JP2011502994A5 - - Google Patents
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- JP2011502994A5 JP2011502994A5 JP2010532265A JP2010532265A JP2011502994A5 JP 2011502994 A5 JP2011502994 A5 JP 2011502994A5 JP 2010532265 A JP2010532265 A JP 2010532265A JP 2010532265 A JP2010532265 A JP 2010532265A JP 2011502994 A5 JP2011502994 A5 JP 2011502994A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- group
- halogen
- optionally
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 *C(*)(*)c1cc(*)cc(-c2c(*)cnc3c2c(*)n[n]3)c1 Chemical compound *C(*)(*)c1cc(*)cc(-c2c(*)cnc3c2c(*)n[n]3)c1 0.000 description 17
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98487507P | 2007-11-02 | 2007-11-02 | |
| US60/984,875 | 2007-11-02 | ||
| US4457508P | 2008-04-14 | 2008-04-14 | |
| US61/044,575 | 2008-04-14 | ||
| US10080808P | 2008-09-29 | 2008-09-29 | |
| US61/100,808 | 2008-09-29 | ||
| PCT/US2008/081933 WO2009073300A1 (en) | 2007-11-02 | 2008-10-31 | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011502994A JP2011502994A (ja) | 2011-01-27 |
| JP2011502994A5 true JP2011502994A5 (2) | 2012-12-13 |
| JP5444239B2 JP5444239B2 (ja) | 2014-03-19 |
Family
ID=40220120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532265A Expired - Fee Related JP5444239B2 (ja) | 2007-11-02 | 2008-10-31 | タンパク質キナーゼＣ−θとしての［１Ｈ−ピラゾロ［３，４−Ｂ］ピリジン−４−イル］−フェニレンまたは−ピリジン−２−イル誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8173635B2 (2) |
| EP (1) | EP2215089B1 (2) |
| JP (1) | JP5444239B2 (2) |
| KR (1) | KR20100093552A (2) |
| CN (1) | CN101903384A (2) |
| AR (1) | AR069174A1 (2) |
| AU (1) | AU2008331733A1 (2) |
| CA (1) | CA2704266A1 (2) |
| CL (1) | CL2008003280A1 (2) |
| ES (1) | ES2389992T3 (2) |
| IL (1) | IL205458A0 (2) |
| MX (1) | MX2010004819A (2) |
| NZ (1) | NZ585063A (2) |
| TW (1) | TW200924762A (2) |
| WO (1) | WO2009073300A1 (2) |
| ZA (1) | ZA201003050B (2) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3456189B2 (ja) | 2000-03-31 | 2003-10-14 | 日本電気株式会社 | 移動通信システム |
| UA95940C2 (uk) | 2006-01-17 | 2011-09-26 | Вертекс Фармасьютикалс Інкорпорейтед | Азаіндоли як інгібітори кіназ януса |
| CN101678022A (zh) | 2006-12-21 | 2010-03-24 | 弗特克斯药品有限公司 | 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物 |
| TW200924762A (en) | 2007-11-02 | 2009-06-16 | Vertex Pharma | Kinase inhibitors |
| JP2011513483A (ja) * | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| CA2732765A1 (en) | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
| SG174214A1 (en) | 2009-03-25 | 2011-10-28 | Abbott Lab | Antiviral compounds and uses thereof |
| CA2760705A1 (en) * | 2009-05-06 | 2010-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
| LT3141252T (lt) | 2009-06-17 | 2018-11-12 | Vertex Pharmaceuticals Inc. | Gripo virusų replikacijos inhibitoriai |
| EP2582702A1 (en) | 2010-01-27 | 2013-04-24 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
| JP5769733B2 (ja) * | 2010-01-27 | 2015-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ピラゾロピリジンキナーゼ阻害剤 |
| MX2012008642A (es) * | 2010-01-27 | 2012-11-23 | Vertex Pharma | Inhibidores de cinasas de pirazolopiridinas. |
| CA2787079A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
| CN102471342A (zh) * | 2010-05-05 | 2012-05-23 | 沃泰克斯药物股份有限公司 | 用作PKC-θ抑制剂的4取代的吡唑并吡啶类 |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| CN103562205A (zh) | 2010-12-16 | 2014-02-05 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
| CA2822059A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| EP2858984A1 (en) | 2012-06-08 | 2015-04-15 | Vertex Pharmaceuticals Inc. | Inhibitors of influenza viruses replication |
| US9523045B2 (en) | 2013-01-30 | 2016-12-20 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| LT3068776T (lt) | 2013-11-13 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Gripo virusų replikacijos inhibitoriai |
| JP6618901B2 (ja) | 2013-11-13 | 2019-12-11 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| US9556126B2 (en) | 2013-12-20 | 2017-01-31 | Signal Pharmaceuticals, Llc | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
| TW201613919A (en) | 2014-07-02 | 2016-04-16 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| EP3197450A1 (en) | 2014-09-22 | 2017-08-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of fibrosis |
| AU2016250539B2 (en) | 2015-04-22 | 2020-06-11 | Championx Usa Inc. | Development of a novel high temperature stable scavenger for removal of hydrogen sulfide |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| WO2017044248A1 (en) | 2015-09-08 | 2017-03-16 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US10407626B2 (en) | 2015-09-08 | 2019-09-10 | Ecolab Usa Inc. | Hydrocarbon soluble/dispersible hemiformals as hydrogen sulfide scavengers |
| EP3491106B1 (en) | 2016-07-29 | 2020-07-15 | Ecolab Usa Inc. | Antifouling and hydrogen sulfide scavenging compositions |
| CR20190119A (es) * | 2016-09-09 | 2019-06-03 | Novartis Ag | Compuestos y composiciones como inhibidores de los receptores endosomales tipo peaje |
| US10538710B2 (en) | 2017-07-13 | 2020-01-21 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| EP3914676A1 (en) | 2019-01-23 | 2021-12-01 | ChampionX USA Inc. | Complete removal of solids during hydrogen sulfide scavenging operations using a scavenger and a michael acceptor |
| CA3136348A1 (en) * | 2019-04-09 | 2020-10-15 | Nurix Therapeutics, Inc. | 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus |
| CN111529533B (zh) * | 2020-06-05 | 2021-06-11 | 南华大学附属第一医院 | 溴结构域蛋白4抑制剂jq1或其衍生物在制备治疗脓毒症肠屏障损伤药物中的应用 |
| WO2022234298A1 (en) * | 2021-05-06 | 2022-11-10 | Exscientia Ai Limited | Pkc-theta modulators |
| PE20250019A1 (es) * | 2021-05-06 | 2025-01-07 | Exscientia Ai Ltd | MODULADORES DE PKC-theta |
Family Cites Families (52)
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| US2080531A (en) * | 1936-01-08 | 1937-05-18 | United Shoe Machinery Corp | Manufacture of shoes |
| US3314941A (en) * | 1964-06-23 | 1967-04-18 | American Cyanamid Co | Novel substituted pyridodiazepins |
| GB1159487A (en) | 1968-04-04 | 1969-07-23 | Standard Telephones Cables Ltd | Capacitors |
| US4988705A (en) * | 1985-06-13 | 1991-01-29 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
| JP2890448B2 (ja) | 1988-04-26 | 1999-05-17 | 日産化学工業株式会社 | ピラゾロピリジン系メバロノラクトン類 |
| US5100768A (en) * | 1989-05-09 | 1992-03-31 | Kabushiki Kaisha Toshiba | Photosensitive composition |
| JPH03206450A (ja) * | 1990-01-09 | 1991-09-09 | Fuji Photo Film Co Ltd | 新規な色素形成カプラー及びそれを用いたハロゲン化銀カラー写真感光材料及びその処理方法 |
| JPH03271289A (ja) | 1990-03-16 | 1991-12-03 | Nissan Chem Ind Ltd | ピラゾロピリジン誘導体の製造法及びジヒドロピラゾロピリジン誘導体 |
| US5338740A (en) * | 1993-07-13 | 1994-08-16 | Pfizer Inc. | Angiotensin II receptor antagonists |
| US5646330A (en) * | 1995-02-17 | 1997-07-08 | Ciba-Geigy Corporation | Production of enantiomerically enriched ortho-substituted α,α-diaromatic methanols |
| US6194581B1 (en) * | 1995-04-07 | 2001-02-27 | Merck & Co., Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| US6452008B2 (en) * | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| GB9908410D0 (en) * | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| AR029289A1 (es) * | 2000-07-05 | 2003-06-18 | Ishihara Sangyo Kaisha | Derivado de benzoilpiridina o su sal, fungicida que lo contiene como un ingrediente activo, su proceso de produccion e intermediario para producirlo |
| JP2002020386A (ja) | 2000-07-07 | 2002-01-23 | Ono Pharmaceut Co Ltd | ピラゾロピリジン誘導体 |
| DE10035908A1 (de) * | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
| WO2002020500A2 (en) * | 2000-09-01 | 2002-03-14 | Icos Corporation | Materials and methods to potentiate cancer treatment |
| GB0128287D0 (en) | 2001-11-26 | 2002-01-16 | Smithkline Beecham Plc | Novel method and compounds |
| JP2005516927A (ja) * | 2001-12-13 | 2005-06-09 | アボット・ラボラトリーズ | 癌治療用のキナーゼ阻害剤としての３−（フェニル−アルコキシ）−５−（フェニル）−ピリジン誘導体および関連化合物 |
| US20030187026A1 (en) * | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| DE10222550A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Substituierte Benzyl-pyrazolopyridine |
| JPWO2004002531A1 (ja) * | 2002-06-26 | 2005-10-27 | 小野薬品工業株式会社 | 血管の収縮または拡張による疾患治療剤 |
| EP1545515A1 (en) | 2002-08-12 | 2005-06-29 | Sugen, Inc. | 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors |
| US20040242613A1 (en) * | 2003-01-30 | 2004-12-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyrimidine derivatives useful as inhibitors of PKC-theta |
| CA2518398A1 (en) | 2003-03-10 | 2004-09-23 | Schering Corporation | Heterocyclic kinase inhibitors: methods of use and synthesis |
| US20050203067A1 (en) * | 2003-05-12 | 2005-09-15 | Hresko Michelle C. | Pesticidal compositions and methods |
| EP1660087A2 (en) * | 2003-07-22 | 2006-05-31 | Janssen Pharmaceutica N.V. | Quinolinone derivatives as inhibitors of c-fms kinase |
| WO2005044181A2 (en) | 2003-09-09 | 2005-05-19 | Temple University-Of The Commonwealth System Of Higher Education | Protection of tissues and cells from cytotoxic effects of ionizing radiation by abl inhibitors |
| JP4805166B2 (ja) * | 2003-12-22 | 2011-11-02 | バジリア ファルマスーチカ アーゲー | アロイルフランおよびアロイルチオフェン |
| UY29177A1 (es) * | 2004-10-25 | 2006-05-31 | Astex Therapeutics Ltd | Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos |
| ATE554087T1 (de) * | 2004-10-29 | 2012-05-15 | Abbott Lab | Neue kinaseinhibitoren |
| WO2006050076A1 (en) | 2004-10-29 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| EP1812450A2 (en) | 2004-11-10 | 2007-08-01 | Eli Lilly And Company | Tgf-beta inhibitors |
| DE102004061288A1 (de) * | 2004-12-14 | 2006-06-29 | Schering Ag | 3-Amino-Pyrazolo[3,4b]pyridine als Inhibitoren von Proteintyrosinkinasen, deren Herstellung und Verwendung als Arzneimittel |
| PE20061119A1 (es) * | 2005-01-19 | 2006-11-27 | Aventis Pharma Sa | PIRAZOLO PIRIDINAS SUSTITUIDAS COMO INHIBIDORES DE CINASAS FAK, KDR Y Tie |
| WO2006101456A1 (en) | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors |
| RU2387653C2 (ru) * | 2005-05-16 | 2010-04-27 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназ |
| US7846941B2 (en) | 2005-05-17 | 2010-12-07 | Plexxikon, Inc. | Compounds modulating c-kit and c-fms activity and uses therefor |
| DE102005035417A1 (de) | 2005-07-28 | 2007-02-01 | Robert Bosch Gmbh | Entfernungsmessgerät und Verfahren zum Befestigen einer elektrooptischen Einheit an einer Leiterträgereinheit |
| US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| DE102005048897A1 (de) | 2005-10-12 | 2007-04-19 | Sanofi-Aventis Deutschland Gmbh | Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
| WO2007076423A2 (en) | 2005-12-22 | 2007-07-05 | Smithkline Beecham Corporation | INHIBITORS OF Akt ACTIVITY |
| WO2007084667A2 (en) | 2006-01-19 | 2007-07-26 | Osi Pharmaceutical, Inc. | Fused heterobicyclic kinase inhibitors |
| DK3421471T3 (da) * | 2006-04-25 | 2021-06-14 | Astex Therapeutics Ltd | Purin- og deazapurinderivater som farmaceutiske forbindelser |
| TW200815438A (en) | 2006-06-13 | 2008-04-01 | Bayer Schering Pharma Ag | Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| MX337906B (es) | 2006-10-19 | 2016-03-28 | Signal Pharm Llc | Compuestos de heteroarilo, composiciones de los mismos, y su uso como inhibidores de proteina cinasas. |
| JP2008132121A (ja) * | 2006-11-28 | 2008-06-12 | Sanshin Kinzoku Kogyo Kk | 移動ラック装置 |
| EP2118088B1 (en) | 2006-12-20 | 2012-05-30 | Amgen Inc. | Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer |
| WO2008132121A1 (en) * | 2007-04-26 | 2008-11-06 | Glaxo Group Limited | Lh-indazole-3-amine compounds as ikk1 inhibitors |
| TW200924762A (en) | 2007-11-02 | 2009-06-16 | Vertex Pharma | Kinase inhibitors |
-
2008
- 2008-10-31 TW TW097142239A patent/TW200924762A/zh unknown
- 2008-10-31 EP EP08857976A patent/EP2215089B1/en active Active
- 2008-10-31 JP JP2010532265A patent/JP5444239B2/ja not_active Expired - Fee Related
- 2008-10-31 MX MX2010004819A patent/MX2010004819A/es active IP Right Grant
- 2008-10-31 CA CA2704266A patent/CA2704266A1/en not_active Abandoned
- 2008-10-31 KR KR1020107012153A patent/KR20100093552A/ko not_active Withdrawn
- 2008-10-31 CN CN2008801218567A patent/CN101903384A/zh active Pending
- 2008-10-31 ES ES08857976T patent/ES2389992T3/es active Active
- 2008-10-31 AU AU2008331733A patent/AU2008331733A1/en not_active Abandoned
- 2008-10-31 WO PCT/US2008/081933 patent/WO2009073300A1/en not_active Ceased
- 2008-10-31 US US12/262,459 patent/US8173635B2/en not_active Expired - Fee Related
- 2008-10-31 NZ NZ585063A patent/NZ585063A/en not_active IP Right Cessation
- 2008-11-03 CL CL2008003280A patent/CL2008003280A1/es unknown
- 2008-11-03 AR ARP080104815A patent/AR069174A1/es unknown
-
2010
- 2010-04-29 IL IL205458A patent/IL205458A0/en unknown
- 2010-04-30 ZA ZA2010/03050A patent/ZA201003050B/en unknown
-
2011
- 2011-10-18 US US13/275,551 patent/US8367697B2/en not_active Expired - Fee Related
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