JP2014507464A5 - - Google Patents
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- Publication number
- JP2014507464A5 JP2014507464A5 JP2013557190A JP2013557190A JP2014507464A5 JP 2014507464 A5 JP2014507464 A5 JP 2014507464A5 JP 2013557190 A JP2013557190 A JP 2013557190A JP 2013557190 A JP2013557190 A JP 2013557190A JP 2014507464 A5 JP2014507464 A5 JP 2014507464A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- represented
- acceptable salt
- compound according
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- OTNFNNBDWPZFES-LJQANCHMSA-N (2r)-4-[5-fluoro-2-oxo-4-[4-(triazol-2-yl)phenyl]pyridin-1-yl]-n-hydroxy-2-methyl-2-methylsulfonylbutanamide Chemical compound O=C1N(CC[C@](C)(C(=O)NO)S(C)(=O)=O)C=C(F)C(C=2C=CC(=CC=2)N2N=CC=N2)=C1 OTNFNNBDWPZFES-LJQANCHMSA-N 0.000 claims 1
- -1 2-fluoro-4-methoxyphenyl Chemical group 0.000 claims 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449825P | 2011-03-07 | 2011-03-07 | |
| US61/449,825 | 2011-03-07 | ||
| PCT/IB2012/050812 WO2012120397A1 (en) | 2011-03-07 | 2012-02-22 | Fluoro-pyridinone derivatives useful as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507464A JP2014507464A (ja) | 2014-03-27 |
| JP2014507464A5 true JP2014507464A5 (2) | 2014-08-07 |
| JP5620020B2 JP5620020B2 (ja) | 2014-11-05 |
Family
ID=45841548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557190A Expired - Fee Related JP5620020B2 (ja) | 2011-03-07 | 2012-02-22 | 抗菌剤として有用なフルオロ−ピリジノン誘導体 |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US8624034B2 (2) |
| EP (1) | EP2683689B1 (2) |
| JP (1) | JP5620020B2 (2) |
| KR (1) | KR101593288B1 (2) |
| CN (2) | CN104529883A (2) |
| AP (1) | AP3336A (2) |
| AR (1) | AR085615A1 (2) |
| AU (1) | AU2012226473B8 (2) |
| BR (1) | BR112013022536B1 (2) |
| CA (1) | CA2828337C (2) |
| CL (1) | CL2013002417A1 (2) |
| CO (1) | CO6761338A2 (2) |
| CR (1) | CR20130403A (2) |
| CU (1) | CU20130117A7 (2) |
| DO (1) | DOP2013000200A (2) |
| EA (1) | EA024782B1 (2) |
| EC (1) | ECSP13012928A (2) |
| ES (1) | ES2626457T3 (2) |
| GE (1) | GEP20156370B (2) |
| GT (1) | GT201300213A (2) |
| HK (1) | HK1209734A1 (2) |
| IL (1) | IL228100A0 (2) |
| MA (1) | MA34963B1 (2) |
| MX (1) | MX341977B (2) |
| NI (1) | NI201300077A (2) |
| PE (1) | PE20140397A1 (2) |
| PH (1) | PH12013501780A1 (2) |
| SG (1) | SG192766A1 (2) |
| TN (1) | TN2013000353A1 (2) |
| TW (1) | TWI453197B (2) |
| UA (1) | UA107423C2 (2) |
| UY (1) | UY33936A (2) |
| WO (1) | WO2012120397A1 (2) |
| ZA (1) | ZA201306515B (2) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010032147A2 (en) | 2008-09-19 | 2010-03-25 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| DK2512474T3 (en) | 2009-12-16 | 2014-12-01 | Pfizer | N-linked hydroxamic acid derivatives which can be used as antibacterial agents |
| MA34963B1 (fr) | 2011-03-07 | 2014-03-01 | Pfizer | Derives de fluoro-pyridinone utiles en tant qu'agents antibacteriens |
| CA2830866A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| WO2012137094A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
| AR097617A1 (es) * | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| WO2015085238A1 (en) * | 2013-12-05 | 2015-06-11 | The Regents Of The University Of California, A California Corporation | Inhibitors of lpxc |
| AU2014368619B2 (en) * | 2013-12-19 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Antibacterial 1H-indazole and 1H-indole derivatives |
| AR099612A1 (es) * | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| EP3134401B1 (en) | 2014-04-22 | 2018-06-13 | Novartis AG | Isoxazoline hydroxamic acid derivatives as lpxc inhibitors |
| ES2687040T3 (es) | 2014-05-16 | 2018-10-23 | Idorsia Pharmaceuticals Ltd | Derivados antibacterianos de quinazolin4(3H)ona |
| JP6195684B2 (ja) | 2014-06-03 | 2017-09-13 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ピラゾール化合物及びｔ型カルシウムチャンネルブロッカーとしてのそれらの使用 |
| SG11201703992YA (en) | 2014-11-19 | 2017-06-29 | Actelion Pharmaceuticals Ltd | Antibacterial benzothiazole derivatives |
| HRP20192009T1 (hr) | 2014-12-16 | 2020-02-07 | Novartis Ag | Spojevi izoksazol hidroksamske kiseline kao inhibitori lpxc-a |
| CN104876883B (zh) * | 2015-06-05 | 2017-11-28 | 安徽联创生物医药股份有限公司 | 抗失眠药物苏沃雷生中间体的合成方法 |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| SG11201810656WA (en) | 2016-06-14 | 2018-12-28 | Novartis Ag | Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent |
| CN110072521B (zh) | 2016-12-16 | 2022-11-29 | 爱杜西亚药品有限公司 | 包含t型钙通道阻断剂的药物组合 |
| MA47409A (fr) | 2017-02-06 | 2019-12-11 | Idorsia Pharmaceuticals Ltd | Nouveau procédé de synthèse de 1-aryl-1-trifluorométhylcyclopropanes |
| CN111867600A (zh) * | 2018-03-15 | 2020-10-30 | 辉瑞大药厂 | 用作抗菌剂的吡啶酮和嘧啶酮磷酸盐和硼酸盐 |
| US11981696B2 (en) | 2018-03-15 | 2024-05-14 | Pfizer Inc. | Fluoro-pyridinone phosphates and boronates useful as antibacterial agents |
| CN110699312B (zh) * | 2019-11-28 | 2022-08-12 | 西北农林科技大学 | 一种猪种布鲁氏菌bi-1基因缺失菌株及其构建方法和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769461A (en) | 1986-09-16 | 1988-09-06 | American Home Products Corporation | Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents |
| US5110831A (en) | 1990-11-30 | 1992-05-05 | Du Pont Merck Pharmaceutical Company | Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors |
| GB2349884A (en) | 1998-02-07 | 2000-11-15 | British Biotech Pharm | Antibacterial agents |
| GB9925470D0 (en) | 1999-10-27 | 1999-12-29 | Smithkline Beecham Plc | Novel compounds |
| JPWO2002074298A1 (ja) | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Ｉｌ−６産生阻害剤 |
| ES2180456B1 (es) | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| RS52392B (sr) * | 2002-02-14 | 2013-02-28 | Pharmacia Corporation | Supstituisani piridinoni kao modulatori p38 map kinaze |
| CA2851462A1 (en) | 2003-01-08 | 2004-07-29 | University Of Washington | Antibacterial agents |
| GB0302431D0 (en) | 2003-01-30 | 2003-03-05 | Glaxo Group Ltd | Novel compounds |
| MX2007006961A (es) | 2004-12-10 | 2007-10-04 | Univ Emory | Analogos nucleosidos de ciclobutilo 2' y 3'-sustituidos para el tratamiento de infeccciones virales y proliferacion celular anormal. |
| WO2006118155A1 (ja) | 2005-04-27 | 2006-11-09 | Ishihara Sangyo Kaisha, Ltd. | ビフェニル誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤 |
| WO2006124897A2 (en) | 2005-05-13 | 2006-11-23 | Lexicon Genetics Incorporated | Methods and compositions for improving cognition |
| WO2007069020A2 (en) * | 2005-12-15 | 2007-06-21 | Vicuron Pharmaceuticals Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
| WO2008045671A1 (en) | 2006-10-06 | 2008-04-17 | Janssen Pharmaceutica, N.V. | Matrix metalloprotease inhibitors |
| US7879911B2 (en) | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
| WO2008105515A1 (ja) | 2007-02-28 | 2008-09-04 | Taisho Pharmaceutical Co., Ltd. | 新規なヒドロキサム酸誘導体 |
| US20080234297A1 (en) | 2007-03-20 | 2008-09-25 | Changgeng Qian | HSP90 Inhibitors Containing a Zinc Binding Moiety |
| CN101239978A (zh) * | 2008-03-05 | 2008-08-13 | 南方医科大学 | 一种咪唑并吡啶类化合物 |
| EP2315746A1 (en) | 2008-08-04 | 2011-05-04 | Schering Corporation | Urea derivatives as antibacterial agents |
| JP5455913B2 (ja) | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−ｎ−オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| WO2010032147A2 (en) | 2008-09-19 | 2010-03-25 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2010147969A2 (en) * | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| US20120245158A1 (en) * | 2009-06-16 | 2012-09-27 | Xianhai Huang | Gamma secretase modulators |
| DK2512474T3 (en) | 2009-12-16 | 2014-12-01 | Pfizer | N-linked hydroxamic acid derivatives which can be used as antibacterial agents |
| MA34963B1 (fr) | 2011-03-07 | 2014-03-01 | Pfizer | Derives de fluoro-pyridinone utiles en tant qu'agents antibacteriens |
| CA2830866A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| WO2012137094A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
-
2012
- 2012-02-22 MA MA36233A patent/MA34963B1/fr unknown
- 2012-02-22 AU AU2012226473A patent/AU2012226473B8/en active Active
- 2012-02-22 WO PCT/IB2012/050812 patent/WO2012120397A1/en not_active Ceased
- 2012-02-22 BR BR112013022536-0A patent/BR112013022536B1/pt active IP Right Grant
- 2012-02-22 EA EA201391072A patent/EA024782B1/ru not_active IP Right Cessation
- 2012-02-22 AP AP2013007074A patent/AP3336A/xx active
- 2012-02-22 EP EP12709179.1A patent/EP2683689B1/en active Active
- 2012-02-22 UA UAA201310358A patent/UA107423C2/ru unknown
- 2012-02-22 ES ES12709179.1T patent/ES2626457T3/es active Active
- 2012-02-22 PE PE2013002016A patent/PE20140397A1/es not_active Application Discontinuation
- 2012-02-22 MX MX2013010276A patent/MX341977B/es active IP Right Grant
- 2012-02-22 CA CA2828337A patent/CA2828337C/en active Active
- 2012-02-22 CN CN201410611970.5A patent/CN104529883A/zh active Pending
- 2012-02-22 JP JP2013557190A patent/JP5620020B2/ja not_active Expired - Fee Related
- 2012-02-22 PH PH1/2013/501780A patent/PH12013501780A1/en unknown
- 2012-02-22 KR KR1020137026034A patent/KR101593288B1/ko not_active Expired - Fee Related
- 2012-02-22 CN CN201280012230.9A patent/CN103443079B/zh active Active
- 2012-02-22 GE GEAP201213215A patent/GEP20156370B/en unknown
- 2012-02-22 SG SG2013061643A patent/SG192766A1/en unknown
- 2012-03-05 AR ARP120100708A patent/AR085615A1/es unknown
- 2012-03-05 TW TW101107363A patent/TWI453197B/zh not_active IP Right Cessation
- 2012-03-06 UY UY0001033936A patent/UY33936A/es not_active Application Discontinuation
- 2012-03-07 US US13/414,057 patent/US8624034B2/en active Active
-
2013
- 2013-08-20 CR CR20130403A patent/CR20130403A/es unknown
- 2013-08-21 CL CL2013002417A patent/CL2013002417A1/es unknown
- 2013-08-22 IL IL228100A patent/IL228100A0/en unknown
- 2013-08-26 CU CU2013000117A patent/CU20130117A7/es unknown
- 2013-08-27 TN TNP2013000353A patent/TN2013000353A1/fr unknown
- 2013-08-29 ZA ZA2013/06515A patent/ZA201306515B/en unknown
- 2013-09-06 CO CO13211884A patent/CO6761338A2/es active IP Right Grant
- 2013-09-06 GT GT201300213A patent/GT201300213A/es unknown
- 2013-09-06 DO DO2013000200A patent/DOP2013000200A/es unknown
- 2013-09-06 NI NI201300077A patent/NI201300077A/es unknown
- 2013-10-07 EC ECSP13012928 patent/ECSP13012928A/es unknown
- 2013-10-31 US US14/068,956 patent/US8779148B2/en active Active
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2014
- 2014-06-06 HK HK15110423.9A patent/HK1209734A1/xx unknown