MA50438B1 - Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ci - Google Patents

Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ci

Info

Publication number
MA50438B1
MA50438B1 MA50438A MA50438A MA50438B1 MA 50438 B1 MA50438 B1 MA 50438B1 MA 50438 A MA50438 A MA 50438A MA 50438 A MA50438 A MA 50438A MA 50438 B1 MA50438 B1 MA 50438B1
Authority
MA
Morocco
Prior art keywords
prodrugs
triazol
carboxamide
trifluoro
chlorophenyl
Prior art date
Application number
MA50438A
Other languages
English (en)
Other versions
MA50438A (fr
Inventor
Klemens Lustig
Hanna Tinel
Ursula Krenz
Pierre Wasnaire
Axel Kretschmer
Carsten Schmeck
Peter Kolkhof
Thomas Mondritzki
Elisabeth Pook
Heiko Schirmer
Matthias Wittwer
Thomas Neubauer
Hana Cernecka
Anja Buchmueller
Marie-Pierre Collin-Kroepelin
Chantal Fuerstner
Karoline Droebner
Robert Fricke
Guillaume Levilain
Norbert Witowski
Original Assignee
Bayer Pharma AG
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer Ag filed Critical Bayer Pharma AG
Publication of MA50438A publication Critical patent/MA50438A/fr
Publication of MA50438B1 publication Critical patent/MA50438B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des promédicaments de 3-({3-(4-chlorophényl)-5-oxo-4-[(2s)-3,3,3-trifluoro- 2-hydroxypropyl] -4,5-dihydro- 1h-1,2,4-triazol-1-yl jméthyl)-1- [3-(trifluorométhyl)-pyridin-2-yl] - 1h-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophényl)-5-oxo-4-[(2s)-3,3,3-trifluoro-2- hydroxypropyl] -4,5-dihydro- 1h-1,2,4-triazol-1-yl} méthyl)-1- [2-(trifluorométhyl)-phényl] -1h- 1,2,4-triazole-5-carboxamide et 3-({3-(4-chlorophényl)-5-oxo-4-[(2s)-3,3,3-trifluoro-2- hydroxypropyl] -4,5-dihydro-1h-1,2,4-triazol-1-yl} méthyl)-1-(3-chloropyridin-2-yl)-1h-1,2,4- triazole-5-carboxamide, des procédés pour la préparation de tels composés, des compositions pharmaceutiques contenant de tels composés, et l'utilisation de tels composés ou compositions pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de maladies rénales et cardiovasculaires.
MA50438A 2017-10-24 2018-10-17 Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ci MA50438B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17197935 2017-10-24
PCT/EP2018/078364 WO2019081292A1 (fr) 2017-10-24 2018-10-17 Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ci

Publications (2)

Publication Number Publication Date
MA50438A MA50438A (fr) 2020-09-02
MA50438B1 true MA50438B1 (fr) 2022-03-31

Family

ID=60162099

Family Applications (1)

Application Number Title Priority Date Filing Date
MA50438A MA50438B1 (fr) 2017-10-24 2018-10-17 Promédicaments de dérivés de triazole substitués, et utilisations de ceux-ci

Country Status (38)

Country Link
US (1) US11298367B2 (fr)
EP (1) EP3700913B1 (fr)
JP (1) JP2021500365A (fr)
KR (1) KR20200069361A (fr)
CN (1) CN111225921A (fr)
AR (1) AR113791A1 (fr)
AU (1) AU2018356352A1 (fr)
BR (1) BR112020007983A2 (fr)
CA (1) CA3079767A1 (fr)
CL (1) CL2020001076A1 (fr)
CO (1) CO2020004945A2 (fr)
CR (1) CR20200176A (fr)
CU (1) CU24604B1 (fr)
CY (1) CY1124938T1 (fr)
DK (1) DK3700913T3 (fr)
DO (1) DOP2020000076A (fr)
EA (1) EA202091025A1 (fr)
EC (1) ECSP20023056A (fr)
ES (1) ES2906305T3 (fr)
HR (1) HRP20220060T1 (fr)
HU (1) HUE057278T2 (fr)
IL (1) IL273949A (fr)
JO (1) JOP20200099A1 (fr)
LT (1) LT3700913T (fr)
MA (1) MA50438B1 (fr)
MX (1) MX2020004191A (fr)
NI (1) NI202000030A (fr)
PE (1) PE20210394A1 (fr)
PH (1) PH12020550473A1 (fr)
PL (1) PL3700913T3 (fr)
PT (1) PT3700913T (fr)
RS (1) RS62984B1 (fr)
SG (1) SG11202003049WA (fr)
SI (1) SI3700913T1 (fr)
TW (1) TW201932117A (fr)
UA (1) UA126456C2 (fr)
UY (1) UY37948A (fr)
WO (1) WO2019081292A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021259852A1 (fr) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Procédé de préparation de dérivés de 5-(alcoxycarbonyle)-et de 5- (carboxamide)-1-aryl-1,2,4-triazole
WO2022112213A1 (fr) 2020-11-30 2022-06-02 Bayer Aktiengesellschaft Formes cristallines de 3-[[3-(4-chlorophényl)-5-oxo-4-((2s)-3,3,3-trifluoro-2-hydroxypropyl)-4,5-dihydro-1h-1,2,4-triazol-1-yl]méthyl]-1-[3- (trifluorométhyl)pyridin-2-yl]-1h-1,2,4-triazole-5-carboxamide

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966781A (en) 1970-12-17 1976-06-29 Merck Sharp & Dohme (I.A.) Corporation Deuteration of functional group-containing hydrocarbons
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
AP2331A (en) 2003-12-22 2011-12-05 Pfizer Triazole derivatives as vasopressin antagonists.
US20070225333A1 (en) 2004-04-28 2007-09-27 Bryans Justin S 3-Heterocyclyl-4-Phenyl-Triazole Derivatives as Inhibitors of the Vasopressin Via Receptor
WO2009061271A1 (fr) * 2007-11-06 2009-05-14 Astrazeneca Ab Certains dérivés de 2-pyrazinone et leur utilisation comme inhibiteurs d'élastase des neutrophiles
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
AR076542A1 (es) * 2009-05-22 2011-06-22 Merck Sharp & Dohme Antagonistas del receptor de orexina de isonicotinamida
ES2635340T3 (es) 2010-02-27 2017-10-03 Bayer Intellectual Property Gmbh Ariltriazolonas ligadas a bis-arilo y su uso
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
EP2590979A1 (fr) 2010-07-09 2013-05-15 Bayer Intellectual Property GmbH Pyrimidines et triazines annelées et leur utilisation pour traiter ou prévenir des affections du système cardio-vasculaire
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
EP2675440B1 (fr) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Inhibiteurs de cystéine protéases, les cathepsines
BR112016007643B1 (pt) * 2013-10-16 2021-03-23 Bayer Cropscience Aktiengesellschaft Composições fungicidas com derivado de carboxamida e composto fungicida, seus processos de produção, seus usos e método para o controle de fungos nocivos fitopatogênicos
US20170313665A1 (en) 2014-11-03 2017-11-02 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
UY36571A (es) * 2015-03-05 2016-09-30 Bayer Cropscience Ag Combinaciones de compuestos activos
US9988367B2 (en) 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
EP3452457B1 (fr) 2016-05-03 2020-03-18 Bayer Pharma Aktiengesellschaft Dérivés de phényltriazole à substitution oxoalkyle et utilisations associées
WO2017191114A1 (fr) 2016-05-03 2017-11-09 Bayer Aktiengesellschaft Dérivés d'hétéroaryltriazole substitués par hydroxyalkyle et utilisations associées
EP3452469A1 (fr) 2016-05-03 2019-03-13 Bayer Pharma Aktiengesellschaft Dérivés d'aryltriazole à substitution fluoroalkyle et utilisations desdits dérivés
AR108265A1 (es) 2016-05-03 2018-08-01 Bayer Pharma AG Derivados de feniltriazol sustituidos con amida y usos de estos
WO2017191105A1 (fr) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Dérivés d'aryltriazole à substitution amide et leurs utilisations
US10927098B2 (en) 2016-10-20 2021-02-23 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted triazole derivatives and uses thereof

Also Published As

Publication number Publication date
DK3700913T3 (da) 2022-02-07
NI202000030A (es) 2020-10-09
CY1124938T1 (el) 2023-01-05
AR113791A1 (es) 2020-06-10
LT3700913T (lt) 2022-01-25
HRP20220060T1 (hr) 2022-04-15
EA202091025A1 (ru) 2020-07-30
US11298367B2 (en) 2022-04-12
JOP20200099A1 (ar) 2020-05-06
MA50438A (fr) 2020-09-02
PE20210394A1 (es) 2021-03-02
CU20200040A7 (es) 2021-03-11
PT3700913T (pt) 2022-01-31
PH12020550473A1 (en) 2021-03-08
BR112020007983A2 (pt) 2020-10-27
CL2020001076A1 (es) 2021-02-19
DOP2020000076A (es) 2020-08-31
IL273949A (en) 2020-05-31
US20200338096A1 (en) 2020-10-29
EP3700913B1 (fr) 2021-11-10
ECSP20023056A (es) 2020-12-31
HUE057278T2 (hu) 2022-04-28
AU2018356352A1 (en) 2020-04-16
UY37948A (es) 2019-05-31
CO2020004945A2 (es) 2020-05-05
MX2020004191A (es) 2020-08-03
KR20200069361A (ko) 2020-06-16
CN111225921A (zh) 2020-06-02
SG11202003049WA (en) 2020-04-29
CU24604B1 (es) 2022-06-06
EP3700913A1 (fr) 2020-09-02
CA3079767A1 (fr) 2019-05-02
TW201932117A (zh) 2019-08-16
ES2906305T3 (es) 2022-04-18
PL3700913T3 (pl) 2022-02-21
WO2019081292A1 (fr) 2019-05-02
UA126456C2 (uk) 2022-10-05
RS62984B1 (sr) 2022-03-31
CR20200176A (es) 2020-07-24
SI3700913T1 (sl) 2022-02-28
JP2021500365A (ja) 2021-01-07

Similar Documents

Publication Publication Date Title
MA44851B1 (fr) Dérivés pyridinyltriazole substitués par des groupements amides et leurs utilisations
MA47368B1 (fr) N-[4-fluoro-5-[[(2s,4s)-2-méthyl-4-[(5-méthyl-1,2,4-oxadiazol-3-yl)méthoxy]-1-pipéridyl]méthyl]thiazol-2-yl]acétamide utilisés en tant qu'inhibiteur d'oga
MA49952B1 (fr) Dérivés de 3-(1-oxoisoindolin-2-yl)pipéridine-2,6-dione et leurs utilisations
MA31683B1 (fr) Composes et procedes pour moduler fxr
MA49673B1 (fr) Combinaison comprenant du palbociclib et 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulène-2-acide carboxylique et sa utilisation pour le traitement du cancer
MA45020B1 (fr) Dérivés sulfonamides aromatiques
KR910021398A (ko) 트리아졸 항진균제
TNSN04164A1 (fr) Inhibiteurs de acc.
NZ595035A (en) Substituted diazole and triazole compounds and compositions and methods of use
MA30351B1 (fr) Composes de tetrahydropyridothienopyrimidine et leurs procedes d'utilisation
MA29816B1 (fr) Composes de benzimidazole thiophene
MA29377B1 (fr) Derives de la pyrimidine pour traitement de troubles a caractere hyperproliferatif
MA30629B1 (fr) Derives de pyrazole servant d'inhibiteurs du cytochrome p450
MA56038B1 (fr) Inhibiteurs à petite molécule de kinase induisant nf-kb
MA30166B1 (fr) Imidazoles substitues et leur utilisation comme pesticides.
MA46101A (fr) Modulateurs allostériques positifs du récepteur muscarinique m1
MA38358B1 (fr) Formulations de composés organiques
MA46076A1 (fr) Composés fongicides et mélanges de régulation des champignons dans les céréales
MA38425A1 (fr) Composés bicycliques pour une utilisation comme agonistes selectifs pour le recepteur s1p1
MA31863B1 (fr) Dérivés de pyrazole comme inhibiteurs de 5-lo
PH12020550473A1 (en) Prodrugs of substituted triazole derivatives and uses thereof
FR3089117B1 (fr) Compositions cosmétiques déodorantes anhydres comprenant du carbonate de calcium
MA46077A1 (fr) Composés et mélanges fongicides pour la lutte contre les maladies fongiques dans des céréales
MA44965A (fr) Dérivés de pyridinyle, compositions pharmaceutiques et utilisations de ceux-ci en tant qu'inhibiteurs d'aoc3
MA56441B1 (fr) Carboxamides de thiophène substitués et leurs dérivés comme microbicides