JP2004504268A - トコフェロール、トコトリエノール、その他のクロマン、及びそれらの側鎖誘導体とその利用法 - Google Patents

トコフェロール、トコトリエノール、その他のクロマン、及びそれらの側鎖誘導体とその利用法 Download PDF

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Publication number: JP2004504268A
Authority: JP; Japan
Prior art keywords: yloxy; chroman; acetic acid; tetramethyl; trimethyltridecyl
Prior art date: 2000-02-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

JP2001558439A

Other languages

English (en)

Japanese (ja)

Inventor

サンダース，ロバート　ジィ．

クリーン，キンバリィ

ハーレイ，ローレンス

ガードナー，ロブ

メンシャカ，マーラ

ユー，ウエイピング

ラマナン，プュチュコード　エヌ．

リュー，シェンクアン

イスラエル，カレン

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Research Development Foundation

Original Assignee

Research Development Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-11

Filing date

2001-02-09

Publication date

2004-02-12

2000-02-11 Priority claimed from US09/502,592 external-priority patent/US6770672B1/en

2001-02-09 Application filed by Research Development Foundation filed Critical Research Development Foundation

2004-02-12 Publication of JP2004504268A publication Critical patent/JP2004504268A/ja

Status Ceased legal-status Critical Current

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Classifications

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- C—CHEMISTRY; METALLURGY
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
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Public Health (AREA)
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Oncology (AREA)
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Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
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AIDS & HIV (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
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Neurosurgery (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Quinoline Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP2001558439A 2000-02-11 2001-02-09 トコフェロール、トコトリエノール、その他のクロマン、及びそれらの側鎖誘導体とその利用法 Ceased JP2004504268A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/502,592 US6770672B1 (en)	1998-09-23	2000-02-11	Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
PCT/US2001/004168 WO2001058889A1 (fr)	2000-02-11	2001-02-09	Tocopherols, tocotrienols, autres derives a chaines chromane et laterales et utilisations de ces derniers

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JP2004504268A true JP2004504268A (ja)	2004-02-12

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Country Status (14)

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US (2)	US7312232B2 (fr)
EP (1)	EP1254130B1 (fr)
JP (1)	JP2004504268A (fr)
KR (1)	KR100847678B1 (fr)
CN (1)	CN1243000C (fr)
AT (1)	ATE382615T1 (fr)
AU (2)	AU3680501A (fr)
CA (1)	CA2399802C (fr)
DE (1)	DE60132171D1 (fr)
IL (2)	IL151108A0 (fr)
NZ (1)	NZ520798A (fr)
RU (1)	RU2263672C2 (fr)
WO (1)	WO2001058889A1 (fr)
ZA (1)	ZA200206243B (fr)

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* Cited by examiner, † Cited by third party
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JP2012523458A (ja) *	2009-04-13	2012-10-04	ザオハイオステートユニバーシティーリサーチファウンデーション	タンパク質ホスファターゼ２ａ活性化剤
JP2016532714A (ja) *	2013-09-06	2016-10-20	リサーチディベロップメントファウンデーション	アルファ−ｔｅａ塩形態：疾患を処置するための組成物および使用

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US6703384B2 (en)	1998-09-23	2004-03-09	Research Development Foundation	Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
RU2263672C2 (ru)	2000-02-11	2005-11-10	Рисерч Дивелопмент Фаундейшн	Токоферолы, токотриенолы, другие хроманы и производные по боковым цепям и их применение
AUPR549901A0 (en)	2001-06-06	2001-07-12	Vital Health Sciences Pty Ltd	Topical formulation containing tocopheryl phosphates
DE60140141D1 (de) *	2000-11-14	2009-11-19	Vital Health Sciences Pty Ltd	Zusammensetzungen umfassend Komplexe von Tocopherolphosphatderivaten
BR0211673A (pt) *	2001-07-27	2004-07-13	Vital Health Sciences Pty Ltd	Terapia dermal utilizando derivados de fosfato de agentes de transferência de elétrons
ATE487456T1 (de) *	2001-12-13	2010-11-15	Vital Health Sciences Pty Ltd	Transdermaler transport von verbindungen
US20030236301A1 (en) *	2001-12-19	2003-12-25	Bob Sanders	Liposomal delivery of vitamin E based compounds
AU2002950713A0 (en)	2002-08-09	2002-09-12	Vital Health Sciences Pty Ltd	Carrier
EP1589964B1 (fr) *	2003-01-17	2011-11-23	Vital Health Sciences Pty Ltd.	Composes possedant des proprietes antiproliferatives
AU2003901815A0 (en) *	2003-04-15	2003-05-01	Vital Health Sciences Pty Ltd	Phosphate derivatives
GB0313612D0 (en)	2003-06-12	2003-07-16	Novartis Ag	Organic compounds
EP1664067A2 (fr) *	2003-09-15	2006-06-07	DSM IP Assets B.V.	NOUVEAU PROCEDE DE PRODUCTION D'ALKANOATES D'alpha-TOCOPHEROLE, D'alpha-TOCOPHERYLE ET PRECURSEURS ASSOCIES
JP4847437B2 (ja) *	2004-03-03	2011-12-28	バイタルヘルスサイエンシズプロプライアタリーリミティド	アルカロイド製剤
WO2006092024A1 (fr) *	2005-03-03	2006-09-08	Vital Health Sciences Pty Ltd	Composés ayant des propriétés anticancéreuses
US9168216B2 (en)	2005-06-17	2015-10-27	Vital Health Sciences Pty. Ltd.	Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
WO2007070981A1 (fr) *	2005-12-23	2007-06-28	Vital Health Sciences Pty Ltd	Composés ayant des propriétés modulatrices de la cytokine
WO2007098139A2 (fr) *	2006-02-21	2007-08-30	The Ohio State University Research Foundation	Agents anticancéreux
WO2007143081A2 (fr)	2006-06-02	2007-12-13	The Ohio State University Research Foundation	Agents thérapeutiques destinés au traitement de malignités lymphoïdes
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- 2001-02-09 RU RU2002124135/04A patent/RU2263672C2/ru not_active IP Right Cessation
- 2001-02-09 KR KR1020027010387A patent/KR100847678B1/ko not_active Expired - Fee Related
- 2001-02-09 AT AT01909008T patent/ATE382615T1/de not_active IP Right Cessation
- 2001-02-09 IL IL15110801A patent/IL151108A0/xx active IP Right Grant
- 2001-02-09 WO PCT/US2001/004168 patent/WO2001058889A1/fr not_active Ceased
- 2001-02-09 AU AU3680501A patent/AU3680501A/xx active Pending
- 2001-02-09 CN CNB018075363A patent/CN1243000C/zh not_active Expired - Fee Related
- 2001-02-09 AU AU2001236805A patent/AU2001236805B2/en not_active Ceased
- 2001-02-09 CA CA002399802A patent/CA2399802C/fr not_active Expired - Fee Related
- 2001-02-09 EP EP01909008A patent/EP1254130B1/fr not_active Expired - Lifetime
- 2001-02-09 NZ NZ520798A patent/NZ520798A/en not_active IP Right Cessation
- 2001-02-09 DE DE60132171T patent/DE60132171D1/de not_active Expired - Lifetime
- 2001-02-09 JP JP2001558439A patent/JP2004504268A/ja not_active Ceased
2002
- 2002-08-06 ZA ZA200206243A patent/ZA200206243B/xx unknown
- 2002-08-06 IL IL151108A patent/IL151108A/en not_active IP Right Cessation
2003
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2007
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DE60132171D1 (de)	2008-02-14
US20040235938A1 (en)	2004-11-25
RU2263672C2 (ru)	2005-11-10
IL151108A (en)	2006-08-01
EP1254130B1 (fr)	2008-01-02
CN1243000C (zh)	2006-02-22
CA2399802A1 (fr)	2001-08-16
KR100847678B1 (ko)	2008-07-23
EP1254130A4 (fr)	2003-04-23
ATE382615T1 (de)	2008-01-15
IL151108A0 (en)	2003-04-10
KR20030005186A (ko)	2003-01-17
ZA200206243B (en)	2009-10-28
AU3680501A (en)	2001-08-20
US7312232B2 (en)	2007-12-25
CN1529701A (zh)	2004-09-15
WO2001058889A1 (fr)	2001-08-16
US20080119514A1 (en)	2008-05-22
RU2002124135A (ru)	2004-01-10
US7608638B2 (en)	2009-10-27
NZ520798A (en)	2004-05-28
AU2001236805B2 (en)	2005-07-14
EP1254130A1 (fr)	2002-11-06
CA2399802C (fr)	2009-12-08

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Publication	Publication Date	Title
JP2004504268A (ja)	2004-02-12	トコフェロール、トコトリエノール、その他のクロマン、及びそれらの側鎖誘導体とその利用法
US6770672B1 (en)	2004-08-03	Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US7300954B2 (en)	2007-11-27	Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
EP1115398B1 (fr)	2010-05-05	Tocopherols, tocotrienols, autres derives de chromane et de chaines laterales et leurs utilisations
AU2001236805A1 (en)	2001-11-01	Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
EP0022317A1 (fr)	1981-01-14	Dérivés de l'oxo-2 benzothiazoline, de la benzoxazoline ou de l'indoline, leur préparation et compositions pharmaceutiques contenant de tels composés
US5420132A (en)	1995-05-30	Substituted benzodioxins
US5627204A (en)	1997-05-06	Chromone derivative, and aldose reductase inhibitor comprising said compound as active component

JP2004504268A - トコフェロール、トコトリエノール、その他のクロマン、及びそれらの側鎖誘導体とその利用法 - Google Patents

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