JP2013514345A5 - - Google Patents
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- Publication number
- JP2013514345A5 JP2013514345A5 JP2012543942A JP2012543942A JP2013514345A5 JP 2013514345 A5 JP2013514345 A5 JP 2013514345A5 JP 2012543942 A JP2012543942 A JP 2012543942A JP 2012543942 A JP2012543942 A JP 2012543942A JP 2013514345 A5 JP2013514345 A5 JP 2013514345A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- represented
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28703509P | 2009-12-16 | 2009-12-16 | |
| US61/287,035 | 2009-12-16 | ||
| PCT/IB2010/055596 WO2011073845A1 (en) | 2009-12-16 | 2010-12-06 | N-linked hydroxamic acid derivatives useful as antibacterial agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015142292A Division JP2016006064A (ja) | 2009-12-16 | 2015-07-16 | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514345A JP2013514345A (ja) | 2013-04-25 |
| JP2013514345A5 true JP2013514345A5 (2) | 2014-02-06 |
| JP5793766B2 JP5793766B2 (ja) | 2015-10-14 |
Family
ID=43571291
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543942A Active JP5793766B2 (ja) | 2009-12-16 | 2010-12-06 | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
| JP2015142292A Pending JP2016006064A (ja) | 2009-12-16 | 2015-07-16 | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015142292A Pending JP2016006064A (ja) | 2009-12-16 | 2015-07-16 | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8664401B2 (2) |
| EP (1) | EP2512474B1 (2) |
| JP (2) | JP5793766B2 (2) |
| CA (2) | CA2899583A1 (2) |
| DK (1) | DK2512474T3 (2) |
| ES (1) | ES2525820T3 (2) |
| PL (1) | PL2512474T3 (2) |
| PT (1) | PT2512474E (2) |
| SI (1) | SI2512474T1 (2) |
| WO (1) | WO2011073845A1 (2) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI519508B (zh) | 2007-06-12 | 2016-02-01 | Achaogen Inc | 抗菌劑 |
| JP5524215B2 (ja) | 2008-09-19 | 2014-06-18 | ファイザー・インク | 抗菌剤として有用なヒドロキサム酸誘導体 |
| WO2011073845A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| WO2012031298A2 (en) | 2010-09-03 | 2012-03-08 | Duke University | Ethynylbenzene derivatives |
| ES2626457T3 (es) | 2011-03-07 | 2017-07-25 | Pfizer Inc. | Derivados de fluoro-piridinona útiles como agentes antibacterianos |
| CA2830866A1 (en) * | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| ES2526687T3 (es) | 2011-04-08 | 2015-01-14 | Pfizer Inc. | Derivados de isoxazol útiles como agentes antibacterianos |
| EP2847168A1 (en) * | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| CA2890009C (en) * | 2012-11-08 | 2017-11-28 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| WO2015024021A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Antibacterial compounds |
| US10647664B2 (en) | 2013-08-16 | 2020-05-12 | Duke University | Substituted hydroxamic acid compounds |
| WO2015024016A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | 2-piperidinyl substituted n,3-dihydroxybutanamides |
| JP6434522B2 (ja) | 2013-09-05 | 2018-12-05 | ダウ アグロサイエンシィズ エルエルシー | ホウ素化アレーンを生成する方法 |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| EP2860177A3 (en) * | 2013-09-20 | 2015-06-10 | Bayer Intellectual Property GmbH | Synthesis of functionalized arenes |
| EA030730B1 (ru) | 2013-12-19 | 2018-09-28 | Идорсиа Фармасьютиклз Лтд | Антибактериальные производные 1h-индазола и 1h-индола |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| EP3134401B1 (en) | 2014-04-22 | 2018-06-13 | Novartis AG | Isoxazoline hydroxamic acid derivatives as lpxc inhibitors |
| EP3134405B1 (en) | 2014-04-25 | 2019-08-28 | Pfizer Inc | Heteroaromatic compounds and their use as dopamine d1 ligands |
| CA2946990A1 (en) | 2014-04-28 | 2015-11-05 | Pfizer Inc. | Heterocyclic compounds and their use as dopamine d1 ligands |
| CA2948077A1 (en) * | 2014-05-16 | 2015-11-19 | Actelion Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
| TW201625354A (zh) | 2014-06-16 | 2016-07-16 | 陶氏農業科學公司 | 用於製備氧硼基化芳烴之方法 |
| KR20170086079A (ko) | 2014-11-19 | 2017-07-25 | 액테리온 파마슈티칼 리미티드 | 항균성 벤조티아졸 유도체 |
| DK3233843T3 (da) * | 2014-12-16 | 2019-11-18 | Novartis Ag | Isoxazol-hydraxamsyreforbindelser som LPXC-hæmmere |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105889A1 (es) * | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| EP3386950A1 (en) * | 2015-12-08 | 2018-10-17 | GlaxoSmithKline Intellectual Property Development Limited | Substituted benzazinones as antibacterial compounds |
| WO2017198647A1 (en) * | 2016-05-17 | 2017-11-23 | Idorsia Pharmaceuticals Ltd | 6-(buta-1,3-diyn-1-yl)benzo[d]thiazole derivatives |
| JP6941630B2 (ja) | 2016-06-14 | 2021-09-29 | ノバルティス アーゲー | 抗菌剤としての（ｒ）−４（５−（シクロプロピルエチニル）イソオキサゾール−３−イル）−ｎ−ヒドロキシ−２−メチル−２−（メチルスルホニル）ブタンアミドの結晶形 |
| AR108864A1 (es) | 2016-06-23 | 2018-10-03 | Achaogen Inc | Agentes antibacterianos |
| EP3601259B1 (en) | 2017-03-30 | 2022-02-23 | F. Hoffmann-La Roche AG | Isoquinolines as inhibitors of hpk1 |
| BR112020016270A2 (pt) | 2018-02-10 | 2020-12-15 | Kbp Biosciences Co., Ltd. | Composto atuando como antibióticos |
| JP2021518351A (ja) * | 2018-03-15 | 2021-08-02 | ファイザー・インク | 抗菌剤として有用なピリジノンおよびピリミジノンホスフェートおよびピリミジノンボロネート |
| TW202019905A (zh) | 2018-07-24 | 2020-06-01 | 瑞士商赫孚孟拉羅股份公司 | 異喹啉化合物及其用途 |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| BR112021019656A2 (pt) * | 2019-04-02 | 2022-01-18 | Venatorx Pharmaceuticals Inc | Formas sólidas de um inibidor de beta-lactamase dispensado por via oral e usos das mesmas |
| WO2023015236A2 (en) * | 2021-08-04 | 2023-02-09 | The Research Foundation For The State University Of New York | Composition and method for treatment of gram negative bacterial infection |
| EP4499610B1 (en) * | 2022-03-30 | 2025-12-31 | Zoetis Services LLC | USEFUL INTERMEDIATES FOR THE PREPARATION OF AN LPXC ANALOGUE, AND THEIR PREPARATION PROCESSES |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3995042A (en) * | 1973-09-07 | 1976-11-30 | E. R. Squibb & Sons, Inc. | Pyridine containing compounds |
| US4769461A (en) | 1986-09-16 | 1988-09-06 | American Home Products Corporation | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents |
| US5110831A (en) | 1990-11-30 | 1992-05-05 | Du Pont Merck Pharmaceutical Company | Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors |
| DK1052984T3 (da) | 1998-02-07 | 2004-09-20 | Vernalis Oxford Ltd | Antibakterielle midler |
| GB9925470D0 (en) | 1999-10-27 | 1999-12-29 | Smithkline Beecham Plc | Novel compounds |
| US6852752B2 (en) | 1999-12-17 | 2005-02-08 | Vicuron Pharmaceuticals Inc. | Urea compounds, compositions and methods of use and preparation |
| JPWO2002074298A1 (ja) | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Ｉｌ−６産生阻害剤 |
| ES2180456B1 (es) | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| KR101076018B1 (ko) | 2003-01-08 | 2011-10-21 | 유니버시티 오브 워싱톤 | 항균제 |
| GB0302431D0 (en) | 2003-01-30 | 2003-03-05 | Glaxo Group Ltd | Novel compounds |
| US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| MX2007006961A (es) | 2004-12-10 | 2007-10-04 | Univ Emory | Analogos nucleosidos de ciclobutilo 2' y 3'-sustituidos para el tratamiento de infeccciones virales y proliferacion celular anormal. |
| WO2006118155A1 (ja) | 2005-04-27 | 2006-11-09 | Ishihara Sangyo Kaisha, Ltd. | ビフェニル誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤 |
| US20060258691A1 (en) | 2005-05-13 | 2006-11-16 | Joseph Barbosa | Methods and compositions for improving cognition |
| JP2009520695A (ja) * | 2005-12-15 | 2009-05-28 | ヴィキュロン ファーマシューティカルズ インコーポレイテッド | 抗菌活性を有するｎ−ヒドロキシアミド誘導体 |
| WO2007093904A1 (en) | 2006-02-14 | 2007-08-23 | Pfizer Products Inc. | Benzoxazinone and benzoxazepinone oxazolidinones as antibacterial agents |
| WO2008045671A1 (en) | 2006-10-06 | 2008-04-17 | Janssen Pharmaceutica, N.V. | Matrix metalloprotease inhibitors |
| CN101016270B (zh) | 2006-12-30 | 2012-05-09 | 天津药物研究院 | 取代的哌嗪基苯基异噁唑啉衍生物及其用途 |
| US7879911B2 (en) * | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
| JP5227304B2 (ja) | 2007-02-28 | 2013-07-03 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
| WO2008115262A2 (en) | 2007-03-20 | 2008-09-25 | Curis, Inc. | Hsp90 inhibitors containing a zinc binding moiety |
| WO2010017060A1 (en) | 2008-08-04 | 2010-02-11 | Schering Corporation | Urea derivatives as antibacterial agents |
| JP5455913B2 (ja) | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−ｎ−オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| JP5524215B2 (ja) | 2008-09-19 | 2014-06-18 | ファイザー・インク | 抗菌剤として有用なヒドロキサム酸誘導体 |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2011045703A2 (en) * | 2009-10-13 | 2011-04-21 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| WO2011073845A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| ES2626457T3 (es) | 2011-03-07 | 2017-07-25 | Pfizer Inc. | Derivados de fluoro-piridinona útiles como agentes antibacterianos |
| CA2830866A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| ES2526687T3 (es) | 2011-04-08 | 2015-01-14 | Pfizer Inc. | Derivados de isoxazol útiles como agentes antibacterianos |
-
2010
- 2010-12-06 WO PCT/IB2010/055596 patent/WO2011073845A1/en not_active Ceased
- 2010-12-06 JP JP2012543942A patent/JP5793766B2/ja active Active
- 2010-12-06 US US13/515,607 patent/US8664401B2/en active Active
- 2010-12-06 DK DK10803646.8T patent/DK2512474T3/en active
- 2010-12-06 PL PL10803646T patent/PL2512474T3/pl unknown
- 2010-12-06 CA CA2899583A patent/CA2899583A1/en not_active Abandoned
- 2010-12-06 CA CA2782453A patent/CA2782453C/en active Active
- 2010-12-06 SI SI201030802T patent/SI2512474T1/sl unknown
- 2010-12-06 ES ES10803646.8T patent/ES2525820T3/es active Active
- 2010-12-06 PT PT108036468T patent/PT2512474E/pt unknown
- 2010-12-06 EP EP10803646.8A patent/EP2512474B1/en active Active
-
2014
- 2014-01-14 US US14/154,239 patent/US8846933B2/en active Active
- 2014-07-31 US US14/447,788 patent/US9018384B2/en active Active
-
2015
- 2015-03-12 US US14/656,123 patent/US9180123B2/en active Active
- 2015-07-16 JP JP2015142292A patent/JP2016006064A/ja active Pending
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