JP2003201210A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a stabilized cosmetic comprising collagen derived from a fish and formulated therein, for further detail, having off-flavor preventing effects during formulation. <P>SOLUTION: This cosmetic comprises the collagen derived from the fish and an ultraviolet light absorber, especially oxybenzone. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to the stabilization of cosmetics containing fish-derived collagen, and more particularly to the effect of preventing off-flavors in preparations.

[0002]

BACKGROUND OF THE INVENTION Collagen is generally a raw material commonly used as a moisturizing agent in cosmetics for the purpose of preventing and improving aging such as wrinkles and for keeping skin moisturized. . Among them, fish-derived collagen is collagen extracted and purified from fish, and it is said that collagen having a lower denaturation temperature as a protein is more effective in improving wrinkles and maintaining skin moisture than collagen of mammals.

However, this fish-derived collagen contains a very small amount of fish oil, which cannot be removed in the extraction and purification step, and thus has a drawback that when it is incorporated into a cosmetic composition, an offensive odor is generated under the influence of temperature.

Therefore, it has been desired to develop a technique for blending fish-derived collagen with no offensive odor.

[0005]

Means for Solving the Problems As a result of diligent efforts in view of such circumstances, the present inventors have found that a cosmetic containing a specific component described below has an action of preventing the offensive odor of fish-derived collagen. The present invention has been completed.

[0006] That is, the present invention provides a cosmetic characterized by containing fish-derived collagen and an ultraviolet absorber, and particularly a cosmetic characterized by containing oxybenzone among the ultraviolet absorbers. is there.

[0007] In general, an ultraviolet absorber is used for absorbing ultraviolet rays to stabilize the preparation, but its stability with respect to temperature has not been known.

As a result of intensive studies in view of the above circumstances, it was revealed that the inclusion of fish-derived collagen and an ultraviolet absorber finds not only the stability of ultraviolet rays but also the stability against temperature.

The ultraviolet absorber used in the present invention is not particularly limited, but preferred examples include oxybenzone, p-aminobenzoic acid, cinoxate, urocanic acid, and derivatives thereof.

Of these, oxybenzone was found to be the most effective of the above-mentioned ultraviolet absorbers by the inventors' search.

The ultraviolet absorber used in the present invention may be a natural product or a chemically synthesized product.
The manufacturing method is not particularly limited. A commercially available product can be used as the ultraviolet absorber.

The amount of the ultraviolet absorber incorporated into the cosmetic of the present invention is not particularly limited, but is 0.005 to 5% by weight (hereinafter, simply referred to as "%"), preferably 0.05 to 3%. It is desirable because it has a sufficient effect of preventing offensive odors and has excellent storage stability and usability.

One or more of the above-mentioned ultraviolet absorbers are blended in the cosmetic of the present invention.

Examples of fish-derived collagen used in the present invention include those shown below. As the fish, for example, the solubilized collagen component was extracted through washing, degreasing, acid filtration, enzyme treatment, salting-out, dialysis, heat treatment, etc. of skins such as salmon, goldfish, codfish, flounder and the like. After that, what can be obtained is mentioned. These are generally commercially available as a fish-derived collagen aqueous solution. It does not need to be an atherogenic treatment or a hydrolysis treatment.

The solution may be used as it is, and if necessary,
It may be used after being subjected to treatments such as concentration, dilution and filtration, and decolorization and deodorization with activated carbon or the like. Furthermore, the extracted solution may be concentrated to dryness, spray-dried, freeze-dried and the like and used as a dried product.

The amount of fish-derived collagen used in the present invention is not particularly limited, but is preferably 0.0001% in terms of solid content based on the total amount of the cosmetic of the present invention.
The above is preferable, and 0.0005 to 50% is more preferable. If it is less than 0.0001%, it is difficult to exert a sufficient effect. When it is blended over 50%, the enhancement of the effect is small and it is uneconomical. Regarding the method of addition, it may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

In the cosmetic of the present invention, if necessary,
In addition to the above components, various components usually used in cosmetics, quasi drugs, pharmaceuticals and the like can be appropriately blended as needed, as long as the effects of the present invention are not impaired. Examples of such components include purified water, ethanol, oily substances, moisturizers, thickeners, preservatives, emulsifiers, medicinal components, powders, dyes, fragrances, emulsion stabilizers, pH adjusters and the like. .

The cosmetics of the present invention can be used in both cosmetics and quasi-drugs, and examples of their dosage forms include lotion, cream, emulsion, gel, aerosol, essence, pack, Examples include cleaning agents, bath agents, foundations, dusting powders, lipsticks and the like.

[0019]

EXAMPLES In order to explain the present invention in detail, production examples of the extract used in the present invention, prescription examples of the present invention and experimental examples will be given below, but the present invention is not limited thereto. Absent.

Production Example 1 Acid-Soluble Atherosclerotic Fish-Derived Collagen Solution Salmon skin is washed, defatted, acid-treated, filtered, salted out and dialyzed to obtain an acid-soluble collagen solution. For example, an “acid-soluble atelo-ized marine collagen solution” (Ibara Suisan Co., Ltd., dry residue 1%) can be mentioned.

Production Example 2 Water-Soluble Fish-Derived Collagen Solution An acid-soluble collagen solution is obtained by washing, degreasing, acid-treating, filtering, salting-out and dialysis the goldfish snapper skin. For example, "water-soluble marine collagen solution" (Technoble, dry residue 0.3%) can be mentioned.

Example 1 Cream Formulation Amount 1. Oxybenzone 0.05 part 2. Acid-soluble atherinated marine collagen solution (Ihara Suisan) 30.0 3. Squalane 5.5 4. Olive oil 3.0 5. Stearic acid 2.0 6. Beeswax 2.0 7. Octyldodecyl myristate 3.5 8. Polyoxyethylene cetyl ether (20 EO) 3.0 9. Behenyl alcohol 1.5 10. Glycerin monostearate 2.5 11. Fragrance 0.1 12.1, 3-butylene glycol 8.5 13. Ethyl paraoxybenzoate 0.05 14. Methyl paraoxybenzoate 0.2 15. [Manufacturing method] The total amount is 100 with purified water Components 1 and 3 to 10 are dissolved by heating and mixed, and the mixture is kept at 70 ° C to obtain an oil phase. Ingredients 2 and 12 to 15 are dissolved by heating and mixed, and the mixture is kept at 75 ° C to form an aqueous phase. Add the water phase to the oil phase to emulsify and cool with stirring to 45 ° C.
Ingredient 11 is added and the product is further cooled to 30 ° C.

Example 2 Lotion Formulation Amount 1. Oxybenzone 0.1 part 2. Acid-soluble atherosclerosis marine collagen solution (made by Ihara Suisan) 0.05 3.1, 3-butylene glycol 8.0 4. Glycerin 2.0 5. Xanthan gum 0.02 6. Citric acid 0.01 7. Sodium citrate 0.1 8. Ethanol 5.0 9. Methyl paraoxybenzoate 0.1 10. Polyoxyethylene hydrogenated castor oil (40 EO) 0.1 11. Perfume proper amount 12. [Production method] components 2 to 7 and 12 and components 1 and 8 to 1 in which the total amount is 100 with purified water
1 is uniformly dissolved, and both are mixed and filtered to obtain a product.

Example 3 Emulsion formulation Compounding amount 1. Oxybenzone 0.5 part 2. Acid-soluble atherinated marine collagen solution (Ihara Suisan) 1.0 3. Squalane 5.0 4. Olive oil 5.0 5. Jojoba oil 5.0 6. Cetanol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene cetyl ether (20 EO) 3.0 9. Polyoxyethylene sorbitan monooleate (20 EO) 2.0 10. Perfume 0.1 11. Propylene glycol 1.0 12. Glycerin 2.0 13. Methyl paraoxybenzoate 0.2 14. [Manufacturing method] The total amount is 100 with purified water. Components 1 and 3 to 9 are heated and dissolved and mixed,
Keep at 70 ° C to make an oil phase. Ingredients 2 and 11-14 are heated and dissolved, mixed, and kept at 75 ° C to form an aqueous phase. The water phase is added to the oil phase to emulsify, and the mixture is cooled with stirring, component 10 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.

Example 4 Gel formulation Formulation amount 1. Oxybenzone 0.1 part 2. Acid-soluble atherinated marine collagen solution (Ibara Suisan) 20.0 3. Ethanol 5.0 4. Methyl paraoxybenzoate 0.1 5. Polyoxyethylene hydrogenated castor oil (20EO) 0.1 6. Fragrance suitable amount 7.1,3-butylene glycol 5.0 8. Glycerin 5.0 9. Xanthan gum 0.1 10. Potassium hydroxide 0.2 11. [Production method] components 2 and 7 to 11 and components 1 and 3 to 6 whose total amount is 100 with purified water
Are uniformly dissolved, and both are mixed to obtain a product.

[0026]   Example 5 Pack Prescription amount 1. Oxybenzone 0.2 parts 2. Water-soluble marine collagen solution (Technoble) 10.0 3. Polyvinyl alcohol 12.0 4. Ethanol 5.0 5.1,3-butylene glycol 8.0 6. Methyl paraoxybenzoate 0.2 7. Polyoxyethylene hydrogenated castor oil (20EO) 0.5 8. Citric acid 0.1 9. Sodium citrate 0.3 10. Fragrance suitable amount 11. Adjust the total volume to 100 with purified water [Production method] Components 1 to 11 are uniformly dissolved to obtain a product.

Example 6 Foundation Formulation Amount 1. Oxybenzone 0.5 part 2. Acid-soluble atherinated marine collagen solution (Ihara Suisan) 0.01 3. Stearic acid 2.4 4. Polyoxyethylene sorbitan monostearate (20EO) 1.0 5. Polyoxyethylene cetyl ether (20 EO) 2.0 6. Cetanol 1.0 7. Liquid lanolin 2.0 8. Liquid paraffin 3.0 9. Isopropyl myristate 6.5 10. Butyl paraoxybenzoate 0.1 11. Carboxymethyl cellulose sodium 0.1 12. Propylene glycol 4.0 13. Triethanolamine 1.1 14. Methyl paraoxybenzoate 0.2 15. Titanium dioxide 8.0 16. Talc 4.0 17. Red iron oxide 1.0 18. Yellow iron oxide 2.0 19. Perfume appropriate amount 20. [Manufacturing method] The total amount is 100 with purified water. Components 1 and 3 to 10 are dissolved by heating, and the temperature is 80 ° C.
Keep it in the oil phase. Ingredient 20 is well swelled with ingredient 11, and subsequently ingredients 2 and 12-14 are added and mixed uniformly. Components 15 to 18 crushed and mixed with a crusher are added to this, and the mixture is stirred with a homomixer and kept at 75 ° C to form an aqueous phase. Add the oil phase to this water phase while stirring and cool.
Ingredient 19 is added at 5 ° C, and the product is cooled to 30 ° C with stirring.

[0028]   Example 7 Bath agent Prescription amount 1. Oxybenzone 1 part 2. Freeze-dried water-soluble marine collagen solution (Technoble) 5 3. Sodium hydrogen carbonate 50 4. Yellow No. 202 (1) Suitable amount 5. Fragrance suitable amount 6. Adjust the total amount to 100 with anhydrous sodium sulfate [Production method] Components 1 to 6 are uniformly mixed to obtain a product.

Next, in order to explain the effects of the present invention in detail, experimental examples will be given.

Comparative Example 1 Comparative Cream 1 Comparative Example 1 was prepared by replacing oxybenzone in Example 1 with p-aminobenzoic acid.

Comparative Example 2 Comparative Cream 2 Comparative Example 2 was prepared by replacing oxybenzone with sinoxate in Example 1.

Comparative Example 3 Comparative Cream 3 Comparative Example 3 was prepared by replacing oxybenzone in Example 1 with urocanic acid.

COMPARATIVE EXAMPLE 4 Conventional Cream A conventional cream was prepared by replacing oxybenzone in Example 1 with purified water.

Experimental Example 1 Offensive Odor Prevention Test 1 The cream of Example 1 had an oxybenzone concentration of 0 to 5%.
A test for the effect of preventing offensive odor was conducted using the cream replaced with. That is, all the creams were kept in a thermostatic chamber at 40 ° C. for 3 months, and after being kept, the smell of the cream was changed by 20 women (25
~ 40 years old). As a result, as shown in Table 1, no offensive odor-preventing effect was observed in the products containing no oxybenzone, and a slight effect was observed in the products containing 0.005%.
A sufficient effect was obtained at 0.05% or more. However, as a result of observing changes in the cream, the 5% blended product had a good effect of preventing offensive odor, but some crystallization of oxybenzone was observed in the refrigeration test, so that it was not in a preferable state. Others were good. From these facts, it was found that the blending amount of oxybenzone is more preferably 0.05% to 3%.

[0035]

[Table 1] Table 1. Odor prevention test results

Experimental Example 2 Odor Prevention Test 2 Using the cream of Example 1 and Comparative Cream 1 of Comparative Example 1, Comparative Cream 2 of Comparative Example 2, Comparative Cream 3 of Comparative Example 3 and the conventional cream of Comparative Example 4 A test for the effect of preventing offensive odor was conducted. That is, all the creams were kept in a thermostatic chamber at 40 ° C. for 2 weeks, and the smell of the cream was confirmed by 20 women (25 to 40 years old) after the holding. As a result, as shown in Table 2, the cream containing the ultraviolet absorber showed a superior effect to the conventional cream, and the cream of Example 1 showed the best effect. From these things, the ultraviolet absorber prevents the offensive odor of the fish-derived acid-soluble atelocollagen collagen solution,
Above all, it was revealed that oxybenzone has a high effect, and that the addition of an ultraviolet absorber exhibits an excellent offensive odor prevention effect. The cosmetics of Examples 2 to 7 were also subjected to the same test, and good results were obtained.

[0037]

[Table 2] Table 2. Odor prevention test results

[0038]

From the above, the present invention showed an excellent effect of preventing off-flavor by containing fish-derived collagen and an ultraviolet absorber, particularly by containing oxybenzone.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 U 7/021 7/021 7/48 7/48 7/50 7/50 (72) Inventor Satoru Nakata 2-7 Torimicho, Nishi-ku, Nagoya-shi F-term in the Research Institute of Japan Menard Cosmetics Co., Ltd. (reference) 4C083 AA071 AA072 AA082 AA122 AB032 AB232 AB242 AB312 AB432 AC022 AC072 AC102 AC122 AC172 AC182 AC242 AC302 AC341 AC352 AC422 AC432 AC432 AC442 AC482 AC542 AC551 AC552 AC842 AC851 AD112 AD272 AD352 AD431 AD432 AD471 AD472 AD512 CC04 CC05 CC07 CC12 CC25 DD23 DD31 DD41 EE01 EE06

Claims (6)

[Claims] 1. A cosmetic comprising collagen derived from fish and an ultraviolet absorber. 2. The cosmetic composition according to claim 1, wherein the ultraviolet absorber is oxybenzone, p-aminobenzoic acid, sinoxate, urocanic acid, or a derivative thereof. 3. The cosmetic according to claim 1, wherein the ultraviolet absorber is oxybenzone. 4. A collagen content of 0.0 as a solid content.
001-50%, and the compounding quantity of an absorber is 0.005-5%, The cosmetics of Claims 1-3 characterized by the above-mentioned. 5. The cosmetic material according to claim 1, wherein the collagen is atelolated collagen or water-soluble collagen. 6. The cosmetic material according to claim 5, wherein the collagen is atelolated collagen.