CL2008003280A1 - Compuestos derivados de 1h-pirazolo[3,4-b]piridina)-4-aril sustituidas; la composicion farmaceutica que los contiene; y sus procesos de preparacion. - Google Patents

Compuestos derivados de 1h-pirazolo[3,4-b]piridina)-4-aril sustituidas; la composicion farmaceutica que los contiene; y sus procesos de preparacion.

Info

Publication number: CL2008003280A1
Authority: CL; Chile
Prior art keywords: pyrazolo; pyridine; pharmaceutical composition; compounds derived; aryl substituted
Prior art date: 2007-11-02

Application number

CL2008003280A

Other languages

English (en)

Spanish (es)

Inventor

-M Jimenez J

Mortimore M

Collier P

Miller A

young S

Mak C

davis C

Twin H

Brenchley G

Boyall D

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-02

Filing date

2008-11-03

Publication date

2010-01-04

2008-11-03 Application filed by Vertex Pharma filed Critical Vertex Pharma

2010-01-04 Publication of CL2008003280A1 publication Critical patent/CL2008003280A1/es

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
GVLRTOYGRNLSDW-UHFFFAOYSA-N 1h-pyrazolo[3,4-b]pyridine Chemical compound C1=CC=C2C=NNC2=N1 GVLRTOYGRNLSDW-UHFFFAOYSA-N 0.000 title 1
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
102000001253 Protein Kinase Human genes 0.000 abstract 1
-1 [1h-pyrazolo [3,4-b] pyridine-4-yl] -phenyl Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000003463 hyperproliferative effect Effects 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
108060006633 protein kinase Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

CL2008003280A 2007-11-02 2008-11-03 Compuestos derivados de 1h-pirazolo[3,4-b]piridina)-4-aril sustituidas; la composicion farmaceutica que los contiene; y sus procesos de preparacion. CL2008003280A1 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US98487507P	2007-11-02	2007-11-02
US4457508P	2008-04-14	2008-04-14
US10080808P	2008-09-29	2008-09-29

Publications (1)

Publication Number	Publication Date
CL2008003280A1 true CL2008003280A1 (es)	2010-01-04

Family

ID=40220120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2008003280A CL2008003280A1 (es)	2007-11-02	2008-11-03	Compuestos derivados de 1h-pirazolo[3,4-b]piridina)-4-aril sustituidas; la composicion farmaceutica que los contiene; y sus procesos de preparacion.

Country Status (16)

Country	Link
US (2)	US8173635B2 (2)
EP (1)	EP2215089B1 (2)
JP (1)	JP5444239B2 (2)
KR (1)	KR20100093552A (2)
CN (1)	CN101903384A (2)
AR (1)	AR069174A1 (2)
AU (1)	AU2008331733A1 (2)
CA (1)	CA2704266A1 (2)
CL (1)	CL2008003280A1 (2)
ES (1)	ES2389992T3 (2)
IL (1)	IL205458A0 (2)
MX (1)	MX2010004819A (2)
NZ (1)	NZ585063A (2)
TW (1)	TW200924762A (2)
WO (1)	WO2009073300A1 (2)
ZA (1)	ZA201003050B (2)

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EP2118088B1 (en)	2006-12-20	2012-05-30	Amgen Inc.	Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer
WO2008132121A1 (en) *	2007-04-26	2008-11-06	Glaxo Group Limited	Lh-indazole-3-amine compounds as ikk1 inhibitors
TW200924762A (en)	2007-11-02	2009-06-16	Vertex Pharma	Kinase inhibitors

2008
- 2008-10-31 TW TW097142239A patent/TW200924762A/zh unknown
- 2008-10-31 EP EP08857976A patent/EP2215089B1/en active Active
- 2008-10-31 JP JP2010532265A patent/JP5444239B2/ja not_active Expired - Fee Related
- 2008-10-31 MX MX2010004819A patent/MX2010004819A/es active IP Right Grant
- 2008-10-31 CA CA2704266A patent/CA2704266A1/en not_active Abandoned
- 2008-10-31 KR KR1020107012153A patent/KR20100093552A/ko not_active Withdrawn
- 2008-10-31 CN CN2008801218567A patent/CN101903384A/zh active Pending
- 2008-10-31 ES ES08857976T patent/ES2389992T3/es active Active
- 2008-10-31 AU AU2008331733A patent/AU2008331733A1/en not_active Abandoned
- 2008-10-31 WO PCT/US2008/081933 patent/WO2009073300A1/en not_active Ceased
- 2008-10-31 US US12/262,459 patent/US8173635B2/en not_active Expired - Fee Related
- 2008-10-31 NZ NZ585063A patent/NZ585063A/en not_active IP Right Cessation
- 2008-11-03 CL CL2008003280A patent/CL2008003280A1/es unknown
- 2008-11-03 AR ARP080104815A patent/AR069174A1/es unknown
2010
- 2010-04-29 IL IL205458A patent/IL205458A0/en unknown
- 2010-04-30 ZA ZA2010/03050A patent/ZA201003050B/en unknown
2011
- 2011-10-18 US US13/275,551 patent/US8367697B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20090291937A1 (en)	2009-11-26
JP2011502994A (ja)	2011-01-27
JP5444239B2 (ja)	2014-03-19
ZA201003050B (en)	2011-07-27
CN101903384A (zh)	2010-12-01
US8173635B2 (en)	2012-05-08
WO2009073300A1 (en)	2009-06-11
EP2215089A1 (en)	2010-08-11
MX2010004819A (es)	2010-07-05
ES2389992T3 (es)	2012-11-05
EP2215089B1 (en)	2012-06-27
IL205458A0 (en)	2010-12-30
TW200924762A (en)	2009-06-16
KR20100093552A (ko)	2010-08-25
US8367697B2 (en)	2013-02-05
CA2704266A1 (en)	2009-06-11
AU2008331733A1 (en)	2009-06-11
US20120149680A1 (en)	2012-06-14
AR069174A1 (es)	2010-01-06
NZ585063A (en)	2012-05-25

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