ITRM910246A1 - Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti - Google Patents

Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Info

Publication number: ITRM910246A1
Authority: IT; Italy
Prior art keywords: activators; compounds; memory; pharmaceutical compositions; acid derivatives
Prior art date: 1991-04-11

Application number

IT000246A

Other languages

English (en)

Inventor

Roberto Cozzolino

Maria Grazia Gallo

Fabio Giannessi

Domenico Misiti

Maria Ornella Tinti

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-11

Filing date

1991-04-11

Publication date

1992-10-11

1991-04-11 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1991-04-11 Priority to ITRM910246A priority Critical patent/IT1244507B/it

1991-04-11 Publication of ITRM910246A0 publication Critical patent/ITRM910246A0/it

1992-04-07 Priority to US07/864,688 priority patent/US5227496A/en

1992-04-10 Priority to JP4090851A priority patent/JPH05117232A/ja

1992-04-10 Priority to EP19920830175 priority patent/EP0511943A3/en

1992-10-11 Publication of ITRM910246A1 publication Critical patent/ITRM910246A1/it

1994-07-15 Application granted granted Critical

1994-07-15 Publication of IT1244507B publication Critical patent/IT1244507B/it

Links

ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical class OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 title 1
239000012190 activator Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)

ITRM910246A 1991-04-11 1991-04-11 Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti IT1244507B (it)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
ITRM910246A IT1244507B (it)	1991-04-11	1991-04-11	Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
US07/864,688 US5227496A (en)	1991-04-11	1992-04-07	Pyroglutamic acid derivatives as enhancers of learning processes and memory and pharmaceutical compositions comprising same
JP4090851A JPH05117232A (ja)	1991-04-11	1992-04-10	ピログルタミン酸誘導体および医薬組成物
EP19920830175 EP0511943A3 (en)	1991-04-11	1992-04-10	Pyroglutamic acid derivatives as enhancers of learning processes and memory and pharmaceutical compositions comprising same

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITRM910246A IT1244507B (it)	1991-04-11	1991-04-11	Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Publications (3)

Publication Number	Publication Date
ITRM910246A0 ITRM910246A0 (it)	1991-04-11
ITRM910246A1 true ITRM910246A1 (it)	1992-10-11
IT1244507B IT1244507B (it)	1994-07-15

Family

ID=11400081

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITRM910246A IT1244507B (it)	1991-04-11	1991-04-11	Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Country Status (4)

Country	Link
US (1)	US5227496A (it)
EP (1)	EP0511943A3 (it)
JP (1)	JPH05117232A (it)
IT (1)	IT1244507B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4681132B2 (ja) *	2001-01-29	2011-05-11	味の素株式会社	一酸化窒素合成酵素産生促進剤および化粧料若しくは医薬組成物
IL187159A0 (en)	2007-07-03	2009-02-11	Gur Megiddo	Use of metadoxine in relief of alcohol intoxication
WO2010013242A1 (en)	2008-07-29	2010-02-04	Alcobra Ltd.	Substituted pyridoxine-lactam carboxylate salts
WO2010065668A1 (en)	2008-12-03	2010-06-10	Presidio Pharmaceuticals, Inc.	Inhibitors of hcv ns5a
NZ597319A (en)	2009-06-25	2014-06-27	Alcobra Ltd	A method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition
EP2758371B1 (en) *	2011-09-19	2016-06-15	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	New thio derivatives bearing lactams as potent hdac inhibitors and their uses as medicaments

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2651639A (en) *	1951-08-22	1953-09-08	American Cyanamid Co	2-pyrrolidone-5-carboxamide derivatives and methods of preparing the same
US3051722A (en) *	1960-10-21	1962-08-28	Lakeside Lab Inc	5-pyrrolidone-2-carboxamides
US4452989A (en) *	1982-06-01	1984-06-05	Charles Of The Ritz Group Ltd.	Substantive moisturizing derivatives of 2-pyrrolidone-5-carboxylic acid and compositions containing same
FR2597100A1 (fr) *	1986-01-21	1987-10-16	Nippon Shinyaku Co Ltd	Derives du pyroglutamide
JPH0699307B2 (ja) *	1987-08-20	1994-12-07	キッセイ薬品工業株式会社	抗痴呆剤
US4772601A (en) *	1988-01-25	1988-09-20	Hoechst-Roussel Pharmaceuticals, Inc.	5-Substituted 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinones, pharmaceutical compositions and use

1991
- 1991-04-11 IT ITRM910246A patent/IT1244507B/it active IP Right Grant
1992
- 1992-04-07 US US07/864,688 patent/US5227496A/en not_active Expired - Fee Related
- 1992-04-10 JP JP4090851A patent/JPH05117232A/ja active Pending
- 1992-04-10 EP EP19920830175 patent/EP0511943A3/en not_active Withdrawn

Also Published As

Publication number	Publication date
US5227496A (en)	1993-07-13
EP0511943A2 (en)	1992-11-04
JPH05117232A (ja)	1993-05-14
ITRM910246A0 (it)	1991-04-11
EP0511943A3 (en)	1992-12-09
IT1244507B (it)	1994-07-15

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Legal Events

Date	Code	Title	Description
1994-07-15	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19960307