JO3593B1 - مركبات تعمل على زيادة الخلايا الجذعية المكونة للدم - Google Patents

مركبات تعمل على زيادة الخلايا الجذعية المكونة للدم

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Publication number
JO3593B1
JO3593B1 JOP/2009/0399A JOP20090399A JO3593B1 JO 3593 B1 JO3593 B1 JO 3593B1 JO P20090399 A JOP20090399 A JO P20090399A JO 3593 B1 JO3593 B1 JO 3593B1
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JO
Jordan
Prior art keywords
compounds
stem cells
hematopoietic stem
expand hematopoietic
hematopoietic
Prior art date
Application number
JOP/2009/0399A
Other languages
English (en)
Inventor
Wan Yongqin
Wang Xing
Pan Shifeng
E Boitano Anthony
Cooke Michael
Tellew John
G Schultz Peter
Original Assignee
Novartis Ag
Scripps Research Inst
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42111339&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3593(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Scripps Research Inst filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3593B1 publication Critical patent/JO3593B1/ar

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
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    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors

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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
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  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

يتعلق الاختراع الحالى بمركبات وتركيبات لزيادة عدد خلايا CD34+ للزرع. يتعلق الاختراع أيضاً بمجموعة خلية تشتمل على خلايا جذعية مكونة للدم زائدة (HSCs) واستخدامها فى الزرع الذاتى أو الخيفى لعلاج مرضى مصابين بنقص مناعة وراثى وأمراض مناعة ذاتية واضطرابات تكون دم متعددة لإعادة تشكيل سلالات الخلية المكونة للدم وجهاز الدفاع المناعى.
JOP/2009/0399A 2008-10-30 2009-10-29 مركبات تعمل على زيادة الخلايا الجذعية المكونة للدم JO3593B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10982108P 2008-10-30 2008-10-30
US24276509P 2009-09-15 2009-09-15

Publications (1)

Publication Number Publication Date
JO3593B1 true JO3593B1 (ar) 2020-07-05

Family

ID=42111339

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2009/0399A JO3593B1 (ar) 2008-10-30 2009-10-29 مركبات تعمل على زيادة الخلايا الجذعية المكونة للدم

Country Status (41)

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US (4) US8927281B2 (ar)
EP (2) EP2350078B1 (ar)
JP (1) JP5390626B2 (ar)
KR (1) KR101434719B1 (ar)
CN (1) CN102203096B (ar)
AR (1) AR074063A1 (ar)
AU (1) AU2009317898B2 (ar)
BR (1) BRPI0921799B8 (ar)
CA (3) CA2740589C (ar)
CL (2) CL2009002010A1 (ar)
CO (1) CO6410309A2 (ar)
CR (1) CR20110192A (ar)
CU (1) CU24495B1 (ar)
CY (1) CY1121857T1 (ar)
DK (1) DK2350078T3 (ar)
DO (1) DOP2011000114A (ar)
EA (1) EA019872B1 (ar)
EC (1) ECSP11011090A (ar)
ES (2) ES2736728T3 (ar)
GE (1) GEP20146053B (ar)
HN (1) HN2011001195A (ar)
HR (1) HRP20191238T1 (ar)
HU (1) HUE044802T2 (ar)
IL (1) IL212368A (ar)
JO (1) JO3593B1 (ar)
LT (1) LT2350078T (ar)
MA (1) MA32828B1 (ar)
MX (1) MX347834B (ar)
MY (1) MY155137A (ar)
NI (1) NI201100083A (ar)
NZ (1) NZ592435A (ar)
PE (1) PE20100362A1 (ar)
PL (1) PL2350078T3 (ar)
PT (1) PT2350078T (ar)
RS (1) RS59027B1 (ar)
SI (1) SI2350078T1 (ar)
SM (1) SMP201100024B (ar)
SV (1) SV2011003888A (ar)
TN (1) TN2011000174A1 (ar)
TW (1) TWI532486B (ar)
WO (1) WO2010059401A2 (ar)

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