JOP20200099A1 - عقاقير أولية من مشتقات تريازول مستبدلة واستخداماتها - Google Patents

عقاقير أولية من مشتقات تريازول مستبدلة واستخداماتها

Info

Publication number
JOP20200099A1
JOP20200099A1 JOP/2020/0099A JOP20200099A JOP20200099A1 JO P20200099 A1 JOP20200099 A1 JO P20200099A1 JO P20200099 A JOP20200099 A JO P20200099A JO P20200099 A1 JOP20200099 A1 JO P20200099A1
Authority
JO
Jordan
Prior art keywords
prodrugs
triazol
carboxamide
trifluoro
triazole
Prior art date
Application number
JOP/2020/0099A
Other languages
English (en)
Inventor
Schmeck Carsten
Droebner Karoline
Buchmueller Anja
Levilain Guillaume
Schirmer Heiko
Fuerstner Chantal
Kolkhof Peter
Mondritzki Thomas
Lustig Klemens
Beat Wittwer Matthias
Collin-Kroepelin Marie-Pierre
Tinel Hanna
Pook Elisabeth
Kretschmer Axel
Neubauer Thomas
Cernecka Hana
Krenz Ursula
Wasnaire Pierre
Fricke Robert
Witowski Norbert
Original Assignee
Bayer Pharma AG
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer Ag filed Critical Bayer Pharma AG
Publication of JOP20200099A1 publication Critical patent/JOP20200099A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق الاختراع الحالي بعقاقير أولية من 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide، 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide و 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide، ويتعلق بعمليات لتحضير هذه المركبات، وبتراكيب صيدلية تحتوي على هذه المركبات، وباستخدام هذه المركبات أو التراكيب للمعالجة و/أو الوقاية من أمراض، وتحديدا للمعالجة و/أو الوقاية من أمراض الكلى والأمراض الوعائية القلبية.
JOP/2020/0099A 2017-10-24 2018-10-17 عقاقير أولية من مشتقات تريازول مستبدلة واستخداماتها JOP20200099A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17197935 2017-10-24
PCT/EP2018/078364 WO2019081292A1 (en) 2017-10-24 2018-10-17 PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF

Publications (1)

Publication Number Publication Date
JOP20200099A1 true JOP20200099A1 (ar) 2020-05-06

Family

ID=60162099

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0099A JOP20200099A1 (ar) 2017-10-24 2018-10-17 عقاقير أولية من مشتقات تريازول مستبدلة واستخداماتها

Country Status (38)

Country Link
US (1) US11298367B2 (ar)
EP (1) EP3700913B1 (ar)
JP (1) JP2021500365A (ar)
KR (1) KR20200069361A (ar)
CN (1) CN111225921A (ar)
AR (1) AR113791A1 (ar)
AU (1) AU2018356352A1 (ar)
BR (1) BR112020007983A2 (ar)
CA (1) CA3079767A1 (ar)
CL (1) CL2020001076A1 (ar)
CO (1) CO2020004945A2 (ar)
CR (1) CR20200176A (ar)
CU (1) CU24604B1 (ar)
CY (1) CY1124938T1 (ar)
DK (1) DK3700913T3 (ar)
DO (1) DOP2020000076A (ar)
EA (1) EA202091025A1 (ar)
EC (1) ECSP20023056A (ar)
ES (1) ES2906305T3 (ar)
HR (1) HRP20220060T1 (ar)
HU (1) HUE057278T2 (ar)
IL (1) IL273949A (ar)
JO (1) JOP20200099A1 (ar)
LT (1) LT3700913T (ar)
MA (1) MA50438B1 (ar)
MX (1) MX2020004191A (ar)
NI (1) NI202000030A (ar)
PE (1) PE20210394A1 (ar)
PH (1) PH12020550473A1 (ar)
PL (1) PL3700913T3 (ar)
PT (1) PT3700913T (ar)
RS (1) RS62984B1 (ar)
SG (1) SG11202003049WA (ar)
SI (1) SI3700913T1 (ar)
TW (1) TW201932117A (ar)
UA (1) UA126456C2 (ar)
UY (1) UY37948A (ar)
WO (1) WO2019081292A1 (ar)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
WO2022112213A1 (en) 2020-11-30 2022-06-02 Bayer Aktiengesellschaft Crystalline forms of 3-[[3-(4-chlorophenyl)-5-oxo-4-((2s)-3,3,3-trifluoro- 2-hydroxypropyl)-4,5-dihydro-1h-1,2,4-triazol-1-yl]methyl]-1-[3- (trifluoromethyl)pyridin-2-yl]-1h-1,2,4-triazole-5-carboxamide

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966781A (en) 1970-12-17 1976-06-29 Merck Sharp & Dohme (I.A.) Corporation Deuteration of functional group-containing hydrocarbons
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
AP2331A (en) 2003-12-22 2011-12-05 Pfizer Triazole derivatives as vasopressin antagonists.
US20070225333A1 (en) 2004-04-28 2007-09-27 Bryans Justin S 3-Heterocyclyl-4-Phenyl-Triazole Derivatives as Inhibitors of the Vasopressin Via Receptor
JP2011502982A (ja) * 2007-11-06 2011-01-27 アストラゼネカ・アクチエボラーグ 好中球エラスターゼの阻害剤としてのある種の２−ピラジノン誘導体およびその使用
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
AR076542A1 (es) * 2009-05-22 2011-06-22 Merck Sharp & Dohme Antagonistas del receptor de orexina de isonicotinamida
CN103189363B (zh) 2010-02-27 2015-07-29 拜耳知识产权有限责任公司 双芳基连接的芳基三唑酮及其用途
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
PE20130779A1 (es) 2010-07-09 2013-06-21 Bayer Ip Gmbh Pirimidinas y triazinas condensadas y su uso
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
US8791162B2 (en) 2011-02-14 2014-07-29 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015055707A1 (en) * 2013-10-16 2015-04-23 Bayer Cropscience Ag Active compound combinations comprising a (thio)carboxamide derivative and a fungicidal compound
PE20170945A1 (es) 2014-11-03 2017-07-13 Bayer Pharma AG Derivados de feniltriazol sustituido con hidroxialquilo y sus usos
UY36571A (es) * 2015-03-05 2016-09-30 Bayer Cropscience Ag Combinaciones de compuestos activos
WO2017191105A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Amide-substituted aryltriazole derivatives and uses thereof
WO2017191114A1 (en) 2016-05-03 2017-11-09 Bayer Aktiengesellschaft Hydroxyalkyl-substituted heteroaryltriazole derivatives and uses thereof
CA3022755A1 (en) 2016-05-03 2017-11-09 Carsten Schmeck Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
US10525041B2 (en) 2016-05-03 2020-01-07 Bayer Pharma Aktiengesellschaft Fluoroalkyl-substituted aryltriazole derivatives and uses thereof
US10815205B2 (en) 2016-05-03 2020-10-27 Bayer Pharma Aktiengesellschaft Amide-substituted phenyltriazole derivatives and uses thereof
US9988367B2 (en) 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
US10927098B2 (en) 2016-10-20 2021-02-23 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted triazole derivatives and uses thereof

Also Published As

Publication number Publication date
CL2020001076A1 (es) 2021-02-19
US11298367B2 (en) 2022-04-12
NI202000030A (es) 2020-10-09
MA50438B1 (fr) 2022-03-31
MA50438A (fr) 2020-09-02
RS62984B1 (sr) 2022-03-31
BR112020007983A2 (pt) 2020-10-27
IL273949A (en) 2020-05-31
JP2021500365A (ja) 2021-01-07
ES2906305T3 (es) 2022-04-18
UA126456C2 (uk) 2022-10-05
WO2019081292A1 (en) 2019-05-02
US20200338096A1 (en) 2020-10-29
CY1124938T1 (el) 2023-01-05
MX2020004191A (es) 2020-08-03
UY37948A (es) 2019-05-31
EP3700913A1 (en) 2020-09-02
EP3700913B1 (en) 2021-11-10
CU20200040A7 (es) 2021-03-11
PE20210394A1 (es) 2021-03-02
SG11202003049WA (en) 2020-04-29
CN111225921A (zh) 2020-06-02
CO2020004945A2 (es) 2020-05-05
ECSP20023056A (es) 2020-12-31
SI3700913T1 (sl) 2022-02-28
CU24604B1 (es) 2022-06-06
PT3700913T (pt) 2022-01-31
HRP20220060T1 (hr) 2022-04-15
PL3700913T3 (pl) 2022-02-21
PH12020550473A1 (en) 2021-03-08
AR113791A1 (es) 2020-06-10
TW201932117A (zh) 2019-08-16
EA202091025A1 (ru) 2020-07-30
HUE057278T2 (hu) 2022-04-28
LT3700913T (lt) 2022-01-25
DK3700913T3 (da) 2022-02-07
KR20200069361A (ko) 2020-06-16
AU2018356352A1 (en) 2020-04-16
CR20200176A (es) 2020-07-24
DOP2020000076A (es) 2020-08-31
CA3079767A1 (en) 2019-05-02

Similar Documents

Publication Publication Date Title
PE20190116A1 (es) Derivados de piridiniltriazol sustituidos con amida y usos de estos
PH12017500802B1 (en) Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
IL281196B (en) Process for the preparation of methyl 6-(4,2-dichlorophenyl)-5-[4-[(s3)-1-(3-fluoropropyl)pyrrolidine-3-yl]oxyphenyl]-9,8-dihydro-h7-benzo[ 7] Anolene-2-carboxylate
JOP20170104A1 (ar) مشتقات فنيل تريازول مستبدلة بأميد واستخدامها
CL2014000384A1 (es) Compuestos fungicidas de 1-(2-(2-halo-4-(4-halogen-fenoxi)-fenil)-2-alcoxi-2-alquinil/alquenil-etil)-1h-(1,2,4) triazol sustituidos; proceso para preparar dichos compuestos; composiciones agroquímicas.
PH12020500091A1 (en) Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7] annulene-2-carboxylic acid and its use for the treatment of cancer
CL2009000906A1 (es) Compuestos derivados de 4-imidazolil y 4-triazolil de 2-(6-(4-cicloalquilpiperazin-1-il)pirimidin-4-il)-1h-pirazol-3(2h)ona inhibidores de hif-prolil-4-hidroxilasas; procedimiento de preparacion; composicion farmaceutica; y uso del compuesto en el tratamiento de enfermedades cardiovasculares, renales y hematologicas.
PH12020550473A1 (en) Prodrugs of substituted triazole derivatives and uses thereof
MX2017010299A (es) Terapia de combinacion de inhibidores de la proteina de choque termico 90 (hsp90) e inhibidores de muerte programada 1(pd-1) para tratar cancer.
BR112017009282A2 (pt) misturas fungicidas, composição pesticida, métodos para controlar pragas fitopatogênicas, para melhorar a fitossanidade e para proteção de material de propagação de plantas contra pragas, e, material de propagação de plantas.
MX2019014836A (es) Formulaciones estabilizadas que contienen protioconazol con bajo contenido de 2-(1-clorociclopropanil)-1-(2-clorofenil)-3-(1h-1,2,4 -triazol-1-il)propan-2-ol.
JOP20170103A1 (ar) عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
MA46137B2 (fr) Composés fongicides et mélanges de régulation des champignons dans les céréales
WO2007013096A8 (en) Improved process for the preparation of 2r, 3s-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol (voriconazole)
MX2017008077A (es) Composiciones de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h-indazol-5- il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il)fenil)-3,6-dihidrop iridin-1(2h)-il)-2-oxoetil)-3-(metiltio)pirrolidin-3-carboxamida para preparaciones farmaceuticas.
EP3233079A4 (en) (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations
NZ748056B2 (en) Polymorphs of n-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1 -({4-[2-oxopyridin-1 -yl)methyl]phenyl} methyl) pyrazole -4-carboxamide as kallikrein inhibitors
PL406149A1 (pl) Pochodne 4-amino-3, 5-dimetylo-4H-1, 2,4-triazoli, sposób ich otrzymywania, środek farmaceutyczny zawierający te związki oraz ich zastosowanie