JP2003511652A - 位置特異性配列を有する結合パートナーの特定方法 - Google Patents

位置特異性配列を有する結合パートナーの特定方法

Info

Publication number
JP2003511652A
JP2003511652A JP2001522083A JP2001522083A JP2003511652A JP 2003511652 A JP2003511652 A JP 2003511652A JP 2001522083 A JP2001522083 A JP 2001522083A JP 2001522083 A JP2001522083 A JP 2001522083A JP 2003511652 A JP2003511652 A JP 2003511652A
Authority
JP
Japan
Prior art keywords
sequence
peptide
protein
mass spectrometry
cell lysate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001522083A
Other languages
English (en)
Japanese (ja)
Inventor
クラウゼ,エーベルハルト
ブリットルフ,トーマス
シュナイダー−メルゲネール,イェン
Original Assignee
エリーニ アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エリーニ アーゲー filed Critical エリーニ アーゲー
Publication of JP2003511652A publication Critical patent/JP2003511652A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2001522083A 1999-09-03 2000-09-01 位置特異性配列を有する結合パートナーの特定方法 Pending JP2003511652A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19943743.2 1999-09-03
DE19943743A DE19943743C2 (de) 1999-09-03 1999-09-03 Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
PCT/DE2000/003071 WO2001018545A2 (de) 1999-09-03 2000-09-01 Verfahren zur identifizierung von bindungspartnern mit positions-spezifischen arrays

Publications (1)

Publication Number Publication Date
JP2003511652A true JP2003511652A (ja) 2003-03-25

Family

ID=7921806

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001522083A Pending JP2003511652A (ja) 1999-09-03 2000-09-01 位置特異性配列を有する結合パートナーの特定方法

Country Status (9)

Country Link
EP (1) EP1212622A2 (de)
JP (1) JP2003511652A (de)
AU (1) AU7644200A (de)
CA (1) CA2386607A1 (de)
CZ (1) CZ2002660A3 (de)
DE (2) DE19943743C2 (de)
HU (1) HUP0203074A2 (de)
PL (1) PL353995A1 (de)
WO (1) WO2001018545A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141464A1 (de) * 2001-08-23 2004-03-04 Genprofile Ag I.Ins. Sequenzvarianten des für neuropsychiatrische Krankheiten verantwortlichen Gens 22444 und deren Verwendung
EP1319954A1 (de) * 2001-12-12 2003-06-18 Centre National de Genotypage Verfahren zur Proteinanalyse durch Protein bindende Arrays
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
CN1665790A (zh) 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 用于检测和分离磷酸化分子的组合物及方法
US7445894B2 (en) 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US7469076B2 (en) 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
EP1613737A4 (de) 2003-03-28 2008-12-03 Receptors Llc Reversibel immobilisierte bausteine beinhaltend künstliche rezeptoren und verfahren
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US7884052B2 (en) 2004-09-03 2011-02-08 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
EP1789792A2 (de) 2004-09-11 2007-05-30 Receptors LLC Kombinatorische künstliche rezeptoren mit peptidbausteinen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027675C2 (de) * 1990-08-31 1997-05-07 Biotechnolog Forschung Gmbh Verfahren zur parallelen Herstellung von trägergebundenen oder freien Peptiden, trägergebundene Peptide und ihre Verwendung
CA2095633C (en) * 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
US5834318A (en) * 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
WO1997043301A2 (en) * 1996-05-10 1997-11-20 Novartis Ag Identification of members of combinatorial libraries by mass spectrometry
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
GB9800378D0 (en) * 1998-01-08 1998-03-04 Univ Liverpool Proteome analysis

Also Published As

Publication number Publication date
WO2001018545A2 (de) 2001-03-15
AU7644200A (en) 2001-04-10
DE19943743A1 (de) 2001-03-15
EP1212622A2 (de) 2002-06-12
DE19943743C2 (de) 2002-02-07
WO2001018545A3 (de) 2001-09-13
DE10082703D2 (de) 2002-02-14
CZ2002660A3 (cs) 2002-10-16
CA2386607A1 (en) 2001-03-15
PL353995A1 (en) 2003-12-15
HUP0203074A2 (hu) 2002-12-28

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