JO3764B1 - جزيئات إرتباط il-18 - Google Patents

جزيئات إرتباط il-18

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Publication number
JO3764B1
JO3764B1 JOP/2013/0269A JOP20130269A JO3764B1 JO 3764 B1 JO3764 B1 JO 3764B1 JO P20130269 A JOP20130269 A JO P20130269A JO 3764 B1 JO3764 B1 JO 3764B1
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JO
Jordan
Prior art keywords
binding molecules
bind
bound
complex
strong
Prior art date
Application number
JOP/2013/0269A
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English (en)
Inventor
Rene Rondeau Jean-Michel
Eberth Adina
Michelle Campbell Emma
Brannett Barbara
Carsten Silvester Christian
Anselmus Van Heeke Gino
Alfred Schlaeppi Jean-Marc
Diefenbach-Streiber Beate
Otto Bardroff Michael
Marshall Sylwia
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Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49596347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3764(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
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Publication of JO3764B1 publication Critical patent/JO3764B1/ar

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

<h1> </h1> <strong>يشارك في كلٍّ من المناعة الفطرية والمكتسبة. يتم تنظيم النشاط الحيوي لـ </strong><strong><span dir="LTR">IL-18</span></strong><strong> سلبيا عن طريق بروتين ربط </strong><strong><span dir="LTR">IL-18</span></strong> <strong><span dir="LTR">(IL18BP)</span></strong><strong>، وهو مثبط طبيعي وعالي التخصص. يشكل هذا البروتين الذائب مركّب مع </strong><strong><span dir="LTR">IL-18</span></strong><strong> الحر يمنع تفاعله مع مستقبل </strong><strong><span dir="LTR">IL-18</span></strong><strong>، بالتالي تتمّ معادلة نشاطه البيولوجي وتثبيطه. يتضمن الإختراع الحالي جزيئات الإرتباط، وبشكل خاص الأجسام المضادة أو شظايا منها، تربط </strong><strong><span dir="LTR">IL-18</span></strong><strong> ولا تربط </strong><strong><span dir="LTR">IL-18</span></strong><strong> المرتبط بـ </strong><strong><span dir="LTR">IL-18BP</span></strong><strong> (معقد </strong><strong><span dir="LTR">IL-18/IL-18BP</span></strong><strong>). بعيدا عن الدور الفسيولوجي، تبيّن أنّ </strong><strong><span dir="LTR">IL-18</span></strong><strong> يعمل كوسيطٍ في مختلف الأمراض ذاتية المناعة والإلتهابية. يمكن استخدام جزيئات الإرتباط الخاصة بالإختراع كجزيئات علاجية لمعالجة الأمراض الإلتهابية وذاتية المناعة المتعلقة بـ </strong><strong><span dir="LTR">IL-18</span></strong><strong> أو أدوات تشخيصية لتوصيف وكشف و/أو قياس </strong><strong><span dir="LTR">IL-18</span></strong><strong> غير المرتبط بـ </strong><strong><span dir="LTR">IL-18BP</span></strong><strong> كمكون من </strong><strong><span dir="LTR">IL-18</span></strong><strong> الكلي.</strong>
JOP/2013/0269A 2012-09-07 2013-09-05 جزيئات إرتباط il-18 JO3764B1 (ar)

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US201261697981P 2012-09-07 2012-09-07

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JOP/2020/0308A JOP20200308A1 (ar) 2012-09-07 2020-11-29 جزيئات إرتباط il-18

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US (5) US9376489B2 (ar)
EP (2) EP2892923B1 (ar)
JP (3) JP6404817B2 (ar)
KR (2) KR102330653B1 (ar)
CN (2) CN104640879B (ar)
AP (1) AP2015008266A0 (ar)
AR (1) AR092465A1 (ar)
AU (4) AU2013311234A1 (ar)
BR (2) BR112015004783B1 (ar)
CA (1) CA2883821C (ar)
CL (1) CL2015000532A1 (ar)
CO (1) CO7400884A2 (ar)
CR (1) CR20150121A (ar)
CU (1) CU24249B1 (ar)
CY (1) CY1123071T1 (ar)
DK (1) DK2892923T3 (ar)
EA (2) EA201992614A3 (ar)
EC (1) ECSP15013209A (ar)
ES (1) ES2804704T3 (ar)
GT (1) GT201500054A (ar)
HR (1) HRP20200906T1 (ar)
HU (1) HUE050464T2 (ar)
IL (2) IL237161B (ar)
JO (2) JO3764B1 (ar)
LT (1) LT2892923T (ar)
MA (1) MA37892A1 (ar)
MX (2) MX373426B (ar)
MY (1) MY174691A (ar)
PE (1) PE20150649A1 (ar)
PH (1) PH12015500466B1 (ar)
PL (1) PL2892923T3 (ar)
PT (1) PT2892923T (ar)
RS (1) RS60394B1 (ar)
SG (2) SG11201501559VA (ar)
SI (1) SI2892923T1 (ar)
TN (1) TN2015000057A1 (ar)
TW (2) TWI613217B (ar)
UY (1) UY35016A (ar)
WO (1) WO2014037899A2 (ar)
ZA (1) ZA201500954B (ar)

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