042030A/ko
Priority to US10/415,896 priority patent/US6887892B2/en
Priority to HK04104343.2A priority patent/HK1061244B/xx
Priority to BR0115119-3A priority patent/BR0115119A/pt
Priority to CZ20031042A priority patent/CZ297299B6/cs
Priority to EP01983768A priority patent/EP1343789B1/en
Priority to PCT/IT2001/000526 priority patent/WO2002036597A1/en
Priority to SK534-2003A priority patent/SK5342003A3/sk
Priority to CA002427568A priority patent/CA2427568A1/en
Priority to AT01983768T priority patent/ATE302780T1/de
Priority to AU1518602A priority patent/AU1518602A/xx
Priority to DE60112966T priority patent/DE60112966T2/de
Priority to CNB018181996A priority patent/CN1247589C/zh
Priority to HU0400546A priority patent/HUP0400546A3/hu
Priority to JP2002539355A priority patent/JP2004513130A/ja
Priority to PL01364908A priority patent/PL364908A1/xx
Publication of ITRM20000570A1 publication Critical patent/ITRM20000570A1/it
Application granted granted Critical
Publication of IT1317926B1 publication Critical patent/IT1317926B1/it
Priority to US11/032,068 priority patent/US20050124647A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT2000RM000570A 2000-11-03 2000-11-03 Derivati triciclici dell'indolo ad attivita' antiangiogenica. IT1317926B1 (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IT2000RM000570A IT1317926B1 (it) 2000-11-03 2000-11-03 Derivati triciclici dell'indolo ad attivita' antiangiogenica.
PCT/IT2001/000526 WO2002036597A1 (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity
CA002427568A CA2427568A1 (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity
ES01983768T ES2247182T3 (es) 2000-11-03 2001-10-16 Derivados triciclicos de indol con actividad antigiogenica.
KR10-2003-7005651A KR20030042030A (ko) 2000-11-03 2001-10-16 혈관형성 억제 활성을 갖는 인돌의 트리사이클릭 유도체
US10/415,896 US6887892B2 (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity
HK04104343.2A HK1061244B (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity
BR0115119-3A BR0115119A (pt) 2000-11-03 2001-10-16 Derivados tricìclicos de indol com atividade antiangiogênica
CZ20031042A CZ297299B6 (cs) 2000-11-03 2001-10-16 Tricyklické deriváty indolu s antiangiogenními úcinky
EP01983768A EP1343789B1 (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity
DK01983768T DK1343789T3 (da) 2000-11-03 2001-10-16 Tricykliske derivater af indol med antiangiogen aktivitet
SK534-2003A SK5342003A3 (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity
MXPA03003798A MXPA03003798A (es) 2000-11-03 2001-10-16 Derivados triciclicos de indol con actividad antiangiogenica.
AT01983768T ATE302780T1 (de) 2000-11-03 2001-10-16 Trizyklische indolderivate mit antiangiogenischer wirkung
AU1518602A AU1518602A (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity
DE60112966T DE60112966T2 (de) 2000-11-03 2001-10-16 Trizyklische indolderivate mit antiangiogenischer wirkung
CNB018181996A CN1247589C (zh) 2000-11-03 2001-10-16 具有抗血管生成活性的吲哚的三环衍生物
HU0400546A HUP0400546A3 (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity and pharmaceutical compositions containing them
JP2002539355A JP2004513130A (ja) 2000-11-03 2001-10-16 抗血管新生活性を有するインドールの三環系誘導体
PL01364908A PL364908A1 (en) 2000-11-03 2001-10-16 Tricyclic derivatives of indole with antiangiogenic activity
US11/032,068 US20050124647A1 (en) 2000-11-03 2005-01-11 Tricyclic derivatives of indole with antiangiogenic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000RM000570A IT1317926B1 (it) 2000-11-03 2000-11-03 Derivati triciclici dell'indolo ad attivita' antiangiogenica.

Publications (3)

Publication Number Publication Date
ITRM20000570A0 true ITRM20000570A0 (it) 2000-11-03
ITRM20000570A1 ITRM20000570A1 (it) 2002-05-03
IT1317926B1 IT1317926B1 (it) 2003-07-15

Family

ID=11454976

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000RM000570A IT1317926B1 (it) 2000-11-03 2000-11-03 Derivati triciclici dell'indolo ad attivita' antiangiogenica.

Country Status (19)

Country Link
US (2) US6887892B2 (it)
EP (1) EP1343789B1 (it)
JP (1) JP2004513130A (it)
KR (1) KR20030042030A (it)
CN (1) CN1247589C (it)
AT (1) ATE302780T1 (it)
AU (1) AU1518602A (it)
BR (1) BR0115119A (it)
CA (1) CA2427568A1 (it)
CZ (1) CZ297299B6 (it)
DE (1) DE60112966T2 (it)
DK (1) DK1343789T3 (it)
ES (1) ES2247182T3 (it)
HU (1) HUP0400546A3 (it)
IT (1) IT1317926B1 (it)
MX (1) MXPA03003798A (it)
PL (1) PL364908A1 (it)
SK (1) SK5342003A3 (it)
WO (1) WO2002036597A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849656B1 (en) 1999-09-17 2005-02-01 Baylor University Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
US7632955B2 (en) 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
US6800655B2 (en) 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
JP2008530229A (ja) * 2005-02-17 2008-08-07 ワイス シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
DE502007005017D1 (de) * 2006-04-25 2010-10-28 Merck Patent Gmbh Hexahydro-dibenzofuranderivate
FR2928645A1 (fr) * 2008-03-14 2009-09-18 Sanofi Aventis Sa Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
EP2895462A1 (en) * 2012-09-13 2015-07-22 Baden-Württemberg Stiftung gGmbH Specific inhibitors of protein p21 as therapeutic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100891A (en) * 1991-01-18 1992-03-31 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
US5350762A (en) * 1993-03-08 1994-09-27 Hoechst-Roussel Pharmaceuticals Incorporated Tetrahydrocyclopent[B]indole methanamines and related compounds

Also Published As

Publication number Publication date
AU1518602A (en) 2002-05-15
CN1247589C (zh) 2006-03-29
IT1317926B1 (it) 2003-07-15
CZ20031042A3 (cs) 2003-10-15
KR20030042030A (ko) 2003-05-27
WO2002036597A1 (en) 2002-05-10
DE60112966D1 (de) 2005-09-29
DK1343789T3 (da) 2005-12-27
EP1343789A1 (en) 2003-09-17
US20040034052A1 (en) 2004-02-19
HUP0400546A2 (hu) 2004-06-28
ES2247182T3 (es) 2006-03-01
EP1343789B1 (en) 2005-08-24
ATE302780T1 (de) 2005-09-15
DE60112966T2 (de) 2006-05-24
JP2004513130A (ja) 2004-04-30
CN1471535A (zh) 2004-01-28
CZ297299B6 (cs) 2006-11-15
MXPA03003798A (es) 2004-04-20
HK1061244A1 (en) 2004-09-10
HUP0400546A3 (en) 2007-08-28
ITRM20000570A1 (it) 2002-05-03
US6887892B2 (en) 2005-05-03
CA2427568A1 (en) 2002-05-10
PL364908A1 (en) 2004-12-27
US20050124647A1 (en) 2005-06-09
SK5342003A3 (en) 2003-10-07
BR0115119A (pt) 2003-09-30

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