JP2013504585A - 細胞外標的化薬物複合体 - Google Patents

細胞外標的化薬物複合体 Download PDF

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JP2013504585A
JP2013504585A JP2012528898A JP2012528898A JP2013504585A JP 2013504585 A JP2013504585 A JP 2013504585A JP 2012528898 A JP2012528898 A JP 2012528898A JP 2012528898 A JP2012528898 A JP 2012528898A JP 2013504585 A JP2013504585 A JP 2013504585A
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antibody
edc
drug
target
linker
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JP2013504585A5 (2
Inventor
ジェイムズ アール． プルーデント，
ジョン エス． トーソン，
ジル ハッチンソン ボレティエリ，
チャールズ アール ハッチンソン，
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セントローズ， エルエルシー
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    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2012528898A 2009-09-09 2010-09-09 細胞外標的化薬物複合体 Withdrawn JP2013504585A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US24077509P 2009-09-09 2009-09-09
US61/240,775 2009-09-09
US28981109P 2009-12-23 2009-12-23
US61/289,811 2009-12-23
US34582010P 2010-05-18 2010-05-18
US61/345,820 2010-05-18
PCT/US2010/048284 WO2011031870A1 (en) 2009-09-09 2010-09-09 Extracellular targeted drug conjugates

Related Child Applications (1)

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JP2016007092A Division JP6158962B2 (ja) 2009-09-09 2016-01-18 細胞外標的化薬物複合体

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JP2013504585A true JP2013504585A (ja) 2013-02-07
JP2013504585A5 JP2013504585A5 (2) 2013-03-21

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JP2012528898A Withdrawn JP2013504585A (ja) 2009-09-09 2010-09-09 細胞外標的化薬物複合体
JP2016007092A Active JP6158962B2 (ja) 2009-09-09 2016-01-18 細胞外標的化薬物複合体
JP2017028938A Pending JP2017088624A (ja) 2009-09-09 2017-02-20 細胞外標的化薬物複合体

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JP2017028938A Pending JP2017088624A (ja) 2009-09-09 2017-02-20 細胞外標的化薬物複合体

Country Status (8)

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US (4) US8470980B2 (2)
EP (1) EP2475391B1 (2)
JP (3) JP2013504585A (2)
AU (1) AU2010292172A1 (2)
CA (1) CA2809819A1 (2)
IL (1) IL218523A0 (2)
IN (1) IN2012DN03025A (2)
WO (1) WO2011031870A1 (2)

Cited By (1)

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JP2017506640A (ja) * 2014-02-14 2017-03-09 セントローズ， エルエルシー 細胞外標的化薬物共役体

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CN103980337B (zh) 2010-01-15 2016-08-24 苏州润新生物科技有限公司 蟾蜍灵衍生物、其药物组合物及用途
CN102167812B (zh) 2010-02-26 2016-04-20 北京科美森医药研发有限公司 聚乙二醇化环巴胺类似物及其制备方法和用途
CN103619865B (zh) 2011-02-02 2016-10-12 苏州润新生物科技有限公司 某些化学个体、组合物及方法
US20140079722A1 (en) * 2011-03-09 2014-03-20 Centrose, Llc Extracellular targeted drug conjugates
EP2715354A4 (en) * 2011-05-27 2015-04-29 Univ Drexel CLEAR MARKING DURING A CANCER SURGERY
CN107080847A (zh) * 2011-06-24 2017-08-22 森彻斯有限公司 细胞外靶向药物缀合物
US20150118290A1 (en) * 2011-08-24 2015-04-30 National Cheng Kung University Method for reducing established metastatic tumor by pharmaceutical composition containing polypeptide
CN104427873B (zh) 2012-04-29 2018-11-06 润新生物公司 某些化学个体、组合物及方法
US9371555B2 (en) 2012-06-01 2016-06-21 Concordia Laboratories Inc. Lighting systems and methods of using lighting systems for in vitro potency assay for photofrin
NZ630363A (en) 2012-07-25 2018-09-28 Celldex Therapeutics Inc Anti-kit antibodies and uses thereof
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